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Murcko scaffold

Ring system with 4 rings and 21 atoms

24 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
21
Chemicals
24
With full pages
10
Scaffold SMILES

c1ccc(-c2cnc3c(-c4ccccc4)cnn3c2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold c1ccc(-c2cnc3c(-c4ccccc4)cnn3c2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 24 of 24 chemicals

3-(4-Chlorophenyl)-2,5-dimethyl-6-phenylpyrazolo[1,5-a]pyrimidin-7-amine chemical structure, C20H17ClN4, CAS 433238-46-1
3-(4-Chlorophenyl)-2,5-dimethyl-6-phenylpyrazolo[1,5-a]pyrimidin-7-amine
CAS 433238-46-1C20H17ClN4
2,5-Dimethyl-3,6-diphenylpyrazolo[1,5-a]pyrimidin-7-amine chemical structure, C20H18N4, CAS 311796-44-8
2,5-Dimethyl-3,6-diphenylpyrazolo[1,5-a]pyrimidin-7-amine
CAS 311796-44-8C20H18N4
6-(4-Chlorophenyl)-2-methyl-3-phenylpyrazolo[1,5-a]pyrimidin-7-amine chemical structure, C19H15ClN4, CAS 639463-29-9
6-(4-Chlorophenyl)-2-methyl-3-phenylpyrazolo[1,5-a]pyrimidin-7-amine
CAS 639463-29-9C19H15ClN4
6-(4-Chlorophenyl)-3-(2-methoxyphenyl)-2-methylpyrazolo[1,5-a]pyrimidin-7-amine chemical structure, C20H17ClN4O, CAS 701226-61-1
6-(4-Chlorophenyl)-3-(2-methoxyphenyl)-2-methylpyrazolo[1,5-a]pyrimidin-7-amine
CAS 701226-61-1C20H17ClN4O
3-(4-Fluorophenyl)-5-methyl-6-phenylpyrazolo[1,5-a]pyrimidin-7-amine chemical structure, C19H15FN4, CAS 861209-16-7
3-(4-Fluorophenyl)-5-methyl-6-phenylpyrazolo[1,5-a]pyrimidin-7-amine
CAS 861209-16-7C19H15FN4
3-(4-Chlorophenyl)-6-(4-fluorophenyl)-5-methylpyrazolo[1,5-a]pyrimidin-7-amine chemical structure, C19H14ClFN4, CAS 439107-57-0
3-(4-Chlorophenyl)-6-(4-fluorophenyl)-5-methylpyrazolo[1,5-a]pyrimidin-7-amine
CAS 439107-57-0C19H14ClFN4
3-(4-Fluorophenyl)-6-(4-methoxyphenyl)pyrazolo[1,5-a]pyrimidin-7-amine chemical structure, C19H15FN4O, CAS 865657-97-2
3-(4-Fluorophenyl)-6-(4-methoxyphenyl)pyrazolo[1,5-a]pyrimidin-7-amine
CAS 865657-97-2C19H15FN4O
6-(4-Chlorophenyl)-3-(4-fluorophenyl)pyrazolo[1,5-a]pyrimidin-7-amine chemical structure, C18H12ClFN4, CAS 439107-85-4
6-(4-Chlorophenyl)-3-(4-fluorophenyl)pyrazolo[1,5-a]pyrimidin-7-amine
CAS 439107-85-4C18H12ClFN4
3,6-Bis(4-fluorophenyl)-5-methylpyrazolo[1,5-a]pyrimidin-7-amine chemical structure, C19H14F2N4, CAS 865658-06-6
3,6-Bis(4-fluorophenyl)-5-methylpyrazolo[1,5-a]pyrimidin-7-amine
CAS 865658-06-6C19H14F2N4
3,6-Bis(4-fluorophenyl)pyrazolo[1,5-a]pyrimidin-7-amine chemical structure, C18H12F2N4, CAS 685106-99-4
3,6-Bis(4-fluorophenyl)pyrazolo[1,5-a]pyrimidin-7-amine
CAS 685106-99-4C18H12F2N4
3-(4-Fluorophenyl)-6-(4-methoxyphenyl)-5-methylpyrazolo[1,5-a]pyrimidin-7-amine chemical structure, C20H17FN4O, CAS 685109-42-6
