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Murcko scaffold

Ring system with 3 rings and 16 atoms

36 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
16
Chemicals
36
With full pages
4
Scaffold SMILES

O=C(c1ccccc1)c1csc2c1CCC2

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(c1ccccc1)c1csc2c1CCC2

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 36 of 36 chemicals

3-(4-Chlorobenzoyl)-4H,5H,6H-cyclopenta(b)thiophen-2-amine chemical structure, C14H12ClNOS, CAS 304018-04-0
3-(4-Chlorobenzoyl)-4H,5H,6H-cyclopenta(b)thiophen-2-amine
CAS 304018-04-0C14H12ClNOS
3-(4-Bromobenzoyl)-4H,5H,6H-cyclopenta[b]thiophen-2-amine chemical structure, C14H12BrNOS, CAS 223423-37-8
3-(4-Bromobenzoyl)-4H,5H,6H-cyclopenta[b]thiophen-2-amine
CAS 223423-37-8C14H12BrNOS
(2-Amino-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl)-p-tolyl-methanone chemical structure, C15H15NOS, CAS 436093-41-3
(2-Amino-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl)-p-tolyl-methanone
CAS 436093-41-3C15H15NOS
3-(3-Chlorobenzoyl)-4H,5H,6H-cyclopenta[b]thiophen-2-amine chemical structure, C14H12ClNOS, CAS 399043-34-6
3-(3-Chlorobenzoyl)-4H,5H,6H-cyclopenta[b]thiophen-2-amine
CAS 399043-34-6C14H12ClNOS
3-Benzoyl-4H,5H,6H-cyclopenta[b]thiophen-2-amine chemical structure, C14H13NOS, CAS 40312-29-6
3-Benzoyl-4H,5H,6H-cyclopenta[b]thiophen-2-amine
CAS 40312-29-6C14H13NOS
2-Chloro-N-[3-(2-methoxy-benzoyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-2-yl]-acetamide chemical structure, C17H16ClNO3S, CAS 919036-46-7
2-Chloro-N-[3-(2-methoxy-benzoyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-2-yl]-acetamide
CAS 919036-46-7C17H16ClNO3S
Methyl 2-amino-3-(2-chlorobenzoyl)-5,6-dihydro-4H-cyclopenta[b]thiophene-5-carboxylate chemical structure, C16H14ClNO3S, CAS 114777-66-1
Methyl 2-amino-3-(2-chlorobenzoyl)-5,6-dihydro-4H-cyclopenta[b]thiophene-5-carboxylate
CAS 114777-66-1C16H14ClNO3S
3-(4-Fluorobenzoyl)-4H,5H,6H-cyclopenta[b]thiophen-2-amine chemical structure, C14H12FNOS, CAS 304018-03-9
3-(4-Fluorobenzoyl)-4H,5H,6H-cyclopenta[b]thiophen-2-amine
CAS 304018-03-9C14H12FNOS
3-(2,4-Dimethylbenzoyl)-4H,5H,6H-cyclopenta[b]thiophen-2-amine chemical structure, C16H17NOS, CAS 1082778-95-7
3-(2,4-Dimethylbenzoyl)-4H,5H,6H-cyclopenta[b]thiophen-2-amine
CAS 1082778-95-7C16H17NOS
3-(3,4-Dichlorobenzoyl)-4H,5H,6H-cyclopenta[b]thiophen-2-amine chemical structure, C14H11Cl2NOS, CAS 893383-55-6
3-(3,4-Dichlorobenzoyl)-4H,5H,6H-cyclopenta[b]thiophen-2-amine
CAS 893383-55-6C14H11Cl2NOS
3-(4-Methoxybenzoyl)-4H,5H,6H-cyclopenta[b]thiophen-2-amine chemical structure, C15H15NO2S, CAS 56416-46-7
3-(4-Methoxybenzoyl)-4H,5H,6H-cyclopenta[b]thiophen-2-amine
CAS 56416-46-7C15H15NO2S
3-(3-Methoxybenzoyl)-4H,5H,6H-cyclopenta[b]thiophen-2-amine chemical structure, C15H15NO2S, CAS 1082867-22-8
