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Murcko scaffold

Ring system with 4 rings and 24 atoms

25 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
24
Chemicals
25
With full pages
21
Scaffold SMILES

S=c1[nH]nc(-c2ccccc2)n1N=Cc1cccc2ccccc12

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold S=c1[nH]nc(-c2ccccc2)n1N=Cc1cccc2ccccc12

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 25 of 25 chemicals

1-[(1Z)-2-(5-Phenyl-3-sulfanyl(1,2,4-triazol-4-yl))-2-azavinyl]naphthalen-2-ol chemical structure, C19H14N4OS
1-[(1Z)-2-(5-Phenyl-3-sulfanyl(1,2,4-triazol-4-yl))-2-azavinyl]naphthalen-2-ol
C19H14N4OS
5-(3-Ethoxy-PH)-4-(((2-meo-1-naphthyl)methylene)amino)-4H-1,2,4-triazole-3-thiol chemical structure, C22H20N4O2S, CAS 613249-90-4
5-(3-Ethoxy-PH)-4-(((2-meo-1-naphthyl)methylene)amino)-4H-1,2,4-triazole-3-thiol
CAS 613249-90-4C22H20N4O2S
4-(((2-Meo-1-naphthyl)methylene)amino)-5-(3-methyl-PH)-4H-1,2,4-triazole-3-thiol chemical structure, C21H18N4OS, CAS 478256-43-8
4-(((2-Meo-1-naphthyl)methylene)amino)-5-(3-methyl-PH)-4H-1,2,4-triazole-3-thiol
CAS 478256-43-8C21H18N4OS
5-(3-CL-Phenyl)-4-(((2-meo-1-naphthyl)methylene)amino)-4H-1,2,4-triazole-3-thiol chemical structure, C20H15ClN4OS, CAS 478255-47-9
5-(3-CL-Phenyl)-4-(((2-meo-1-naphthyl)methylene)amino)-4H-1,2,4-triazole-3-thiol
CAS 478255-47-9C20H15ClN4OS
5-(2-Fluorophenyl)-4-((1-naphthylmethylene)amino)-4H-1,2,4-triazole-3-thiol chemical structure, C19H13FN4S, CAS 573975-68-5
5-(2-Fluorophenyl)-4-((1-naphthylmethylene)amino)-4H-1,2,4-triazole-3-thiol
CAS 573975-68-5C19H13FN4S
5-(4-Fluorophenyl)-4-((1-naphthylmethylene)amino)-4H-1,2,4-triazole-3-thiol chemical structure, C19H13FN4S, CAS 587002-83-3
5-(4-Fluorophenyl)-4-((1-naphthylmethylene)amino)-4H-1,2,4-triazole-3-thiol
CAS 587002-83-3C19H13FN4S
5-(3-Methoxyphenyl)-4-((1-naphthylmethylene)amino)-4H-1,2,4-triazole-3-thiol chemical structure, C20H16N4OS, CAS 478257-83-9
5-(3-Methoxyphenyl)-4-((1-naphthylmethylene)amino)-4H-1,2,4-triazole-3-thiol
CAS 478257-83-9C20H16N4OS
5-(2-CL-Phenyl)-4-(((2-meo-1-naphthyl)methylene)amino)-4H-1,2,4-triazole-3-thiol chemical structure, C20H15ClN4OS, CAS 478254-58-9
5-(2-CL-Phenyl)-4-(((2-meo-1-naphthyl)methylene)amino)-4H-1,2,4-triazole-3-thiol
CAS 478254-58-9C20H15ClN4OS
5-(2-F-Phenyl)-4-(((2-meo-1-naphthyl)methylene)amino)-4H-1,2,4-triazole-3-thiol chemical structure, C20H15FN4OS, CAS 677304-15-3
5-(2-F-Phenyl)-4-(((2-meo-1-naphthyl)methylene)amino)-4H-1,2,4-triazole-3-thiol
CAS 677304-15-3C20H15FN4OS
4-(((2-Meo-1-naphthyl)methylene)amino)-5-(2-meo-PH)-4H-1,2,4-triazole-3-thiol chemical structure, C21H18N4O2S, CAS 497920-36-2
4-(((2-Meo-1-naphthyl)methylene)amino)-5-(2-meo-PH)-4H-1,2,4-triazole-3-thiol
CAS 497920-36-2C21H18N4O2S
5-(2-Chlorophenyl)-4-((1-naphthylmethylene)amino)-4H-1,2,4-triazole-3-thiol chemical structure, C19H13ClN4S, CAS 478253-88-2
5-(2-Chlorophenyl)-4-((1-naphthylmethylene)amino)-4H-1,2,4-triazole-3-thiol
CAS 478253-88-2C19H13ClN4S
