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Murcko scaffold

Ring system with 3 rings and 19 atoms

16 chemicals on CompoundList share this ring system.

Rings: 3
Scaffold atoms: 19
Chemicals: 16
With full pages: 0

Scaffold SMILES

O=C(C=Cc1ccc2c(c1)OCO2)Nc1cccs1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=C(C=Cc1ccc2c(c1)OCO2)Nc1cccs1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 16 of 16 chemicals

2-[[(E)-3-(1,3-Benzodioxol-5-yl)prop-2-enoyl]amino]-4,5-dimethylthiophene-3-carboxamide chemical structure, C17H16N2O4S, CAS 383381-62-2

2-[[(E)-3-(1,3-Benzodioxol-5-yl)prop-2-enoyl]amino]-4,5-dimethylthiophene-3-carboxamide

CAS 383381-62-2C₁₇H₁₆N₂O₄S

Methyl 2-{[3-(1,3-benzodioxol-5-yl)acryloyl]amino}-4-ethyl-5-methyl-3-thiophenecarboxylate chemical structure, C19H19NO5S, CAS 1164561-41-4

Methyl 2-{[3-(1,3-benzodioxol-5-yl)acryloyl]amino}-4-ethyl-5-methyl-3-thiophenecarboxylate

CAS 1164561-41-4C₁₉H₁₉NO₅S

Methyl 2-{[3-(1,3-benzodioxol-5-yl)acryloyl]amino}-4,5-dimethyl-3-thiophenecarboxylate chemical structure, C18H17NO5S, CAS 1164551-52-3

Methyl 2-{[3-(1,3-benzodioxol-5-yl)acryloyl]amino}-4,5-dimethyl-3-thiophenecarboxylate

CAS 1164551-52-3C₁₈H₁₇NO₅S

Ethyl 2-[[(E)-3-(1,3-benzodioxol-5-yl)prop-2-enoyl]amino]-5-(dimethylcarbamoyl)-4-methylthiophene-3-carboxylate chemical structure, C21H22N2O6S, CAS 545358-96-1

Ethyl 2-[[(E)-3-(1,3-benzodioxol-5-yl)prop-2-enoyl]amino]-5-(dimethylcarbamoyl)-4-methylthiophene-3-carboxylate

CAS 545358-96-1C₂₁H₂₂N₂O₆S

Ethyl 2-{[3-(1,3-benzodioxol-5-yl)acryloyl]amino}-4-ethyl-5-methyl-3-thiophenecarboxylate chemical structure, C20H21NO5S, CAS 1164487-41-5

Ethyl 2-{[3-(1,3-benzodioxol-5-yl)acryloyl]amino}-4-ethyl-5-methyl-3-thiophenecarboxylate

CAS 1164487-41-5C₂₀H₂₁NO₅S

Ethyl 5-acetyl-2-{[3-(1,3-benzodioxol-5-yl)acryloyl]amino}-4-methyl-3-thiophenecarboxylate chemical structure, C20H19NO6S, CAS 300828-21-1

Ethyl 5-acetyl-2-{[3-(1,3-benzodioxol-5-yl)acryloyl]amino}-4-methyl-3-thiophenecarboxylate

CAS 300828-21-1C₂₀H₁₉NO₆S

Methyl 2-{[3-(1,3-benzodioxol-5-yl)acryloyl]amino}-5-[(diethylamino)carbonyl]-4-methyl-3-thiophenecarboxylate chemical structure, C22H24N2O6S, CAS 557776-20-2

Methyl 2-{[3-(1,3-benzodioxol-5-yl)acryloyl]amino}-5-[(diethylamino)carbonyl]-4-methyl-3-thiophenecarboxylate

CAS 557776-20-2C₂₂H₂₄N₂O₆S

Isopropyl 2-{[3-(1,3-benzodioxol-5-yl)acryloyl]amino}-4-ethyl-5-methyl-3-thiophenecarboxylate chemical structure, C21H23NO5S, CAS 550306-89-3

Isopropyl 2-{[3-(1,3-benzodioxol-5-yl)acryloyl]amino}-4-ethyl-5-methyl-3-thiophenecarboxylate

