Murcko scaffold
Ring system with 4 rings and 27 atoms
180 chemicals on CompoundList share this ring system.
- Rings
- 4
- Scaffold atoms
- 27
- Chemicals
- 180
- With full pages
- 135
Scaffold SMILES
O=C(CN1C(=O)C(=C2SC(=S)NC2=O)c2ccccc21)Nc1ccccc1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 48 of 180 chemicals
![N-(4-Chlorophenyl)-2-[(3Z)-2-oxo-3-(4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene)indol-1-yl]acetamide chemical structure, C19H12ClN3O3S2, CAS 380891-27-0](/s/LHAXOTRXDXQENK-NXVVXOECSA-N.svg)
N-(4-Chlorophenyl)-2-[(3Z)-2-oxo-3-(4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene)indol-1-yl]acetamide
CAS 380891-27-0C19H12ClN3O3S2
![2-[(3Z)-2-Oxo-3-(4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene)indol-1-yl]-N-[3-(trifluoromethyl)phenyl]acetamide chemical structure, C20H12F3N3O3S2, CAS 381681-69-2](/s/DNFPHCAFCHVYES-NXVVXOECSA-N.svg)
2-[(3Z)-2-Oxo-3-(4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene)indol-1-yl]-N-[3-(trifluoromethyl)phenyl]acetamide
CAS 381681-69-2C20H12F3N3O3S2
![N-(4-Fluorophenyl)-2-[(3Z)-2-oxo-3-(4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)-2,3-dihydro-1H-indol-1-yl]acetamide chemical structure, C19H12FN3O3S2, CAS 381717-01-7](/s/QJQLQVLNWLEURO-NXVVXOECSA-N.svg)
N-(4-Fluorophenyl)-2-[(3Z)-2-oxo-3-(4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)-2,3-dihydro-1H-indol-1-yl]acetamide
CAS 381717-01-7C19H12FN3O3S2
![2-[(3Z)-2-Oxo-3-(4-oxo-3-propan-2-yl-2-sulfanylidene-1,3-thiazolidin-5-ylidene)indol-1-yl]-N-phenylacetamide chemical structure, C22H19N3O3S2, CAS 381188-91-6](/s/IPFOYJMTGJDRMI-HNENSFHCSA-N.svg)
2-[(3Z)-2-Oxo-3-(4-oxo-3-propan-2-yl-2-sulfanylidene-1,3-thiazolidin-5-ylidene)indol-1-yl]-N-phenylacetamide
CAS 381188-91-6C22H19N3O3S2
![N-(3-Methylphenyl)-2-[(3Z)-2-oxo-3-(4-oxo-3-prop-2-enyl-2-sulfanylidene-1,3-thiazolidin-5-ylidene)indol-1-yl]acetamide chemical structure, C23H19N3O3S2, CAS 380878-10-4](/s/QRCLRBGKLXCTBB-VXPUYCOJSA-N.svg)
N-(3-Methylphenyl)-2-[(3Z)-2-oxo-3-(4-oxo-3-prop-2-enyl-2-sulfanylidene-1,3-thiazolidin-5-ylidene)indol-1-yl]acetamide
CAS 380878-10-4C23H19N3O3S2
![N-(3-Chlorophenyl)-2-[(3Z)-3-[3-(2-methoxyethyl)-4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene]-2-oxoindol-1-yl]acetamide chemical structure, C22H18ClN3O4S2, CAS 381198-40-9](/s/PROOFPFMESXYBP-HNENSFHCSA-N.svg)
N-(3-Chlorophenyl)-2-[(3Z)-3-[3-(2-methoxyethyl)-4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene]-2-oxoindol-1-yl]acetamide
CAS 381198-40-9C22H18ClN3O4S2
![2-[(3Z)-3-(3-Methyl-4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene)-2-oxoindol-1-yl]-N-phenylacetamide chemical structure, C20H15N3O3S2, CAS 381185-17-7](/s/VXSCQOFVWBGUGZ-MSUUIHNZSA-N.svg)
2-[(3Z)-3-(3-Methyl-4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene)-2-oxoindol-1-yl]-N-phenylacetamide
CAS 381185-17-7C20H15N3O3S2
![2-[(3Z)-3-[3-(3-Methoxypropyl)-4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene]-2-oxoindol-1-yl]-N-(4-methylphenyl)acetamide chemical structure, C24H23N3O4S2, CAS 381207-62-1](/s/LRZNOWSXKWFHCN-MRCUWXFGSA-N.svg)
2-[(3Z)-3-[3-(3-Methoxypropyl)-4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene]-2-oxoindol-1-yl]-N-(4-methylphenyl)acetamide
CAS 381207-62-1C24H23N3O4S2
