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Murcko scaffold

Ring system with 4 rings and 29 atoms

34 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
29
Chemicals
34
With full pages
6
Scaffold SMILES

O=C(CSc1nnc(Cc2ccccc2)n1-c1ccccc1)Nc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(CSc1nnc(Cc2ccccc2)n1-c1ccccc1)Nc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 34 of 34 chemicals

2-((5-Benzyl-4-phenyl-4H-1,2,4-triazol-3-yl)thio)-N-(4-chlorophenyl)acetamide chemical structure, C23H19ClN4OS, CAS 332907-30-9
2-((5-Benzyl-4-phenyl-4H-1,2,4-triazol-3-yl)thio)-N-(4-chlorophenyl)acetamide
CAS 332907-30-9C23H19ClN4OS
2-((5-Benzyl-4-phenyl-4H-1,2,4-triazol-3-yl)thio)-N-(2,4-dimethylphenyl)acetamide chemical structure, C25H24N4OS, CAS 493032-75-0
2-((5-Benzyl-4-phenyl-4H-1,2,4-triazol-3-yl)thio)-N-(2,4-dimethylphenyl)acetamide
CAS 493032-75-0C25H24N4OS
2-((5-Benzyl-4-phenyl-4H-1,2,4-triazol-3-yl)thio)-N-(2-methoxyphenyl)acetamide chemical structure, C24H22N4O2S, CAS 332907-37-6
2-((5-Benzyl-4-phenyl-4H-1,2,4-triazol-3-yl)thio)-N-(2-methoxyphenyl)acetamide
CAS 332907-37-6C24H22N4O2S
2-((5-Benzyl-4-phenyl-4H-1,2,4-triazol-3-yl)thio)-N-(4-ethoxyphenyl)acetamide chemical structure, C25H24N4O2S, CAS 493032-76-1
2-((5-Benzyl-4-phenyl-4H-1,2,4-triazol-3-yl)thio)-N-(4-ethoxyphenyl)acetamide
CAS 493032-76-1C25H24N4O2S
2-((5-Benzyl-4-phenyl-4H-1,2,4-triazol-3-yl)thio)-N-(o-tolyl)acetamide chemical structure, C24H22N4OS, CAS 332907-27-4
2-((5-Benzyl-4-phenyl-4H-1,2,4-triazol-3-yl)thio)-N-(o-tolyl)acetamide
CAS 332907-27-4C24H22N4OS
2-((5-Benzyl-4-phenyl-4H-1,2,4-triazol-3-yl)thio)-N-(4-methoxyphenyl)acetamide chemical structure, C24H22N4O2S, CAS 332907-36-5
2-((5-Benzyl-4-phenyl-4H-1,2,4-triazol-3-yl)thio)-N-(4-methoxyphenyl)acetamide
CAS 332907-36-5C24H22N4O2S
2-((5-Benzyl-4-phenyl-4H-1,2,4-triazol-3-yl)thio)-N-(2-ethyl-6-methylphenyl)acetamide chemical structure, C26H26N4OS, CAS 332922-56-2
2-((5-Benzyl-4-phenyl-4H-1,2,4-triazol-3-yl)thio)-N-(2-ethyl-6-methylphenyl)acetamide
CAS 332922-56-2C26H26N4OS
2-[(5-Benzyl-4-phenyl-4H-1,2,4-triazol-3-yl)sulfanyl]-N-(2-methoxy-5-methylphenyl)acetamide chemical structure, C25H24N4O2S, CAS 720667-78-7
2-[(5-Benzyl-4-phenyl-4H-1,2,4-triazol-3-yl)sulfanyl]-N-(2-methoxy-5-methylphenyl)acetamide
CAS 720667-78-7C25H24N4O2S
2-((5-Benzyl-4-phenyl-4H-1,2,4-triazol-3-yl)thio)-N-(4-methylphenyl)acetamide chemical structure, C24H22N4OS, CAS 332907-28-5
2-((5-Benzyl-4-phenyl-4H-1,2,4-triazol-3-yl)thio)-N-(4-methylphenyl)acetamide
CAS 332907-28-5C24H22N4OS
2-((5-Benzyl-4-phenyl-4H-1,2,4-triazol-3-yl)thio)-N-(m-tolyl)acetamide chemical structure, C24H22N4OS, CAS 332907-29-6
2-((5-Benzyl-4-phenyl-4H-1,2,4-triazol-3-yl)thio)-N-(m-tolyl)acetamide
CAS 332907-29-6C24H22N4OS
2-((5-Benzyl-4-phenyl-4H-1,2,4-triazol-3-yl)thio)-N-(3,5-dimethylphenyl)acetamide chemical structure, C25H24N4OS, CAS 332907-31-0
2-((5-Benzyl-4-phenyl-4H-1,2,4-triazol-3-yl)thio)-N-(3,5-dimethylphenyl)acetamide
CAS 332907-31-0C25H24N4OS
2-((5-Benzyl-4-phenyl-4H-1,2,4-triazol-3-yl)thio)-N-(2,3-dimethylphenyl)acetamide chemical structure, C25H24N4OS, CAS 332907-32-1
