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Murcko scaffold

4-(3,4-Dihydro-1H-isoquinolin-2-ylsulfonyl)-N-(4-phenyl-1,3-thiazol-2-yl)benzamide scaffold

17 chemicals on CompoundList share this ring system.

Rings
5
Scaffold atoms
33
Chemicals
17
With full pages
4
Scaffold SMILES

O=C(Nc1nc(-c2ccccc2)cs1)c1ccc(S(=O)(=O)N2CCc3ccccc3C2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 4-(3,4-Dihydro-1H-isoquinolin-2-ylsulfonyl)-N-(4-phenyl-1,3-thiazol-2-yl)benzamide page
Murcko scaffold O=C(Nc1nc(-c2ccccc2)cs1)c1ccc(S(=O)(=O)N2CCc3ccccc3C2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 17 of 17 chemicals

4-((3,4-Dihydroisoquinolin-2(1H)-yl)sulfonyl)-N-(4-(4-ethoxyphenyl)thiazol-2-yl)benzamide chemical structure, C27H25N3O4S2, CAS 361171-47-3
4-((3,4-Dihydroisoquinolin-2(1H)-yl)sulfonyl)-N-(4-(4-ethoxyphenyl)thiazol-2-yl)benzamide
CAS 361171-47-3C27H25N3O4S2
N-[4-(4-Bromophenyl)-1,3-thiazol-2-yl]-4-(3,4-dihydro-1H-isoquinolin-2-ylsulfonyl)benzamide chemical structure, C25H20BrN3O3S2, CAS 361480-59-3
N-[4-(4-Bromophenyl)-1,3-thiazol-2-yl]-4-(3,4-dihydro-1H-isoquinolin-2-ylsulfonyl)benzamide
CAS 361480-59-3C25H20BrN3O3S2
N-[4-(3,4-Dichlorophenyl)-1,3-thiazol-2-yl]-4-(3,4-dihydro-1H-isoquinolin-2-ylsulfonyl)benzamide chemical structure, C25H19Cl2N3O3S2, CAS 361480-72-0
N-[4-(3,4-Dichlorophenyl)-1,3-thiazol-2-yl]-4-(3,4-dihydro-1H-isoquinolin-2-ylsulfonyl)benzamide
CAS 361480-72-0C25H19Cl2N3O3S2
4-(3,4-Dihydro-1H-isoquinolin-2-ylsulfonyl)-N-[4-(4-iodophenyl)-1,3-thiazol-2-yl]benzamide chemical structure, C25H20IN3O3S2, CAS 361480-61-7
4-(3,4-Dihydro-1H-isoquinolin-2-ylsulfonyl)-N-[4-(4-iodophenyl)-1,3-thiazol-2-yl]benzamide
CAS 361480-61-7C25H20IN3O3S2
4-((3,4-Dihydroisoquinolin-2(1H)-yl)sulfonyl)-N-(4-mesitylthiazol-2-yl)benzamide chemical structure, C28H27N3O3S2, CAS 361480-68-4
4-((3,4-Dihydroisoquinolin-2(1H)-yl)sulfonyl)-N-(4-mesitylthiazol-2-yl)benzamide
CAS 361480-68-4C28H27N3O3S2
N-(4-(4-Cyanophenyl)thiazol-2-yl)-4-((3,4-dihydroisoquinolin-2(1H)-yl)sulfonyl)benzamide chemical structure, C26H20N4O3S2, CAS 361480-69-5
N-(4-(4-Cyanophenyl)thiazol-2-yl)-4-((3,4-dihydroisoquinolin-2(1H)-yl)sulfonyl)benzamide
CAS 361480-69-5C26H20N4O3S2
Ethyl 2-(4-((3,4-dihydroisoquinolin-2(1H)-yl)sulfonyl)benzamido)-4-phenylthiazole-5-carboxylate chemical structure, C28H25N3O5S2, CAS 361480-73-1
Ethyl 2-(4-((3,4-dihydroisoquinolin-2(1H)-yl)sulfonyl)benzamido)-4-phenylthiazole-5-carboxylate
CAS 361480-73-1C28H25N3O5S2
4-((3,4-Dihydroisoquinolin-2(1H)-yl)sulfonyl)-N-(4-(3-nitrophenyl)thiazol-2-yl)benzamide chemical structure, C25H20N4O5S2, CAS 361480-65-1
