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Murcko scaffold

Ring system with 4 rings and 24 atoms

30 chemicals on CompoundList share this ring system.

Rings: 4
Scaffold atoms: 24
Chemicals: 30
With full pages: 7

Scaffold SMILES

O=C(C1=CC(=O)N(c2ccon2)C1c1ccccc1)c1cccs1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=C(C1=CC(=O)N(c2ccon2)C1c1ccccc1)c1cccs1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 30 of 30 chemicals

3-Hydroxy-5-(4-hydroxy-3-methoxyphenyl)-1-(5-methylisoxazol-3-yl)-4-(thiophene-2-carbonyl)-1H-pyrrol-2(5H)-one chemical structure, C20H16N2O6S, CAS 618873-15-7

3-Hydroxy-5-(4-hydroxy-3-methoxyphenyl)-1-(5-methylisoxazol-3-yl)-4-(thiophene-2-carbonyl)-1H-pyrrol-2(5H)-one

CAS 618873-15-7C₂₀H₁₆N₂O₆S

3-Hydroxy-5-(3-methoxyphenyl)-1-(5-methylisoxazol-3-yl)-4-(thiophene-2-carbonyl)-1H-pyrrol-2(5H)-one chemical structure, C20H16N2O5S, CAS 618873-21-5

3-Hydroxy-5-(3-methoxyphenyl)-1-(5-methylisoxazol-3-yl)-4-(thiophene-2-carbonyl)-1H-pyrrol-2(5H)-one

CAS 618873-21-5C₂₀H₁₆N₂O₅S

(4E)-5-(2,5-Dimethoxyphenyl)-4-[hydroxy(thiophen-2-yl)methylidene]-1-(5-methyl-1,2-oxazol-3-yl)pyrrolidine-2,3-dione chemical structure, C21H18N2O6S, CAS 618873-39-5

(4E)-5-(2,5-Dimethoxyphenyl)-4-[hydroxy(thiophen-2-yl)methylidene]-1-(5-methyl-1,2-oxazol-3-yl)pyrrolidine-2,3-dione

CAS 618873-39-5C₂₁H₁₈N₂O₆S

(4E)-5-(4-Chlorophenyl)-4-[hydroxy(thiophen-2-yl)methylidene]-1-(5-methyl-1,2-oxazol-3-yl)pyrrolidine-2,3-dione chemical structure, C19H13ClN2O4S, CAS 618872-97-2

(4E)-5-(4-Chlorophenyl)-4-[hydroxy(thiophen-2-yl)methylidene]-1-(5-methyl-1,2-oxazol-3-yl)pyrrolidine-2,3-dione

CAS 618872-97-2C₁₉H₁₃ClN₂O₄S

(4E)-5-(3-Ethoxy-4-hydroxyphenyl)-4-[hydroxy(thiophen-2-yl)methylidene]-1-(5-methyl-1,2-oxazol-3-yl)pyrrolidine-2,3-dione chemical structure, C21H18N2O6S, CAS 618873-17-9

(4E)-5-(3-Ethoxy-4-hydroxyphenyl)-4-[hydroxy(thiophen-2-yl)methylidene]-1-(5-methyl-1,2-oxazol-3-yl)pyrrolidine-2,3-dione

CAS 618873-17-9C₂₁H₁₈N₂O₆S

(4E)-4-[Hydroxy(thiophen-2-yl)methylidene]-1-(5-methyl-1,2-oxazol-3-yl)-5-(3,4,5-trimethoxyphenyl)pyrrolidine-2,3-dione chemical structure, C22H20N2O7S, CAS 618873-45-3

(4E)-4-[Hydroxy(thiophen-2-yl)methylidene]-1-(5-methyl-1,2-oxazol-3-yl)-5-(3,4,5-trimethoxyphenyl)pyrrolidine-2,3-dione

CAS 618873-45-3C₂₂H₂₀N₂O₇S

5-(2-Fluorophenyl)-3-hydroxy-1-(5-methylisoxazol-3-yl)-4-(thiophene-2-carbonyl)-1H-pyrrol-2(5H)-one chemical structure, C19H13FN2O4S, CAS 618872-91-6

5-(2-Fluorophenyl)-3-hydroxy-1-(5-methylisoxazol-3-yl)-4-(thiophene-2-carbonyl)-1H-pyrrol-2(5H)-one

CAS 618872-91-6C₁₉H₁₃FN₂O₄S

3-Hydroxy-5-(4-hydroxyphenyl)-1-(5-methylisoxazol-3-yl)-4-(thiophene-2-carbonyl)-1H-pyrrol-2(5H)-one chemical structure, C19H14N2O5S, CAS 618873-13-5

