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Murcko scaffold

Ring system with 4 rings and 25 atoms

6 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
25
Chemicals
6
With full pages
3
Scaffold SMILES

O=C(c1ccccc1-c1nc(-c2ccccc2)no1)N1CCNCC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(c1ccccc1-c1nc(-c2ccccc2)no1)N1CCNCC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 6 of 6 chemicals

[2-[3-(4-Methylphenyl)-1,2,4-oxadiazol-5-yl]phenyl]-(4-methylpiperazin-1-yl)methanone chemical structure, C21H22N4O2, CAS 850803-27-9
[2-[3-(4-Methylphenyl)-1,2,4-oxadiazol-5-yl]phenyl]-(4-methylpiperazin-1-yl)methanone
CAS 850803-27-9C21H22N4O2
(4-Methylpiperazin-1-yl)-[2-(3-phenyl-1,2,4-oxadiazol-5-yl)phenyl]methanone chemical structure, C20H20N4O2, CAS 862199-83-5
(4-Methylpiperazin-1-yl)-[2-(3-phenyl-1,2,4-oxadiazol-5-yl)phenyl]methanone
CAS 862199-83-5C20H20N4O2
1-{2-[3-(4-Chlorophenyl)-1,2,4-oxadiazol-5-yl]benzoyl}-4-methylpiperazine chemical structure, C20H19ClN4O2, CAS 831234-80-1
1-{2-[3-(4-Chlorophenyl)-1,2,4-oxadiazol-5-yl]benzoyl}-4-methylpiperazine
CAS 831234-80-1C20H19ClN4O2
[2-[3-(4-Methoxyphenyl)-1,2,4-oxadiazol-5-yl]phenyl]-(4-methylpiperazin-1-yl)methanone chemical structure, C21H22N4O3, CAS 850186-98-0
[2-[3-(4-Methoxyphenyl)-1,2,4-oxadiazol-5-yl]phenyl]-(4-methylpiperazin-1-yl)methanone
CAS 850186-98-0C21H22N4O3
[2-[3-(2-Chlorophenyl)-1,2,4-oxadiazol-5-yl]phenyl]-(4-methylpiperazin-1-yl)methanone chemical structure, C20H19ClN4O2, CAS 850193-23-6
[2-[3-(2-Chlorophenyl)-1,2,4-oxadiazol-5-yl]phenyl]-(4-methylpiperazin-1-yl)methanone
CAS 850193-23-6C20H19ClN4O2
[2-[3-(2-Methoxyphenyl)-1,2,4-oxadiazol-5-yl]phenyl]-(4-methylpiperazin-1-yl)methanone chemical structure, C21H22N4O3, CAS 830354-17-1
[2-[3-(2-Methoxyphenyl)-1,2,4-oxadiazol-5-yl]phenyl]-(4-methylpiperazin-1-yl)methanone
CAS 830354-17-1C21H22N4O3