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Murcko scaffold

Ring system with 4 rings and 20 atoms

376 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
20
Chemicals
376
With full pages
10
Scaffold SMILES

O=c1[nH]c(=O)c2c(nc3n2CCN3c2ccccc2)[nH]1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=c1[nH]c(=O)c2c(nc3n2CCN3c2ccccc2)[nH]1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 376 chemicals

1,3-Dimethyl-8-(4-methylphenyl)-7,8-dihydro-1H-imidazo[2,1-f]purine-2,4(3H,6H)-dione chemical structure, C16H17N5O2, CAS 32086-94-5
1,3-Dimethyl-8-(4-methylphenyl)-7,8-dihydro-1H-imidazo[2,1-f]purine-2,4(3H,6H)-dione
CAS 32086-94-5C16H17N5O2
8-(3-Chloro-2-methylphenyl)-1-methyl-3-(2-methylallyl)-7,8-dihydro-1H-imidazo[2,1-f]purine-2,4(3H,6H)-dione chemical structure, C19H20ClN5O2, CAS 893965-98-5
8-(3-Chloro-2-methylphenyl)-1-methyl-3-(2-methylallyl)-7,8-dihydro-1H-imidazo[2,1-f]purine-2,4(3H,6H)-dione
CAS 893965-98-5C19H20ClN5O2
6-(3-Chloro-2-methylphenyl)-4-methyl-2-prop-2-enyl-7,8-dihydropurino[7,8-a]imidazole-1,3-dione chemical structure, C18H18ClN5O2, CAS 893965-90-7
6-(3-Chloro-2-methylphenyl)-4-methyl-2-prop-2-enyl-7,8-dihydropurino[7,8-a]imidazole-1,3-dione
CAS 893965-90-7C18H18ClN5O2
1-Methyl-8-(4-methylphenyl)-1,3,5-trihydroimidazolidino[1,2-h]purine-2,4-dione chemical structure, C15H15N5O2, CAS 77351-10-1
1-Methyl-8-(4-methylphenyl)-1,3,5-trihydroimidazolidino[1,2-h]purine-2,4-dione
CAS 77351-10-1C15H15N5O2
7,8-Dihydro-1,3-dimethyl-8-(m-tolyl)-1H-imidazo[2,1-f]purine-2,4(3H,6H)-dione chemical structure, C16H17N5O2, CAS 28557-26-8
7,8-Dihydro-1,3-dimethyl-8-(m-tolyl)-1H-imidazo[2,1-f]purine-2,4(3H,6H)-dione
CAS 28557-26-8C16H17N5O2
7,8-Dihydro-8-(p-methoxyphenyl)-1,3-dimethyl-1H-imidazo[2,1-f]purine-2,4(3H,6H)-dione chemical structure, C16H17N5O3, CAS 28557-28-0
7,8-Dihydro-8-(p-methoxyphenyl)-1,3-dimethyl-1H-imidazo[2,1-f]purine-2,4(3H,6H)-dione
CAS 28557-28-0C16H17N5O3
1,3-Dimethyl-8-phenyl-7,8-dihydro-1H-imidazo[2,1-f]purine-2,4(3H,6H)-dione chemical structure, C15H15N5O2, CAS 97417-33-9
1,3-Dimethyl-8-phenyl-7,8-dihydro-1H-imidazo[2,1-f]purine-2,4(3H,6H)-dione
CAS 97417-33-9C15H15N5O2
1-Methyl-8-phenyl-3-propyl-7,8-dihydro-1H-imidazo[2,1-f]purine-2,4(3H,6H)-dione chemical structure, C17H19N5O2, CAS 330818-15-0
1-Methyl-8-phenyl-3-propyl-7,8-dihydro-1H-imidazo[2,1-f]purine-2,4(3H,6H)-dione
CAS 330818-15-0C17H19N5O2
2-Ethyl-4-methyl-6-(4-methylphenyl)-7,8-dihydropurino[7,8-a]imidazole-1,3-dione chemical structure, C17H19N5O2, CAS 330818-17-2
2-Ethyl-4-methyl-6-(4-methylphenyl)-7,8-dihydropurino[7,8-a]imidazole-1,3-dione
CAS 330818-17-2C17H19N5O2
1-Methyl-8-(4-methylphenyl)-3-propyl-7,8-dihydro-1H-imidazo[2,1-f]purine-2,4(3H,6H)-dione chemical structure, C18H21N5O2, CAS 300703-05-3
1-Methyl-8-(4-methylphenyl)-3-propyl-7,8-dihydro-1H-imidazo[2,1-f]purine-2,4(3H,6H)-dione
CAS 300703-05-3C18H21N5O2
4-Methyl-6-phenyl-7,8-dihydropurino[7,8-a]imidazole-1,3-dione chemical structure, C14H13N5O2, CAS 77351-09-8
4-Methyl-6-phenyl-7,8-dihydropurino[7,8-a]imidazole-1,3-dione
CAS 77351-09-8C14H13N5O2
8-(4-Methoxyphenyl)-1-methyl-7,8-dihydro-1H-imidazo[2,1-f]purine-2,4(3H,6H)-dione chemical structure, C15H15N5O3, CAS 77351-11-2
