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Murcko scaffold

Ring system with 5 rings and 33 atoms

15 chemicals on CompoundList share this ring system.

Rings
5
Scaffold atoms
33
Chemicals
15
With full pages
1
Scaffold SMILES

O=C(Nc1nnc(-c2ccccc2)o1)c1ccc(S(=O)(=O)N2CCc3ccccc3C2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(Nc1nnc(-c2ccccc2)o1)c1ccc(S(=O)(=O)N2CCc3ccccc3C2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 15 of 15 chemicals

N-(5-(2-Chlorophenyl)-1,3,4-oxadiazol-2-yl)-4-((3,4-dihydroisoquinolin-2(1H)-yl)sulfonyl)benzamide chemical structure, C24H19ClN4O4S, CAS 533869-30-6
N-(5-(2-Chlorophenyl)-1,3,4-oxadiazol-2-yl)-4-((3,4-dihydroisoquinolin-2(1H)-yl)sulfonyl)benzamide
CAS 533869-30-6C24H19ClN4O4S
4-((3,4-Dihydroisoquinolin-2(1H)-yl)sulfonyl)-N-(5-(2-methoxyphenyl)-1,3,4-oxadiazol-2-yl)benzamide chemical structure, C25H22N4O5S, CAS 533869-74-8
4-((3,4-Dihydroisoquinolin-2(1H)-yl)sulfonyl)-N-(5-(2-methoxyphenyl)-1,3,4-oxadiazol-2-yl)benzamide
CAS 533869-74-8C25H22N4O5S
4-(3,4-Dihydro-1H-isoquinolin-2-ylsulfonyl)-N-[5-(3-methoxyphenyl)-1,3,4-oxadiazol-2-yl]benzamide chemical structure, C25H22N4O5S, CAS 533870-01-8
4-(3,4-Dihydro-1H-isoquinolin-2-ylsulfonyl)-N-[5-(3-methoxyphenyl)-1,3,4-oxadiazol-2-yl]benzamide
CAS 533870-01-8C25H22N4O5S
4-(3,4-Dihydroisoquinolin-2(1H)-ylsulfonyl)-N-[5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl]benzamide chemical structure, C25H22N4O5S, CAS 442881-27-8
4-(3,4-Dihydroisoquinolin-2(1H)-ylsulfonyl)-N-[5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl]benzamide
CAS 442881-27-8C25H22N4O5S
4-((3,4-Dihydroisoquinolin-2(1H)-yl)sulfonyl)-N-(5-(2,4-dimethoxyphenyl)-1,3,4-oxadiazol-2-yl)benzamide chemical structure, C26H24N4O6S, CAS 533870-36-9
4-((3,4-Dihydroisoquinolin-2(1H)-yl)sulfonyl)-N-(5-(2,4-dimethoxyphenyl)-1,3,4-oxadiazol-2-yl)benzamide
CAS 533870-36-9C26H24N4O6S
4-((3,4-Dihydroisoquinolin-2(1H)-yl)sulfonyl)-N-(5-(3,5-dimethoxyphenyl)-1,3,4-oxadiazol-2-yl)benzamide chemical structure, C26H24N4O6S, CAS 533870-65-4
4-((3,4-Dihydroisoquinolin-2(1H)-yl)sulfonyl)-N-(5-(3,5-dimethoxyphenyl)-1,3,4-oxadiazol-2-yl)benzamide
CAS 533870-65-4C26H24N4O6S
4-((3,4-Dihydroisoquinolin-2(1H)-yl)sulfonyl)-N-(5-(3,4,5-trimethoxyphenyl)-1,3,4-oxadiazol-2-yl)benzamide chemical structure, C27H26N4O7S, CAS 533871-46-4
4-((3,4-Dihydroisoquinolin-2(1H)-yl)sulfonyl)-N-(5-(3,4,5-trimethoxyphenyl)-1,3,4-oxadiazol-2-yl)benzamide
