CompoundList
Sign in
Murcko scaffold

Ring system with 4 rings and 25 atoms

40 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
25
Chemicals
40
With full pages
13
Scaffold SMILES

O=C(c1conc1-c1ccccc1)N1CCN(c2ccccc2)CC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(c1conc1-c1ccccc1)N1CCN(c2ccccc2)CC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 40 of 40 chemicals

[3-(2-Chloro-6-fluorophenyl)-5-methyl-1,2-oxazol-4-yl]-[4-(2-methoxyphenyl)piperazin-1-yl]methanone chemical structure, C22H21ClFN3O3, CAS 497060-57-8
[3-(2-Chloro-6-fluorophenyl)-5-methyl-1,2-oxazol-4-yl]-[4-(2-methoxyphenyl)piperazin-1-yl]methanone
CAS 497060-57-8C22H21ClFN3O3
Methanone, [4-(4-chlorophenyl)-1-piperazinyl][3-(2,6-dichlorophenyl)-5-methyl-4-isoxazolyl]- chemical structure, C21H18Cl3N3O2, CAS 545364-71-4
Methanone, [4-(4-chlorophenyl)-1-piperazinyl][3-(2,6-dichlorophenyl)-5-methyl-4-isoxazolyl]-
CAS 545364-71-4C21H18Cl3N3O2
1-(3-Chlorophenyl)-4-{[3-(2-chlorophenyl)-5-methyl-4-isoxazolyl]carbonyl}piperazine chemical structure, C21H19Cl2N3O2, CAS 321532-06-3
1-(3-Chlorophenyl)-4-{[3-(2-chlorophenyl)-5-methyl-4-isoxazolyl]carbonyl}piperazine
CAS 321532-06-3C21H19Cl2N3O2
1-(3-Chlorophenyl)-4-{[3-(2,6-dichlorophenyl)-5-methyl-4-isoxazolyl]carbonyl}piperazine chemical structure, C21H18Cl3N3O2, CAS 331848-07-8
1-(3-Chlorophenyl)-4-{[3-(2,6-dichlorophenyl)-5-methyl-4-isoxazolyl]carbonyl}piperazine
CAS 331848-07-8C21H18Cl3N3O2
1-{[3-(2,6-Dichlorophenyl)-5-methyl-4-isoxazolyl]carbonyl}-4-(4-fluorophenyl)piperazine chemical structure, C21H18Cl2FN3O2, CAS 326902-93-6
1-{[3-(2,6-Dichlorophenyl)-5-methyl-4-isoxazolyl]carbonyl}-4-(4-fluorophenyl)piperazine
CAS 326902-93-6C21H18Cl2FN3O2
1-[(5-Methyl-3-phenyl-4-isoxazolyl)carbonyl]-4-[3-(trifluoromethyl)phenyl]piperazine chemical structure, C22H20F3N3O2, CAS 355003-62-2
1-[(5-Methyl-3-phenyl-4-isoxazolyl)carbonyl]-4-[3-(trifluoromethyl)phenyl]piperazine
CAS 355003-62-2C22H20F3N3O2
[3-(2-Chlorophenyl)-5-methyl-1,2-oxazol-4-yl]-[4-(2-ethoxyphenyl)piperazin-1-yl]methanone chemical structure, C23H24ClN3O3, CAS 543685-21-8
[3-(2-Chlorophenyl)-5-methyl-1,2-oxazol-4-yl]-[4-(2-ethoxyphenyl)piperazin-1-yl]methanone
CAS 543685-21-8C23H24ClN3O3
[3-(2-Chlorophenyl)-5-methyl-1,2-oxazol-4-yl]-[4-(4-fluorophenyl)piperazin-1-yl]methanone chemical structure, C21H19ClFN3O2, CAS 321532-07-4
[3-(2-Chlorophenyl)-5-methyl-1,2-oxazol-4-yl]-[4-(4-fluorophenyl)piperazin-1-yl]methanone
CAS 321532-07-4C21H19ClFN3O2
1-{[3-(2-Chlorophenyl)-5-methyl-4-isoxazolyl]carbonyl}-4-phenylpiperazine chemical structure, C21H20ClN3O2, CAS 331847-86-0
1-{[3-(2-Chlorophenyl)-5-methyl-4-isoxazolyl]carbonyl}-4-phenylpiperazine
CAS 331847-86-0C21H20ClN3O2
[4-(4-Methoxyphenyl)piperazin-1-yl]-(5-methyl-3-phenyl-1,2-oxazol-4-yl)methanone chemical structure, C22H23N3O3, CAS 801224-44-2
[4-(4-Methoxyphenyl)piperazin-1-yl]-(5-methyl-3-phenyl-1,2-oxazol-4-yl)methanone
CAS 801224-44-2C22H23N3O3
[3-(2-Chloro-6-fluorophenyl)-5-methyl-1,2-oxazol-4-yl]-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]methanone chemical structure, C22H18ClF4N3O2, CAS 332174-90-0
[3-(2-Chloro-6-fluorophenyl)-5-methyl-1,2-oxazol-4-yl]-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]methanone
CAS 332174-90-0C22H18ClF4N3O2
