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Murcko scaffold

Ring system with 3 rings and 21 atoms

9 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
21
Chemicals
9
With full pages
7
Scaffold SMILES

O=C(C=Cc1cccs1)N1CCN(c2ccccc2)CC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(C=Cc1cccs1)N1CCN(c2ccccc2)CC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 9 of 9 chemicals

1-Phenyl-4-[3-(2-thienyl)acryloyl]piperazine chemical structure, C17H18N2OS, CAS 116557-96-1
1-Phenyl-4-[3-(2-thienyl)acryloyl]piperazine
CAS 116557-96-1C17H18N2OS
1-(4-Fluorophenyl)-4-[3-(2-thienyl)acryloyl]piperazine chemical structure, C17H17FN2OS, CAS 354546-68-2
1-(4-Fluorophenyl)-4-[3-(2-thienyl)acryloyl]piperazine
CAS 354546-68-2C17H17FN2OS
(E)-1-[4-(2-Methoxyphenyl)piperazin-1-yl]-3-thiophen-2-ylprop-2-en-1-one chemical structure, C18H20N2O2S, CAS 1164504-99-7
(E)-1-[4-(2-Methoxyphenyl)piperazin-1-yl]-3-thiophen-2-ylprop-2-en-1-one
CAS 1164504-99-7C18H20N2O2S
1-(2-Fluorophenyl)-4-[3-(2-thienyl)acryloyl]piperazine chemical structure, C17H17FN2OS, CAS 1164489-85-3
1-(2-Fluorophenyl)-4-[3-(2-thienyl)acryloyl]piperazine
CAS 1164489-85-3C17H17FN2OS
(2E)-3-(3-Methylthiophen-2-yl)-2-[(4-phenylpiperazin-1-yl)carbonyl]prop-2-enenitrile chemical structure, C19H19N3OS, CAS 363579-60-6
(2E)-3-(3-Methylthiophen-2-yl)-2-[(4-phenylpiperazin-1-yl)carbonyl]prop-2-enenitrile
CAS 363579-60-6C19H19N3OS
(E)-1-[4-(2-Ethoxyphenyl)piperazin-1-yl]-3-thiophen-2-ylprop-2-en-1-one chemical structure, C19H22N2O2S, CAS 352691-60-2
(E)-1-[4-(2-Ethoxyphenyl)piperazin-1-yl]-3-thiophen-2-ylprop-2-en-1-one
CAS 352691-60-2C19H22N2O2S
(2E)-3-(5-Chlorothiophen-2-yl)-2-[(4-phenylpiperazin-1-yl)carbonyl]prop-2-enenitrile chemical structure, C18H16ClN3OS, CAS 1164466-58-3
(2E)-3-(5-Chlorothiophen-2-yl)-2-[(4-phenylpiperazin-1-yl)carbonyl]prop-2-enenitrile
CAS 1164466-58-3C18H16ClN3OS
1-(2,3-Dimethylphenyl)-4-[3-(2-thienyl)acryloyl]piperazine chemical structure, C19H22N2OS, CAS 1164518-37-9
1-(2,3-Dimethylphenyl)-4-[3-(2-thienyl)acryloyl]piperazine
CAS 1164518-37-9C19H22N2OS
(E)-3-(5-Nitrothiophen-2-yl)-1-(4-phenylpiperazin-1-yl)prop-2-en-1-one chemical structure, C17H17N3O3S, CAS 476316-46-8
(E)-3-(5-Nitrothiophen-2-yl)-1-(4-phenylpiperazin-1-yl)prop-2-en-1-one
CAS 476316-46-8C17H17N3O3S