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Murcko scaffold

1-(Thiophen-2-yl)-1,2,3,4-tetrahydroisoquinoline scaffold

12 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
15
Chemicals
12
With full pages
3
Scaffold SMILES

c1csc(C2NCCc3ccccc32)c1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1-(Thiophen-2-yl)-1,2,3,4-tetrahydroisoquinoline page
Murcko scaffold c1csc(C2NCCc3ccccc32)c1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 12 of 12 chemicals

[1-(2-Thienyl)-3,4-dihydroisoquinolin-2(1H)-yl]acetic acid chemical structure, C15H15NO2S, CAS 872696-23-6
[1-(2-Thienyl)-3,4-dihydroisoquinolin-2(1H)-yl]acetic acid
CAS 872696-23-6C15H15NO2S
3-(1-(Thiophen-2-yl)-3,4-dihydroisoquinolin-2(1H)-yl)propanoic acid chemical structure, C16H17NO2S, CAS 943119-79-7
3-(1-(Thiophen-2-yl)-3,4-dihydroisoquinolin-2(1H)-yl)propanoic acid
CAS 943119-79-7C16H17NO2S
1-(Thiophen-2-yl)-1,2,3,4-tetrahydroisoquinoline chemical structure, C13H13NS, CAS 120086-35-3
1-(Thiophen-2-yl)-1,2,3,4-tetrahydroisoquinoline
CAS 120086-35-3C13H13NS
1,2,3,4-Tetrahydro-6,7-dimethoxy-1-(2-thienyl)isoquinoline chemical structure, C15H17NO2S, CAS 511239-03-5
1,2,3,4-Tetrahydro-6,7-dimethoxy-1-(2-thienyl)isoquinoline
CAS 511239-03-5C15H17NO2S
1-(3-Methylthiophen-2-yl)-1,2,3,4-tetrahydroisoquinolin-6-ol chemical structure, C14H15NOS, CAS 600647-35-6
1-(3-Methylthiophen-2-yl)-1,2,3,4-tetrahydroisoquinolin-6-ol
CAS 600647-35-6C14H15NOS
1-Thiophen-2-yl-1,2,3,4-tetrahydroisoquinolin-6-ol chemical structure, C13H13NOS, CAS 600646-68-2
1-Thiophen-2-yl-1,2,3,4-tetrahydroisoquinolin-6-ol
CAS 600646-68-2C13H13NOS
1-(5-Methylthiophen-2-yl)-1,2,3,4-tetrahydroisoquinolin-6-ol chemical structure, C14H15NOS, CAS 600646-85-3
1-(5-Methylthiophen-2-yl)-1,2,3,4-tetrahydroisoquinolin-6-ol
CAS 600646-85-3C14H15NOS
3-[1-(2-Thienyl)-3,4-dihydroisoquinolin-2(1H)-yl]propanoic acid hydrochloride chemical structure, C16H18ClNO2S, CAS 1052538-07-4
3-[1-(2-Thienyl)-3,4-dihydroisoquinolin-2(1H)-yl]propanoic acid hydrochloride
CAS 1052538-07-4C16H18ClNO2S
6,7-Dimethoxy-2-prop-2-ynyl-1-thiophen-2-yl-3,4-dihydro-1H-isoquinoline chemical structure, C18H19NO2S, CAS 1334003-66-5
6,7-Dimethoxy-2-prop-2-ynyl-1-thiophen-2-yl-3,4-dihydro-1H-isoquinoline
CAS 1334003-66-5C18H19NO2S
1-[1-(Thiophen-2-yl)-3,4-dihydroisoquinolin-2(1H)-yl]ethan-1-one chemical structure, C15H15NOS, CAS 827320-84-3
1-[1-(Thiophen-2-yl)-3,4-dihydroisoquinolin-2(1H)-yl]ethan-1-one
CAS 827320-84-3C15H15NOS
1-[6,7-Dimethoxy-1-(thiophen-2-yl)-1,2,3,4-tetrahydroisoquinolin-2-yl]prop-2-en-1-one chemical structure, C18H19NO3S, CAS 2108995-07-7
1-[6,7-Dimethoxy-1-(thiophen-2-yl)-1,2,3,4-tetrahydroisoquinolin-2-yl]prop-2-en-1-one
CAS 2108995-07-7C18H19NO3S
2-Chloro-1-(6,7-dimethoxy-1-thiophen-2-yl-3,4-dihydro-1H-isoquinolin-2-yl)propan-1-one chemical structure, C18H20ClNO3S, CAS 2411266-11-8
2-Chloro-1-(6,7-dimethoxy-1-thiophen-2-yl-3,4-dihydro-1H-isoquinolin-2-yl)propan-1-one
CAS 2411266-11-8C18H20ClNO3S