CAS 550306-89-3C₂₁H₂₃NO₅S

Isopropyl 4-(aminocarbonyl)-5-{[3-(1,3-benzodioxol-5-yl)acryloyl]amino}-3-methyl-2-thiophenecarboxylate chemical structure, C20H20N2O6S, CAS 424818-48-4

Isopropyl 4-(aminocarbonyl)-5-{[3-(1,3-benzodioxol-5-yl)acryloyl]amino}-3-methyl-2-thiophenecarboxylate

CAS 424818-48-4C₂₀H₂₀N₂O₆S

Ethyl 5-[[(E)-3-(1,3-benzodioxol-5-yl)prop-2-enoyl]amino]-4-carbamoyl-3-methylthiophene-2-carboxylate chemical structure, C19H18N2O6S, CAS 680994-09-6

Ethyl 5-[[(E)-3-(1,3-benzodioxol-5-yl)prop-2-enoyl]amino]-4-carbamoyl-3-methylthiophene-2-carboxylate

CAS 680994-09-6C₁₉H₁₈N₂O₆S

Dipropan-2-yl 5-[[(E)-3-(1,3-benzodioxol-5-yl)prop-2-enoyl]amino]-3-methylthiophene-2,4-dicarboxylate chemical structure, C23H25NO7S, CAS 424819-01-2

Dipropan-2-yl 5-[[(E)-3-(1,3-benzodioxol-5-yl)prop-2-enoyl]amino]-3-methylthiophene-2,4-dicarboxylate

CAS 424819-01-2C₂₃H₂₅NO₇S

Ethyl 2-[[3-(1,3-benzodioxol-5-yl)-1-oxo-2-propen-1-yl]amino]-4-ethyl-5-methyl-3-thiophenecarboxylate chemical structure, C20H21NO5S, CAS 303132-94-7

Ethyl 2-[[3-(1,3-benzodioxol-5-yl)-1-oxo-2-propen-1-yl]amino]-4-ethyl-5-methyl-3-thiophenecarboxylate

CAS 303132-94-7C₂₀H₂₁NO₅S

1-Methylethyl 5-[[3-(1,3-benzodioxol-5-yl)-1-oxo-2-propen-1-yl]amino]-4-cyano-3-methyl-2-thiophenecarboxylate chemical structure, C20H18N2O5S, CAS 549497-68-9

1-Methylethyl 5-[[3-(1,3-benzodioxol-5-yl)-1-oxo-2-propen-1-yl]amino]-4-cyano-3-methyl-2-thiophenecarboxylate

CAS 549497-68-9C₂₀H₁₈N₂O₅S

Methyl 2-{[(2E)-3-(1,3-benzodioxol-5-yl)-2-cyanoprop-2-enoyl]amino}-5-propylthiophene-3-carboxylate chemical structure, C20H18N2O5S, CAS 587853-02-9

Methyl 2-{[(2E)-3-(1,3-benzodioxol-5-yl)-2-cyanoprop-2-enoyl]amino}-5-propylthiophene-3-carboxylate

CAS 587853-02-9C₂₀H₁₈N₂O₅S

(E)-Ethyl 2-(3-(benzo[d][1,3]dioxol-5-yl)acrylamido)-5-nitrothiophene-3-carboxylate chemical structure, C17H14N2O7S, CAS 1173618-62-6

(E)-Ethyl 2-(3-(benzo[d][1,3]dioxol-5-yl)acrylamido)-5-nitrothiophene-3-carboxylate

CAS 1173618-62-6C₁₇H₁₄N₂O₇S

Ethyl 2-[[(Z)-3-(1,3-benzodioxol-5-yl)-2-cyanoprop-2-enoyl]amino]-5-carbamoyl-4-methylthiophene-3-carboxylate chemical structure, C20H17N3O6S, CAS 855713-58-5

Ethyl 2-[[(Z)-3-(1,3-benzodioxol-5-yl)-2-cyanoprop-2-enoyl]amino]-5-carbamoyl-4-methylthiophene-3-carboxylate

CAS 855713-58-5C₂₀H₁₇N₃O₆S