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Murcko scaffold

Ring system with 5 rings and 26 atoms

416 chemicals on CompoundList share this ring system.

Rings
5
Scaffold atoms
26
Chemicals
416
With full pages
12
Scaffold SMILES

O=c1[nH]c(=O)c2c(nc3n(-c4ccccc4)c(-c4ccccc4)cn23)[nH]1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=c1[nH]c(=O)c2c(nc3n(-c4ccccc4)c(-c4ccccc4)cn23)[nH]1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 337 to 384 of 416 chemicals

8-(2,5-Dimethoxyphenyl)-1-methyl-3-(1-methyl-2-oxopropyl)-7-phenyl-1,3,5-trihy dro-4-imidazolino[1,2-h]purine-2,4-dione chemical structure, C26H25N5O5, CAS 886901-63-9
8-(2,5-Dimethoxyphenyl)-1-methyl-3-(1-methyl-2-oxopropyl)-7-phenyl-1,3,5-trihy dro-4-imidazolino[1,2-h]purine-2,4-dione
CAS 886901-63-9C26H25N5O5
8-(2,3-Dimethylphenyl)-1-methyl-3-(2-oxopropyl)-7-phenyl-1,3,5-trihydro-4-imid azolino[1,2-h]purine-2,4-dione chemical structure, C25H23N5O3, CAS 923377-53-1
8-(2,3-Dimethylphenyl)-1-methyl-3-(2-oxopropyl)-7-phenyl-1,3,5-trihydro-4-imid azolino[1,2-h]purine-2,4-dione
CAS 923377-53-1C25H23N5O3
8-(2,4-Dimethylphenyl)-1-methyl-3-(2-oxopropyl)-7-phenyl-1,3,5-trihydro-4-imid azolino[1,2-h]purine-2,4-dione chemical structure, C25H23N5O3, CAS 922481-44-5
8-(2,4-Dimethylphenyl)-1-methyl-3-(2-oxopropyl)-7-phenyl-1,3,5-trihydro-4-imid azolino[1,2-h]purine-2,4-dione
CAS 922481-44-5C25H23N5O3
8-(2,5-Dimethylphenyl)-1-methyl-3-(2-oxopropyl)-7-phenyl-1,3,5-trihydro-4-imid azolino[1,2-h]purine-2,4-dione chemical structure, C25H23N5O3, CAS 923489-98-9
8-(2,5-Dimethylphenyl)-1-methyl-3-(2-oxopropyl)-7-phenyl-1,3,5-trihydro-4-imid azolino[1,2-h]purine-2,4-dione
CAS 923489-98-9C25H23N5O3
1,3-Dimethyl-7-phenyl-8-[4-(trifluoromethyl)phenyl]-1H,2H,3H,4H,8H-imidazo[1,2-g]purine-2,4-dione chemical structure, C22H16F3N5O2, CAS 922482-99-3
1,3-Dimethyl-7-phenyl-8-[4-(trifluoromethyl)phenyl]-1H,2H,3H,4H,8H-imidazo[1,2-g]purine-2,4-dione
CAS 922482-99-3C22H16F3N5O2
8-(3,4-Dimethylphenyl)-1-methyl-3-(2-oxopropyl)-7-phenyl-1,3,5-trihydro-4-imid azolino[1,2-h]purine-2,4-dione chemical structure, C25H23N5O3, CAS 923393-04-8
8-(3,4-Dimethylphenyl)-1-methyl-3-(2-oxopropyl)-7-phenyl-1,3,5-trihydro-4-imid azolino[1,2-h]purine-2,4-dione
CAS 923393-04-8C25H23N5O3
