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Murcko scaffold

2-(4-Phenylpiperazin-1-yl)-N-(1,3-thiazol-2-yl)acetamide scaffold

30 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
21
Chemicals
30
With full pages
12
Scaffold SMILES

O=C(CN1CCN(c2ccccc2)CC1)Nc1nccs1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 2-(4-Phenylpiperazin-1-yl)-N-(1,3-thiazol-2-yl)acetamide page
Murcko scaffold O=C(CN1CCN(c2ccccc2)CC1)Nc1nccs1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 30 of 30 chemicals

2-(4-(4-Fluorophenyl)piperazin-1-yl)-N-(1,3-thiazol-2-yl)acetamide chemical structure, C15H17FN4OS, CAS 486457-09-4
2-(4-(4-Fluorophenyl)piperazin-1-yl)-N-(1,3-thiazol-2-yl)acetamide
CAS 486457-09-4C15H17FN4OS
2-[4-(4-Fluorophenyl)piperazin-1-yl]-N-(4-methyl-1,3-thiazol-2-yl)acetamide chemical structure, C16H19FN4OS, CAS 123230-08-0
2-[4-(4-Fluorophenyl)piperazin-1-yl]-N-(4-methyl-1,3-thiazol-2-yl)acetamide
CAS 123230-08-0C16H19FN4OS
2-[4-(4-Methoxyphenyl)piperazin-1-yl]-N-(1,3-thiazol-2-yl)acetamide chemical structure, C16H20N4O2S, CAS 483351-23-1
2-[4-(4-Methoxyphenyl)piperazin-1-yl]-N-(1,3-thiazol-2-yl)acetamide
CAS 483351-23-1C16H20N4O2S
2-[4-(3-Chlorophenyl)piperazin-1-yl]-N-(1,3-thiazol-2-yl)acetamide chemical structure, C15H17ClN4OS, CAS 841270-48-2
2-[4-(3-Chlorophenyl)piperazin-1-yl]-N-(1,3-thiazol-2-yl)acetamide
CAS 841270-48-2C15H17ClN4OS
2-[4-(4-Acetylphenyl)piperazin-1-yl]-N-(1,3-thiazol-2-yl)acetamide chemical structure, C17H20N4O2S, CAS 841270-65-3
2-[4-(4-Acetylphenyl)piperazin-1-yl]-N-(1,3-thiazol-2-yl)acetamide
CAS 841270-65-3C17H20N4O2S
2-[4-(2-Fluorophenyl)piperazin-1-yl]-N-(1,3-thiazol-2-yl)acetamide chemical structure, C15H17FN4OS, CAS 835598-43-1
2-[4-(2-Fluorophenyl)piperazin-1-yl]-N-(1,3-thiazol-2-yl)acetamide
CAS 835598-43-1C15H17FN4OS
2-(4-Phenylpiperazin-1-yl)-N-(1,3-thiazol-2-yl)acetamide chemical structure, C15H18N4OS, CAS 833428-46-9
2-(4-Phenylpiperazin-1-yl)-N-(1,3-thiazol-2-yl)acetamide
CAS 833428-46-9C15H18N4OS
2-[4-(3-Methoxyphenyl)piperazin-1-yl]-N-(1,3-thiazol-2-yl)acetamide chemical structure, C16H20N4O2S, CAS 879626-61-6
2-[4-(3-Methoxyphenyl)piperazin-1-yl]-N-(1,3-thiazol-2-yl)acetamide
CAS 879626-61-6C16H20N4O2S
Ethyl 2-({[4-(4-methoxyphenyl)-1-piperazinyl]acetyl}amino)-4-methyl-1,3-thiazole-5-carboxylate chemical structure, C20H26N4O4S, CAS 896261-38-4
Ethyl 2-({[4-(4-methoxyphenyl)-1-piperazinyl]acetyl}amino)-4-methyl-1,3-thiazole-5-carboxylate
CAS 896261-38-4C20H26N4O4S
2-[4-(3,4-Dichlorophenyl)piperazin-1-yl]-N-(1,3-thiazol-2-yl)acetamide chemical structure, C15H16Cl2N4OS, CAS 896231-67-7
2-[4-(3,4-Dichlorophenyl)piperazin-1-yl]-N-(1,3-thiazol-2-yl)acetamide
CAS 896231-67-7C15H16Cl2N4OS
2-[[2-[4-(2-Fluorophenyl)piperazin-1-yl]acetyl]amino]-N,N,4-trimethyl-1,3-thiazole-5-carboxamide chemical structure, C19H24FN5O2S, CAS 896195-23-6
2-[[2-[4-(2-Fluorophenyl)piperazin-1-yl]acetyl]amino]-N,N,4-trimethyl-1,3-thiazole-5-carboxamide
CAS 896195-23-6C19H24FN5O2S
