Murcko scaffold
Ring system with 4 rings and 26 atoms
36 chemicals on CompoundList share this ring system.
- Rings
- 4
- Scaffold atoms
- 26
- Chemicals
- 36
- With full pages
- 2
Scaffold SMILES
O=S(=O)(c1cscc1-c1ccccc1)N1CCN(c2ccccc2)CC1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 36 of 36 chemicals
![Ethyl 3-{[4-(2-fluorophenyl)piperazin-1-yl]sulfonyl}-4-(4-methylphenyl)thiophene-2-carboxylate chemical structure, C24H25FN2O4S2, CAS 946269-00-7](/s/DMTMWDUZERIIMC-UHFFFAOYSA-N.svg)
Ethyl 3-{[4-(2-fluorophenyl)piperazin-1-yl]sulfonyl}-4-(4-methylphenyl)thiophene-2-carboxylate
CAS 946269-00-7C24H25FN2O4S2
![Methyl 4-(4-methylphenyl)-3-[(4-phenylpiperazin-1-yl)sulfonyl]thiophene-2-carboxylate chemical structure, C23H24N2O4S2, CAS 941978-66-1](/s/UGQALQHFMAASTI-UHFFFAOYSA-N.svg)
Methyl 4-(4-methylphenyl)-3-[(4-phenylpiperazin-1-yl)sulfonyl]thiophene-2-carboxylate
CAS 941978-66-1C23H24N2O4S2
![Methyl 3-{[4-(2,4-dimethylphenyl)piperazin-1-yl]sulfonyl}-4-(4-methylphenyl)thiophene-2-carboxylate chemical structure, C25H28N2O4S2, CAS 941935-79-1](/s/IIPXEWWUFJXKCS-UHFFFAOYSA-N.svg)
Methyl 3-{[4-(2,4-dimethylphenyl)piperazin-1-yl]sulfonyl}-4-(4-methylphenyl)thiophene-2-carboxylate
CAS 941935-79-1C25H28N2O4S2
![Methyl 3-{[4-(4-fluorophenyl)piperazin-1-yl]sulfonyl}-4-(4-methylphenyl)thiophene-2-carboxylate chemical structure, C23H23FN2O4S2, CAS 941888-68-2](/s/HUAIDPQKNJTJQT-UHFFFAOYSA-N.svg)
Methyl 3-{[4-(4-fluorophenyl)piperazin-1-yl]sulfonyl}-4-(4-methylphenyl)thiophene-2-carboxylate
CAS 941888-68-2C23H23FN2O4S2
![Methyl 3-{[4-(3-chlorophenyl)piperazin-1-yl]sulfonyl}-4-(4-methylphenyl)thiophene-2-carboxylate chemical structure, C23H23ClN2O4S2, CAS 941935-82-6](/s/NNKBITUGJPDKGJ-UHFFFAOYSA-N.svg)
Methyl 3-{[4-(3-chlorophenyl)piperazin-1-yl]sulfonyl}-4-(4-methylphenyl)thiophene-2-carboxylate
CAS 941935-82-6C23H23ClN2O4S2
![Methyl 3-{[4-(4-methoxyphenyl)piperazin-1-yl]sulfonyl}-4-(4-methylphenyl)thiophene-2-carboxylate chemical structure, C24H26N2O5S2, CAS 941978-72-9](/s/IDBVFMQNTZKERH-UHFFFAOYSA-N.svg)
Methyl 3-{[4-(4-methoxyphenyl)piperazin-1-yl]sulfonyl}-4-(4-methylphenyl)thiophene-2-carboxylate
CAS 941978-72-9C24H26N2O5S2
![Methyl 3-{[4-(3-methoxyphenyl)piperazin-1-yl]sulfonyl}-4-(4-methylphenyl)thiophene-2-carboxylate chemical structure, C24H26N2O5S2, CAS 941935-85-9](/s/DPXIMWYBLCGWPO-UHFFFAOYSA-N.svg)
Methyl 3-{[4-(3-methoxyphenyl)piperazin-1-yl]sulfonyl}-4-(4-methylphenyl)thiophene-2-carboxylate