![2-[(3Z)-3-(3-Ethyl-4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene)-2-oxoindol-1-yl]-N-[3-(trifluoromethyl)phenyl]acetamide chemical structure, C22H16F3N3O3S2, CAS 380891-13-4](/s/TVWMMGZSMLJUSS-ZCXUNETKSA-N.svg)
2-[(3Z)-3-(3-Ethyl-4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene)-2-oxoindol-1-yl]-N-[3-(trifluoromethyl)phenyl]acetamide
CAS 380891-13-4C22H16F3N3O3S2
![N-(4-Methoxyphenyl)-2-{(3Z)-3-[3-(2-methylpropyl)-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene]-2-oxo-2,3-dihydro-1H-indol-1-yl}acetamide chemical structure, C24H23N3O4S2, CAS 381714-60-9](/s/MSJCWXMHIKSMGU-MRCUWXFGSA-N.svg)
N-(4-Methoxyphenyl)-2-{(3Z)-3-[3-(2-methylpropyl)-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene]-2-oxo-2,3-dihydro-1H-indol-1-yl}acetamide
CAS 381714-60-9C24H23N3O4S2
![N-(4-Fluorophenyl)-2-[(3Z)-2-oxo-3-(4-oxo-3-propyl-2-sulfanylidene-1,3-thiazolidin-5-ylidene)indol-1-yl]acetamide chemical structure, C22H18FN3O3S2, CAS 380890-93-7](/s/BYAIEYUVGMTCJC-HNENSFHCSA-N.svg)
N-(4-Fluorophenyl)-2-[(3Z)-2-oxo-3-(4-oxo-3-propyl-2-sulfanylidene-1,3-thiazolidin-5-ylidene)indol-1-yl]acetamide
CAS 380890-93-7C22H18FN3O3S2
![N-(4-Chlorophenyl)-2-[(3Z)-2-oxo-3-(4-oxo-3-propyl-2-sulfanylidene-1,3-thiazolidin-5-ylidene)indol-1-yl]acetamide chemical structure, C22H18ClN3O3S2, CAS 380876-34-6](/s/PWGNUGANIAQTCB-HNENSFHCSA-N.svg)
N-(4-Chlorophenyl)-2-[(3Z)-2-oxo-3-(4-oxo-3-propyl-2-sulfanylidene-1,3-thiazolidin-5-ylidene)indol-1-yl]acetamide
CAS 380876-34-6C22H18ClN3O3S2
![N-(4-Ethoxyphenyl)-2-[(3Z)-3-[3-(2-methylpropyl)-4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene]-2-oxoindol-1-yl]acetamide chemical structure, C25H25N3O4S2, CAS 380878-07-9](/s/ITNCUXODLYMCBV-DQRAZIAOSA-N.svg)
N-(4-Ethoxyphenyl)-2-[(3Z)-3-[3-(2-methylpropyl)-4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene]-2-oxoindol-1-yl]acetamide
CAS 380878-07-9C25H25N3O4S2
![2-[(3Z)-3-(3-Ethyl-4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene)-2-oxoindol-1-yl]-N-(4-fluorophenyl)acetamide chemical structure, C21H16FN3O3S2, CAS 380580-65-4](/s/USHIMFBSHYHLGC-ZCXUNETKSA-N.svg)
2-[(3Z)-3-(3-Ethyl-4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene)-2-oxoindol-1-yl]-N-(4-fluorophenyl)acetamide
CAS 380580-65-4C21H16FN3O3S2
![N-(3-Methylphenyl)-2-[(3Z)-2-oxo-3-(4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene)indol-1-yl]acetamide chemical structure, C20H15N3O3S2, CAS 381681-77-2](/s/GADYJGMTLZNHFP-MSUUIHNZSA-N.svg)
N-(3-Methylphenyl)-2-[(3Z)-2-oxo-3-(4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene)indol-1-yl]acetamide
CAS 381681-77-2C20H15N3O3S2
![3-[(5Z)-5-[1-[2-(4-Fluoroanilino)-2-oxoethyl]-2-oxoindol-3-ylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]propanoic acid chemical structure, C22H16FN3O5S2, CAS 381712-46-5](/s/BLCGWHXFRDSNIK-HNENSFHCSA-N.svg)
3-[(5Z)-5-[1-[2-(4-Fluoroanilino)-2-oxoethyl]-2-oxoindol-3-ylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]propanoic acid
CAS 381712-46-5C22H16FN3O5S2
![N-(4-Methoxyphenyl)-2-[(3Z)-3-[3-(3-methoxypropyl)-4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene]-2-oxoindol-1-yl]acetamide chemical structure, C24H23N3O5S2, CAS 381691-77-6](/s/HQETULVOKDEOCL-MRCUWXFGSA-N.svg)
N-(4-Methoxyphenyl)-2-[(3Z)-3-[3-(3-methoxypropyl)-4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene]-2-oxoindol-1-yl]acetamide
