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Murcko scaffold

Ring system with 4 rings and 27 atoms

7 chemicals on CompoundList share this ring system.

Rings: 4
Scaffold atoms: 27
Chemicals: 7
With full pages: 3

Scaffold SMILES

O=C(NCc1ccc[nH]c1=O)c1cn(CC2CCNCC2)c2ccccc12

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=C(NCc1ccc[nH]c1=O)c1cn(CC2CCNCC2)c2ccccc12

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 7 of 7 chemicals

Cpi-169 chemical structure, C27H36N4O5S, CAS 1802175-07-0

CAS 1802175-07-0C₂₇H₃₆N₄O₅S

Lirametostat chemical structure, C27H33F3N4O3, CAS 1621862-70-1

CAS 1621862-70-1C₂₇H₃₃F₃N₄O₃

(R)-1-(1-(1-(Ethylsulfonyl)piperidin-4-yl)ethyl)-N-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1H-indole-3-carboxamide chemical structure, C27H36N4O5S, CAS 1450655-76-1

(R)-1-(1-(1-(Ethylsulfonyl)piperidin-4-yl)ethyl)-N-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1H-indole-3-carboxamide

CAS 1450655-76-1C₂₇H₃₆N₄O₅S

N-((4-Methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(piperidin-4-yl)ethyl)-1H-indole-3-carboxamide chemical structure, C25H32N4O3, CAS 1450655-12-5

N-((4-Methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(piperidin-4-yl)ethyl)-1H-indole-3-carboxamide

CAS 1450655-12-5C₂₅H₃₂N₄O₃

tert-Butyl 4-(1-(3-(((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)carbamoyl)-2-methyl-1H-indol-1-yl)ethyl)piperidine-1-carboxylate chemical structure, C30H40N4O5, CAS 1450655-10-3

tert-Butyl 4-(1-(3-(((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)carbamoyl)-2-methyl-1H-indol-1-yl)ethyl)piperidine-1-carboxylate

CAS 1450655-10-3C₃₀H₄₀N₄O₅

(R)-N-((4-Methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(piperidin-4-yl)ethyl)-1H-indole-3-carboxamide chemical structure, C25H32N4O3, CAS 1659299-37-2

(R)-N-((4-Methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(piperidin-4-yl)ethyl)-1H-indole-3-carboxamide

CAS 1659299-37-2C₂₅H₃₂N₄O₃

(R)-tert-Butyl 4-(1-(3-(((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)carbamoyl)-2-methyl-1H-indol-1-yl)ethyl)piperidine-1-carboxylate chemical structure, C30H40N4O5, CAS 1659299-33-8

(R)-tert-Butyl 4-(1-(3-(((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)carbamoyl)-2-methyl-1H-indol-1-yl)ethyl)piperidine-1-carboxylate

CAS 1659299-33-8C₃₀H₄₀N₄O₅