CAS 941935-85-9C24H26N2O5S2
![Methyl 3-{[4-(4-acetylphenyl)piperazin-1-yl]sulfonyl}-4-(4-methylphenyl)thiophene-2-carboxylate chemical structure, C25H26N2O5S2, CAS 941888-74-0](/s/LJYGQVIHPAXUQY-UHFFFAOYSA-N.svg)
Methyl 3-{[4-(4-acetylphenyl)piperazin-1-yl]sulfonyl}-4-(4-methylphenyl)thiophene-2-carboxylate
CAS 941888-74-0C25H26N2O5S2
![Methyl 3-{[4-(2-fluorophenyl)piperazin-1-yl]sulfonyl}-4-(4-methylphenyl)thiophene-2-carboxylate chemical structure, C23H23FN2O4S2, CAS 941888-77-3](/s/XCYGWMYZAUTJIT-UHFFFAOYSA-N.svg)
Methyl 3-{[4-(2-fluorophenyl)piperazin-1-yl]sulfonyl}-4-(4-methylphenyl)thiophene-2-carboxylate
CAS 941888-77-3C23H23FN2O4S2
![Ethyl 4-(4-methylphenyl)-3-[(4-phenylpiperazin-1-yl)sulfonyl]thiophene-2-carboxylate chemical structure, C24H26N2O4S2, CAS 946322-88-9](/s/YLFRYCASQOXTLQ-UHFFFAOYSA-N.svg)
Ethyl 4-(4-methylphenyl)-3-[(4-phenylpiperazin-1-yl)sulfonyl]thiophene-2-carboxylate
CAS 946322-88-9C24H26N2O4S2
![Methyl 3-{[4-(4-methoxyphenyl)piperazin-1-yl]sulfonyl}-4-phenylthiophene-2-carboxylate chemical structure, C23H24N2O5S2, CAS 899965-92-5](/s/VXIDNFQUJHHYTD-UHFFFAOYSA-N.svg)
Methyl 3-{[4-(4-methoxyphenyl)piperazin-1-yl]sulfonyl}-4-phenylthiophene-2-carboxylate
CAS 899965-92-5C23H24N2O5S2
![Methyl 3-{[4-(4-acetylphenyl)piperazin-1-yl]sulfonyl}-4-phenylthiophene-2-carboxylate chemical structure, C24H24N2O5S2, CAS 899949-65-6](/s/ZKZBXDPZCPVDME-UHFFFAOYSA-N.svg)
Methyl 3-{[4-(4-acetylphenyl)piperazin-1-yl]sulfonyl}-4-phenylthiophene-2-carboxylate
CAS 899949-65-6C24H24N2O5S2
![Ethyl 4-phenyl-3-[(4-phenylpiperazin-1-yl)sulfonyl]thiophene-2-carboxylate chemical structure, C23H24N2O4S2, CAS 932353-85-0](/s/MONRYIVNOQOXSK-UHFFFAOYSA-N.svg)
Ethyl 4-phenyl-3-[(4-phenylpiperazin-1-yl)sulfonyl]thiophene-2-carboxylate
CAS 932353-85-0C23H24N2O4S2
![Methyl 3-{[4-(4-chlorophenyl)piperazin-1-yl]sulfonyl}-4-phenylthiophene-2-carboxylate chemical structure, C22H21ClN2O4S2, CAS 899725-12-3](/s/NCHWAGCZIHQISD-UHFFFAOYSA-N.svg)
Methyl 3-{[4-(4-chlorophenyl)piperazin-1-yl]sulfonyl}-4-phenylthiophene-2-carboxylate
CAS 899725-12-3C22H21ClN2O4S2
![Methyl 3-{[4-(3-chlorophenyl)piperazin-1-yl]sulfonyl}-4-phenylthiophene-2-carboxylate chemical structure, C22H21ClN2O4S2, CAS 899949-64-5](/s/NYUAFVAQRZNZPY-UHFFFAOYSA-N.svg)
Methyl 3-{[4-(3-chlorophenyl)piperazin-1-yl]sulfonyl}-4-phenylthiophene-2-carboxylate
CAS 899949-64-5C22H21ClN2O4S2