CAS 381691-77-6C24H23N3O5S2
![2-[(3Z)-3-[3-(3-Methoxypropyl)-4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene]-2-oxoindol-1-yl]-N-(3-methylphenyl)acetamide chemical structure, C24H23N3O4S2, CAS 380872-84-4](/s/RNPMQICDTATXBK-MRCUWXFGSA-N.svg)
2-[(3Z)-3-[3-(3-Methoxypropyl)-4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene]-2-oxoindol-1-yl]-N-(3-methylphenyl)acetamide
CAS 380872-84-4C24H23N3O4S2
![2-[(3Z)-2-Oxo-3-(4-oxo-3-propyl-2-thioxo-1,3-thiazolidin-5-ylidene)-2,3-dihydro-1H-indol-1-yl]-N-[3-(trifluoromethyl)phenyl]acetamide chemical structure, C23H18F3N3O3S2, CAS 383370-10-3](/s/WRKHEFGMDMKAKK-HNENSFHCSA-N.svg)
2-[(3Z)-2-Oxo-3-(4-oxo-3-propyl-2-thioxo-1,3-thiazolidin-5-ylidene)-2,3-dihydro-1H-indol-1-yl]-N-[3-(trifluoromethyl)phenyl]acetamide
CAS 383370-10-3C23H18F3N3O3S2
![N-(4-Methylphenyl)-2-[(3Z)-2-oxo-3-(4-oxo-3-propyl-2-sulfanylidene-1,3-thiazolidin-5-ylidene)indol-1-yl]acetamide chemical structure, C23H21N3O3S2, CAS 380547-44-4](/s/GLQRJMWHRAEWNS-VXPUYCOJSA-N.svg)
N-(4-Methylphenyl)-2-[(3Z)-2-oxo-3-(4-oxo-3-propyl-2-sulfanylidene-1,3-thiazolidin-5-ylidene)indol-1-yl]acetamide
CAS 380547-44-4C23H21N3O3S2
![Ethyl 4-[[2-[(3Z)-3-(3-ethyl-4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene)-2-oxoindol-1-yl]acetyl]amino]benzoate chemical structure, C24H21N3O5S2, CAS 380889-80-5](/s/MWVLGNMUVUZMIO-VXPUYCOJSA-N.svg)
Ethyl 4-[[2-[(3Z)-3-(3-ethyl-4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene)-2-oxoindol-1-yl]acetyl]amino]benzoate
CAS 380889-80-5C24H21N3O5S2
![N-(4-Fluorophenyl)-2-[(3Z)-3-[3-(2-methoxyethyl)-4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene]-2-oxoindol-1-yl]acetamide chemical structure, C22H18FN3O4S2, CAS 380595-04-0](/s/VFJHVTPEHBVLAV-HNENSFHCSA-N.svg)
N-(4-Fluorophenyl)-2-[(3Z)-3-[3-(2-methoxyethyl)-4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene]-2-oxoindol-1-yl]acetamide
CAS 380595-04-0C22H18FN3O4S2
![N-(4-Fluorophenyl)-2-[(3Z)-3-[3-(3-methoxypropyl)-4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene]-2-oxoindol-1-yl]acetamide chemical structure, C23H20FN3O4S2, CAS 381709-26-8](/s/JHVCURFDVMVFQO-VXPUYCOJSA-N.svg)
N-(4-Fluorophenyl)-2-[(3Z)-3-[3-(3-methoxypropyl)-4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene]-2-oxoindol-1-yl]acetamide
CAS 381709-26-8C23H20FN3O4S2
![2-[(3Z)-3-[3-(2-Methoxyethyl)-4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene]-2-oxoindol-1-yl]-N-(4-methoxyphenyl)acetamide chemical structure, C23H21N3O5S2, CAS 380890-88-0](/s/BITGIPHSUDVEGO-VXPUYCOJSA-N.svg)
2-[(3Z)-3-[3-(2-Methoxyethyl)-4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene]-2-oxoindol-1-yl]-N-(4-methoxyphenyl)acetamide
CAS 380890-88-0C23H21N3O5S2
- N-(4-Methoxyphenyl)-2-[(3Z)-2-oxo-3-(4-oxo-3-propan-2-yl-2-sulfanylidene-1,3-thiazolidin-5-ylidene)indol-1-yl]acetamide380881-84-5C23H21N3O4S2
- 2-[(3Z)-3-(3-Butyl-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)-2-oxo-2,3-dihydro-1H-indol-1-yl]-N-(4-methylphenyl)acetamide381712-54-5C24H23N3O3S2
- 2-[(3Z)-3-(3-Butyl-4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene)-2-oxoindol-1-yl]-N-(3-methylphenyl)acetamide378765-64-1C24H23N3O3S2
- N-(4-Ethoxyphenyl)-2-{(3Z)-2-oxo-3-[4-oxo-3-(prop-2-en-1-yl)-2-thioxo-1,3-thiazolidin-5-ylidene]-2,3-dihydro-1H-indol-1-yl}acetamide381717-55-1C24H21N3O4S2
