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Murcko scaffold

Ring system with 7 rings and 38 atoms

8 chemicals on CompoundList share this ring system.

Rings
7
Scaffold atoms
38
Chemicals
8
With full pages
1
Scaffold SMILES

O=[PH]1OCC2OC(n3cnc4cncnc43)CC2O[PH](=O)OCC2OC(n3cnc4cncnc43)CC2O1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=[PH]1OCC2OC(n3cnc4cncnc43)CC2O[PH](=O)OCC2OC(n3cnc4cncnc43)CC2O1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 8 of 8 chemicals

Cyclic di-AMP chemical structure, C20H24N10O12P2, CAS 54447-84-6
Cyclic di-AMP
CAS 54447-84-6C20H24N10O12P2
(2R,3R,3aR,7aR,9R,10R,10aR,14aR)-2,9-Bis(6-amino-9H-purin-9-yl)-3,10-bis((tert-butyldimethylsilyl)oxy)-5,12-dihydroxydecahydrodifuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine 5,12-dioxide chemical structure, C32H52N10O12P2Si2, CAS 1353637-08-7
(2R,3R,3aR,7aR,9R,10R,10aR,14aR)-2,9-Bis(6-amino-9H-purin-9-yl)-3,10-bis((tert-butyldimethylsilyl)oxy)-5,12-dihydroxydecahydrodifuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine 5,12-dioxide
CAS 1353637-08-7C32H52N10O12P2Si2
2'-Fluoro-,3',3'-c-di-AMP chemical structure, C20H22F2N10O10P2, CAS 3036544-46-1
2'-Fluoro-,3',3'-c-di-AMP
CAS 3036544-46-1C20H22F2N10O10P2
c-di-AMP disodium chemical structure, C20H22N10Na2O12P2, CAS 2734909-87-4
c-di-AMP disodium
CAS 2734909-87-4C20H22N10Na2O12P2
9-[17-(6-Aminopurin-9-yl)-9,18-bis[[tert-butyl(dimethyl)silyl]oxy]-3,12-dihydroxy-3,12-dioxo-2,4,7,11,13,16-hexaoxa-3lambda5,12lambda5-diphosphatricyclo[13.3.0.06,10]octadecan-8-yl]purin-6-amine chemical structure, C32H52N10O12P2Si2
9-[17-(6-Aminopurin-9-yl)-9,18-bis[[tert-butyl(dimethyl)silyl]oxy]-3,12-dihydroxy-3,12-dioxo-2,4,7,11,13,16-hexaoxa-3lambda5,12lambda5-diphosphatricyclo[13.3.0.06,10]octadecan-8-yl]purin-6-amine
C32H52N10O12P2Si2
c-di-AMP-Copper(II) trifluoromethanesulfonate chemical structure, C22H24CuF6N10O18P2S2, CAS 2395795-35-2
c-di-AMP-Copper(II) trifluoromethanesulfonate
CAS 2395795-35-2C22H24CuF6N10O18P2S2
cGAMP Disodium [STING Ligand] chemical structure, C20H22N10Na2O13P2
cGAMP Disodium [STING Ligand]
C20H22N10Na2O13P2
Orb3180290 chemical structure, C20H26N12O12P2, CAS 1863930-80-6
Orb3180290
CAS 1863930-80-6C20H26N12O12P2