![Methyl 3-{[4-(5-chloro-2-methylphenyl)piperazin-1-yl]sulfonyl}-4-phenylthiophene-2-carboxylate chemical structure, C23H23ClN2O4S2, CAS 899725-47-4](/s/JCSJCZNFPOKQLB-UHFFFAOYSA-N.svg)
Methyl 3-{[4-(5-chloro-2-methylphenyl)piperazin-1-yl]sulfonyl}-4-phenylthiophene-2-carboxylate
CAS 899725-47-4C23H23ClN2O4S2
![Ethyl 3-{[4-(4-fluorophenyl)piperazin-1-yl]sulfonyl}-4-phenylthiophene-2-carboxylate chemical structure, C23H23FN2O4S2, CAS 899724-34-6](/s/TYYNYZPGERCJAS-UHFFFAOYSA-N.svg)
Ethyl 3-{[4-(4-fluorophenyl)piperazin-1-yl]sulfonyl}-4-phenylthiophene-2-carboxylate
CAS 899724-34-6C23H23FN2O4S2
![Ethyl 3-{[4-(2-fluorophenyl)piperazin-1-yl]sulfonyl}-4-phenylthiophene-2-carboxylate chemical structure, C23H23FN2O4S2, CAS 899972-17-9](/s/AYVKUWAZKSJSQY-UHFFFAOYSA-N.svg)
Ethyl 3-{[4-(2-fluorophenyl)piperazin-1-yl]sulfonyl}-4-phenylthiophene-2-carboxylate
CAS 899972-17-9C23H23FN2O4S2
![Methyl 3-{[4-(4-chlorophenyl)piperazin-1-yl]sulfonyl}-4-(4-methylphenyl)thiophene-2-carboxylate chemical structure, C23H23ClN2O4S2, CAS 941935-91-7](/s/UUBKKZQASAUZTM-UHFFFAOYSA-N.svg)
Methyl 3-{[4-(4-chlorophenyl)piperazin-1-yl]sulfonyl}-4-(4-methylphenyl)thiophene-2-carboxylate
CAS 941935-91-7C23H23ClN2O4S2
![Ethyl 3-{[4-(3-methoxyphenyl)piperazin-1-yl]sulfonyl}-4-phenylthiophene-2-carboxylate chemical structure, C24H26N2O5S2, CAS 932464-00-1](/s/CPQZWEPOQJHIFS-UHFFFAOYSA-N.svg)
Ethyl 3-{[4-(3-methoxyphenyl)piperazin-1-yl]sulfonyl}-4-phenylthiophene-2-carboxylate
CAS 932464-00-1C24H26N2O5S2
![Methyl 3-{[4-(2,5-dimethylphenyl)piperazin-1-yl]sulfonyl}-4-(4-methylphenyl)thiophene-2-carboxylate chemical structure, C25H28N2O4S2, CAS 941935-88-2](/s/VRDOOIUOASAKAF-UHFFFAOYSA-N.svg)
Methyl 3-{[4-(2,5-dimethylphenyl)piperazin-1-yl]sulfonyl}-4-(4-methylphenyl)thiophene-2-carboxylate
CAS 941935-88-2C25H28N2O4S2
![Methyl 3-{[4-(2,3-dimethylphenyl)piperazin-1-yl]sulfonyl}-4-(4-methylphenyl)thiophene-2-carboxylate chemical structure, C25H28N2O4S2, CAS 941978-78-5](/s/GNUDZKPWCMBFML-UHFFFAOYSA-N.svg)
Methyl 3-{[4-(2,3-dimethylphenyl)piperazin-1-yl]sulfonyl}-4-(4-methylphenyl)thiophene-2-carboxylate
CAS 941978-78-5C25H28N2O4S2
![Methyl 3-{[3-methyl-4-(3-methylphenyl)piperazin-1-yl]sulfonyl}-4-(4-methylphenyl)thiophene-2-carboxylate chemical structure, C25H28N2O4S2, CAS 941888-80-8](/s/KCPQKHRRPIGBOI-UHFFFAOYSA-N.svg)
Methyl 3-{[3-methyl-4-(3-methylphenyl)piperazin-1-yl]sulfonyl}-4-(4-methylphenyl)thiophene-2-carboxylate