[4-(2,3-Dimethylphenyl)piperazin-1-yl]-(5-methyl-3-phenyl-1,2-oxazol-4-yl)methanone chemical structure, C23H25N3O2, CAS 313392-55-1
[4-(2,3-Dimethylphenyl)piperazin-1-yl]-(5-methyl-3-phenyl-1,2-oxazol-4-yl)methanone
CAS 313392-55-1C23H25N3O2
Ethanone, 1-[4-[4-[[3-(2-chlorophenyl)-5-methyl-4-isoxazolyl]carbonyl]-1-piperazinyl]phenyl]- chemical structure, C23H22ClN3O3, CAS 775300-34-0
Ethanone, 1-[4-[4-[[3-(2-chlorophenyl)-5-methyl-4-isoxazolyl]carbonyl]-1-piperazinyl]phenyl]-
CAS 775300-34-0C23H22ClN3O3
[3-(2,6-Dichlorophenyl)-5-methyl-1,2-oxazol-4-yl]-[4-(2-fluorophenyl)piperazin-1-yl]methanone chemical structure, C21H18Cl2FN3O2, CAS 442564-97-8
[3-(2,6-Dichlorophenyl)-5-methyl-1,2-oxazol-4-yl]-[4-(2-fluorophenyl)piperazin-1-yl]methanone
CAS 442564-97-8C21H18Cl2FN3O2
[3-(2,6-Dichlorophenyl)-5-methyl-1,2-oxazol-4-yl]-[4-(2,3-dimethylphenyl)piperazin-1-yl]methanone chemical structure, C23H23Cl2N3O2, CAS 349614-20-6
[3-(2,6-Dichlorophenyl)-5-methyl-1,2-oxazol-4-yl]-[4-(2,3-dimethylphenyl)piperazin-1-yl]methanone
CAS 349614-20-6C23H23Cl2N3O2
[3-(2-Chlorophenyl)-5-methyl-1,2-oxazol-4-yl]-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]methanone chemical structure, C22H19ClF3N3O2, CAS 332174-85-3
[3-(2-Chlorophenyl)-5-methyl-1,2-oxazol-4-yl]-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]methanone
CAS 332174-85-3C22H19ClF3N3O2
(5-Methyl-3-phenyl-1,2-oxazol-4-yl)-(4-phenylpiperazin-1-yl)methanone chemical structure, C21H21N3O2, CAS 303135-76-4
(5-Methyl-3-phenyl-1,2-oxazol-4-yl)-(4-phenylpiperazin-1-yl)methanone
CAS 303135-76-4C21H21N3O2
Benzonitrile, 4-[4-[[3-(2,6-dichlorophenyl)-5-methyl-4-isoxazolyl]carbonyl]-1-piperazinyl]- chemical structure, C22H18Cl2N4O2, CAS 883042-07-7
Benzonitrile, 4-[4-[[3-(2,6-dichlorophenyl)-5-methyl-4-isoxazolyl]carbonyl]-1-piperazinyl]-
CAS 883042-07-7C22H18Cl2N4O2
[3-(2,6-Dichlorophenyl)-5-methyl-1,2-oxazol-4-yl]-[4-(4-nitrophenyl)piperazin-1-yl]methanone chemical structure, C21H18Cl2N4O4, CAS 331848-28-3
[3-(2,6-Dichlorophenyl)-5-methyl-1,2-oxazol-4-yl]-[4-(4-nitrophenyl)piperazin-1-yl]methanone
CAS 331848-28-3C21H18Cl2N4O4
(5-Methyl-3-phenyl-1,2-oxazol-4-yl)-[4-(4-nitrophenyl)piperazin-1-yl]methanone chemical structure, C21H20N4O4, CAS 313392-70-0
(5-Methyl-3-phenyl-1,2-oxazol-4-yl)-[4-(4-nitrophenyl)piperazin-1-yl]methanone
CAS 313392-70-0C21H20N4O4
Nucleozin chemical structure, C21H19ClN4O4, CAS 341001-38-5
Nucleozin
CAS 341001-38-5C21H19ClN4O4
[4-(4-Chloro-2-nitrophenyl)piperazin-1-yl]-(5-methyl-3-phenyl-1,2-oxazol-4-yl)methanone chemical structure, C21H19ClN4O4, CAS 312536-58-6
[4-(4-Chloro-2-nitrophenyl)piperazin-1-yl]-(5-methyl-3-phenyl-1,2-oxazol-4-yl)methanone
CAS 312536-58-6C21H19ClN4O4
[4-(4-Chloro-2-nitrophenyl)piperazin-1-yl]-[3-(2-chlorophenyl)-5-methyl-1,2-oxazol-4-yl]methanone chemical structure, C21H18Cl2N4O4, CAS 312537-31-8
[4-(4-Chloro-2-nitrophenyl)piperazin-1-yl]-[3-(2-chlorophenyl)-5-methyl-1,2-oxazol-4-yl]methanone
CAS 312537-31-8C21H18Cl2N4O4
3-(2,6-Dichlorophenyl)-5-methylisoxazol-4-yl 4-(3-(trifluoromethyl)phenyl)piperazinyl ketone chemical structure, C22H18Cl2F3N3O2, CAS 378753-06-1
3-(2,6-Dichlorophenyl)-5-methylisoxazol-4-yl 4-(3-(trifluoromethyl)phenyl)piperazinyl ketone
CAS 378753-06-1C22H18Cl2F3N3O2