8-(4-Methoxyphenyl)-1-methyl-7,8-dihydro-1H-imidazo[2,1-f]purine-2,4(3H,6H)-dione
CAS 77351-11-2C15H15N5O3
2-[(Z)-3-Chlorobut-2-enyl]-6-(4-methoxyphenyl)-4-methyl-7,8-dihydropurino[7,8-a]imidazole-1,3-dione chemical structure, C19H20ClN5O3, CAS 330990-64-2
2-[(Z)-3-Chlorobut-2-enyl]-6-(4-methoxyphenyl)-4-methyl-7,8-dihydropurino[7,8-a]imidazole-1,3-dione
CAS 330990-64-2C19H20ClN5O3
Ethyl (1-methyl-2,4-dioxo-8-phenyl-1,2,4,6,7,8-hexahydro-3H-imidazo[2,1-f]purin-3-yl)acetate chemical structure, C18H19N5O4, CAS 302799-01-5
Ethyl (1-methyl-2,4-dioxo-8-phenyl-1,2,4,6,7,8-hexahydro-3H-imidazo[2,1-f]purin-3-yl)acetate
CAS 302799-01-5C18H19N5O4
Ethyl 2-[8-(4-methoxyphenyl)-1-methyl-2,4-dioxo-1,3,5-trihydroimidazolidino[1, 2-h]purin-3-yl]acetate chemical structure, C19H21N5O5, CAS 313549-58-5
Ethyl 2-[8-(4-methoxyphenyl)-1-methyl-2,4-dioxo-1,3,5-trihydroimidazolidino[1, 2-h]purin-3-yl]acetate
CAS 313549-58-5C19H21N5O5
6-(2-Methoxyphenyl)-2,4-dimethyl-7,8-dihydropurino[7,8-a]imidazole-1,3-dione chemical structure, C16H17N5O3, CAS 838866-80-1
6-(2-Methoxyphenyl)-2,4-dimethyl-7,8-dihydropurino[7,8-a]imidazole-1,3-dione
CAS 838866-80-1C16H17N5O3
8-(4-Fluorophenyl)-1-methyl-1,3,5-trihydroimidazolidino[1,2-h]purine-2,4-dione chemical structure, C14H12FN5O2, CAS 838871-20-8
8-(4-Fluorophenyl)-1-methyl-1,3,5-trihydroimidazolidino[1,2-h]purine-2,4-dione
CAS 838871-20-8C14H12FN5O2
1-Methyl-3-(2-oxopropyl)-8-(m-tolyl)-7,8-dihydro-1H-imidazo[2,1-f]purine-2,4(3H,6H)-dione chemical structure, C18H19N5O3, CAS 838884-53-0
1-Methyl-3-(2-oxopropyl)-8-(m-tolyl)-7,8-dihydro-1H-imidazo[2,1-f]purine-2,4(3H,6H)-dione
CAS 838884-53-0C18H19N5O3
2-Ethyl-6-(4-methoxyphenyl)-4-methyl-7,8-dihydropurino[7,8-a]imidazole-1,3-dione chemical structure, C17H19N5O3, CAS 838885-17-9
2-Ethyl-6-(4-methoxyphenyl)-4-methyl-7,8-dihydropurino[7,8-a]imidazole-1,3-dione
CAS 838885-17-9C17H19N5O3
6-(3-Chloro-2-methylphenyl)-4-methyl-7,8-dihydropurino[7,8-a]imidazole-1,3-dione chemical structure, C15H14ClN5O2, CAS 838885-40-8
6-(3-Chloro-2-methylphenyl)-4-methyl-7,8-dihydropurino[7,8-a]imidazole-1,3-dione
CAS 838885-40-8C15H14ClN5O2
8-(3,4-Dimethylphenyl)-1-methyl-1,3,5-trihydroimidazolidino[1,2-h]purine-2,4-d ione chemical structure, C16H17N5O2, CAS 838887-02-8
8-(3,4-Dimethylphenyl)-1-methyl-1,3,5-trihydroimidazolidino[1,2-h]purine-2,4-d ione
CAS 838887-02-8C16H17N5O2
8-(2-Hydroxyphenyl)-1-methyl-1,3,5-trihydroimidazolidino[1,2-h]purine-2,4-dion e chemical structure, C14H13N5O3, CAS 838890-52-1
8-(2-Hydroxyphenyl)-1-methyl-1,3,5-trihydroimidazolidino[1,2-h]purine-2,4-dion e
CAS 838890-52-1C14H13N5O3
6-(3-Chlorophenyl)-2-(2-ethoxyethyl)-4-methyl-7,8-dihydropurino[7,8-a]imidazole-1,3-dione chemical structure, C18H20ClN5O3, CAS 893980-31-9
6-(3-Chlorophenyl)-2-(2-ethoxyethyl)-4-methyl-7,8-dihydropurino[7,8-a]imidazole-1,3-dione
CAS 893980-31-9C18H20ClN5O3
6-(3-Chlorophenyl)-4-methyl-2-prop-2-enyl-7,8-dihydropurino[7,8-a]imidazole-1,3-dione chemical structure, C17H16ClN5O2, CAS 838894-50-1
6-(3-Chlorophenyl)-4-methyl-2-prop-2-enyl-7,8-dihydropurino[7,8-a]imidazole-1,3-dione
CAS 838894-50-1C17H16ClN5O2