- 2-[(3Z)-3-[3-(2-Methoxyethyl)-4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene]-2-oxoindol-1-yl]-N-phenylacetamide381176-30-3C22H19N3O4S2
- N-(3-Chlorophenyl)-2-[(3Z)-3-(3-methyl-4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene)-2-oxoindol-1-yl]acetamide381199-75-3C20H14ClN3O3S2
- 2-[(3Z)-3-(3-Hexyl-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)-2-oxo-2,3-dihydro-1H-indol-1-yl]-N-(4-methylphenyl)acetamide383372-39-2C26H27N3O3S2
- Methyl 4-((((3Z)-3-(3-methyl-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)-2-oxo-2,3-dihydro-1H-indol-1-yl)acetyl)amino)benzoate609796-90-9C22H17N3O5S2
- N-(2,5-Dimethylphenyl)-2-((3Z)-3-(3-isopropyl-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)-2-oxo-2,3-dihydro-1H-indol-1-yl)acetamide609796-94-3C24H23N3O3S2
- N-(2,4-Dimethoxyphenyl)-2-[(3Z)-2-oxo-3-(4-oxo-3-propyl-2-thioxo-1,3-thiazolidin-5-ylidene)-2,3-dihydro-1H-indol-1-yl]acetamide617694-78-7C24H23N3O5S2
- 2-((3Z)-3-(3-Allyl-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)-2-oxo-2,3-dihydro-1H-indol-1-yl)-N-(2,4-dimethoxyphenyl)acetamide617694-82-3C24H21N3O5S2
- N-(2,4-Dimethoxyphenyl)-2-[(3Z)-3-(3-methyl-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)-2-oxo-2,3-dihydro-1H-indol-1-yl]acetamide617694-84-5C22H19N3O5S2
- N-(2,4-Dimethoxyphenyl)-2-((3Z)-3-(3-ethyl-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)-2-oxo-2,3-dihydro-1H-indol-1-yl)acetamide617694-85-6C23H21N3O5S2
- N-(2,4-Dimethoxyphenyl)-2-[(3Z)-3-(3-isopropyl-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)-2-oxo-2,3-dihydro-1H-indol-1-yl]acetamide617694-86-7C24H23N3O5S2
- N-(2-Fluorophenyl)-2-[(3Z)-3-(3-isopropyl-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)-2-oxo-2,3-dihydro-1H-indol-1-yl]acetamide617698-52-9C22H18FN3O3S2
- 2-((3Z)-3-(3-Allyl-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)-2-oxo-2,3-dihydro-1H-indol-1-yl)-N-(2-fluorophenyl)acetamide617698-53-0C22H16FN3O3S2
- N-(2,4-Dimethylphenyl)-2-((3Z)-3-(3-isobutyl-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)-2-oxo-2,3-dihydro-1H-indol-1-yl)acetamide618072-11-0C25H25N3O3S2
- N-(2-Fluorophenyl)-2-[(3Z)-2-oxo-3-(4-oxo-3-propyl-2-thioxo-1,3-thiazolidin-5-ylidene)-2,3-dihydro-1H-indol-1-yl]acetamide618072-53-0C22H18FN3O3S2
- 2-((3Z)-3-(3-Isopropyl-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)-2-oxo-2,3-dihydro-1H-indol-1-yl)-N-(2-methylphenyl)acetamide618072-91-6C23H21N3O3S2
- 2-((3Z)-3-(3-Allyl-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)-2-oxo-2,3-dihydro-1H-indol-1-yl)-N-(3,4-dimethylphenyl)acetamide618075-88-0C24H21N3O3S2
- N-(2,6-Dimethylphenyl)-2-[(3Z)-2-oxo-3-(4-oxo-3-propyl-2-thioxo-1,3-thiazolidin-5-ylidene)-2,3-dihydro-1H-indol-1-yl]acetamide618076-02-1C24H23N3O3S2
- N-(3,4-Dimethylphenyl)-2-((3Z)-3-(3-isobutyl-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)-2-oxo-2,3-dihydro-1H-indol-1-yl)acetamide618076-06-5C25H25N3O3S2
- N-(2-Chlorophenyl)-2-[(3Z)-2-oxo-3-(4-oxo-3-propyl-2-thioxo-1,3-thiazolidin-5-ylidene)-2,3-dihydro-1H-indol-1-yl]acetamide618076-96-3C22H18ClN3O3S2
- N-(2-Chlorophenyl)-2-[(3Z)-3-(3-isobutyl-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)-2-oxo-2,3-dihydro-1H-indol-1-yl]acetamide618077-04-6C23H20ClN3O3S2