4-((3,4-Dihydroisoquinolin-2(1H)-yl)sulfonyl)-N-(4-(3-nitrophenyl)thiazol-2-yl)benzamide
CAS 361480-65-1C25H20N4O5S2
4-((3,4-Dihydroisoquinolin-2(1H)-yl)sulfonyl)-N-(4-(3,4-dimethylphenyl)thiazol-2-yl)benzamide chemical structure, C27H25N3O3S2, CAS 361480-63-9
4-((3,4-Dihydroisoquinolin-2(1H)-yl)sulfonyl)-N-(4-(3,4-dimethylphenyl)thiazol-2-yl)benzamide
CAS 361480-63-9C27H25N3O3S2
4-(3,4-Dihydro-1H-isoquinolin-2-ylsulfonyl)-N-(4-phenyl-1,3-thiazol-2-yl)benzamide chemical structure, C25H21N3O3S2, CAS 361480-57-1
4-(3,4-Dihydro-1H-isoquinolin-2-ylsulfonyl)-N-(4-phenyl-1,3-thiazol-2-yl)benzamide
CAS 361480-57-1C25H21N3O3S2
N-(5-Acetyl-4-phenylthiazol-2-yl)-4-((3,4-dihydroisoquinolin-2(1H)-yl)sulfonyl)benzamide chemical structure, C27H23N3O4S2, CAS 361480-64-0
N-(5-Acetyl-4-phenylthiazol-2-yl)-4-((3,4-dihydroisoquinolin-2(1H)-yl)sulfonyl)benzamide
CAS 361480-64-0C27H23N3O4S2
4-(3,4-Dihydro-1H-isoquinolin-2-ylsulfonyl)-N-[4-(2,5-dimethylphenyl)-1,3-thiazol-2-yl]benzamide chemical structure, C27H25N3O3S2, CAS 361480-62-8
4-(3,4-Dihydro-1H-isoquinolin-2-ylsulfonyl)-N-[4-(2,5-dimethylphenyl)-1,3-thiazol-2-yl]benzamide
CAS 361480-62-8C27H25N3O3S2
4-((3,4-Dihydroisoquinolin-2(1H)-yl)sulfonyl)-N-(4-(4-propoxyphenyl)thiazol-2-yl)benzamide chemical structure, C28H27N3O4S2, CAS 361480-67-3
4-((3,4-Dihydroisoquinolin-2(1H)-yl)sulfonyl)-N-(4-(4-propoxyphenyl)thiazol-2-yl)benzamide
CAS 361480-67-3C28H27N3O4S2
4-((3,4-Dihydroisoquinolin-2(1H)-yl)sulfonyl)-N-(4-(2,4-dimethoxyphenyl)thiazol-2-yl)benzamide chemical structure, C27H25N3O5S2, CAS 361481-83-6
4-((3,4-Dihydroisoquinolin-2(1H)-yl)sulfonyl)-N-(4-(2,4-dimethoxyphenyl)thiazol-2-yl)benzamide
CAS 361481-83-6C27H25N3O5S2
4-((3,4-Dihydroisoquinolin-2(1H)-yl)sulfonyl)-N-(4-(4-methoxyphenyl)thiazol-2-yl)benzamide chemical structure, C26H23N3O4S2, CAS 361480-58-2
4-((3,4-Dihydroisoquinolin-2(1H)-yl)sulfonyl)-N-(4-(4-methoxyphenyl)thiazol-2-yl)benzamide
CAS 361480-58-2C26H23N3O4S2
Methyl 4-[2-[[4-(3,4-dihydro-1H-isoquinolin-2-ylsulfonyl)benzoyl]amino]-1,3-thiazol-4-yl]benzoate chemical structure, C27H23N3O5S2, CAS 361173-95-7
Methyl 4-[2-[[4-(3,4-dihydro-1H-isoquinolin-2-ylsulfonyl)benzoyl]amino]-1,3-thiazol-4-yl]benzoate
CAS 361173-95-7C27H23N3O5S2
4-(3,4-Dihydro-1H-isoquinolin-2-ylsulfonyl)-N-[4-(4-propan-2-ylphenyl)-1,3-thiazol-2-yl]benzamide chemical structure, C28H27N3O3S2, CAS 684231-83-2
4-(3,4-Dihydro-1H-isoquinolin-2-ylsulfonyl)-N-[4-(4-propan-2-ylphenyl)-1,3-thiazol-2-yl]benzamide
CAS 684231-83-2C28H27N3O3S2