Murcko scaffold
Ring system with 8 rings and 24 atoms
36 chemicals on CompoundList share this ring system.
- Rings
- 8
- Scaffold atoms
- 24
- Chemicals
- 36
- With full pages
- 11
Scaffold SMILES
c1cc2c3c(c1)OC1C4CCC5(CC4)C(C2)N(CC2CC2)CCC315
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 36 of 36 chemicals
17-(Cyclopropylmethyl)-18-(2-hydroxy-3,3-dimethylbutan-2-yl)-6-methoxy-18,19-dihydro-4,5-epoxy-6,14-ethenomorphinan-3-ol
CAS 136781-89-0C29H41NO4
Diprenorphine
CAS 14357-78-9C26H35NO4
Buprenorphine
CAS 52485-79-7C29H41NO4
Buprenorphine hydrochloride
CAS 53152-21-9C29H42ClNO4
Diprenorphine C-11
CAS 113707-17-8C26H35NO4
Fdpn F-18
CAS 315209-00-8C27H36FNO4
![(5A,14b,18R)-17-[(2,2-2H2)cyclopropyl(2H2)methyl]-18-[(2S)-2-hydroxy-3,3-dimethylbutan-2-yl]-6-methoxy-18,19-dihydro-4,5-epoxy-6,14-ethenomorphinan-3-ol chemical structure, C29H41NO4](/s/RMRJXGBAOAMLHD-LXUQYKFSSA-N.svg)
(5A,14b,18R)-17-[(2,2-2H2)cyclopropyl(2H2)methyl]-18-[(2S)-2-hydroxy-3,3-dimethylbutan-2-yl]-6-methoxy-18,19-dihydro-4,5-epoxy-6,14-ethenomorphinan-3-ol
C29H41NO4
Buprenorphine 3-hexanoate
CAS 171018-32-9C35H51NO5
Buprenorphine hydrochloride, naloxone hydrochloride
CAS 352020-56-5C48H62N2O8
![1-[(5a,7a)-17-(Cyclopropylmethyl)-4,5-epoxy-18,19-dihydro-3,6-dimethoxy-6,14-ethenomorphinan-7-yl]ethanone chemical structure, C26H33NO4, CAS 152427-77-5](/s/LZMUFYYDCOJGDN-ZLKVESQBSA-N.svg)
1-[(5a,7a)-17-(Cyclopropylmethyl)-4,5-epoxy-18,19-dihydro-3,6-dimethoxy-6,14-ethenomorphinan-7-yl]ethanone
CAS 152427-77-5C26H33NO4
6-O-Desmethyl buprenorphine
CAS 130668-48-3C28H39NO4
(AlphaS,5alpha,7alpha)-17-(Cyclopropylmethyl)-alpha-(1,1-dimethylethyl)-4,5-epoxy-18,19-dihydro-3,6-dimethoxy-alpha-methyl-6,14-ethenomorphinan-7-methanol
CAS 16524-65-5C30H43NO4
6,14-Ethenomorphinan-7-methanol, 17-(cyclopropylmethyl)-4,5-epoxy-18,19-dihydro-3-hydroxy-6-methoxy-alpha,alpha-dimethyl-, hydrochloride (1:1), (5alpha,7alpha)-
CAS 16808-86-9C26H36ClNO4
Buprenorphine methiodide
CAS 1026987-90-5C30H44INO4
Methoxybuprenorphine
CAS 1391587-11-3C30H43NO4
Buprenorphine-d3 hydrochloride
CAS 1261083-89-9C29H42ClNO4
![5-(Cyclopropylmethyl)-16-(2-hydroxy-3,3-dimethylbutan-2-yl)-15-methoxy-13-oxa-5-azahexacyclo[13.2.2.12,8.01,6.02,14.012,20]icosa-8(20),9,11-trien-11-ol, iodomethane chemical structure, C30H44INO4](/s/KPCDBLMZUHQJQQ-UHFFFAOYSA-N.svg)
5-(Cyclopropylmethyl)-16-(2-hydroxy-3,3-dimethylbutan-2-yl)-15-methoxy-13-oxa-5-azahexacyclo[13.2.2.12,8.01,6.02,14.012,20]icosa-8(20),9,11-trien-11-ol, iodomethane
C30H44INO4
RefChem:121802
CAS 1333904-22-5C30H43NO4
Buprenorphine hemiadipate hydrochloride
CAS 951123-35-6C35H50ClNO7
Buprenorphine hemiadipate
CAS 951123-45-8C35H49NO7
RefChem:1049515
CAS 112242-17-8C29H41NO5
3-O-(tert-Butyldimethylsilyloxy)-6-O-desmethyl Buprenorphine
CAS 130668-49-4C34H53NO4Si
7-Dehydroxy buprenorphine(buprenorphine impurity F)
CAS 97203-04-8C29H39NO3
6-O-Desmethyl buprenorphine
C28H39NO4
- Fluoroethyldiprenorphine1391522-66-9C27H36FNO4
- 6,14-Ethenomorphinan-7-methanol, 17-(cyclopropylmethyl)-4,5-epoxy-18,19-dihydro-3-hydroxy-6-methoxy-I+/--methyl-I+/--(1-methylethyl)-, (I+/-R,5I+/-,7I+/-)-1429173-66-9C28H39NO4
- Buprenorphine-d4C29H41NO4
- N-(Cyclopropylmethyl)-19-isopentylnororvinol hydrochloride53056-01-2C30H44ClNO4
- RefChem:15483316524-73-5C28H39NO4
- Buprenorphine-d4C29H41NO4
- 7-(S)-Buprenorphine152610-73-6C29H41NO4
- 2-Amino-N-[[5-(cyclopropylmethyl)-11-hydroxy-15-methoxy-13-oxa-5-azahexacyclo[13.2.2.12,8.01,6.02,14.012,20]icosa-8(20),9,11-trien-16-yl]methyl]-3-hydroxypropanamide1111638-35-7C27H37N3O5
- (2S,6R,14S,15S,16R)-5-(Cyclopropylmethyl)-16-[(2R)-2-hydroxy-3,3-dimethylbutan-2-yl]-13-oxa-5-azahexacyclo[13.2.2.12,8.01,6.02,14.012,20]icosa-8(20),9,11-triene-11,15-diolC28H39NO4
- Buprenorphine-d91134630-65-1C29H41NO4
- O-Methyl 7-(S)-buprenorphine213404-55-8C30H43NO4
- (1S,2S,6R,14R,15R,16R)-5-(Cyclopropylmethyl)-16-[(2S)-2-hydroxy-5-methylhexan-2-yl]-15-methoxy-13-oxa-5-azahexacyclo[13.2.2.12,8.01,6.02,14.012,20]icosa-8(20),9,11-trien-11-ol, hydrochloride1429188-83-9C30H44ClNO4
Related scaffolds
Same ring framework with different atoms or bond orders