3-(3-Methoxybenzoyl)-4H,5H,6H-cyclopenta[b]thiophen-2-amine
CAS 1082867-22-8C15H15NO2S
3-[4-(Trifluoromethyl)benzoyl]-4H,5H,6H-cyclopenta[b]thiophen-2-amine chemical structure, C15H12F3NOS, CAS 1256257-04-1
3-[4-(Trifluoromethyl)benzoyl]-4H,5H,6H-cyclopenta[b]thiophen-2-amine
CAS 1256257-04-1C15H12F3NOS
3-(4-Chloro-3-fluorobenzoyl)-4H,5H,6H-cyclopenta[b]thiophen-2-amine chemical structure, C14H11ClFNOS, CAS 1443981-54-1
3-(4-Chloro-3-fluorobenzoyl)-4H,5H,6H-cyclopenta[b]thiophen-2-amine
CAS 1443981-54-1C14H11ClFNOS
3-(3-Fluoro-4-methylbenzoyl)-4H,5H,6H-cyclopenta[b]thiophen-2-amine chemical structure, C15H14FNOS, CAS 1443980-89-9
3-(3-Fluoro-4-methylbenzoyl)-4H,5H,6H-cyclopenta[b]thiophen-2-amine
CAS 1443980-89-9C15H14FNOS
3-[4-(Difluoromethoxy)benzoyl]-4H,5H,6H-cyclopenta[b]thiophen-2-amine chemical structure, C15H13F2NO2S, CAS 1443980-40-2
3-[4-(Difluoromethoxy)benzoyl]-4H,5H,6H-cyclopenta[b]thiophen-2-amine
CAS 1443980-40-2C15H13F2NO2S
3-(3-Chloro-4-methoxybenzoyl)-4H,5H,6H-cyclopenta[b]thiophen-2-amine chemical structure, C15H14ClNO2S, CAS 1797174-07-2
3-(3-Chloro-4-methoxybenzoyl)-4H,5H,6H-cyclopenta[b]thiophen-2-amine
CAS 1797174-07-2C15H14ClNO2S
3-[2-Bromo-4-(trifluoromethyl)benzoyl]-4H,5H,6H-cyclopenta[b]thiophen-2-amine chemical structure, C15H11BrF3NOS, CAS 1803590-48-8
3-[2-Bromo-4-(trifluoromethyl)benzoyl]-4H,5H,6H-cyclopenta[b]thiophen-2-amine
CAS 1803590-48-8C15H11BrF3NOS
3-(2-Bromo-4-methylbenzoyl)-4H,5H,6H-cyclopenta[b]thiophen-2-amine chemical structure, C15H14BrNOS, CAS 1798742-74-1
3-(2-Bromo-4-methylbenzoyl)-4H,5H,6H-cyclopenta[b]thiophen-2-amine
CAS 1798742-74-1C15H14BrNOS
4-{2-Amino-4H,5H,6H-cyclopenta[b]thiophene-3-carbonyl}benzonitrile chemical structure, C15H12N2OS, CAS 1803585-73-0
4-{2-Amino-4H,5H,6H-cyclopenta[b]thiophene-3-carbonyl}benzonitrile
CAS 1803585-73-0C15H12N2OS
2-{2-Amino-4H,5H,6H-cyclopenta[b]thiophene-3-carbonyl}-5-methoxybenzonitrile chemical structure, C16H14N2O2S, CAS 1803611-42-8
2-{2-Amino-4H,5H,6H-cyclopenta[b]thiophene-3-carbonyl}-5-methoxybenzonitrile
CAS 1803611-42-8C16H14N2O2S
tert-Butyl N-[3-(4-chlorobenzoyl)-4H,5H,6H-cyclopenta[b]thiophen-2-yl]carbamate chemical structure, C19H20ClNO3S, CAS 2680862-32-0
tert-Butyl N-[3-(4-chlorobenzoyl)-4H,5H,6H-cyclopenta[b]thiophen-2-yl]carbamate
CAS 2680862-32-0C19H20ClNO3S
tert-Butyl N-[3-(4-cyanobenzoyl)-4H,5H,6H-cyclopenta[b]thiophen-2-yl]carbamate chemical structure, C20H20N2O3S, CAS 2680823-86-1
tert-Butyl N-[3-(4-cyanobenzoyl)-4H,5H,6H-cyclopenta[b]thiophen-2-yl]carbamate
CAS 2680823-86-1C20H20N2O3S
tert-Butyl N-{3-benzoyl-4H,5H,6H-cyclopenta[b]thiophen-2-yl}carbamate chemical structure, C19H21NO3S, CAS 2680797-17-3
tert-Butyl N-{3-benzoyl-4H,5H,6H-cyclopenta[b]thiophen-2-yl}carbamate
CAS 2680797-17-3C19H21NO3S