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Murcko scaffold

Ring system with 3 rings and 18 atoms

47 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
18
Chemicals
47
With full pages
6
Scaffold SMILES

N=C1SC2CS(=O)(=O)CC2N1Cc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold N=C1SC2CS(=O)(=O)CC2N1Cc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 47 of 47 chemicals

N-[(2Z)-3-Benzyl-5,5-dioxidotetrahydrothieno[3,4-d][1,3]thiazol-2(3H)-ylidene]butanamide chemical structure, C16H20N2O3S2, CAS 844447-50-3
N-[(2Z)-3-Benzyl-5,5-dioxidotetrahydrothieno[3,4-d][1,3]thiazol-2(3H)-ylidene]butanamide
CAS 844447-50-3C16H20N2O3S2
N-[(2Z)-3-Benzyl-5,5-dioxidotetrahydrothieno[3,4-d][1,3]thiazol-2(3H)-ylidene]acetamide chemical structure, C14H16N2O3S2, CAS 850736-44-6
N-[(2Z)-3-Benzyl-5,5-dioxidotetrahydrothieno[3,4-d][1,3]thiazol-2(3H)-ylidene]acetamide
CAS 850736-44-6C14H16N2O3S2
N-[(2Z)-3-(4-Methoxybenzyl)-5,5-dioxidotetrahydrothieno[3,4-d][1,3]thiazol-2(3H)-ylidene]-3-methylbutanamide chemical structure, C18H24N2O4S2, CAS 896594-82-4
N-[(2Z)-3-(4-Methoxybenzyl)-5,5-dioxidotetrahydrothieno[3,4-d][1,3]thiazol-2(3H)-ylidene]-3-methylbutanamide
CAS 896594-82-4C18H24N2O4S2
2-Methyl-N-[(2Z)-3-(4-methylbenzyl)-5,5-dioxidotetrahydrothieno[3,4-d][1,3]thiazol-2(3H)-ylidene]propanamide chemical structure, C17H22N2O3S2, CAS 896811-01-1
2-Methyl-N-[(2Z)-3-(4-methylbenzyl)-5,5-dioxidotetrahydrothieno[3,4-d][1,3]thiazol-2(3H)-ylidene]propanamide
CAS 896811-01-1C17H22N2O3S2
4-{[(2Z)-3-(4-Methylbenzyl)-5,5-dioxidotetrahydrothieno[3,4-d][1,3]thiazol-2(3H)-ylidene]amino}-4-oxobutanoic acid chemical structure, C17H20N2O5S2, CAS 892637-92-2
4-{[(2Z)-3-(4-Methylbenzyl)-5,5-dioxidotetrahydrothieno[3,4-d][1,3]thiazol-2(3H)-ylidene]amino}-4-oxobutanoic acid
CAS 892637-92-2C17H20N2O5S2
5-{[(2Z)-3-(4-Methylbenzyl)-5,5-dioxidotetrahydrothieno[3,4-d][1,3]thiazol-2(3H)-ylidene]amino}-5-oxopentanoic acid chemical structure, C18H22N2O5S2, CAS 896837-09-5
5-{[(2Z)-3-(4-Methylbenzyl)-5,5-dioxidotetrahydrothieno[3,4-d][1,3]thiazol-2(3H)-ylidene]amino}-5-oxopentanoic acid
CAS 896837-09-5C18H22N2O5S2
3-(4-Methoxybenzyl)tetrahydrothieno[3,4-d][1,3]thiazol-2(3H)-imine 5,5-dioxide chemical structure, C13H16N2O3S2, CAS 896845-15-1
3-(4-Methoxybenzyl)tetrahydrothieno[3,4-d][1,3]thiazol-2(3H)-imine 5,5-dioxide
CAS 896845-15-1C13H16N2O3S2
N-[(2Z)-3-(4-Methoxybenzyl)-5,5-dioxidotetrahydrothieno[3,4-d][1,3]thiazol-2(3H)-ylidene]-2-methylpropanamide chemical structure, C17H22N2O4S2, CAS 896849-02-8
