Murcko scaffold
2',3',4',9'-Tetrahydrospiro[indoline-3,1'-pyrido[3,4-b]indol]-2-one scaffold
88 chemicals on CompoundList share this ring system.
- Rings
- 5
- Scaffold atoms
- 22
- Chemicals
- 88
- With full pages
- 4
Scaffold SMILES
O=C1Nc2ccccc2C12NCCc1c2[nH]c2ccccc12
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
![Murcko scaffold O=C1Nc2ccccc2C12NCCc1c2[nH]c2ccccc12](/scaffold/ICRRYXOCBMBKIC-UHFFFAOYSA-N/structure.svg)
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 48 of 88 chemicals
![1'-Methyl-2,3,4,9-tetrahydrospiro[beta-carboline-1,3'-indol]-2'(1'H)-one chemical structure, C19H17N3O, CAS 777872-03-4](/s/CLNDPGGCZWREBJ-UHFFFAOYSA-N.svg)
1'-Methyl-2,3,4,9-tetrahydrospiro[beta-carboline-1,3'-indol]-2'(1'H)-one
CAS 777872-03-4C19H17N3O
![5'-Bromo-2,3,4,9-tetrahydrospiro[beta-carboline-1,3'-indol]-2'(1'H)-one chemical structure, C18H14BrN3O, CAS 838598-75-7](/s/PNLXNAGKABBCNM-UHFFFAOYSA-N.svg)
5'-Bromo-2,3,4,9-tetrahydrospiro[beta-carboline-1,3'-indol]-2'(1'H)-one
CAS 838598-75-7C18H14BrN3O
![5-Bromo-6'-methylspiro[1H-indole-3,1'-2,3,4,9-tetrahydropyrido[3,4-b]indole]-2-one chemical structure, C19H16BrN3O, CAS 775292-32-5](/s/KTHRSTWJMJOKRI-UHFFFAOYSA-N.svg)
5-Bromo-6'-methylspiro[1H-indole-3,1'-2,3,4,9-tetrahydropyrido[3,4-b]indole]-2-one
CAS 775292-32-5C19H16BrN3O
6-Chloro-1',2,2',3,4,9-hexahydrospiro(beta-carboline-1,3'-indole)-2'-one
CAS 775292-34-7C18H14ClN3O
![7-Methoxy-2,3,4,9-tetrahydrospiro[beta-carboline-1,3'-indol]-2'(1'H)-one chemical structure, C19H17N3O2, CAS 775292-35-8](/s/WMAYESUWLHFVIV-UHFFFAOYSA-N.svg)
7-Methoxy-2,3,4,9-tetrahydrospiro[beta-carboline-1,3'-indol]-2'(1'H)-one
CAS 775292-35-8C19H17N3O2
![2',3',4',9'-Tetrahydrospiro[indoline-3,1'-pyrido[3,4-b]indol]-2-one chemical structure, C18H15N3O, CAS 796887-09-7](/s/ICRRYXOCBMBKIC-UHFFFAOYSA-N.svg)
2',3',4',9'-Tetrahydrospiro[indoline-3,1'-pyrido[3,4-b]indol]-2-one
CAS 796887-09-7C18H15N3O
![6-Methyl-2,3,4,9-tetrahydrospiro[beta-carboline-1,3'-indol]-2'(1'H)-one chemical structure, C19H17N3O, CAS 775292-31-4](/s/LQUFCEDIAFHNSQ-UHFFFAOYSA-N.svg)
6-Methyl-2,3,4,9-tetrahydrospiro[beta-carboline-1,3'-indol]-2'(1'H)-one
CAS 775292-31-4C19H17N3O
![5'-Bromo-6-chloro-2,3,4,9-tetrahydrospiro[beta-carboline-1,3'-indol]-2'(1'H)-one chemical structure, C18H13BrClN3O, CAS 775292-33-6](/s/XSOBSQCNNGDVAV-UHFFFAOYSA-N.svg)
5'-Bromo-6-chloro-2,3,4,9-tetrahydrospiro[beta-carboline-1,3'-indol]-2'(1'H)-one
CAS 775292-33-6C18H13BrClN3O
