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Murcko scaffold

Ring system with 4 rings and 24 atoms

33 chemicals on CompoundList share this ring system.

Rings: 4
Scaffold atoms: 24
Chemicals: 33
With full pages: 6

Scaffold SMILES

O=C(C1=CC(=O)N(c2nncs2)C1c1ccccc1)c1cccs1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=C(C1=CC(=O)N(c2nncs2)C1c1ccccc1)c1cccs1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 33 of 33 chemicals

5-(2-Fluorophenyl)-3-hydroxy-1-(1,3,4-thiadiazol-2-yl)-4-(thiophene-2-carbonyl)-1,5-dihydro-2H-pyrrol-2-one chemical structure, C17H10FN3O3S2, CAS 6237-80-5

5-(2-Fluorophenyl)-3-hydroxy-1-(1,3,4-thiadiazol-2-yl)-4-(thiophene-2-carbonyl)-1,5-dihydro-2H-pyrrol-2-one

CAS 6237-80-5C₁₇H₁₀FN₃O₃S₂

3-Hydroxy-5-(4-methoxyphenyl)-1-(1,3,4-thiadiazol-2-yl)-4-(thiophen-2-ylcarbonyl)-1,5-dihydro-2H-pyrrol-2-one chemical structure, C18H13N3O4S2, CAS 307541-59-9

3-Hydroxy-5-(4-methoxyphenyl)-1-(1,3,4-thiadiazol-2-yl)-4-(thiophen-2-ylcarbonyl)-1,5-dihydro-2H-pyrrol-2-one

CAS 307541-59-9C₁₈H₁₃N₃O₄S₂

3-Hydroxy-1-(1,3,4-thiadiazol-2-yl)-4-(thiophene-2-carbonyl)-5-(p-tolyl)-1H-pyrrol-2(5H)-one chemical structure, C18H13N3O3S2, CAS 307541-56-6

3-Hydroxy-1-(1,3,4-thiadiazol-2-yl)-4-(thiophene-2-carbonyl)-5-(p-tolyl)-1H-pyrrol-2(5H)-one

CAS 307541-56-6C₁₈H₁₃N₃O₃S₂

3-Hydroxy-5-[4-(propan-2-yl)phenyl]-1-(1,3,4-thiadiazol-2-yl)-4-(thiophen-2-ylcarbonyl)-1,5-dihydro-2H-pyrrol-2-one chemical structure, C20H17N3O3S2, CAS 307541-57-7

3-Hydroxy-5-[4-(propan-2-yl)phenyl]-1-(1,3,4-thiadiazol-2-yl)-4-(thiophen-2-ylcarbonyl)-1,5-dihydro-2H-pyrrol-2-one

CAS 307541-57-7C₂₀H₁₇N₃O₃S₂

2-(4-Fluorophenyl)-4-hydroxy-1-(1,3,4-thiadiazol-2-yl)-3-(thiophene-2-carbonyl)-2H-pyrrol-5-one chemical structure, C17H10FN3O3S2, CAS 307541-62-4

2-(4-Fluorophenyl)-4-hydroxy-1-(1,3,4-thiadiazol-2-yl)-3-(thiophene-2-carbonyl)-2H-pyrrol-5-one

CAS 307541-62-4C₁₇H₁₀FN₃O₃S₂

5-(3,4-Dimethoxyphenyl)-3-hydroxy-1-(1,3,4-thiadiazol-2-yl)-4-(thiophene-2-carbonyl)-1H-pyrrol-2(5H)-one chemical structure, C19H15N3O5S2, CAS 307541-60-2

5-(3,4-Dimethoxyphenyl)-3-hydroxy-1-(1,3,4-thiadiazol-2-yl)-4-(thiophene-2-carbonyl)-1H-pyrrol-2(5H)-one

CAS 307541-60-2C₁₉H₁₅N₃O₅S₂

5-(4-Chlorophenyl)-3-hydroxy-1-(1,3,4-thiadiazol-2-yl)-4-(thiophene-2-carbonyl)-1H-pyrrol-2(5H)-one chemical structure, C17H10ClN3O3S2, CAS 6240-28-4

5-(4-Chlorophenyl)-3-hydroxy-1-(1,3,4-thiadiazol-2-yl)-4-(thiophene-2-carbonyl)-1H-pyrrol-2(5H)-one

CAS 6240-28-4C₁₇H₁₀ClN₃O₃S₂

3-Hydroxy-1-(5-methyl-1,3,4-thiadiazol-2-yl)-5-[4-(prop-2-en-1-yloxy)phenyl]-4-(thiophen-2-ylcarbonyl)-1,5-dihydro-2H-pyrrol-2-one chemical structure, C21H17N3O4S2, CAS 432002-66-9