N,N,4-trimethyl-2-[[2-[4-(2-methylphenyl)piperazin-1-yl]acetyl]amino]-1,3-thiazole-5-carboxamide chemical structure, C20H27N5O2S, CAS 902695-53-8
N,N,4-trimethyl-2-[[2-[4-(2-methylphenyl)piperazin-1-yl]acetyl]amino]-1,3-thiazole-5-carboxamide
CAS 902695-53-8C20H27N5O2S
2-[[2-[4-(3-Chlorophenyl)piperazin-1-yl]acetyl]amino]-N,N,4-trimethyl-1,3-thiazole-5-carboxamide chemical structure, C19H24ClN5O2S, CAS 896233-75-3
2-[[2-[4-(3-Chlorophenyl)piperazin-1-yl]acetyl]amino]-N,N,4-trimethyl-1,3-thiazole-5-carboxamide
CAS 896233-75-3C19H24ClN5O2S
2-[[2-[4-(3-Methoxyphenyl)piperazin-1-yl]acetyl]amino]-N,N,4-trimethyl-1,3-thiazole-5-carboxamide chemical structure, C20H27N5O3S, CAS 885448-58-8
2-[[2-[4-(3-Methoxyphenyl)piperazin-1-yl]acetyl]amino]-N,N,4-trimethyl-1,3-thiazole-5-carboxamide
CAS 885448-58-8C20H27N5O3S
2-[[2-[4-(2-Methoxyphenyl)piperazin-1-yl]acetyl]amino]-N,N,4-trimethyl-1,3-thiazole-5-carboxamide chemical structure, C20H27N5O3S, CAS 885422-37-7
2-[[2-[4-(2-Methoxyphenyl)piperazin-1-yl]acetyl]amino]-N,N,4-trimethyl-1,3-thiazole-5-carboxamide
CAS 885422-37-7C20H27N5O3S
Ethyl 4-methyl-2-{[(4-phenyl-1-piperazinyl)acetyl]amino}-1,3-thiazole-5-carboxylate chemical structure, C19H24N4O3S, CAS 889589-14-4
Ethyl 4-methyl-2-{[(4-phenyl-1-piperazinyl)acetyl]amino}-1,3-thiazole-5-carboxylate
CAS 889589-14-4C19H24N4O3S
2-[4-(2-Methoxyphenyl)piperazin-1-yl]-N-(1,3-thiazol-2-yl)acetamide chemical structure, C16H20N4O2S, CAS 879618-48-1
2-[4-(2-Methoxyphenyl)piperazin-1-yl]-N-(1,3-thiazol-2-yl)acetamide
CAS 879618-48-1C16H20N4O2S
N-(4-Methyl-1,3-thiazol-2-yl)-2-(4-phenylpiperazin-1-yl)acetamide chemical structure, C16H20N4OS, CAS 123229-98-1
N-(4-Methyl-1,3-thiazol-2-yl)-2-(4-phenylpiperazin-1-yl)acetamide
CAS 123229-98-1C16H20N4OS
2-(4-Phenylpiperazin-1-yl)-N-(1,3-thiazol-2-yl)propanamide chemical structure, C16H20N4OS, CAS 916036-21-0
2-(4-Phenylpiperazin-1-yl)-N-(1,3-thiazol-2-yl)propanamide
CAS 916036-21-0C16H20N4OS
N-(4,5-Dimethyl-1,3-thiazol-2-yl)-2-(4-phenylpiperazin-1-yl)acetamide chemical structure, C17H22N4OS, CAS 924973-87-5
N-(4,5-Dimethyl-1,3-thiazol-2-yl)-2-(4-phenylpiperazin-1-yl)acetamide
CAS 924973-87-5C17H22N4OS
N-(4-Methyl-1,3-thiazol-2-yl)-2-(4-phenylpiperazin-1-yl)propanamide chemical structure, C17H22N4OS, CAS 916032-02-5
N-(4-Methyl-1,3-thiazol-2-yl)-2-(4-phenylpiperazin-1-yl)propanamide
CAS 916032-02-5C17H22N4OS
N-(4,5-Dimethyl-1,3-thiazol-2-yl)-2-[4-(2-fluorophenyl)piperazin-1-yl]acetamide chemical structure, C17H21FN4OS, CAS 924964-31-8
N-(4,5-Dimethyl-1,3-thiazol-2-yl)-2-[4-(2-fluorophenyl)piperazin-1-yl]acetamide
CAS 924964-31-8C17H21FN4OS
N-(4,5-Dimethyl-1,3-thiazol-2-yl)-2-[4-(2-fluorophenyl)piperazin-1-yl]propanamide chemical structure, C18H23FN4OS, CAS 924964-32-9
N-(4,5-Dimethyl-1,3-thiazol-2-yl)-2-[4-(2-fluorophenyl)piperazin-1-yl]propanamide
CAS 924964-32-9C18H23FN4OS
2-[4-(2-Fluorophenyl)piperazin-1-yl]-N-(4-methyl-1,3-thiazol-2-yl)acetamide chemical structure, C16H19FN4OS, CAS 123230-06-8
2-[4-(2-Fluorophenyl)piperazin-1-yl]-N-(4-methyl-1,3-thiazol-2-yl)acetamide
CAS 123230-06-8C16H19FN4OS