CompoundList
Sign in
Murcko scaffold

Ring system with 4 rings and 23 atoms

160 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
23
Chemicals
160
With full pages
135
Scaffold SMILES

O=C1CCCC2=C1C(c1ccccc1)C=CN2c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C1CCCC2=C1C(c1ccccc1)C=CN2c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 160 chemicals

2-Amino-1-(4-chlorophenyl)-7,7-dimethyl-4-(3-nitrophenyl)-5-oxo-1,4,5,6,7,8-hexahydro-3-quinolinecarbonitrile chemical structure, C24H21ClN4O3, CAS 311318-16-8
2-Amino-1-(4-chlorophenyl)-7,7-dimethyl-4-(3-nitrophenyl)-5-oxo-1,4,5,6,7,8-hexahydro-3-quinolinecarbonitrile
CAS 311318-16-8C24H21ClN4O3
2-Amino-1-(4-chlorophenyl)-4-(4-methoxyphenyl)-7,7-dimethyl-5-oxo-1,4,5,6,7,8-hexahydro-3-quinolinecarbonitrile chemical structure, C25H24ClN3O2, CAS 312272-81-4
2-Amino-1-(4-chlorophenyl)-4-(4-methoxyphenyl)-7,7-dimethyl-5-oxo-1,4,5,6,7,8-hexahydro-3-quinolinecarbonitrile
CAS 312272-81-4C25H24ClN3O2
2-Amino-4-(3,4-dimethoxyphenyl)-1-(4-nitrophenyl)-5-oxo-1,4,5,6,7,8-hexahydro-3-quinolinecarbonitrile chemical structure, C24H22N4O5, CAS 311331-82-5
2-Amino-4-(3,4-dimethoxyphenyl)-1-(4-nitrophenyl)-5-oxo-1,4,5,6,7,8-hexahydro-3-quinolinecarbonitrile
CAS 311331-82-5C24H22N4O5
2-Amino-1-(4-bromophenyl)-4-(4-methoxyphenyl)-5-oxo-1,4,5,6,7,8-hexahydro-3-quinolinecarbonitrile chemical structure, C23H20BrN3O2, CAS 351166-33-1
2-Amino-1-(4-bromophenyl)-4-(4-methoxyphenyl)-5-oxo-1,4,5,6,7,8-hexahydro-3-quinolinecarbonitrile
CAS 351166-33-1C23H20BrN3O2
2-Amino-1-(4-chlorophenyl)-4-(3,4-dimethoxyphenyl)-5-oxo-1,4,5,6,7,8-hexahydro-3-quinolinecarbonitrile chemical structure, C24H22ClN3O3, CAS 311330-82-2
2-Amino-1-(4-chlorophenyl)-4-(3,4-dimethoxyphenyl)-5-oxo-1,4,5,6,7,8-hexahydro-3-quinolinecarbonitrile
CAS 311330-82-2C24H22ClN3O3
2-Amino-1-(4-bromophenyl)-4-[4-(diethylamino)phenyl]-7,7-dimethyl-5-oxo-1,4,5,6,7,8-hexahydro-3-quinolinecarbonitrile chemical structure, C28H31BrN4O, CAS 311797-78-1
2-Amino-1-(4-bromophenyl)-4-[4-(diethylamino)phenyl]-7,7-dimethyl-5-oxo-1,4,5,6,7,8-hexahydro-3-quinolinecarbonitrile
CAS 311797-78-1C28H31BrN4O
4-[2-Amino-4-(2-chlorophenyl)-3-cyano-7,7-dimethyl-5-oxo-6,8-dihydro-4H-quinolin-1-yl]benzenesulfonamide chemical structure, C24H23ClN4O3S, CAS 713506-28-6
4-[2-Amino-4-(2-chlorophenyl)-3-cyano-7,7-dimethyl-5-oxo-6,8-dihydro-4H-quinolin-1-yl]benzenesulfonamide
CAS 713506-28-6C24H23ClN4O3S
