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Murcko scaffold

Ring system with 4 rings and 26 atoms

18 chemicals on CompoundList share this ring system.

Rings: 4
Scaffold atoms: 26
Chemicals: 18
With full pages: 2

Scaffold SMILES

O=C1NCC(C(=O)c2ccccc2)C(c2ccc(-c3ccccc3)o2)N1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=C1NCC(C(=O)c2ccccc2)C(c2ccc(-c3ccccc3)o2)N1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 18 of 18 chemicals

5-Benzoyl-4-hydroxy-6-[5-(3-nitrophenyl)furan-2-yl]-4-(trifluoromethyl)-1,3-diazinan-2-one chemical structure, C22H16F3N3O6, CAS 474255-19-1

5-Benzoyl-4-hydroxy-6-[5-(3-nitrophenyl)furan-2-yl]-4-(trifluoromethyl)-1,3-diazinan-2-one

CAS 474255-19-1C₂₂H₁₆F₃N₃O₆

6-[5-(3-Chlorophenyl)furan-2-yl]-5-(4-fluorobenzoyl)-4-hydroxy-4-(trifluoromethyl)-1,3-diazinan-2-one chemical structure, C22H15ClF4N2O4, CAS 474255-38-4

6-[5-(3-Chlorophenyl)furan-2-yl]-5-(4-fluorobenzoyl)-4-hydroxy-4-(trifluoromethyl)-1,3-diazinan-2-one

CAS 474255-38-4C₂₂H₁₅ClF₄N₂O₄

5-Benzoyl-6-[5-(4-chlorophenyl)furan-2-yl]-4-hydroxy-4-(trifluoromethyl)-1,3-diazinan-2-one chemical structure, C22H16ClF3N2O4, CAS 474255-48-6

5-Benzoyl-6-[5-(4-chlorophenyl)furan-2-yl]-4-hydroxy-4-(trifluoromethyl)-1,3-diazinan-2-one

CAS 474255-48-6C₂₂H₁₆ClF₃N₂O₄

4-Hydroxy-5-(4-methylbenzoyl)-6-[5-(2-nitrophenyl)furan-2-yl]-4-(trifluoromethyl)-1,3-diazinan-2-one chemical structure, C23H18F3N3O6, CAS 474303-04-3

4-Hydroxy-5-(4-methylbenzoyl)-6-[5-(2-nitrophenyl)furan-2-yl]-4-(trifluoromethyl)-1,3-diazinan-2-one

CAS 474303-04-3C₂₃H₁₈F₃N₃O₆

6-[5-(2,3-Dichlorophenyl)furan-2-yl]-4-hydroxy-5-(4-methoxybenzoyl)-4-(trifluoromethyl)-1,3-diazinan-2-one chemical structure, C23H17Cl2F3N2O5, CAS 1005066-28-3

6-[5-(2,3-Dichlorophenyl)furan-2-yl]-4-hydroxy-5-(4-methoxybenzoyl)-4-(trifluoromethyl)-1,3-diazinan-2-one

CAS 1005066-28-3C₂₃H₁₇Cl₂F₃N₂O₅

5-(4-Chlorobenzoyl)-6-[5-(4-fluorophenyl)-2-furyl]-4-hydroxy-4-(trifluoromethyl)tetrahydropyrimidin-2(1H)-one chemical structure, C22H15ClF4N2O4, CAS 1005041-22-4

5-(4-Chlorobenzoyl)-6-[5-(4-fluorophenyl)-2-furyl]-4-hydroxy-4-(trifluoromethyl)tetrahydropyrimidin-2(1H)-one

CAS 1005041-22-4C₂₂H₁₅ClF₄N₂O₄

5-(4-Chlorobenzoyl)-4-hydroxy-6-[5-(2-nitrophenyl)furan-2-yl]-4-(trifluoromethyl)-1,3-diazinan-2-one chemical structure, C22H15ClF3N3O6, CAS 1005096-14-9

5-(4-Chlorobenzoyl)-4-hydroxy-6-[5-(2-nitrophenyl)furan-2-yl]-4-(trifluoromethyl)-1,3-diazinan-2-one

CAS 1005096-14-9C₂₂H₁₅ClF₃N₃O₆

5-(4-Fluorobenzoyl)-4-hydroxy-6-[5-(2-nitrophenyl)furan-2-yl]-4-(trifluoromethyl)-1,3-diazinan-2-one chemical structure, C22H15F4N3O6, CAS 1005159-53-4

5-(4-Fluorobenzoyl)-4-hydroxy-6-[5-(2-nitrophenyl)furan-2-yl]-4-(trifluoromethyl)-1,3-diazinan-2-one

CAS 1005159-53-4C₂₂H₁₅F₄N₃O₆

6-[5-(2,4-Dichlorophenyl)-2-furyl]-5-(4-fluorobenzoyl)-4-hydroxy-4-(trifluoromethyl)tetrahydropyrimidin-2(1H)-one chemical structure, C22H14Cl2F4N2O4, CAS 1005106-70-6

6-[5-(2,4-Dichlorophenyl)-2-furyl]-5-(4-fluorobenzoyl)-4-hydroxy-4-(trifluoromethyl)tetrahydropyrimidin-2(1H)-one