![5'-Bromo-7-methoxy-2,3,4,9-tetrahydrospiro[beta-carboline-1,3'-indol]-2'(1'H)-one chemical structure, C19H16BrN3O2, CAS 775292-36-9](/s/QMHZDTMWKBEVIS-UHFFFAOYSA-N.svg)
5'-Bromo-7-methoxy-2,3,4,9-tetrahydrospiro[beta-carboline-1,3'-indol]-2'(1'H)-one
CAS 775292-36-9C19H16BrN3O2
![2-(2-Ethylbutanoyl)-6-methyl-2,3,4,9-tetrahydrospiro[beta-carboline-1,3'-indol]-2'(1'H)-one chemical structure, C25H27N3O2, CAS 880067-54-9](/s/JPCIDDGBAXZVFC-UHFFFAOYSA-N.svg)
2-(2-Ethylbutanoyl)-6-methyl-2,3,4,9-tetrahydrospiro[beta-carboline-1,3'-indol]-2'(1'H)-one
CAS 880067-54-9C25H27N3O2
![2-Acetyl-1'-methyl-2,3,4,9-tetrahydrospiro[beta-carboline-1,3'-indol]-2'(1'H)-one chemical structure, C21H19N3O2, CAS 879776-56-4](/s/QTVPMJUKTMPIAB-UHFFFAOYSA-N.svg)
2-Acetyl-1'-methyl-2,3,4,9-tetrahydrospiro[beta-carboline-1,3'-indol]-2'(1'H)-one
CAS 879776-56-4C21H19N3O2
![2-Acetyl-5'-bromo-2,3,4,9-tetrahydrospiro[beta-carboline-1,3'-indol]-2'(1'H)-one chemical structure, C20H16BrN3O2, CAS 879772-76-6](/s/LTXQVCNJSCAUTA-UHFFFAOYSA-N.svg)
2-Acetyl-5'-bromo-2,3,4,9-tetrahydrospiro[beta-carboline-1,3'-indol]-2'(1'H)-one
CAS 879772-76-6C20H16BrN3O2
![2-Acetyl-2,3,4,9-tetrahydrospiro[beta-carboline-1,3'-indol]-2'(1'H)-one chemical structure, C20H17N3O2, CAS 904261-43-4](/s/JBFYBXHWCGNNGC-UHFFFAOYSA-N.svg)
2-Acetyl-2,3,4,9-tetrahydrospiro[beta-carboline-1,3'-indol]-2'(1'H)-one
CAS 904261-43-4C20H17N3O2
![5'-Bromo-1'-methyl-2,3,4,9-tetrahydrospiro[beta-carboline-1,3'-indol]-2'(1'H)-one chemical structure, C19H16BrN3O, CAS 904261-55-8](/s/JAYMFVKDUPYNNJ-UHFFFAOYSA-N.svg)
5'-Bromo-1'-methyl-2,3,4,9-tetrahydrospiro[beta-carboline-1,3'-indol]-2'(1'H)-one
CAS 904261-55-8C19H16BrN3O
![5'-Bromo-1'-methyl-2-propanoyl-2,3,4,9-tetrahydrospiro[beta-carboline-1,3'-indol]-2'(1'H)-one chemical structure, C22H20BrN3O2, CAS 904516-31-0](/s/BLSQCXQEGWDTPP-UHFFFAOYSA-N.svg)
5'-Bromo-1'-methyl-2-propanoyl-2,3,4,9-tetrahydrospiro[beta-carboline-1,3'-indol]-2'(1'H)-one
CAS 904516-31-0C22H20BrN3O2
![1'-Methyl-2-propanoyl-2,3,4,9-tetrahydrospiro[beta-carboline-1,3'-indol]-2'(1'H)-one chemical structure, C22H21N3O2, CAS 904516-36-5](/s/ZKUIJVSVLREFHB-UHFFFAOYSA-N.svg)
1'-Methyl-2-propanoyl-2,3,4,9-tetrahydrospiro[beta-carboline-1,3'-indol]-2'(1'H)-one
CAS 904516-36-5C22H21N3O2
![2-(3-Methylbutanoyl)-2,3,4,9-tetrahydrospiro[beta-carboline-1,3'-indol]-2'(1'H)-one chemical structure, C23H23N3O2, CAS 904516-46-7](/s/RQLLQDWQKCKVTO-UHFFFAOYSA-N.svg)