2-Amino-4-(2-chloro-6-fluorophenyl)-7,7-dimethyl-1-(4-nitrophenyl)-5-oxo-6,8-dihydro-4H-quinoline-3-carbonitrile chemical structure, C24H20ClFN4O3, CAS 714202-76-3
2-Amino-4-(2-chloro-6-fluorophenyl)-7,7-dimethyl-1-(4-nitrophenyl)-5-oxo-6,8-dihydro-4H-quinoline-3-carbonitrile
CAS 714202-76-3C24H20ClFN4O3
2-Amino-4-(4-chlorophenyl)-7,7-dimethyl-1-(4-methylphenyl)-5-oxo-1,4,5,6,7,8-hexahydro-3-quinolinecarbonitrile chemical structure, C25H24ClN3O, CAS 354796-78-4
2-Amino-4-(4-chlorophenyl)-7,7-dimethyl-1-(4-methylphenyl)-5-oxo-1,4,5,6,7,8-hexahydro-3-quinolinecarbonitrile
CAS 354796-78-4C25H24ClN3O
4-[2-Amino-3-cyano-4-(3-methoxyphenyl)-7,7-dimethyl-5-oxo-6,8-dihydro-4H-quinolin-1-yl]benzenesulfonamide chemical structure, C25H26N4O4S, CAS 717891-62-8
4-[2-Amino-3-cyano-4-(3-methoxyphenyl)-7,7-dimethyl-5-oxo-6,8-dihydro-4H-quinolin-1-yl]benzenesulfonamide
CAS 717891-62-8C25H26N4O4S
4-[2-Amino-3-cyano-7,7-dimethyl-4-(4-nitrophenyl)-5-oxo-6,8-dihydro-4H-quinolin-1-yl]benzenesulfonamide chemical structure, C24H23N5O5S, CAS 718602-19-8
4-[2-Amino-3-cyano-7,7-dimethyl-4-(4-nitrophenyl)-5-oxo-6,8-dihydro-4H-quinolin-1-yl]benzenesulfonamide
CAS 718602-19-8C24H23N5O5S
2-Amino-4-(4-fluorophenyl)-7,7-dimethyl-1-(4-nitrophenyl)-5-oxo-1,4,5,6,7,8-hexahydro-3-quinolinecarbonitrile chemical structure, C24H21FN4O3, CAS 311773-58-7
2-Amino-4-(4-fluorophenyl)-7,7-dimethyl-1-(4-nitrophenyl)-5-oxo-1,4,5,6,7,8-hexahydro-3-quinolinecarbonitrile
CAS 311773-58-7C24H21FN4O3
2-Amino-1-(3-chloro-2-methylphenyl)-4-(4-methoxyphenyl)-5-oxo-1,4,5,6,7,8-hexahydro-3-quinolinecarbonitrile chemical structure, C24H22ClN3O2, CAS 311328-74-2
2-Amino-1-(3-chloro-2-methylphenyl)-4-(4-methoxyphenyl)-5-oxo-1,4,5,6,7,8-hexahydro-3-quinolinecarbonitrile
CAS 311328-74-2C24H22ClN3O2
2-Amino-5-oxo-1,4-diphenyl-1,4,5,6,7,8-hexahydro-3-quinolinecarbonitrile chemical structure, C22H19N3O, CAS 187398-67-0
2-Amino-5-oxo-1,4-diphenyl-1,4,5,6,7,8-hexahydro-3-quinolinecarbonitrile
CAS 187398-67-0C22H19N3O
2-Amino-4-(4-ethoxyphenyl)-1-(3-nitrophenyl)-5-oxo-1,4,5,6,7,8-hexahydro-3-quinolinecarbonitrile chemical structure, C24H22N4O4, CAS 311328-88-8
2-Amino-4-(4-ethoxyphenyl)-1-(3-nitrophenyl)-5-oxo-1,4,5,6,7,8-hexahydro-3-quinolinecarbonitrile
CAS 311328-88-8C24H22N4O4
2-Amino-4-(2-chlorophenyl)-1-(2-chloro-5-(trifluoromethyl)phenyl)-7,7-dimethyl-5-oxo-1,4,5,6,7,8-hexahydro-3-quinolinecarbonitrile chemical structure, C25H20Cl2F3N3O, CAS 444933-97-5