3-(4-Fluorophenyl)-6-(4-methoxyphenyl)-5-methylpyrazolo[1,5-a]pyrimidin-7-amine
CAS 685109-42-6C20H17FN4O
6-(3-Chlorophenyl)-3-(4-methoxyphenyl)pyrazolo[1,5-a]pyrimidine chemical structure, C19H14ClN3O, CAS 866132-29-8
6-(3-Chlorophenyl)-3-(4-methoxyphenyl)pyrazolo[1,5-a]pyrimidine
CAS 866132-29-8C19H14ClN3O
3-(4-Fluorophenyl)-6-(4-methylphenyl)pyrazolo[1,5-a]pyrimidine chemical structure, C19H14FN3, CAS 866132-31-2
3-(4-Fluorophenyl)-6-(4-methylphenyl)pyrazolo[1,5-a]pyrimidine
CAS 866132-31-2C19H14FN3
3,6-Diphenylpyrazolo[1,5-a]pyrimidin-7-amine chemical structure, C18H14N4, CAS 32016-25-4
3,6-Diphenylpyrazolo[1,5-a]pyrimidin-7-amine
CAS 32016-25-4C18H14N4
6-(4-Methoxy-phenyl)-3-phenyl-pyrazolo[1,5-a]pyrimidine chemical structure, C19H15N3O, CAS 216661-54-0
6-(4-Methoxy-phenyl)-3-phenyl-pyrazolo[1,5-a]pyrimidine
CAS 216661-54-0C19H15N3O
6-(4-Chlorophenyl)-3-phenylpyrazolo[1,5-a]pyrimidin-7-amine chemical structure, C18H13ClN4, CAS 899379-10-3
6-(4-Chlorophenyl)-3-phenylpyrazolo[1,5-a]pyrimidin-7-amine
CAS 899379-10-3C18H13ClN4
3-[7-Amino-3-(2-methoxyphenyl)pyrazolo[1,5-a]pyrimidin-6-yl]phenol chemical structure, C19H16N4O2, CAS 861249-79-8
3-[7-Amino-3-(2-methoxyphenyl)pyrazolo[1,5-a]pyrimidin-6-yl]phenol
CAS 861249-79-8C19H16N4O2
3-(3,4-Diethoxyphenyl)-6-(4-methoxyphenyl)pyrazolo[1,5-a]pyrimidine chemical structure, C23H23N3O3, CAS 893612-73-2
3-(3,4-Diethoxyphenyl)-6-(4-methoxyphenyl)pyrazolo[1,5-a]pyrimidine
CAS 893612-73-2C23H23N3O3
4-(3-Phenyl-pyrazolo[1,5-A]pyrimidin-6-yl)-phenol methanesulfonate chemical structure, C19H17N3O4S, CAS 1177295-41-8
4-(3-Phenyl-pyrazolo[1,5-A]pyrimidin-6-yl)-phenol methanesulfonate
CAS 1177295-41-8C19H17N3O4S
3-Phenyl-6-(3,4,5-trimethoxyphenyl)pyrazolo[1,5-a]pyrimidine chemical structure, C21H19N3O3, CAS 893613-41-7
3-Phenyl-6-(3,4,5-trimethoxyphenyl)pyrazolo[1,5-a]pyrimidine
CAS 893613-41-7C21H19N3O3
2-(Methoxymethyl)-6-(4-methylphenyl)-3-phenylpyrazolo[1,5-a]pyrimidin-7-amine chemical structure, C21H20N4O, CAS 948142-20-9
2-(Methoxymethyl)-6-(4-methylphenyl)-3-phenylpyrazolo[1,5-a]pyrimidin-7-amine
CAS 948142-20-9C21H20N4O
3-(4-Methoxyphenyl)-6-(4-methylphenyl)pyrazolo[1,5-a]pyrimidin-7-amine chemical structure, C20H18N4O, CAS 948240-59-3
3-(4-Methoxyphenyl)-6-(4-methylphenyl)pyrazolo[1,5-a]pyrimidin-7-amine
CAS 948240-59-3C20H18N4O
6-(4-Chlorophenyl)-2-(methoxymethyl)-3-phenylpyrazolo[1,5-a]pyrimidin-7-amine chemical structure, C20H17ClN4O, CAS 950253-90-4
6-(4-Chlorophenyl)-2-(methoxymethyl)-3-phenylpyrazolo[1,5-a]pyrimidin-7-amine
CAS 950253-90-4C20H17ClN4O
N-(3,6-Diphenylpyrazolo[1,5-a]pyrimidin-7-yl)acetamide chemical structure, C20H16N4O, CAS 32016-26-5
N-(3,6-Diphenylpyrazolo[1,5-a]pyrimidin-7-yl)acetamide
CAS 32016-26-5C20H16N4O