N-[(2Z)-3-(4-Methoxybenzyl)-5,5-dioxidotetrahydrothieno[3,4-d][1,3]thiazol-2(3H)-ylidene]-2-methylpropanamide
CAS 896849-02-8C17H22N2O4S2
N-[(2Z)-3-(4-Methylbenzyl)-5,5-dioxidotetrahydrothieno[3,4-d][1,3]thiazol-2(3H)-ylidene]acetamide chemical structure, C15H18N2O3S2, CAS 896849-23-3
N-[(2Z)-3-(4-Methylbenzyl)-5,5-dioxidotetrahydrothieno[3,4-d][1,3]thiazol-2(3H)-ylidene]acetamide
CAS 896849-23-3C15H18N2O3S2
5-{[(2Z)-3-(4-Methoxybenzyl)-5,5-dioxidotetrahydrothieno[3,4-d][1,3]thiazol-2(3H)-ylidene]amino}-5-oxopentanoic acid chemical structure, C18H22N2O6S2, CAS 896852-99-6
5-{[(2Z)-3-(4-Methoxybenzyl)-5,5-dioxidotetrahydrothieno[3,4-d][1,3]thiazol-2(3H)-ylidene]amino}-5-oxopentanoic acid
CAS 896852-99-6C18H22N2O6S2
4-{[(2Z)-3-(4-Chlorobenzyl)-5,5-dioxidotetrahydrothieno[3,4-d][1,3]thiazol-2(3H)-ylidene]amino}-4-oxobutanoic acid chemical structure, C16H17ClN2O5S2, CAS 896851-53-9
4-{[(2Z)-3-(4-Chlorobenzyl)-5,5-dioxidotetrahydrothieno[3,4-d][1,3]thiazol-2(3H)-ylidene]amino}-4-oxobutanoic acid
CAS 896851-53-9C16H17ClN2O5S2
4-{[(2Z)-3-(4-Methoxybenzyl)-5,5-dioxidotetrahydrothieno[3,4-d][1,3]thiazol-2(3H)-ylidene]amino}-4-oxobutanoic acid chemical structure, C17H20N2O6S2, CAS 899412-42-1
4-{[(2Z)-3-(4-Methoxybenzyl)-5,5-dioxidotetrahydrothieno[3,4-d][1,3]thiazol-2(3H)-ylidene]amino}-4-oxobutanoic acid
CAS 899412-42-1C17H20N2O6S2
3-(1-Phenylethyl)tetrahydrothieno[3,4-d][1,3]thiazol-2(3H)-imine 5,5-dioxide chemical structure, C13H16N2O2S2, CAS 1008645-31-5
3-(1-Phenylethyl)tetrahydrothieno[3,4-d][1,3]thiazol-2(3H)-imine 5,5-dioxide
CAS 1008645-31-5C13H16N2O2S2
N-[(2Z)-3-(4-Chlorobenzyl)-5,5-dioxidotetrahydrothieno[3,4-d][1,3]thiazol-2(3H)-ylidene]-2-methylpropanamide chemical structure, C16H19ClN2O3S2, CAS 899406-98-5
N-[(2Z)-3-(4-Chlorobenzyl)-5,5-dioxidotetrahydrothieno[3,4-d][1,3]thiazol-2(3H)-ylidene]-2-methylpropanamide
CAS 899406-98-5C16H19ClN2O3S2
N-[(2Z)-3-Benzyl-5,5-dioxidotetrahydrothieno[3,4-d][1,3]thiazol-2(3H)-ylidene]-3-methylbutanamide chemical structure, C17H22N2O3S2, CAS 1164534-64-8
N-[(2Z)-3-Benzyl-5,5-dioxidotetrahydrothieno[3,4-d][1,3]thiazol-2(3H)-ylidene]-3-methylbutanamide
CAS 1164534-64-8C17H22N2O3S2
3-(4-Methylbenzyl)tetrahydrothieno[3,4-d][1,3]thiazol-2(3H)-imine 5,5-dioxide chemical structure, C13H16N2O2S2, CAS 900290-81-5
3-(4-Methylbenzyl)tetrahydrothieno[3,4-d][1,3]thiazol-2(3H)-imine 5,5-dioxide
