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Murcko scaffold

Ring system with 3 rings and 15 atoms

14 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
15
Chemicals
14
With full pages
4
Scaffold SMILES

c1ccc(-c2ccnc(C3CC3)c2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold c1ccc(-c2ccnc(C3CC3)c2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 14 of 14 chemicals

{[3-Cyano-6-cyclopropyl-4-(4-methoxyphenyl)pyridin-2-yl]sulfanyl}acetic acid chemical structure, C18H16N2O3S, CAS 313956-66-0
{[3-Cyano-6-cyclopropyl-4-(4-methoxyphenyl)pyridin-2-yl]sulfanyl}acetic acid
CAS 313956-66-0C18H16N2O3S
2-Amino-4-(2-chlorophenyl)-6-cyclopropylnicotinonitrile chemical structure, C15H12ClN3, CAS 303130-96-3
2-Amino-4-(2-chlorophenyl)-6-cyclopropylnicotinonitrile
CAS 303130-96-3C15H12ClN3
2-Amino-4-(4-chlorophenyl)-6-cyclopropylpyridine-3-carbonitrile chemical structure, C15H12ClN3, CAS 312508-99-9
2-Amino-4-(4-chlorophenyl)-6-cyclopropylpyridine-3-carbonitrile
CAS 312508-99-9C15H12ClN3
6-Cyclopropyl-2-methylsulfanyl-4-phenylpyridine-3-carbonitrile chemical structure, C16H14N2S, CAS 299198-03-1
6-Cyclopropyl-2-methylsulfanyl-4-phenylpyridine-3-carbonitrile
CAS 299198-03-1C16H14N2S
2-Amino-4-(3-bromophenyl)-6-cyclopropylpyridine-3-carbonitrile chemical structure, C15H12BrN3, CAS 294876-58-7
2-Amino-4-(3-bromophenyl)-6-cyclopropylpyridine-3-carbonitrile
CAS 294876-58-7C15H12BrN3
2-Amino-6-cyclopropyl-4-(2-methoxyphenyl)nicotinonitrile chemical structure, C16H15N3O, CAS 328275-99-6
2-Amino-6-cyclopropyl-4-(2-methoxyphenyl)nicotinonitrile
CAS 328275-99-6C16H15N3O
4-(4-Chlorophenyl)-6-cyclopropyl-2-(methylthio)nicotinonitrile chemical structure, C16H13ClN2S, CAS 371955-31-6
4-(4-Chlorophenyl)-6-cyclopropyl-2-(methylthio)nicotinonitrile
CAS 371955-31-6C16H13ClN2S
6-Cyclopropyl-2-(ethylsulfanyl)-4-(4-methoxyphenyl)pyridine-3-carbonitrile chemical structure, C18H18N2OS, CAS 314033-97-1
6-Cyclopropyl-2-(ethylsulfanyl)-4-(4-methoxyphenyl)pyridine-3-carbonitrile
CAS 314033-97-1C18H18N2OS
Ethyl 2-[3-cyano-6-cyclopropyl-4-(4-methoxyphenyl)pyridin-2-yl]sulfanylacetate chemical structure, C20H20N2O3S, CAS 5716-58-5
Ethyl 2-[3-cyano-6-cyclopropyl-4-(4-methoxyphenyl)pyridin-2-yl]sulfanylacetate
CAS 5716-58-5C20H20N2O3S
6-Cyclopropyl-4-phenyl-2-prop-2-enylsulfanylpyridine-3-carbonitrile chemical structure, C18H16N2S, CAS 189132-38-5
6-Cyclopropyl-4-phenyl-2-prop-2-enylsulfanylpyridine-3-carbonitrile
CAS 189132-38-5C18H16N2S
3-(2-Cyclopropyl-4-pyridinyl)benzonitrile chemical structure, C15H12N2, CAS 579476-65-6
3-(2-Cyclopropyl-4-pyridinyl)benzonitrile
CAS 579476-65-6C15H12N2
3-(2-Cyclopropyl-6-methyl-4-pyridinyl)benzonitrile chemical structure, C16H14N2, CAS 579475-92-6
3-(2-Cyclopropyl-6-methyl-4-pyridinyl)benzonitrile
CAS 579475-92-6C16H14N2
3-[3-(2-Cyclopropyl-pyridin-4-yl)-phenyl]-3-oxo-propionic acid tert-butyl ester chemical structure, C21H23NO3, CAS 579476-64-5
3-[3-(2-Cyclopropyl-pyridin-4-yl)-phenyl]-3-oxo-propionic acid tert-butyl ester
CAS 579476-64-5C21H23NO3
3-[3-(2-Cyclopropyl-6-methyl-pyridin-4-yl)-phenyl]-3-oxo-propionic acid tert-butyl ester chemical structure, C22H25NO3, CAS 579475-89-1
3-[3-(2-Cyclopropyl-6-methyl-pyridin-4-yl)-phenyl]-3-oxo-propionic acid tert-butyl ester
CAS 579475-89-1C22H25NO3