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Murcko scaffold

Ring system with 4 rings and 21 atoms

20 chemicals on CompoundList share this ring system.

Rings: 4
Scaffold atoms: 21
Chemicals: 20
With full pages: 4

Scaffold SMILES

N=C1C(c2nc3ccccc3[nH]2)=CCN1c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold N=C1C(c2nc3ccccc3[nH]2)=CCN1c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 20 of 20 chemicals

5-Amino-4-(1H-benzimidazol-2-yl)-1-(2-fluorophenyl)-1,2-dihydro-3H-pyrrol-3-one chemical structure, C17H13FN4O, CAS 459137-98-5

5-Amino-4-(1H-benzimidazol-2-yl)-1-(2-fluorophenyl)-1,2-dihydro-3H-pyrrol-3-one

CAS 459137-98-5C₁₇H₁₃FN₄O

5-Amino-4-(1H-1,3-benzodiazol-2-yl)-1-(4-methoxyphenyl)-2,3-dihydro-1H-pyrrol-3-one chemical structure, C18H16N4O2, CAS 459137-96-3

5-Amino-4-(1H-1,3-benzodiazol-2-yl)-1-(4-methoxyphenyl)-2,3-dihydro-1H-pyrrol-3-one

CAS 459137-96-3C₁₈H₁₆N₄O₂

5-Amino-4-(1H-1,3-benzodiazol-2-yl)-1-(4-chlorophenyl)-2,3-dihydro-1H-pyrrol-3-one chemical structure, C17H13ClN4O, CAS 459137-95-2

5-Amino-4-(1H-1,3-benzodiazol-2-yl)-1-(4-chlorophenyl)-2,3-dihydro-1H-pyrrol-3-one

CAS 459137-95-2C₁₇H₁₃ClN₄O

5-Amino-4-(1H-1,3-benzodiazol-2-yl)-1-(4-fluorophenyl)-2,3-dihydro-1H-pyrrol-3-one chemical structure, C17H13FN4O, CAS 459137-97-4

5-Amino-4-(1H-1,3-benzodiazol-2-yl)-1-(4-fluorophenyl)-2,3-dihydro-1H-pyrrol-3-one

CAS 459137-97-4C₁₇H₁₃FN₄O

5-Amino-4-(1H-1,3-benzodiazol-2-yl)-1-(2-methoxyphenyl)-2,3-dihydro-1H-pyrrol-3-one chemical structure, C18H16N4O2, CAS 459138-16-0

5-Amino-4-(1H-1,3-benzodiazol-2-yl)-1-(2-methoxyphenyl)-2,3-dihydro-1H-pyrrol-3-one

CAS 459138-16-0C₁₈H₁₆N₄O₂

5-Amino-4-(1H-benzimidazol-2-yl)-2-methyl-1-phenyl-1,2-dihydro-3H-pyrrol-3-one chemical structure, C18H16N4O, CAS 97427-29-7

5-Amino-4-(1H-benzimidazol-2-yl)-2-methyl-1-phenyl-1,2-dihydro-3H-pyrrol-3-one

CAS 97427-29-7C₁₈H₁₆N₄O

5-Amino-4-(1H-1,3-benzodiazol-2-yl)-1-phenyl-2,3-dihydro-1H-pyrrol-3-one chemical structure, C17H14N4O, CAS 64532-07-6

5-Amino-4-(1H-1,3-benzodiazol-2-yl)-1-phenyl-2,3-dihydro-1H-pyrrol-3-one

CAS 64532-07-6C₁₇H₁₄N₄O

5-Amino-4-(1H-benzimidazol-2-yl)-1-(5-fluoro-2-methylphenyl)-1,2-dihydro-3H-pyrrol-3-one chemical structure, C18H15FN4O, CAS 872319-78-3

5-Amino-4-(1H-benzimidazol-2-yl)-1-(5-fluoro-2-methylphenyl)-1,2-dihydro-3H-pyrrol-3-one

CAS 872319-78-3C₁₈H₁₅FN₄O

2-Amino-3-(1-methylbenzimidazol-2-yl)-1-phenyl-2-pyrrolin-4-one chemical structure, C18H16N4O, CAS 97426-85-2

2-Amino-3-(1-methylbenzimidazol-2-yl)-1-phenyl-2-pyrrolin-4-one

CAS 97426-85-2C₁₈H₁₆N₄O

5-Amino-4-(1H-benzimidazol-2-yl)-1-(4-ethoxyphenyl)-2H-pyrrol-3-one chemical structure, C19H18N4O2, CAS 380657-93-2