3-Hydroxy-5-(4-hydroxyphenyl)-1-(5-methylisoxazol-3-yl)-4-(thiophene-2-carbonyl)-1H-pyrrol-2(5H)-one

CAS 618873-13-5C₁₉H₁₄N₂O₅S

5-(3,4-Dichlorophenyl)-3-hydroxy-1-(5-methyl-1,2-oxazol-3-yl)-4-(thiophene-2-carbonyl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C19H12Cl2N2O4S, CAS 618872-99-4

5-(3,4-Dichlorophenyl)-3-hydroxy-1-(5-methyl-1,2-oxazol-3-yl)-4-(thiophene-2-carbonyl)-2,5-dihydro-1H-pyrrol-2-one

CAS 618872-99-4C₁₉H₁₂Cl₂N₂O₄S

(4E)-5-(4-Ethoxy-3-methoxyphenyl)-4-[hydroxy(thiophen-2-yl)methylidene]-1-(5-methyl-1,2-oxazol-3-yl)pyrrolidine-2,3-dione chemical structure, C22H20N2O6S, CAS 618873-43-1

(4E)-5-(4-Ethoxy-3-methoxyphenyl)-4-[hydroxy(thiophen-2-yl)methylidene]-1-(5-methyl-1,2-oxazol-3-yl)pyrrolidine-2,3-dione

CAS 618873-43-1C₂₂H₂₀N₂O₆S

3-Hydroxy-5-(4-isopropoxyphenyl)-1-(5-methylisoxazol-3-yl)-4-(thiophene-2-carbonyl)-1H-pyrrol-2(5H)-one chemical structure, C22H20N2O5S, CAS 618873-31-7

3-Hydroxy-5-(4-isopropoxyphenyl)-1-(5-methylisoxazol-3-yl)-4-(thiophene-2-carbonyl)-1H-pyrrol-2(5H)-one

CAS 618873-31-7C₂₂H₂₀N₂O₅S

5-(4-Ethoxyphenyl)-3-hydroxy-1-(5-methylisoxazol-3-yl)-4-(thiophene-2-carbonyl)-1H-pyrrol-2(5H)-one chemical structure, C21H18N2O5S, CAS 618873-25-9

5-(4-Ethoxyphenyl)-3-hydroxy-1-(5-methylisoxazol-3-yl)-4-(thiophene-2-carbonyl)-1H-pyrrol-2(5H)-one

CAS 618873-25-9C₂₁H₁₈N₂O₅S

5-(3-Chlorophenyl)-3-hydroxy-1-(5-methylisoxazol-3-yl)-4-(thiophene-2-carbonyl)-1H-pyrrol-2(5H)-one chemical structure, C19H13ClN2O4S, CAS 618872-95-0

5-(3-Chlorophenyl)-3-hydroxy-1-(5-methylisoxazol-3-yl)-4-(thiophene-2-carbonyl)-1H-pyrrol-2(5H)-one

CAS 618872-95-0C₁₉H₁₃ClN₂O₄S

3-Hydroxy-1-(5-methylisoxazol-3-yl)-5-(4-propoxyphenyl)-4-(thiophene-2-carbonyl)-1H-pyrrol-2(5H)-one chemical structure, C22H20N2O5S, CAS 618873-29-3

3-Hydroxy-1-(5-methylisoxazol-3-yl)-5-(4-propoxyphenyl)-4-(thiophene-2-carbonyl)-1H-pyrrol-2(5H)-one

CAS 618873-29-3C₂₂H₂₀N₂O₅S

5-(4-Bromophenyl)-3-hydroxy-1-(5-methylisoxazol-3-yl)-4-(thiophene-2-carbonyl)-1H-pyrrol-2(5H)-one chemical structure, C19H13BrN2O4S, CAS 618873-03-3

5-(4-Bromophenyl)-3-hydroxy-1-(5-methylisoxazol-3-yl)-4-(thiophene-2-carbonyl)-1H-pyrrol-2(5H)-one

CAS 618873-03-3C₁₉H₁₃BrN₂O₄S

3-Hydroxy-1-(5-methylisoxazol-3-yl)-5-phenyl-4-(thiophene-2-carbonyl)-1H-pyrrol-2(5H)-one chemical structure, C19H14N2O4S, CAS 618872-82-5

