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Murcko scaffold

Ring system with 8 rings and 24 atoms

14 chemicals on CompoundList share this ring system.

Rings
8
Scaffold atoms
24
Chemicals
14
With full pages
2
Scaffold SMILES

C1=CC23CCC1C1Oc4cccc5c4C12CCN(CC1CC1)C3C5

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold C1=CC23CCC1C1Oc4cccc5c4C12CCN(CC1CC1)C3C5

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 14 of 14 chemicals

17-(Cyclopropylmethyl)-7-(2-hydroxypropan-2-yl)-6-methoxy-5beta,9alpha,13alpha-4,5-epoxy-6,14-ethenomorphinan-3-ol chemical structure, C26H33NO4
17-(Cyclopropylmethyl)-7-(2-hydroxypropan-2-yl)-6-methoxy-5beta,9alpha,13alpha-4,5-epoxy-6,14-ethenomorphinan-3-ol
C26H33NO4
16-Methylcyprenorphine chemical structure, C27H35NO4, CAS 40994-80-7
16-Methylcyprenorphine
CAS 40994-80-7C27H35NO4
17-(Cyclopropylmethyl)-7-(2-hydroxypropan-2-yl)-6-methoxy-4,5-epoxy-6,14-ethenomorphinan-3-ol chemical structure, C26H33NO4, CAS 17065-88-2
17-(Cyclopropylmethyl)-7-(2-hydroxypropan-2-yl)-6-methoxy-4,5-epoxy-6,14-ethenomorphinan-3-ol
CAS 17065-88-2C26H33NO4
Cyprenorphine chemical structure, C26H33NO4, CAS 4406-22-8
Cyprenorphine
CAS 4406-22-8C26H33NO4
Nih 10236 chemical structure, C28H32N2O6, CAS 88167-37-7
Nih 10236
CAS 88167-37-7C28H32N2O6
Cyprenorphine hydrochloride chemical structure, C26H34ClNO4, CAS 16550-22-4
Cyprenorphine hydrochloride
CAS 16550-22-4C26H34ClNO4
18,19-Dehydrobuprenorphine chemical structure, C29H39NO4, CAS 155203-05-7
18,19-Dehydrobuprenorphine
CAS 155203-05-7C29H39NO4
17-(Cyclopropylmethyl)-18-(2-hydroxypropan-2-yl)-3-methoxy-7,8-didehydro-18,19-dihydro-4,5-epoxy-6,14-ethenomorphinan-6-ol chemical structure, C26H33NO4, CAS 23277-46-5
17-(Cyclopropylmethyl)-18-(2-hydroxypropan-2-yl)-3-methoxy-7,8-didehydro-18,19-dihydro-4,5-epoxy-6,14-ethenomorphinan-6-ol
CAS 23277-46-5C26H33NO4
Homprenorphine chemical structure, C28H37NO4
Homprenorphine
C28H37NO4
Homprenorfina chemical structure, C28H37NO4, CAS 16549-56-7
Homprenorfina
CAS 16549-56-7C28H37NO4
N-Cyclopropylmethyl-6,14-endo-etheno-7-(2-hydroxy-2-propyl)tetrahydronorthebaine chemical structure, C27H35NO4, CAS 7799-27-1
N-Cyclopropylmethyl-6,14-endo-etheno-7-(2-hydroxy-2-propyl)tetrahydronorthebaine
CAS 7799-27-1C27H35NO4
22-Cyclopropyl-7alpha-((R)-1-hydroxy-1-methylpropyl)-6,14-endo-ethenotetrahydrothebaine chemical structure, C28H37NO4
22-Cyclopropyl-7alpha-((R)-1-hydroxy-1-methylpropyl)-6,14-endo-ethenotetrahydrothebaine
C28H37NO4
[5a,7a(S)]-17-(Cyclopropylmethyl)-a-(1,1-dimethylethyl)-4,5-epoxy-3,6-dimethoxy-a-methyl-6,14-ethenomorphinan-7-methanol chemical structure, C30H41NO4, CAS 155203-04-6
[5a,7a(S)]-17-(Cyclopropylmethyl)-a-(1,1-dimethylethyl)-4,5-epoxy-3,6-dimethoxy-a-methyl-6,14-ethenomorphinan-7-methanol
CAS 155203-04-6C30H41NO4
2-[(2S)-5-(Cyclopropylmethyl)-11,15-dimethoxy-13-oxa-5-azahexacyclo[13.2.2.12,8.01,6.02,14.012,20]icosa-8(20),9,11,18-tetraen-16-yl]butan-2-ol chemical structure, C28H37NO4
2-[(2S)-5-(Cyclopropylmethyl)-11,15-dimethoxy-13-oxa-5-azahexacyclo[13.2.2.12,8.01,6.02,14.012,20]icosa-8(20),9,11,18-tetraen-16-yl]butan-2-ol
C28H37NO4