7-(4-Chlorophenyl)-1-methyl-8-(p-tolyl)-1H-imidazo[2,1-f]purine-2,4(3H,8H)-dione chemical structure, C21H16ClN5O2, CAS 923461-07-8
7-(4-Chlorophenyl)-1-methyl-8-(p-tolyl)-1H-imidazo[2,1-f]purine-2,4(3H,8H)-dione
CAS 923461-07-8C21H16ClN5O2
7-(4-Fluorophenyl)-1-methyl-8-phenyl-1H-imidazo[2,1-f]purine-2,4(3H,8H)-dione chemical structure, C20H14FN5O2, CAS 922471-93-0
7-(4-Fluorophenyl)-1-methyl-8-phenyl-1H-imidazo[2,1-f]purine-2,4(3H,8H)-dione
CAS 922471-93-0C20H14FN5O2
8-(3,4-Dimethylphenyl)-7-(4-fluorophenyl)-1-methyl-1H-imidazo[2,1-f]purine-2,4(3H,8H)-dione chemical structure, C22H18FN5O2, CAS 923504-92-1
8-(3,4-Dimethylphenyl)-7-(4-fluorophenyl)-1-methyl-1H-imidazo[2,1-f]purine-2,4(3H,8H)-dione
CAS 923504-92-1C22H18FN5O2
8-(3,5-Dimethylphenyl)-7-(4-fluorophenyl)-1-methyl-1H-imidazo[2,1-f]purine-2,4(3H,8H)-dione chemical structure, C22H18FN5O2, CAS 923461-81-8
8-(3,5-Dimethylphenyl)-7-(4-fluorophenyl)-1-methyl-1H-imidazo[2,1-f]purine-2,4(3H,8H)-dione
CAS 923461-81-8C22H18FN5O2
8-(4-Ethylphenyl)-7-(4-fluorophenyl)-1-methyl-1H,2H,3H,4H,8H-imidazo[1,2-g]purine-2,4-dione chemical structure, C22H18FN5O2, CAS 922472-00-2
8-(4-Ethylphenyl)-7-(4-fluorophenyl)-1-methyl-1H,2H,3H,4H,8H-imidazo[1,2-g]purine-2,4-dione
CAS 922472-00-2C22H18FN5O2
8-(2-Ethylphenyl)-7-(4-fluorophenyl)-1-methyl-1H,2H,3H,4H,8H-imidazo[1,2-g]purine-2,4-dione chemical structure, C22H18FN5O2, CAS 923368-46-1
8-(2-Ethylphenyl)-7-(4-fluorophenyl)-1-methyl-1H,2H,3H,4H,8H-imidazo[1,2-g]purine-2,4-dione
CAS 923368-46-1C22H18FN5O2
7-(4-Fluorophenyl)-4-hydroxy-8-(4-methoxyphenyl)-1-methyl-1H-imidazo[2,1-f]purin-2(8H)-one chemical structure, C21H16FN5O3, CAS 895851-01-1
7-(4-Fluorophenyl)-4-hydroxy-8-(4-methoxyphenyl)-1-methyl-1H-imidazo[2,1-f]purin-2(8H)-one
CAS 895851-01-1C21H16FN5O3
7-(4-Fluorophenyl)-8-(2-methoxyphenyl)-1-methyl-1H-imidazo[2,1-f]purine-2,4(3H,8H)-dione chemical structure, C21H16FN5O3, CAS 923504-95-4
7-(4-Fluorophenyl)-8-(2-methoxyphenyl)-1-methyl-1H-imidazo[2,1-f]purine-2,4(3H,8H)-dione
CAS 923504-95-4C21H16FN5O3
7-(4-Fluorophenyl)-8-(3-methoxyphenyl)-1-methyl-1H-imidazo[2,1-f]purine-2,4(3H,8H)-dione chemical structure, C21H16FN5O3, CAS 923461-84-1
7-(4-Fluorophenyl)-8-(3-methoxyphenyl)-1-methyl-1H-imidazo[2,1-f]purine-2,4(3H,8H)-dione
CAS 923461-84-1C21H16FN5O3
8-(4-Chlorophenyl)-7-(4-fluorophenyl)-1-methyl-1H-imidazo[2,1-f]purine-2,4(3H,8H)-dione chemical structure, C20H13ClFN5O2, CAS 922472-07-9