5-Amino-4-(1H-benzimidazol-2-yl)-1-(4-ethoxyphenyl)-2H-pyrrol-3-one

CAS 380657-93-2C₁₉H₁₈N₄O₂

5-Amino-4-(1H-1,3-benzodiazol-2-yl)-1-(3,4-dimethoxyphenyl)-2,3-dihydro-1H-pyrrol-3-one chemical structure, C19H18N4O3, CAS 881045-56-3

5-Amino-4-(1H-1,3-benzodiazol-2-yl)-1-(3,4-dimethoxyphenyl)-2,3-dihydro-1H-pyrrol-3-one

CAS 881045-56-3C₁₉H₁₈N₄O₃

5-Amino-4-(1H-1,3-benzodiazol-2-yl)-1-[4-(pentyloxy)phenyl]-2,3-dihydro-1H-pyrrol-3-one chemical structure, C22H24N4O2, CAS 927970-11-4

5-Amino-4-(1H-1,3-benzodiazol-2-yl)-1-[4-(pentyloxy)phenyl]-2,3-dihydro-1H-pyrrol-3-one

CAS 927970-11-4C₂₂H₂₄N₄O₂

5-Amino-4-(1H-1,3-benzodiazol-2-yl)-1-(4-hydroxyphenyl)-2,3-dihydro-1H-pyrrol-3-one chemical structure, C17H14N4O2, CAS 857492-70-7

5-Amino-4-(1H-1,3-benzodiazol-2-yl)-1-(4-hydroxyphenyl)-2,3-dihydro-1H-pyrrol-3-one

CAS 857492-70-7C₁₇H₁₄N₄O₂

3-[3-(1H-Benzimidazol-2-yl)-4-hydroxy-2-imino-2,5-dihydro-1H-pyrrol-1-yl]-N-methylbenzamide chemical structure, C19H17N5O2, CAS 1676069-82-1

3-[3-(1H-Benzimidazol-2-yl)-4-hydroxy-2-imino-2,5-dihydro-1H-pyrrol-1-yl]-N-methylbenzamide

CAS 1676069-82-1C₁₉H₁₇N₅O₂

4-(1H-Benzimidazol-2-yl)-5-imino-1-(3,4,5-trimethoxyphenyl)-2,5-dihydro-1H-pyrrol-3-ol chemical structure, C20H20N4O4, CAS 1676068-23-7

4-(1H-Benzimidazol-2-yl)-5-imino-1-(3,4,5-trimethoxyphenyl)-2,5-dihydro-1H-pyrrol-3-ol

CAS 1676068-23-7C₂₀H₂₀N₄O₄

5-Amino-4-(1H-benzimidazol-2-yl)-1-(4-bromophenyl)-1,2-dihydro-3H-pyrrol-3-one chemical structure, C17H13BrN4O, CAS 880447-06-3

5-Amino-4-(1H-benzimidazol-2-yl)-1-(4-bromophenyl)-1,2-dihydro-3H-pyrrol-3-one

CAS 880447-06-3C₁₇H₁₃BrN₄O

5-Amino-4-(1H-benzo[d]imidazol-2-yl)-1-(4-butoxyphenyl)-1H-pyrrol-3(2H)-one chemical structure, C21H22N4O2, CAS 885190-33-0

5-Amino-4-(1H-benzo[d]imidazol-2-yl)-1-(4-butoxyphenyl)-1H-pyrrol-3(2H)-one

CAS 885190-33-0C₂₁H₂₂N₄O₂

5-Amino-4-(1H-benzimidazol-2-yl)-1-(3-chloro-4-fluorophenyl)-1,2-dihydro-3H-pyrrol-3-one chemical structure, C17H12ClFN4O, CAS 459138-14-8

5-Amino-4-(1H-benzimidazol-2-yl)-1-(3-chloro-4-fluorophenyl)-1,2-dihydro-3H-pyrrol-3-one

CAS 459138-14-8C₁₇H₁₂ClFN₄O

5-Amino-4-(1H-benzo[d]imidazol-2-yl)-1-(3-bromophenyl)-1H-pyrrol-3(2H)-one chemical structure, C17H13BrN4O, CAS 881567-12-0

5-Amino-4-(1H-benzo[d]imidazol-2-yl)-1-(3-bromophenyl)-1H-pyrrol-3(2H)-one

CAS 881567-12-0C₁₇H₁₃BrN₄O

3-[5-Amino-4-(1H-benzimidazol-2-yl)-3-oxo-2,3-dihydro-1H-pyrrol-1-yl]benzonitrile chemical structure, C18H13N5O, CAS 1029797-43-0

3-[5-Amino-4-(1H-benzimidazol-2-yl)-3-oxo-2,3-dihydro-1H-pyrrol-1-yl]benzonitrile

CAS 1029797-43-0C₁₈H₁₃N₅O