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Murcko scaffold

Ring system with 5 rings and 28 atoms

7 chemicals on CompoundList share this ring system.

Rings
5
Scaffold atoms
28
Chemicals
7
With full pages
1
Scaffold SMILES

c1ccc2c(CCCOc3cncc(-c4ccc5n[nH]cc5c4)c3)c[nH]c2c1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold c1ccc2c(CCCOc3cncc(-c4ccc5n[nH]cc5c4)c3)c[nH]c2c1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 7 of 7 chemicals

Rizavasertib chemical structure, C24H23N5O, CAS 552325-16-3
Rizavasertib
CAS 552325-16-3C24H23N5O
1-(1H-Indol-3-yl)-3-[5-(3-methyl-2H-indazol-5-yl)pyridin-3-yl]oxypropan-2-amine chemical structure, C24H23N5O, CAS 552326-17-7
1-(1H-Indol-3-yl)-3-[5-(3-methyl-2H-indazol-5-yl)pyridin-3-yl]oxypropan-2-amine
CAS 552326-17-7C24H23N5O
PrINZ chemical structure, C27H29N5O, CAS 1174182-25-2
PrINZ
CAS 1174182-25-2C27H29N5O
(R)-1-(1H-Indol-3-yl)-3-((5-(3-methyl-1H-indazol-5-yl)pyridin-3-yl)oxy)propan-2-amine chemical structure, C24H23N5O
(R)-1-(1H-Indol-3-yl)-3-((5-(3-methyl-1H-indazol-5-yl)pyridin-3-yl)oxy)propan-2-amine
C24H23N5O
Carbamic acid, [(1S)-2-(1H-indol-3-yl)-1-[[[5-(3-methyl-1H-indazol-5-yl)-3-pyridinyl]oxy]methyl]ethyl]-, 1,1-dimethylethyl ester (9CI) chemical structure, C29H31N5O3, CAS 911305-63-0
Carbamic acid, [(1S)-2-(1H-indol-3-yl)-1-[[[5-(3-methyl-1H-indazol-5-yl)-3-pyridinyl]oxy]methyl]ethyl]-, 1,1-dimethylethyl ester (9CI)
CAS 911305-63-0C29H31N5O3
1H-Indazole-3-carboxylic acid,5-[5-[(2s)-2-[[(1,1-dimethylethoxy)carbonyl]amino]-3-(1H-indol-3-yl)propoxy]-3-pyridinyl]-6-nitro-,1,1-dimethylethyl ester chemical structure, C33H36N6O7, CAS 929617-46-9
1H-Indazole-3-carboxylic acid,5-[5-[(2s)-2-[[(1,1-dimethylethoxy)carbonyl]amino]-3-(1H-indol-3-yl)propoxy]-3-pyridinyl]-6-nitro-,1,1-dimethylethyl ester
CAS 929617-46-9C33H36N6O7
a-443654 Dihydrochloride chemical structure, C24H25Cl2N5O, CAS 911305-87-8
a-443654 Dihydrochloride
CAS 911305-87-8C24H25Cl2N5O