CAS 1005106-70-6C₂₂H₁₄Cl₂F₄N₂O₄

5-(4-Chlorobenzoyl)-6-[5-(2-chlorophenyl)-2-furyl]-4-hydroxy-4-(trifluoromethyl)tetrahydropyrimidin-2(1H)-one chemical structure, C22H15Cl2F3N2O4, CAS 1005106-03-5

5-(4-Chlorobenzoyl)-6-[5-(2-chlorophenyl)-2-furyl]-4-hydroxy-4-(trifluoromethyl)tetrahydropyrimidin-2(1H)-one

CAS 1005106-03-5C₂₂H₁₅Cl₂F₃N₂O₄

{6-[5-(2,3-Dichlorophenyl)furan-2-yl]-2,4-dihydroxy-4-(trifluoromethyl)-1,4,5,6-tetrahydropyrimidin-5-yl}(phenyl)methanone chemical structure, C22H15Cl2F3N2O4, CAS 1005281-22-0

{6-[5-(2,3-Dichlorophenyl)furan-2-yl]-2,4-dihydroxy-4-(trifluoromethyl)-1,4,5,6-tetrahydropyrimidin-5-yl}(phenyl)methanone

CAS 1005281-22-0C₂₂H₁₅Cl₂F₃N₂O₄

5-Benzoyl-6-[5-(3,4-dichlorophenyl)-2-furyl]-4-hydroxy-4-(trifluoromethyl)tetrahydropyrimidin-2(1H)-one chemical structure, C22H15Cl2F3N2O4, CAS 1212355-77-5

5-Benzoyl-6-[5-(3,4-dichlorophenyl)-2-furyl]-4-hydroxy-4-(trifluoromethyl)tetrahydropyrimidin-2(1H)-one

CAS 1212355-77-5C₂₂H₁₅Cl₂F₃N₂O₄

5-(4-Chlorobenzoyl)-6-[5-(3,4-dichlorophenyl)-2-furyl]-4-hydroxy-4-(trifluoromethyl)tetrahydropyrimidin-2(1H)-one chemical structure, C22H14Cl3F3N2O4, CAS 1005089-23-5

5-(4-Chlorobenzoyl)-6-[5-(3,4-dichlorophenyl)-2-furyl]-4-hydroxy-4-(trifluoromethyl)tetrahydropyrimidin-2(1H)-one

CAS 1005089-23-5C₂₂H₁₄Cl₃F₃N₂O₄

5-Benzoyl-6-[5-(3-chlorophenyl)furan-2-yl]-4-hydroxy-4-(trifluoromethyl)-1,3-diazinan-2-one chemical structure, C22H16ClF3N2O4, CAS 1024451-02-2

5-Benzoyl-6-[5-(3-chlorophenyl)furan-2-yl]-4-hydroxy-4-(trifluoromethyl)-1,3-diazinan-2-one

CAS 1024451-02-2C₂₂H₁₆ClF₃N₂O₄

5-[(4-Chlorophenyl)carbonyl]-6-[5-(2,4-dichlorophenyl)furan-2-yl]-4-hydroxy-4-(trifluoromethyl)tetrahydropyrimidin-2(1H)-one chemical structure, C22H14Cl3F3N2O4, CAS 1005123-55-6

5-[(4-Chlorophenyl)carbonyl]-6-[5-(2,4-dichlorophenyl)furan-2-yl]-4-hydroxy-4-(trifluoromethyl)tetrahydropyrimidin-2(1H)-one

CAS 1005123-55-6C₂₂H₁₄Cl₃F₃N₂O₄

6-[5-(4-Fluorophenyl)furan-2-yl]-4-hydroxy-5-[(4-methylphenyl)carbonyl]-4-(trifluoromethyl)tetrahydropyrimidin-2(1H)-one chemical structure, C23H18F4N2O4, CAS 1212385-17-5

6-[5-(4-Fluorophenyl)furan-2-yl]-4-hydroxy-5-[(4-methylphenyl)carbonyl]-4-(trifluoromethyl)tetrahydropyrimidin-2(1H)-one

CAS 1212385-17-5C₂₃H₁₈F₄N₂O₄

5-Benzoyl-6-[5-(2-chlorophenyl)-2-furyl]-4-hydroxy-4-(trifluoromethyl)tetrahydropyrimidin-2(1H)-one chemical structure, C22H16ClF3N2O4, CAS 1217695-89-0

5-Benzoyl-6-[5-(2-chlorophenyl)-2-furyl]-4-hydroxy-4-(trifluoromethyl)tetrahydropyrimidin-2(1H)-one

CAS 1217695-89-0C₂₂H₁₆ClF₃N₂O₄

6-[5-(4-Acetylphenyl)-2-furanyl]-5-benzoyltetrahydro-4-hydroxy-4-(trifluoromethyl)-2(1H)-pyrimidinone chemical structure, C24H19F3N2O5, CAS 1217618-22-8

6-[5-(4-Acetylphenyl)-2-furanyl]-5-benzoyltetrahydro-4-hydroxy-4-(trifluoromethyl)-2(1H)-pyrimidinone

CAS 1217618-22-8C₂₄H₁₉F₃N₂O₅