Murcko scaffold
Ring system with 4 rings and 29 atoms
13 chemicals on CompoundList share this ring system.
- Rings
- 4
- Scaffold atoms
- 29
- Chemicals
- 13
- With full pages
- 2
Scaffold SMILES
O=C(C=CC1=C(N2CCOCC2)C(=Cc2ccccc2)CC1)Nc1ccccc1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 13 of 13 chemicals
![(E)-2-Cyano-3-[(3E)-2-morpholin-4-yl-3-[(3-nitrophenyl)methylidene]cyclopenten-1-yl]-N-[3-(trifluoromethyl)phenyl]prop-2-enamide chemical structure, C27H23F3N4O4, CAS 328030-11-1](/s/WZATVMBWFDNRRP-KQTOXHKBSA-N.svg)
(E)-2-Cyano-3-[(3E)-2-morpholin-4-yl-3-[(3-nitrophenyl)methylidene]cyclopenten-1-yl]-N-[3-(trifluoromethyl)phenyl]prop-2-enamide
CAS 328030-11-1C27H23F3N4O4
![2-Cyano-N-(2-fluorophenyl)-3-[2-(morpholin-4-yl)-3-(phenylmethylidene)cyclopent-1-en-1-yl]prop-2-enamide chemical structure, C26H24FN3O2, CAS 328030-83-7](/s/CZELQGNDBKMVQU-TYIAYESWSA-N.svg)
2-Cyano-N-(2-fluorophenyl)-3-[2-(morpholin-4-yl)-3-(phenylmethylidene)cyclopent-1-en-1-yl]prop-2-enamide
CAS 328030-83-7C26H24FN3O2
![2-Cyano-N-{4-[(difluoromethyl)sulfanyl]phenyl}-3-[2-(morpholin-4-yl)-3-(phenylmethylidene)cyclopent-1-en-1-yl]prop-2-enamide chemical structure, C27H25F2N3O2S, CAS 327106-85-4](/s/QMLDRRRBFZBFHZ-TYIAYESWSA-N.svg)
2-Cyano-N-{4-[(difluoromethyl)sulfanyl]phenyl}-3-[2-(morpholin-4-yl)-3-(phenylmethylidene)cyclopent-1-en-1-yl]prop-2-enamide
CAS 327106-85-4C27H25F2N3O2S
![(E)-3-[(3E)-3-[(4-Chlorophenyl)methylidene]-2-morpholin-4-ylcyclopenten-1-yl]-2-cyano-N-(2-fluorophenyl)prop-2-enamide chemical structure, C26H23ClFN3O2, CAS 326916-06-7](/s/WYIWEKXQKQANMX-WIDTVHIISA-N.svg)
(E)-3-[(3E)-3-[(4-Chlorophenyl)methylidene]-2-morpholin-4-ylcyclopenten-1-yl]-2-cyano-N-(2-fluorophenyl)prop-2-enamide
CAS 326916-06-7C26H23ClFN3O2
![2-Cyano-3-[3-[(2,4-dichlorophenyl)methylidene]-2-morpholin-4-ylcyclopenten-1-yl]-N-(2-fluorophenyl)prop-2-enamide chemical structure, C26H22Cl2FN3O2](/s/RHRADDNSRSJNRL-UHFFFAOYSA-N.svg)
2-Cyano-3-[3-[(2,4-dichlorophenyl)methylidene]-2-morpholin-4-ylcyclopenten-1-yl]-N-(2-fluorophenyl)prop-2-enamide
C26H22Cl2FN3O2
![2-Cyano-N-(2-fluorophenyl)-3-[2-(morpholin-4-yl)-3-[(3-nitrophenyl)methylidene]cyclopent-1-en-1-yl]prop-2-enamide chemical structure, C26H23FN4O4, CAS 1164565-01-8](/s/UZIJVCHJJSDCHH-UFDHTVHMSA-N.svg)
2-Cyano-N-(2-fluorophenyl)-3-[2-(morpholin-4-yl)-3-[(3-nitrophenyl)methylidene]cyclopent-1-en-1-yl]prop-2-enamide
CAS 1164565-01-8C26H23FN4O4
![(E)-2-Cyano-N-[4-(difluoromethylsulfanyl)phenyl]-3-[(3E)-2-morpholin-4-yl-3-[(3-nitrophenyl)methylidene]cyclopenten-1-yl]prop-2-enamide chemical structure, C27H24F2N4O4S, CAS 327106-93-4](/s/OIBIFPYSVPRTDL-UFDHTVHMSA-N.svg)