CAS 900290-81-5C13H16N2O2S2
5-{[(2Z)-3-(2-Chlorobenzyl)-5,5-dioxidotetrahydrothieno[3,4-d][1,3]thiazol-2(3H)-ylidene]amino}-5-oxopentanoic acid chemical structure, C17H19ClN2O5S2, CAS 879942-05-9
5-{[(2Z)-3-(2-Chlorobenzyl)-5,5-dioxidotetrahydrothieno[3,4-d][1,3]thiazol-2(3H)-ylidene]amino}-5-oxopentanoic acid
CAS 879942-05-9C17H19ClN2O5S2
2-Ethyl-N-[(2E)-3-(4-fluorobenzyl)-5,5-dioxidotetrahydrothieno[3,4-d][1,3]thiazol-2(3H)-ylidene]butanamide chemical structure, C18H23FN2O3S2, CAS 900869-59-2
2-Ethyl-N-[(2E)-3-(4-fluorobenzyl)-5,5-dioxidotetrahydrothieno[3,4-d][1,3]thiazol-2(3H)-ylidene]butanamide
CAS 900869-59-2C18H23FN2O3S2
N-[(2E)-3-(4-Fluorobenzyl)-5,5-dioxidotetrahydrothieno[3,4-d][1,3]thiazol-2(3H)-ylidene]-2-methylpropanamide chemical structure, C16H19FN2O3S2, CAS 892626-76-5
N-[(2E)-3-(4-Fluorobenzyl)-5,5-dioxidotetrahydrothieno[3,4-d][1,3]thiazol-2(3H)-ylidene]-2-methylpropanamide
CAS 892626-76-5C16H19FN2O3S2
(2-{[(2Z)-3-(2-Chlorobenzyl)-5,5-dioxidotetrahydrothieno[3,4-d][1,3]thiazol-2(3H)-ylidene]amino}-2-oxoethoxy)acetic acid chemical structure, C16H17ClN2O6S2, CAS 900890-45-1
(2-{[(2Z)-3-(2-Chlorobenzyl)-5,5-dioxidotetrahydrothieno[3,4-d][1,3]thiazol-2(3H)-ylidene]amino}-2-oxoethoxy)acetic acid
CAS 900890-45-1C16H17ClN2O6S2
(2-{[(2Z)-3-(4-Fluorobenzyl)-5,5-dioxidotetrahydrothieno[3,4-d][1,3]thiazol-2(3H)-ylidene]amino}-2-oxoethoxy)acetic acid chemical structure, C16H17FN2O6S2, CAS 892629-46-8
(2-{[(2Z)-3-(4-Fluorobenzyl)-5,5-dioxidotetrahydrothieno[3,4-d][1,3]thiazol-2(3H)-ylidene]amino}-2-oxoethoxy)acetic acid
CAS 892629-46-8C16H17FN2O6S2
N-[(2Z)-3-(2-Chlorobenzyl)-5,5-dioxidotetrahydrothieno[3,4-d][1,3]thiazol-2(3H)-ylidene]acetamide chemical structure, C14H15ClN2O3S2, CAS 879941-83-0
N-[(2Z)-3-(2-Chlorobenzyl)-5,5-dioxidotetrahydrothieno[3,4-d][1,3]thiazol-2(3H)-ylidene]acetamide
CAS 879941-83-0C14H15ClN2O3S2
N-[(2E)-3-Benzyl-5,5-dioxidotetrahydrothieno[3,4-d][1,3]thiazol-2(3H)-ylidene]-2-methoxyacetamide chemical structure, C15H18N2O4S2, CAS 900899-00-5
N-[(2E)-3-Benzyl-5,5-dioxidotetrahydrothieno[3,4-d][1,3]thiazol-2(3H)-ylidene]-2-methoxyacetamide
CAS 900899-00-5C15H18N2O4S2
2-Methoxy-N-[(2E)-3-(4-methoxybenzyl)-5,5-dioxidotetrahydrothieno[3,4-d][1,3]thiazol-2(3H)-ylidene]acetamide chemical structure, C16H20N2O5S2, CAS 900871-40-1
2-Methoxy-N-[(2E)-3-(4-methoxybenzyl)-5,5-dioxidotetrahydrothieno[3,4-d][1,3]thiazol-2(3H)-ylidene]acetamide
CAS 900871-40-1C16H20N2O5S2