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Murcko scaffold

Ring system with 3 rings and 19 atoms

12 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
19
Chemicals
12
With full pages
9
Scaffold SMILES

O=C(CSc1nncs1)Nc1ccc2c(c1)OCO2

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(CSc1nncs1)Nc1ccc2c(c1)OCO2

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 12 of 12 chemicals

N-(1,3-Benzodioxol-5-yl)-2-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]acetamide chemical structure, C12H11N3O3S2, CAS 361184-99-8
N-(1,3-Benzodioxol-5-yl)-2-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]acetamide
CAS 361184-99-8C12H11N3O3S2
N-(6-Acetyl-1,3-benzodioxol-5-yl)-2-[(5-methyl-1,3,4-thiadiazol-2-yl)thio]acetamide chemical structure, C14H13N3O4S2, CAS 522593-69-7
N-(6-Acetyl-1,3-benzodioxol-5-yl)-2-[(5-methyl-1,3,4-thiadiazol-2-yl)thio]acetamide
CAS 522593-69-7C14H13N3O4S2
2-[(5-Amino-1,3,4-thiadiazol-2-yl)thio]-N-(1,3-benzodioxol-5-yl)acetamide chemical structure, C11H10N4O3S2, CAS 301335-14-8
2-[(5-Amino-1,3,4-thiadiazol-2-yl)thio]-N-(1,3-benzodioxol-5-yl)acetamide
CAS 301335-14-8C11H10N4O3S2
N-(5-((2-(Benzo[d][1,3]dioxol-5-ylamino)-2-oxoethyl)thio)-1,3,4-thiadiazol-2-yl)isobutyramide chemical structure, C15H16N4O4S2, CAS 868972-73-0
N-(5-((2-(Benzo[d][1,3]dioxol-5-ylamino)-2-oxoethyl)thio)-1,3,4-thiadiazol-2-yl)isobutyramide
CAS 868972-73-0C15H16N4O4S2
N-[5-[2-(1,3-Benzodioxol-5-ylamino)-2-oxoethyl]sulfanyl-1,3,4-thiadiazol-2-yl]-3-methylbutanamide chemical structure, C16H18N4O4S2, CAS 868974-00-9
N-[5-[2-(1,3-Benzodioxol-5-ylamino)-2-oxoethyl]sulfanyl-1,3,4-thiadiazol-2-yl]-3-methylbutanamide
CAS 868974-00-9C16H18N4O4S2
2-[(5-Acetamido-1,3,4-thiadiazol-2-yl)sulfanyl]-N-(1,3-benzodioxol-5-yl)acetamide chemical structure, C13H12N4O4S2, CAS 868974-32-7
2-[(5-Acetamido-1,3,4-thiadiazol-2-yl)sulfanyl]-N-(1,3-benzodioxol-5-yl)acetamide
CAS 868974-32-7C13H12N4O4S2
N-[5-[2-(1,3-Benzodioxol-5-ylamino)-2-oxoethyl]sulfanyl-1,3,4-thiadiazol-2-yl]propanamide chemical structure, C14H14N4O4S2, CAS 868974-38-3
N-[5-[2-(1,3-Benzodioxol-5-ylamino)-2-oxoethyl]sulfanyl-1,3,4-thiadiazol-2-yl]propanamide
CAS 868974-38-3C14H14N4O4S2
N-[5-[2-(1,3-Benzodioxol-5-ylamino)-2-oxoethyl]sulfanyl-1,3,4-thiadiazol-2-yl]butanamide chemical structure, C15H16N4O4S2, CAS 868976-20-9
N-[5-[2-(1,3-Benzodioxol-5-ylamino)-2-oxoethyl]sulfanyl-1,3,4-thiadiazol-2-yl]butanamide
CAS 868976-20-9C15H16N4O4S2
N-[5-[2-(1,3-Benzodioxol-5-ylamino)-2-oxoethyl]sulfanyl-1,3,4-thiadiazol-2-yl]pentanamide chemical structure, C16H18N4O4S2, CAS 868976-58-3
N-[5-[2-(1,3-Benzodioxol-5-ylamino)-2-oxoethyl]sulfanyl-1,3,4-thiadiazol-2-yl]pentanamide
CAS 868976-58-3C16H18N4O4S2
N-(5-((2-(Benzo[d][1,3]dioxol-5-ylamino)-2-oxoethyl)thio)-1,3,4-thiadiazol-2-yl)pivalamide chemical structure, C16H18N4O4S2, CAS 868977-00-8
N-(5-((2-(Benzo[d][1,3]dioxol-5-ylamino)-2-oxoethyl)thio)-1,3,4-thiadiazol-2-yl)pivalamide
CAS 868977-00-8C16H18N4O4S2
2-[(5-Amino-1,3,4-thiadiazol-2-yl)sulfanyl]-N-(1,3-benzodioxol-5-yl)propanamide chemical structure, C12H12N4O3S2, CAS 878909-47-8
2-[(5-Amino-1,3,4-thiadiazol-2-yl)sulfanyl]-N-(1,3-benzodioxol-5-yl)propanamide
CAS 878909-47-8C12H12N4O3S2
N-(2H-1,3-Benzodioxol-5-yl)-2-({5-[(tert-butylcarbamoyl)amino]-1,3,4-thiadiazol-2-yl}sulfanyl)acetamide chemical structure, C16H19N5O4S2, CAS 886940-23-4
N-(2H-1,3-Benzodioxol-5-yl)-2-({5-[(tert-butylcarbamoyl)amino]-1,3,4-thiadiazol-2-yl}sulfanyl)acetamide
CAS 886940-23-4C16H19N5O4S2