(E)-2-Cyano-N-[4-(difluoromethylsulfanyl)phenyl]-3-[(3E)-2-morpholin-4-yl-3-[(3-nitrophenyl)methylidene]cyclopenten-1-yl]prop-2-enamide
CAS 327106-93-4C27H24F2N4O4S
![(E)-2-Cyano-N-[4-(difluoromethoxy)phenyl]-3-[(3E)-2-morpholin-4-yl-3-[(4-nitrophenyl)methylidene]cyclopenten-1-yl]prop-2-enamide chemical structure, C27H24F2N4O5, CAS 882135-27-5](/s/JBTRUMZNDUORGH-WIDTVHIISA-N.svg)
(E)-2-Cyano-N-[4-(difluoromethoxy)phenyl]-3-[(3E)-2-morpholin-4-yl-3-[(4-nitrophenyl)methylidene]cyclopenten-1-yl]prop-2-enamide
CAS 882135-27-5C27H24F2N4O5
![(E)-2-Cyano-3-[(3E)-3-[[4-(diethylamino)phenyl]methylidene]-2-morpholin-4-ylcyclopenten-1-yl]-N-(2-fluorophenyl)prop-2-enamide chemical structure, C30H33FN4O2, CAS 1164489-78-4](/s/BZVIQTMIXILUQA-DJCYKTPPSA-N.svg)
(E)-2-Cyano-3-[(3E)-3-[[4-(diethylamino)phenyl]methylidene]-2-morpholin-4-ylcyclopenten-1-yl]-N-(2-fluorophenyl)prop-2-enamide
CAS 1164489-78-4C30H33FN4O2
![2-Cyano-N-(2-fluorophenyl)-3-[2-(morpholin-4-yl)-3-[(4-nitrophenyl)methylidene]cyclopent-1-en-1-yl]prop-2-enamide chemical structure, C26H23FN4O4, CAS 327106-80-9](/s/ZOIRFOKFODUJLH-WIDTVHIISA-N.svg)
2-Cyano-N-(2-fluorophenyl)-3-[2-(morpholin-4-yl)-3-[(4-nitrophenyl)methylidene]cyclopent-1-en-1-yl]prop-2-enamide
CAS 327106-80-9C26H23FN4O4
![(E)-2-Cyano-3-[(3E)-3-[(2,4-dichlorophenyl)methylidene]-2-morpholin-4-ylcyclopenten-1-yl]-N-(2-fluorophenyl)prop-2-enamide chemical structure, C26H22Cl2FN3O2](/s/RHRADDNSRSJNRL-UHOXYHJQSA-N.svg)
(E)-2-Cyano-3-[(3E)-3-[(2,4-dichlorophenyl)methylidene]-2-morpholin-4-ylcyclopenten-1-yl]-N-(2-fluorophenyl)prop-2-enamide
C26H22Cl2FN3O2
![2-Cyano-3-{3-[(2,4-dichlorophenyl)methylidene]-2-(morpholin-4-yl)cyclopent-1-en-1-yl}-N-(2-fluorophenyl)prop-2-enamide chemical structure, C26H22Cl2FN3O2, CAS 326916-05-6](/s/RHRADDNSRSJNRL-DKPWPWCWSA-N.svg)
2-Cyano-3-{3-[(2,4-dichlorophenyl)methylidene]-2-(morpholin-4-yl)cyclopent-1-en-1-yl}-N-(2-fluorophenyl)prop-2-enamide
CAS 326916-05-6C26H22Cl2FN3O2
![(Z)-3-[(3E)-3-Benzylidene-2-morpholin-4-ylcyclopenten-1-yl]-2-cyano-N-[3-(trifluoromethyl)phenyl]prop-2-enamide chemical structure, C27H24F3N3O2, CAS 328027-59-4](/s/CRSSXBGDMIKGBK-OHEWCHTRSA-N.svg)
(Z)-3-[(3E)-3-Benzylidene-2-morpholin-4-ylcyclopenten-1-yl]-2-cyano-N-[3-(trifluoromethyl)phenyl]prop-2-enamide
CAS 328027-59-4C27H24F3N3O2
Related scaffolds
Same ring framework with different atoms or bond orders
![Scaffold O=C(CSc1nnc(Cc2cc(=O)[nH]c(=O)[nH]2)n1-c1ccccc1)Nc1ccccc1](/scaffold/UWUYPSZQXAQZER-UHFFFAOYSA-N/structure.svg)
![Scaffold O=C(CSc1nnc(Cc2cc(=O)[nH]c(=O)[nH]2)n1-c1ccccc1)NC1CCCCC1](/scaffold/UFOPNKSVEXTJGQ-UHFFFAOYSA-N/structure.svg)