2-((5-Benzyl-4-phenyl-4H-1,2,4-triazol-3-yl)thio)-N-(2,3-dimethylphenyl)acetamide
CAS 332907-32-1C25H24N4OS
2-((5-Benzyl-4-phenyl-4H-1,2,4-triazol-3-yl)thio)-N-(2,5-dimethylphenyl)acetamide chemical structure, C25H24N4OS, CAS 332907-33-2
2-((5-Benzyl-4-phenyl-4H-1,2,4-triazol-3-yl)thio)-N-(2,5-dimethylphenyl)acetamide
CAS 332907-33-2C25H24N4OS
2-((5-Benzyl-4-phenyl-4H-1,2,4-triazol-3-yl)thio)-N-(3-chlorophenyl)acetamide chemical structure, C23H19ClN4OS, CAS 444152-67-4
2-((5-Benzyl-4-phenyl-4H-1,2,4-triazol-3-yl)thio)-N-(3-chlorophenyl)acetamide
CAS 444152-67-4C23H19ClN4OS
2-((5-Benzyl-4-phenyl-4H-1,2,4-triazol-3-yl)thio)-N-(4-fluorophenyl)acetamide chemical structure, C23H19FN4OS, CAS 332907-34-3
2-((5-Benzyl-4-phenyl-4H-1,2,4-triazol-3-yl)thio)-N-(4-fluorophenyl)acetamide
CAS 332907-34-3C23H19FN4OS
2-((5-Benzyl-4-phenyl-4H-1,2,4-triazol-3-yl)thio)-N-(4-methyl-3-nitrophenyl)acetamide chemical structure, C24H21N5O3S, CAS 332922-45-9
2-((5-Benzyl-4-phenyl-4H-1,2,4-triazol-3-yl)thio)-N-(4-methyl-3-nitrophenyl)acetamide
CAS 332922-45-9C24H21N5O3S
2-((5-Benzyl-4-phenyl-4H-1,2,4-triazol-3-yl)thio)-N-(4-chloro-3-nitrophenyl)acetamide chemical structure, C23H18ClN5O3S, CAS 332922-47-1
2-((5-Benzyl-4-phenyl-4H-1,2,4-triazol-3-yl)thio)-N-(4-chloro-3-nitrophenyl)acetamide
CAS 332922-47-1C23H18ClN5O3S
HIV-1 inhibitor-46 chemical structure, C24H21ClN4OS, CAS 332947-35-0
HIV-1 inhibitor-46
CAS 332947-35-0C24H21ClN4OS
N-(4-Acetylphenyl)-2-((5-benzyl-4-phenyl-4H-1,2,4-triazol-3-yl)thio)acetamide chemical structure, C25H22N4O2S, CAS 332912-87-5
N-(4-Acetylphenyl)-2-((5-benzyl-4-phenyl-4H-1,2,4-triazol-3-yl)thio)acetamide
CAS 332912-87-5C25H22N4O2S
Methyl 4-[[2-[[5-[(4-methoxyphenyl)methyl]-4-phenyl-1,2,4-triazol-3-yl]sulfanyl]acetyl]amino]benzoate chemical structure, C26H24N4O4S, CAS 634169-51-0
Methyl 4-[[2-[[5-[(4-methoxyphenyl)methyl]-4-phenyl-1,2,4-triazol-3-yl]sulfanyl]acetyl]amino]benzoate
CAS 634169-51-0C26H24N4O4S
2-[[5-Benzyl-4-(3-methylphenyl)-1,2,4-triazol-3-yl]sulfanyl]-N-(3-chloro-4-fluorophenyl)acetamide chemical structure, C24H20ClFN4OS, CAS 663158-39-2
2-[[5-Benzyl-4-(3-methylphenyl)-1,2,4-triazol-3-yl]sulfanyl]-N-(3-chloro-4-fluorophenyl)acetamide
CAS 663158-39-2C24H20ClFN4OS
2-[[5-Benzyl-4-(4-methoxyphenyl)-1,2,4-triazol-3-yl]sulfanyl]-N-(2,4-dichlorophenyl)acetamide chemical structure, C24H20Cl2N4O2S, CAS 663159-04-4
2-[[5-Benzyl-4-(4-methoxyphenyl)-1,2,4-triazol-3-yl]sulfanyl]-N-(2,4-dichlorophenyl)acetamide
CAS 663159-04-4C24H20Cl2N4O2S
2-[[5-Benzyl-4-(4-methoxyphenyl)-1,2,4-triazol-3-yl]sulfanyl]-N-[4-bromo-2-(trifluoromethyl)phenyl]acetamide chemical structure, C25H20BrF3N4O2S, CAS 663214-91-3
2-[[5-Benzyl-4-(4-methoxyphenyl)-1,2,4-triazol-3-yl]sulfanyl]-N-[4-bromo-2-(trifluoromethyl)phenyl]acetamide
CAS 663214-91-3C25H20BrF3N4O2S
2-[[5-Benzyl-4-(3,4-dimethylphenyl)-1,2,4-triazol-3-yl]sulfanyl]-N-(2,3-dichlorophenyl)acetamide chemical structure, C25H22Cl2N4OS, CAS 663213-29-4
2-[[5-Benzyl-4-(3,4-dimethylphenyl)-1,2,4-triazol-3-yl]sulfanyl]-N-(2,3-dichlorophenyl)acetamide
CAS 663213-29-4C25H22Cl2N4OS