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Murcko scaffold

Ring system with 3 rings and 18 atoms

6 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
18
Chemicals
6
With full pages
2
Scaffold SMILES

O=C1C=C(C(=O)c2cccs2)C(c2ccco2)N1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C1C=C(C(=O)c2cccs2)C(c2ccco2)N1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 6 of 6 chemicals

1-[2-(Dimethylamino)ethyl]-5-(2-furyl)-3-hydroxy-4-(2-thienylcarbonyl)-3-pyrro lin-2-one chemical structure, C17H18N2O4S, CAS 378763-68-9
1-[2-(Dimethylamino)ethyl]-5-(2-furyl)-3-hydroxy-4-(2-thienylcarbonyl)-3-pyrro lin-2-one
CAS 378763-68-9C17H18N2O4S
Pyrrol-2-one, 1-(2-dimethylaminoethyl)-3-hydroxy-5-(5-methylfuran-2-yl)-4-(thiophene-2-carbonyl)-1,5-dihydro- chemical structure, C18H20N2O4S, CAS 378758-57-7
Pyrrol-2-one, 1-(2-dimethylaminoethyl)-3-hydroxy-5-(5-methylfuran-2-yl)-4-(thiophene-2-carbonyl)-1,5-dihydro-
CAS 378758-57-7C18H20N2O4S
1-[3-(Dimethylamino)propyl]-4-hydroxy-2-(5-methylfuran-2-yl)-3-(thiophene-2-carbonyl)-2H-pyrrol-5-one chemical structure, C19H22N2O4S, CAS 381182-59-8
1-[3-(Dimethylamino)propyl]-4-hydroxy-2-(5-methylfuran-2-yl)-3-(thiophene-2-carbonyl)-2H-pyrrol-5-one
CAS 381182-59-8C19H22N2O4S
1-[3-(Dimethylamino)propyl]-5-(2-furyl)-3-hydroxy-4-(2-thienylcarbonyl)-3-pyrr olin-2-one chemical structure, C18H20N2O4S, CAS 380581-69-1
1-[3-(Dimethylamino)propyl]-5-(2-furyl)-3-hydroxy-4-(2-thienylcarbonyl)-3-pyrr olin-2-one
CAS 380581-69-1C18H20N2O4S
1-[2-(Diethylamino)ethyl]-3-hydroxy-5-(5-methyl-2-furyl)-4-(2-thienylcarbonyl)-1,5-dihydro-2H-pyrrol-2-one chemical structure, C20H24N2O4S, CAS 615272-74-7
1-[2-(Diethylamino)ethyl]-3-hydroxy-5-(5-methyl-2-furyl)-4-(2-thienylcarbonyl)-1,5-dihydro-2H-pyrrol-2-one
CAS 615272-74-7C20H24N2O4S
1-[2-(Diethylamino)ethyl]-5-(2-furyl)-3-hydroxy-4-(2-thienylcarbonyl)-3-pyrrol in-2-one chemical structure, C19H22N2O4S, CAS 615276-91-0
1-[2-(Diethylamino)ethyl]-5-(2-furyl)-3-hydroxy-4-(2-thienylcarbonyl)-3-pyrrol in-2-one
CAS 615276-91-0C19H22N2O4S