2-(3-Methylbutanoyl)-2,3,4,9-tetrahydrospiro[beta-carboline-1,3'-indol]-2'(1'H)-one
CAS 904516-46-7C23H23N3O2
![6-Methoxy-1'-methyl-2,3,4,9-tetrahydrospiro[beta-carboline-1,3'-indol]-2'(1'H)-one chemical structure, C20H19N3O2, CAS 904516-80-9](/s/FOTLXRGULOUVND-UHFFFAOYSA-N.svg)
6-Methoxy-1'-methyl-2,3,4,9-tetrahydrospiro[beta-carboline-1,3'-indol]-2'(1'H)-one
CAS 904516-80-9C20H19N3O2
![2-Acetyl-1',6-dimethyl-2,3,4,9-tetrahydrospiro[beta-carboline-1,3'-indol]-2'(1'H)-one chemical structure, C22H21N3O2, CAS 904501-20-8](/s/NJTUYOUQQQEHTF-UHFFFAOYSA-N.svg)
2-Acetyl-1',6-dimethyl-2,3,4,9-tetrahydrospiro[beta-carboline-1,3'-indol]-2'(1'H)-one
CAS 904501-20-8C22H21N3O2
![2-(2-Methylpropanoyl)-2,3,4,9-tetrahydrospiro[beta-carboline-1,3'-indol]-2'(1'H)-one chemical structure, C22H21N3O2, CAS 904501-50-4](/s/LCSFEGAGKLIWMC-UHFFFAOYSA-N.svg)
2-(2-Methylpropanoyl)-2,3,4,9-tetrahydrospiro[beta-carboline-1,3'-indol]-2'(1'H)-one
CAS 904501-50-4C22H21N3O2
![1'-Methyl-2-(3-methylbutanoyl)-2,3,4,9-tetrahydrospiro[beta-carboline-1,3'-indol]-2'(1'H)-one chemical structure, C24H25N3O2, CAS 904501-59-3](/s/QKBMDXRZMUJTGE-UHFFFAOYSA-N.svg)
1'-Methyl-2-(3-methylbutanoyl)-2,3,4,9-tetrahydrospiro[beta-carboline-1,3'-indol]-2'(1'H)-one
CAS 904501-59-3C24H25N3O2
![N-Ethyl-6-methoxy-1'-methyl-2'-oxo-1',2',4,9-tetrahydrospiro[beta-carboline-1,3'-indole]-2(3H)-carboxamide chemical structure, C23H24N4O3, CAS 904501-64-0](/s/LLCWKWTZRHBEFP-UHFFFAOYSA-N.svg)
N-Ethyl-6-methoxy-1'-methyl-2'-oxo-1',2',4,9-tetrahydrospiro[beta-carboline-1,3'-indole]-2(3H)-carboxamide
CAS 904501-64-0C23H24N4O3
![2-Propanoyl-2,3,4,9-tetrahydrospiro[beta-carboline-1,3'-indol]-2'(1'H)-one chemical structure, C21H19N3O2, CAS 904501-70-8](/s/RTOXGESUFVUCDK-UHFFFAOYSA-N.svg)
2-Propanoyl-2,3,4,9-tetrahydrospiro[beta-carboline-1,3'-indol]-2'(1'H)-one
CAS 904501-70-8C21H19N3O2
![N-Ethyl-1',6-dimethyl-2'-oxo-1',2',4,9-tetrahydrospiro[beta-carboline-1,3'-indole]-2(3H)-carboxamide chemical structure, C23H24N4O2, CAS 904501-86-6](/s/JZPGYBHIXAPPOV-UHFFFAOYSA-N.svg)
N-Ethyl-1',6-dimethyl-2'-oxo-1',2',4,9-tetrahydrospiro[beta-carboline-1,3'-indole]-2(3H)-carboxamide
CAS 904501-86-6C23H24N4O2
- 5'-Bromo-6-methoxy-1'-methyl-2,3,4,9-tetrahydrospiro[beta-carboline-1,3'-indol]-2'(1'H)-one904501-92-4C20H18BrN3O2
- 2-Acetyl-5'-bromo-1'-methyl-2,3,4,9-tetrahydrospiro[beta-carboline-1,3'-indol]-2'(1'H)-one904501-96-8C21H18BrN3O2
- 5'-Bromo-1',6-dimethyl-2,3,4,9-tetrahydrospiro[beta-carboline-1,3'-indol]-2'(1'H)-one904502-00-7C20H18BrN3O