5-(3-Chlorophenyl)-4-((1-naphthylmethylene)amino)-4H-1,2,4-triazole-3-thiol chemical structure, C19H13ClN4S, CAS 478254-68-1
5-(3-Chlorophenyl)-4-((1-naphthylmethylene)amino)-4H-1,2,4-triazole-3-thiol
CAS 478254-68-1C19H13ClN4S
5-(3-Methylphenyl)-4-((1-naphthylmethylene)amino)-4H-1,2,4-triazole-3-thiol chemical structure, C20H16N4S, CAS 478255-59-3
5-(3-Methylphenyl)-4-((1-naphthylmethylene)amino)-4H-1,2,4-triazole-3-thiol
CAS 478255-59-3C20H16N4S
5-(2-Methoxyphenyl)-4-((1-naphthylmethylene)amino)-4H-1,2,4-triazole-3-thiol chemical structure, C20H16N4OS, CAS 478256-53-0
5-(2-Methoxyphenyl)-4-((1-naphthylmethylene)amino)-4H-1,2,4-triazole-3-thiol
CAS 478256-53-0C20H16N4OS
5-(3-Ethoxyphenyl)-4-((1-naphthylmethylene)amino)-4H-1,2,4-triazole-3-thiol chemical structure, C21H18N4OS, CAS 764711-87-7
5-(3-Ethoxyphenyl)-4-((1-naphthylmethylene)amino)-4H-1,2,4-triazole-3-thiol
CAS 764711-87-7C21H18N4OS
(E)-1-(((3-Mercapto-5-(o-tolyl)-4H-1,2,4-triazol-4-yl)imino)methyl)naphthalen-2-ol chemical structure, C20H16N4OS, CAS 489425-32-3
(E)-1-(((3-Mercapto-5-(o-tolyl)-4H-1,2,4-triazol-4-yl)imino)methyl)naphthalen-2-ol
CAS 489425-32-3C20H16N4OS
1-(((3-(2-Fluorophenyl)-5-mercapto-4H-1,2,4-triazol-4-yl)imino)ME)-2-naphthol chemical structure, C19H13FN4OS, CAS 676333-72-5
1-(((3-(2-Fluorophenyl)-5-mercapto-4H-1,2,4-triazol-4-yl)imino)ME)-2-naphthol
CAS 676333-72-5C19H13FN4OS
1-(((3-(3-Chlorophenyl)-5-mercapto-4H-1,2,4-triazol-4-yl)imino)ME)-2-naphthol chemical structure, C19H13ClN4OS, CAS 478255-10-6
1-(((3-(3-Chlorophenyl)-5-mercapto-4H-1,2,4-triazol-4-yl)imino)ME)-2-naphthol
CAS 478255-10-6C19H13ClN4OS
1-(((3-Mercapto-5-(3-methylphenyl)-4H-1,2,4-triazol-4-yl)imino)ME)-2-naphthol chemical structure, C20H16N4OS, CAS 478256-04-1
1-(((3-Mercapto-5-(3-methylphenyl)-4H-1,2,4-triazol-4-yl)imino)ME)-2-naphthol
CAS 478256-04-1C20H16N4OS
1-(((3-(2-Chlorophenyl)-5-mercapto-4H-1,2,4-triazol-4-yl)imino)ME)-2-naphthol chemical structure, C19H13ClN4OS, CAS 160285-06-3
1-(((3-(2-Chlorophenyl)-5-mercapto-4H-1,2,4-triazol-4-yl)imino)ME)-2-naphthol
CAS 160285-06-3C19H13ClN4OS
1-{[(3-Phenyl-5-sulfanyl-4H-1,2,4-triazol-4-yl)imino]methyl}naphthalen-2-ol chemical structure, C19H14N4OS, CAS 160285-03-0
1-{[(3-Phenyl-5-sulfanyl-4H-1,2,4-triazol-4-yl)imino]methyl}naphthalen-2-ol
CAS 160285-03-0C19H14N4OS
1-(((3-(4-F-PH)-5-Mercapto-4H-1,2,4-triazol-4-yl)imino)methyl)-2-naphthol chemical structure, C19H13FN4OS, CAS 577983-00-7
1-(((3-(4-F-PH)-5-Mercapto-4H-1,2,4-triazol-4-yl)imino)methyl)-2-naphthol
CAS 577983-00-7C19H13FN4OS
1-(((3-(3-Ethoxyphenyl)-5-mercapto-4H-1,2,4-triazol-4-yl)imino)ME)-2-naphthol chemical structure, C21H18N4O2S, CAS 613249-71-1
1-(((3-(3-Ethoxyphenyl)-5-mercapto-4H-1,2,4-triazol-4-yl)imino)ME)-2-naphthol
CAS 613249-71-1C21H18N4O2S
1-({[3-(4-tert-Butylphenyl)-5-sulfanyl-4H-1,2,4-triazol-4-yl]imino}methyl)naphthalen-2-ol chemical structure, C23H22N4OS, CAS 6629-57-8
1-({[3-(4-tert-Butylphenyl)-5-sulfanyl-4H-1,2,4-triazol-4-yl]imino}methyl)naphthalen-2-ol
CAS 6629-57-8C23H22N4OS