CAS 941888-80-8C25H28N2O4S2
![Methyl 3-{[4-(2,4-dimethylphenyl)piperazin-1-yl]sulfonyl}-4-phenylthiophene-2-carboxylate chemical structure, C24H26N2O4S2, CAS 899965-91-4](/s/XCLYQTSMQUTGEG-UHFFFAOYSA-N.svg)
Methyl 3-{[4-(2,4-dimethylphenyl)piperazin-1-yl]sulfonyl}-4-phenylthiophene-2-carboxylate
CAS 899965-91-4C24H26N2O4S2
- Methyl 3-{[4-(4-fluorophenyl)piperazin-1-yl]sulfonyl}-4-phenylthiophene-2-carboxylate899977-29-8C22H21FN2O4S2
- Methyl 3-{[4-(2,5-dimethylphenyl)piperazin-1-yl]sulfonyl}-4-phenylthiophene-2-carboxylate899725-10-1C24H26N2O4S2
- Methyl 3-{[4-(2-fluorophenyl)piperazin-1-yl]sulfonyl}-4-phenylthiophene-2-carboxylate899965-93-6C22H21FN2O4S2
- Methyl 3-{[4-(2,3-dimethylphenyl)piperazin-1-yl]sulfonyl}-4-phenylthiophene-2-carboxylate899977-33-4C24H26N2O4S2
- Ethyl 3-{[4-(2,4-dimethylphenyl)piperazin-1-yl]sulfonyl}-4-phenylthiophene-2-carboxylate899972-15-7C25H28N2O4S2
- Ethyl 3-{[4-(2,3-dimethylphenyl)piperazin-1-yl]sulfonyl}-4-phenylthiophene-2-carboxylate899724-36-8C25H28N2O4S2
- Ethyl 3-{[4-(4-acetylphenyl)piperazin-1-yl]sulfonyl}-4-phenylthiophene-2-carboxylate932353-88-3C25H26N2O5S2
- Ethyl 3-{[4-(2,5-dimethylphenyl)piperazin-1-yl]sulfonyl}-4-phenylthiophene-2-carboxylate932519-79-4C25H28N2O4S2
- Ethyl 3-{[3-methyl-4-(3-methylphenyl)piperazin-1-yl]sulfonyl}-4-phenylthiophene-2-carboxylate932464-04-5C25H28N2O4S2
- Ethyl 3-{[4-(4-fluorophenyl)piperazin-1-yl]sulfonyl}-4-(4-methylphenyl)thiophene-2-carboxylate1105208-90-9C24H25FN2O4S2
- Ethyl 3-{[4-(2,3-dimethylphenyl)piperazin-1-yl]sulfonyl}-4-(4-methylphenyl)thiophene-2-carboxylate1105237-53-3C26H30N2O4S2
- Ethyl 3-{[4-(2,5-dimethylphenyl)piperazin-1-yl]sulfonyl}-4-(4-methylphenyl)thiophene-2-carboxylate946322-91-4C26H30N2O4S2
Related scaffolds
Same ring framework with different atoms or bond orders
O=C(c1conc1-c1ccccc1)N1CCN(c2ccccc2)CC113 chemicals
O=C(C1CNCC1c1ccccc1)N1CCC(c2ccccc2)CC11 chemical
O=C1NS(=O)(=O)C(c2ccccc2)=C1Nc1ccc(N2CCCCC2)cc11 chemical
O=C(C1CCN(c2ccncn2)CC1)N1N=CCC1c1ccccc11 chemical![Scaffold c1ccc(-c2n[nH]cc2CN2CCN(c3ncccn3)CC2)cc1](/scaffold/KYIHMGOAZJFMDQ-UHFFFAOYSA-N/structure.svg)
c1ccc(-c2n[nH]cc2CN2CCN(c3ncccn3)CC2)cc11 chemical
O=C(c1ccnn1-c1ccccc1)N1CCN(c2ccccc2)CC11 chemical
O=C(c1conc1-c1ccccc1)N1CCN(c2ncccn2)CC11 chemical
O=S(=O)(c1ccc(-c2ccccc2)cc1)N1CCSC1c1ccccc11 chemical
O=C(c1nocc1-c1ccccc1)N1CCN(c2ccccc2)CC11 chemical