- 5'-Bromo-N-ethyl-1'-methyl-2'-oxo-1',2',4,9-tetrahydrospiro[beta-carboline-1,3'-indole]-2(3H)-carboxamide904509-92-8C22H21BrN4O2
- 5'-Bromo-1'-methyl-2-(2-methylpropanoyl)-2,3,4,9-tetrahydrospiro[beta-carboline-1,3'-indol]-2'(1'H)-one904509-99-5C23H22BrN3O2
- N-Ethyl-1'-methyl-2'-oxo-1',2',4,9-tetrahydrospiro[beta-carboline-1,3'-indole]-2(3H)-carboxamide904510-06-1C22H22N4O2
- 5'-Bromo-2-isobutyryl-2,3,4,9-tetrahydrospiro[beta-carboline-1,3'-indol]-2'(1'H)-one904510-44-7C22H20BrN3O2
- 5'-Bromo-2-propanoyl-2,3,4,9-tetrahydrospiro[beta-carboline-1,3'-indol]-2'(1'H)-one904510-50-5C21H18BrN3O2
- 5'-Bromo-1'-methyl-2-(3-methylbutanoyl)-2,3,4,9-tetrahydrospiro[beta-carboline-1,3'-indol]-2'(1'H)-one904510-68-5C24H24BrN3O2
- 2-Butanoyl-2,3,4,9-tetrahydrospiro[beta-carboline-1,3'-indol]-2'(1'H)-one904510-77-6C22H21N3O2
- 2-Butanoyl-1'-methyl-2,3,4,9-tetrahydrospiro[beta-carboline-1,3'-indol]-2'(1'H)-one904511-21-3C23H23N3O2
- 5'-Bromo-1'-butyl-6-methoxy-2,3,4,9-tetrahydrospiro[beta-carboline-1,3'-indol]-2'(1'H)-one904511-54-2C23H24BrN3O2
- 5'-Bromo-2-butanoyl-2,3,4,9-tetrahydrospiro[beta-carboline-1,3'-indol]-2'(1'H)-one904503-95-3C22H20BrN3O2
- 5'-Bromo-6-methoxy-1'-propyl-2,3,4,9-tetrahydrospiro[beta-carboline-1,3'-indol]-2'(1'H)-one904503-97-5C22H22BrN3O2
- 2-Acetyl-1'-(2-methylpropyl)-2,3,4,9-tetrahydrospiro[beta-carboline-1,3'-indol]-2'(1'H)-one904504-66-1C24H25N3O2
- 6-Methoxy-1'-pentyl-2,3,4,9-tetrahydrospiro[beta-carboline-1,3'-indol]-2'(1'H)-one904505-05-1C24H27N3O2
- 1'-Isobutyl-6-methoxy-2,3,4,9-tetrahydrospiro[beta-carboline-1,3'-indol]-2'(1'H)-one904505-11-9C23H25N3O2
- 6-Methyl-1'-(3-methylbutyl)-2,3,4,9-tetrahydrospiro[beta-carboline-1,3'-indol]-2'(1'H)-one904513-94-6C24H27N3O
- 6-Methoxy-1'-(3-methylbutyl)-2,3,4,9-tetrahydrospiro[beta-carboline-1,3'-indol]-2'(1'H)-one904514-03-0C24H27N3O2
- 6-Chloro-N-ethyl-1'-methyl-2'-oxo-1',2',4,9-tetrahydrospiro[beta-carboline-1,3'-indole]-2(3H)-carboxamide904514-36-9C22H21ClN4O2
- 6-Fluoro-1'-(3-methylbutyl)-2,3,4,9-tetrahydrospiro[beta-carboline-1,3'-indol]-2'(1'H)-one904503-31-7C23H24FN3O
- 2-Isobutyryl-1'-methyl-2,3,4,9-tetrahydrospiro[beta-carboline-1,3'-indol]-2'(1'H)-one904503-40-8C23H23N3O2
- 6-Chloro-1'-methyl-2-propanoyl-2,3,4,9-tetrahydrospiro[beta-carboline-1,3'-indol]-2'(1'H)-one904503-78-2C22H20ClN3O2
- 6-Fluoro-2,3,4,9-tetrahydrospiro[beta-carboline-1,3'-indol]-2'(1'H)-one886184-82-3C18H14FN3O