CAS 533871-46-4C27H26N4O7S
4-((3,4-Dihydroisoquinolin-2(1H)-yl)sulfonyl)-N-(5-(3,4,5-triethoxyphenyl)-1,3,4-oxadiazol-2-yl)benzamide chemical structure, C30H32N4O7S, CAS 533871-76-0
4-((3,4-Dihydroisoquinolin-2(1H)-yl)sulfonyl)-N-(5-(3,4,5-triethoxyphenyl)-1,3,4-oxadiazol-2-yl)benzamide
CAS 533871-76-0C30H32N4O7S
4-((3,4-Dihydroisoquinolin-2(1H)-yl)sulfonyl)-N-(5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl)benzamide chemical structure, C24H19FN4O4S, CAS 533869-60-2
4-((3,4-Dihydroisoquinolin-2(1H)-yl)sulfonyl)-N-(5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl)benzamide
CAS 533869-60-2C24H19FN4O4S
4-((3,4-Dihydroisoquinolin-2(1H)-yl)sulfonyl)-N-(5-(3,4-dimethoxyphenyl)-1,3,4-oxadiazol-2-yl)benzamide chemical structure, C26H24N4O6S, CAS 921096-15-3
4-((3,4-Dihydroisoquinolin-2(1H)-yl)sulfonyl)-N-(5-(3,4-dimethoxyphenyl)-1,3,4-oxadiazol-2-yl)benzamide
CAS 921096-15-3C26H24N4O6S
N-[5-(2,4-Dimethylphenyl)-1,3,4-oxadiazol-2-yl]-4-(1,2,3,4-tetrahydroisoquinoline-2-sulfonyl)benzamide chemical structure, C26H24N4O4S, CAS 891111-85-6
N-[5-(2,4-Dimethylphenyl)-1,3,4-oxadiazol-2-yl]-4-(1,2,3,4-tetrahydroisoquinoline-2-sulfonyl)benzamide
CAS 891111-85-6C26H24N4O4S
4-((3,4-Dihydroisoquinolin-2(1H)-yl)sulfonyl)-N-(5-(2,5-dimethylphenyl)-1,3,4-oxadiazol-2-yl)benzamide chemical structure, C26H24N4O4S, CAS 891121-05-4
4-((3,4-Dihydroisoquinolin-2(1H)-yl)sulfonyl)-N-(5-(2,5-dimethylphenyl)-1,3,4-oxadiazol-2-yl)benzamide
CAS 891121-05-4C26H24N4O4S
4-((3,4-Dihydroisoquinolin-2(1H)-yl)sulfonyl)-N-(5-(3,4-dimethylphenyl)-1,3,4-oxadiazol-2-yl)benzamide chemical structure, C26H24N4O4S, CAS 899734-53-3
4-((3,4-Dihydroisoquinolin-2(1H)-yl)sulfonyl)-N-(5-(3,4-dimethylphenyl)-1,3,4-oxadiazol-2-yl)benzamide
CAS 899734-53-3C26H24N4O4S
N-(5-(3-Chlorophenyl)-1,3,4-oxadiazol-2-yl)-4-((3,4-dihydroisoquinolin-2(1H)-yl)sulfonyl)benzamide chemical structure, C24H19ClN4O4S, CAS 952893-58-2
N-(5-(3-Chlorophenyl)-1,3,4-oxadiazol-2-yl)-4-((3,4-dihydroisoquinolin-2(1H)-yl)sulfonyl)benzamide
CAS 952893-58-2C24H19ClN4O4S
4-((3,4-Dihydroisoquinolin-2(1H)-yl)sulfonyl)-N-(5-(3-(methylsulfonyl)phenyl)-1,3,4-oxadiazol-2-yl)benzamide chemical structure, C25H22N4O6S2, CAS 922563-55-1
4-((3,4-Dihydroisoquinolin-2(1H)-yl)sulfonyl)-N-(5-(3-(methylsulfonyl)phenyl)-1,3,4-oxadiazol-2-yl)benzamide
CAS 922563-55-1C25H22N4O6S2