3-Hydroxy-1-(5-methyl-1,3,4-thiadiazol-2-yl)-5-[4-(prop-2-en-1-yloxy)phenyl]-4-(thiophen-2-ylcarbonyl)-1,5-dihydro-2H-pyrrol-2-one

CAS 432002-66-9C₂₁H₁₇N₃O₄S₂

5-(3,4-Dimethoxyphenyl)-3-hydroxy-1-(5-methyl-1,3,4-thiadiazol-2-yl)-4-(thiophen-2-ylcarbonyl)-1,5-dihydro-2H-pyrrol-2-one chemical structure, C20H17N3O5S2, CAS 431939-90-1

5-(3,4-Dimethoxyphenyl)-3-hydroxy-1-(5-methyl-1,3,4-thiadiazol-2-yl)-4-(thiophen-2-ylcarbonyl)-1,5-dihydro-2H-pyrrol-2-one

CAS 431939-90-1C₂₀H₁₇N₃O₅S₂

(4E)-5-(2-Fluorophenyl)-4-[hydroxy(thiophen-2-yl)methylidene]-1-(5-methyl-1,3,4-thiadiazol-2-yl)pyrrolidine-2,3-dione chemical structure, C18H12FN3O3S2, CAS 371205-90-2

(4E)-5-(2-Fluorophenyl)-4-[hydroxy(thiophen-2-yl)methylidene]-1-(5-methyl-1,3,4-thiadiazol-2-yl)pyrrolidine-2,3-dione

CAS 371205-90-2C₁₈H₁₂FN₃O₃S₂

5-(3,4-Dichlorophenyl)-3-hydroxy-1-(5-methyl-1,3,4-thiadiazol-2-yl)-4-(thiophen-2-ylcarbonyl)-1,5-dihydro-2H-pyrrol-2-one chemical structure, C18H11Cl2N3O3S2, CAS 431980-74-4

5-(3,4-Dichlorophenyl)-3-hydroxy-1-(5-methyl-1,3,4-thiadiazol-2-yl)-4-(thiophen-2-ylcarbonyl)-1,5-dihydro-2H-pyrrol-2-one

CAS 431980-74-4C₁₈H₁₁Cl₂N₃O₃S₂

4-Hydroxy-2-phenyl-1-(1,3,4-thiadiazol-2-yl)-3-(thiophene-2-carbonyl)-2H-pyrrol-5-one chemical structure, C17H11N3O3S2, CAS 462069-51-8

4-Hydroxy-2-phenyl-1-(1,3,4-thiadiazol-2-yl)-3-(thiophene-2-carbonyl)-2H-pyrrol-5-one

CAS 462069-51-8C₁₇H₁₁N₃O₃S₂

3-Hydroxy-5-phenyl-1-[5-(propan-2-yl)-1,3,4-thiadiazol-2-yl]-4-(thiophen-2-ylcarbonyl)-1,5-dihydro-2H-pyrrol-2-one chemical structure, C20H17N3O3S2, CAS 692275-35-7

3-Hydroxy-5-phenyl-1-[5-(propan-2-yl)-1,3,4-thiadiazol-2-yl]-4-(thiophen-2-ylcarbonyl)-1,5-dihydro-2H-pyrrol-2-one

CAS 692275-35-7C₂₀H₁₇N₃O₃S₂

3-Hydroxy-5-(4-hydroxy-3-methoxyphenyl)-1-(1,3,4-thiadiazol-2-yl)-4-(thiophene-2-carbonyl)-1H-pyrrol-2(5H)-one chemical structure, C18H13N3O5S2, CAS 307541-63-5

3-Hydroxy-5-(4-hydroxy-3-methoxyphenyl)-1-(1,3,4-thiadiazol-2-yl)-4-(thiophene-2-carbonyl)-1H-pyrrol-2(5H)-one

CAS 307541-63-5C₁₈H₁₃N₃O₅S₂

(4E)-4-[Hydroxy(thiophen-2-yl)methylidene]-1-(5-methyl-1,3,4-thiadiazol-2-yl)-5-phenylpyrrolidine-2,3-dione chemical structure, C18H13N3O3S2, CAS 371118-51-3

(4E)-4-[Hydroxy(thiophen-2-yl)methylidene]-1-(5-methyl-1,3,4-thiadiazol-2-yl)-5-phenylpyrrolidine-2,3-dione

CAS 371118-51-3C₁₈H₁₃N₃O₃S₂

(4E)-4-[Hydroxy(thiophen-2-yl)methylidene]-1-(5-methyl-1,3,4-thiadiazol-2-yl)-5-[4-(propan-2-yl)phenyl]pyrrolidine-2,3-dione chemical structure, C21H19N3O3S2, CAS 371206-16-5

(4E)-4-[Hydroxy(thiophen-2-yl)methylidene]-1-(5-methyl-1,3,4-thiadiazol-2-yl)-5-[4-(propan-2-yl)phenyl]pyrrolidine-2,3-dione