8-(4-Chlorophenyl)-7-(4-fluorophenyl)-1-methyl-1H-imidazo[2,1-f]purine-2,4(3H,8H)-dione
CAS 922472-07-9C20H13ClFN5O2
8-(3-Chlorophenyl)-7-(4-fluorophenyl)-1-methyl-1H,2H,3H,4H,8H-imidazo[1,2-g]purine-2,4-dione chemical structure, C20H13ClFN5O2, CAS 923368-49-4
8-(3-Chlorophenyl)-7-(4-fluorophenyl)-1-methyl-1H,2H,3H,4H,8H-imidazo[1,2-g]purine-2,4-dione
CAS 923368-49-4C20H13ClFN5O2
8-(5-Chloro-2-methylphenyl)-7-(4-fluorophenyl)-1-methyl-1H-imidazo[2,1-f]purine-2,4(3H,8H)-dione chemical structure, C21H15ClFN5O2, CAS 923461-87-4
8-(5-Chloro-2-methylphenyl)-7-(4-fluorophenyl)-1-methyl-1H-imidazo[2,1-f]purine-2,4(3H,8H)-dione
CAS 923461-87-4C21H15ClFN5O2
8-(2,5-Dimethylphenyl)-7-(4-fluorophenyl)-1-methyl-1H-imidazo[2,1-f]purine-2,4(3H,8H)-dione chemical structure, C22H18FN5O2, CAS 923461-90-9
8-(2,5-Dimethylphenyl)-7-(4-fluorophenyl)-1-methyl-1H-imidazo[2,1-f]purine-2,4(3H,8H)-dione
CAS 923461-90-9C22H18FN5O2
8-(3-Chloro-4-methylphenyl)-7-(4-fluorophenyl)-1-methyl-1H-imidazo[2,1-f]purine-2,4(3H,8H)-dione chemical structure, C21H15ClFN5O2, CAS 922472-22-8
8-(3-Chloro-4-methylphenyl)-7-(4-fluorophenyl)-1-methyl-1H-imidazo[2,1-f]purine-2,4(3H,8H)-dione
CAS 922472-22-8C21H15ClFN5O2
8-(2,3-Dimethylphenyl)-7-(4-fluorophenyl)-1-methyl-1H,2H,3H,4H,8H-imidazo[1,2-g]purine-2,4-dione chemical structure, C22H18FN5O2, CAS 923461-99-8
8-(2,3-Dimethylphenyl)-7-(4-fluorophenyl)-1-methyl-1H,2H,3H,4H,8H-imidazo[1,2-g]purine-2,4-dione
CAS 923461-99-8C22H18FN5O2
8-(2,4-Dimethylphenyl)-7-(4-fluorophenyl)-1-methyl-1H-imidazo[2,1-f]purine-2,4(3H,8H)-dione chemical structure, C22H18FN5O2, CAS 922472-46-6
8-(2,4-Dimethylphenyl)-7-(4-fluorophenyl)-1-methyl-1H-imidazo[2,1-f]purine-2,4(3H,8H)-dione
CAS 922472-46-6C22H18FN5O2
8-(3,5-Dimethylphenyl)-7-(4-fluorophenyl)-1,3-dimethyl-1H-imidazo[2,1-f]purine-2,4(3H,8H)-dione chemical structure, C23H20FN5O2, CAS 923462-24-2
8-(3,5-Dimethylphenyl)-7-(4-fluorophenyl)-1,3-dimethyl-1H-imidazo[2,1-f]purine-2,4(3H,8H)-dione
CAS 923462-24-2C23H20FN5O2
8-(3-Chloro-2-methylphenyl)-7-(4-fluorophenyl)-1,3-dimethyl-1H-imidazo[2,1-f]purine-2,4(3H,8H)-dione chemical structure, C22H17ClFN5O2, CAS 922473-22-1
8-(3-Chloro-2-methylphenyl)-7-(4-fluorophenyl)-1,3-dimethyl-1H-imidazo[2,1-f]purine-2,4(3H,8H)-dione
CAS 922473-22-1C22H17ClFN5O2