2-Amino-4-(2-chlorophenyl)-1-(2-chloro-5-(trifluoromethyl)phenyl)-7,7-dimethyl-5-oxo-1,4,5,6,7,8-hexahydro-3-quinolinecarbonitrile
CAS 444933-97-5C25H20Cl2F3N3O
2-Amino-7,7-DI-ME-5-oxo-1,4-DI-PH-1,4,5,6,7,8-hexahydro-3-quinolinecarbonitrile chemical structure, C24H23N3O, CAS 156496-74-1
2-Amino-7,7-DI-ME-5-oxo-1,4-DI-PH-1,4,5,6,7,8-hexahydro-3-quinolinecarbonitrile
CAS 156496-74-1C24H23N3O
2-Amino-1-(2-chlorophenyl)-4-(2-methoxyphenyl)-5-oxo-1,4,5,6,7,8-hexahydro-3-quinolinecarbonitrile chemical structure, C23H20ClN3O2, CAS 476483-66-6
2-Amino-1-(2-chlorophenyl)-4-(2-methoxyphenyl)-5-oxo-1,4,5,6,7,8-hexahydro-3-quinolinecarbonitrile
CAS 476483-66-6C23H20ClN3O2
2-Amino-1-(4-bromophenyl)-7,7-dimethyl-5-oxo-4-(3,4,5-trimethoxyphenyl)-1,4,5,6,7,8-hexahydro-3-quinolinecarbonitrile chemical structure, C27H28BrN3O4, CAS 339322-17-7
2-Amino-1-(4-bromophenyl)-7,7-dimethyl-5-oxo-4-(3,4,5-trimethoxyphenyl)-1,4,5,6,7,8-hexahydro-3-quinolinecarbonitrile
CAS 339322-17-7C27H28BrN3O4
2-Amino-4-(4-methoxyphenyl)-1-(4-methylphenyl)-5-oxo-1,4,5,6,7,8-hexahydro-3-quinolinecarbonitrile chemical structure, C24H23N3O2, CAS 311315-97-6
2-Amino-4-(4-methoxyphenyl)-1-(4-methylphenyl)-5-oxo-1,4,5,6,7,8-hexahydro-3-quinolinecarbonitrile
CAS 311315-97-6C24H23N3O2
2-Amino-1-(4-bromo-2-fluorophenyl)-7,7-dimethyl-4-(4-(methylsulfanyl)phenyl)-5-oxo-1,4,5,6,7,8-hexahydro-3-quinolinecarbonitrile chemical structure, C25H23BrFN3OS, CAS 309281-16-1
2-Amino-1-(4-bromo-2-fluorophenyl)-7,7-dimethyl-4-(4-(methylsulfanyl)phenyl)-5-oxo-1,4,5,6,7,8-hexahydro-3-quinolinecarbonitrile
CAS 309281-16-1C25H23BrFN3OS
2-Amino-1-(2-chlorophenyl)-4-(2-methylphenyl)-5-oxo-4,6,7,8-tetrahydroquinoline-3-carbonitrile chemical structure, C23H20ClN3O, CAS 445017-89-0
2-Amino-1-(2-chlorophenyl)-4-(2-methylphenyl)-5-oxo-4,6,7,8-tetrahydroquinoline-3-carbonitrile
CAS 445017-89-0C23H20ClN3O
2-Amino-4-(4-bromophenyl)-1-(3-nitrophenyl)-5-oxo-1,4,5,6,7,8-hexahydro-3-quinolinecarbonitrile chemical structure, C22H17BrN4O3, CAS 360764-43-8
2-Amino-4-(4-bromophenyl)-1-(3-nitrophenyl)-5-oxo-1,4,5,6,7,8-hexahydro-3-quinolinecarbonitrile
CAS 360764-43-8C22H17BrN4O3
2-Amino-1-(4-meo-PH)-5-oxo-4-PH-1,4,5,6,7,8-hexahydro-3-quinolinecarbonitrile chemical structure, C23H21N3O2, CAS 312272-80-3
2-Amino-1-(4-meo-PH)-5-oxo-4-PH-1,4,5,6,7,8-hexahydro-3-quinolinecarbonitrile
CAS 312272-80-3C23H21N3O2