3-Hydroxy-1-(5-methylisoxazol-3-yl)-5-phenyl-4-(thiophene-2-carbonyl)-1H-pyrrol-2(5H)-one

CAS 618872-82-5C₁₉H₁₄N₂O₄S

5-(3,4-Dimethoxyphenyl)-3-hydroxy-1-(5-methylisoxazol-3-yl)-4-(thiophene-2-carbonyl)-1H-pyrrol-2(5H)-one chemical structure, C21H18N2O6S, CAS 618873-41-9

5-(3,4-Dimethoxyphenyl)-3-hydroxy-1-(5-methylisoxazol-3-yl)-4-(thiophene-2-carbonyl)-1H-pyrrol-2(5H)-one

CAS 618873-41-9C₂₁H₁₈N₂O₆S

(4E)-5-(4-Fluorophenyl)-4-[hydroxy(thiophen-2-yl)methylidene]-1-(5-methyl-1,2-oxazol-3-yl)pyrrolidine-2,3-dione chemical structure, C19H13FN2O4S, CAS 618872-93-8

(4E)-5-(4-Fluorophenyl)-4-[hydroxy(thiophen-2-yl)methylidene]-1-(5-methyl-1,2-oxazol-3-yl)pyrrolidine-2,3-dione

CAS 618872-93-8C₁₉H₁₃FN₂O₄S

Methyl 4-(4-hydroxy-1-(5-methylisoxazol-3-yl)-5-oxo-3-(thiophene-2-carbonyl)-2,5-dihydro-1H-pyrrol-2-yl)benzoate chemical structure, C21H16N2O6S, CAS 618873-09-9

Methyl 4-(4-hydroxy-1-(5-methylisoxazol-3-yl)-5-oxo-3-(thiophene-2-carbonyl)-2,5-dihydro-1H-pyrrol-2-yl)benzoate

CAS 618873-09-9C₂₁H₁₆N₂O₆S

3-Hydroxy-5-(3-hydroxyphenyl)-1-(5-methylisoxazol-3-yl)-4-(2-thienylcarbonyl)-3-pyrrolin-2-one chemical structure, C19H14N2O5S, CAS 618873-11-3

3-Hydroxy-5-(3-hydroxyphenyl)-1-(5-methylisoxazol-3-yl)-4-(2-thienylcarbonyl)-3-pyrrolin-2-one

CAS 618873-11-3C₁₉H₁₄N₂O₅S

5-(3-Bromophenyl)-3-hydroxy-1-(5-methylisoxazol-3-yl)-4-(thiophene-2-carbonyl)-1H-pyrrol-2(5H)-one chemical structure, C19H13BrN2O4S, CAS 618873-01-1

5-(3-Bromophenyl)-3-hydroxy-1-(5-methylisoxazol-3-yl)-4-(thiophene-2-carbonyl)-1H-pyrrol-2(5H)-one

CAS 618873-01-1C₁₉H₁₃BrN₂O₄S

(4E)-5-(2,3-Dimethoxyphenyl)-4-[hydroxy(thiophen-2-yl)methylidene]-1-(5-methyl-1,2-oxazol-3-yl)pyrrolidine-2,3-dione chemical structure, C21H18N2O6S, CAS 618873-37-3

(4E)-5-(2,3-Dimethoxyphenyl)-4-[hydroxy(thiophen-2-yl)methylidene]-1-(5-methyl-1,2-oxazol-3-yl)pyrrolidine-2,3-dione

CAS 618873-37-3C₂₁H₁₈N₂O₆S

3-Hydroxy-5-(2-methoxyphenyl)-1-(5-methylisoxazol-3-yl)-4-(thiophene-2-carbonyl)-1H-pyrrol-2(5H)-one chemical structure, C20H16N2O5S, CAS 618873-19-1

3-Hydroxy-5-(2-methoxyphenyl)-1-(5-methylisoxazol-3-yl)-4-(thiophene-2-carbonyl)-1H-pyrrol-2(5H)-one

CAS 618873-19-1C₂₀H₁₆N₂O₅S

5-(4-(tert-Butyl)phenyl)-3-hydroxy-1-(5-methylisoxazol-3-yl)-4-(thiophene-2-carbonyl)-1H-pyrrol-2(5H)-one chemical structure, C23H22N2O4S, CAS 618872-89-2

5-(4-(tert-Butyl)phenyl)-3-hydroxy-1-(5-methylisoxazol-3-yl)-4-(thiophene-2-carbonyl)-1H-pyrrol-2(5H)-one

CAS 618872-89-2C₂₃H₂₂N₂O₄S