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Murcko scaffold

Ring system with 4 rings and 25 atoms

8 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
25
Chemicals
8
With full pages
1
Scaffold SMILES

c1ccc(CNCc2cn(Cc3ccccc3)c3ccccc23)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold c1ccc(CNCc2cn(Cc3ccccc3)c3ccccc23)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 8 of 8 chemicals

1-(4-Methoxybenzyl)-3-(((3-methoxybenzyl)amino)methyl)-6-methyl-1H-indole-2-carboxylic acid chemical structure, C27H28N2O4, CAS 894946-73-7
1-(4-Methoxybenzyl)-3-(((3-methoxybenzyl)amino)methyl)-6-methyl-1H-indole-2-carboxylic acid
CAS 894946-73-7C27H28N2O4
1-[1-(2-Chlorobenzyl)-2-methyl-1H-indol-3-yl]-N-(4-fluorobenzyl)methanamine chemical structure, C24H22ClFN2, CAS 940356-00-3
1-[1-(2-Chlorobenzyl)-2-methyl-1H-indol-3-yl]-N-(4-fluorobenzyl)methanamine
CAS 940356-00-3C24H22ClFN2
3-[(Benzylamino)methyl]-N-hydroxy-1-(4-methoxybenzyl)-1H-indole-6-carboxamide chemical structure, C25H25N3O3, CAS 950763-16-3
3-[(Benzylamino)methyl]-N-hydroxy-1-(4-methoxybenzyl)-1H-indole-6-carboxamide
CAS 950763-16-3C25H25N3O3
3-{[(3-Chlorobenzyl)amino]methyl}-1-(4-methylbenzyl)-1H-indole-2-carboxylic acid chemical structure, C25H23ClN2O2, CAS 893262-85-6
3-{[(3-Chlorobenzyl)amino]methyl}-1-(4-methylbenzyl)-1H-indole-2-carboxylic acid
CAS 893262-85-6C25H23ClN2O2
1-(4-Methoxybenzyl)-3-(((3-methoxybenzyl)amino)methyl)-1H-indole-2-carboxylic acid chemical structure, C26H26N2O4, CAS 892111-16-9
1-(4-Methoxybenzyl)-3-(((3-methoxybenzyl)amino)methyl)-1H-indole-2-carboxylic acid
CAS 892111-16-9C26H26N2O4
1H-Indole-3-methanamine,5-methoxy-1-(phenylmethyl)-N-[[3-(trifluoromethyl)phenyl]methyl]- chemical structure, C25H23F3N2O, CAS 142769-02-6
1H-Indole-3-methanamine,5-methoxy-1-(phenylmethyl)-N-[[3-(trifluoromethyl)phenyl]methyl]-
CAS 142769-02-6C25H23F3N2O
Methyl 3-[(Benzylamino)methyl]-1-(4-methoxybenzyl)-1H-indole-6-carboxylate chemical structure, C26H26N2O3, CAS 950763-37-8
Methyl 3-[(Benzylamino)methyl]-1-(4-methoxybenzyl)-1H-indole-6-carboxylate
CAS 950763-37-8C26H26N2O3
Antitumor agent-54 chemical structure, C29H32N2O3, CAS 2770842-10-7
Antitumor agent-54
CAS 2770842-10-7C29H32N2O3