CAS 371206-16-5C₂₁H₁₉N₃O₃S₂

(4E)-4-[Hydroxy(thiophen-2-yl)methylidene]-5-(4-methoxyphenyl)-1-(5-methyl-1,3,4-thiadiazol-2-yl)pyrrolidine-2,3-dione chemical structure, C19H15N3O4S2, CAS 371140-97-5

(4E)-4-[Hydroxy(thiophen-2-yl)methylidene]-5-(4-methoxyphenyl)-1-(5-methyl-1,3,4-thiadiazol-2-yl)pyrrolidine-2,3-dione

CAS 371140-97-5C₁₉H₁₅N₃O₄S₂

(4E)-5-(4-Fluorophenyl)-4-[hydroxy(thiophen-2-yl)methylidene]-1-(5-methyl-1,3,4-thiadiazol-2-yl)pyrrolidine-2,3-dione chemical structure, C18H12FN3O3S2, CAS 371923-66-9

(4E)-5-(4-Fluorophenyl)-4-[hydroxy(thiophen-2-yl)methylidene]-1-(5-methyl-1,3,4-thiadiazol-2-yl)pyrrolidine-2,3-dione

CAS 371923-66-9C₁₈H₁₂FN₃O₃S₂

5-(3-Ethoxyphenyl)-3-hydroxy-1-(5-methyl-1,3,4-thiadiazol-2-yl)-4-(thiophene-2-carbonyl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C20H17N3O4S2, CAS 619271-64-6

5-(3-Ethoxyphenyl)-3-hydroxy-1-(5-methyl-1,3,4-thiadiazol-2-yl)-4-(thiophene-2-carbonyl)-2,5-dihydro-1H-pyrrol-2-one

CAS 619271-64-6C₂₀H₁₇N₃O₄S₂

(4E)-5-(4-Bromophenyl)-4-[hydroxy(thiophen-2-yl)methylidene]-1-(5-methyl-1,3,4-thiadiazol-2-yl)pyrrolidine-2,3-dione chemical structure, C18H12BrN3O3S2, CAS 371232-35-8

(4E)-5-(4-Bromophenyl)-4-[hydroxy(thiophen-2-yl)methylidene]-1-(5-methyl-1,3,4-thiadiazol-2-yl)pyrrolidine-2,3-dione

CAS 371232-35-8C₁₈H₁₂BrN₃O₃S₂

5-(4-tert-Butylphenyl)-3-hydroxy-1-(1,3,4-thiadiazol-2-yl)-4-(thiophen-2-ylcarbonyl)-1,5-dihydro-2H-pyrrol-2-one chemical structure, C21H19N3O3S2, CAS 307541-58-8

5-(4-tert-Butylphenyl)-3-hydroxy-1-(1,3,4-thiadiazol-2-yl)-4-(thiophen-2-ylcarbonyl)-1,5-dihydro-2H-pyrrol-2-one

CAS 307541-58-8C₂₁H₁₉N₃O₃S₂

(4E)-5-(2-Fluorophenyl)-4-[hydroxy(thiophen-2-yl)methylidene]-1-[5-(methylsulfanyl)-1,3,4-thiadiazol-2-yl]pyrrolidine-2,3-dione chemical structure, C18H12FN3O3S3, CAS 897835-91-5

(4E)-5-(2-Fluorophenyl)-4-[hydroxy(thiophen-2-yl)methylidene]-1-[5-(methylsulfanyl)-1,3,4-thiadiazol-2-yl]pyrrolidine-2,3-dione

CAS 897835-91-5C₁₈H₁₂FN₃O₃S₃

(4E)-4-[Hydroxy(thiophen-2-yl)methylidene]-5-(3-methoxyphenyl)-1-[5-(methylsulfanyl)-1,3,4-thiadiazol-2-yl]pyrrolidine-2,3-dione chemical structure, C19H15N3O4S3, CAS 897835-98-2

(4E)-4-[Hydroxy(thiophen-2-yl)methylidene]-5-(3-methoxyphenyl)-1-[5-(methylsulfanyl)-1,3,4-thiadiazol-2-yl]pyrrolidine-2,3-dione

CAS 897835-98-2C₁₉H₁₅N₃O₄S₃

(4E)-4-[Hydroxy(thiophen-2-yl)methylidene]-5-(4-methoxyphenyl)-1-[5-(methylsulfanyl)-1,3,4-thiadiazol-2-yl]pyrrolidine-2,3-dione chemical structure, C19H15N3O4S3, CAS 897835-96-0

(4E)-4-[Hydroxy(thiophen-2-yl)methylidene]-5-(4-methoxyphenyl)-1-[5-(methylsulfanyl)-1,3,4-thiadiazol-2-yl]pyrrolidine-2,3-dione

CAS 897835-96-0C₁₉H₁₅N₃O₄S₃