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Murcko scaffold

Ring system with 2 rings and 17 atoms

12 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
17
Chemicals
12
With full pages
3
Scaffold SMILES

O=C(C=Cc1ccccc1)c1ccc[nH]c1=O

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(C=Cc1ccccc1)c1ccc[nH]c1=O

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 12 of 12 chemicals

3-[3-(2-Chlorophenyl)prop-2-enoyl]-4,6-dimethyl-1H-pyridin-2-one chemical structure, C16H14ClNO2, CAS 331445-67-1
3-[3-(2-Chlorophenyl)prop-2-enoyl]-4,6-dimethyl-1H-pyridin-2-one
CAS 331445-67-1C16H14ClNO2
RefChem:388717 chemical structure, C18H19NO3, CAS 5376-16-9
RefChem:388717
CAS 5376-16-9C18H19NO3
3-[(E)-3-(2-Chlorophenyl)-2-methylprop-2-enoyl]-4,6-dimethyl-1H-pyridin-2-one chemical structure, C17H16ClNO2, CAS 5376-17-0
3-[(E)-3-(2-Chlorophenyl)-2-methylprop-2-enoyl]-4,6-dimethyl-1H-pyridin-2-one
CAS 5376-17-0C17H16ClNO2
3-[3-(4-Chlorophenyl)-2-methylacryloyl]-4,6-dimethyl-2(1H)-pyridinone chemical structure, C17H16ClNO2, CAS 415940-17-9
3-[3-(4-Chlorophenyl)-2-methylacryloyl]-4,6-dimethyl-2(1H)-pyridinone
CAS 415940-17-9C17H16ClNO2
4,6-Dimethyl-3-[(E)-3-(3,4,5-trimethoxyphenyl)prop-2-enoyl]-1H-pyridin-2-one chemical structure, C19H21NO5, CAS 5543-19-1
4,6-Dimethyl-3-[(E)-3-(3,4,5-trimethoxyphenyl)prop-2-enoyl]-1H-pyridin-2-one
CAS 5543-19-1C19H21NO5
4,6-Dimethyl-3-[(E)-3-phenylprop-2-enoyl]-1H-pyridin-2-one chemical structure, C16H15NO2, CAS 79072-79-0
4,6-Dimethyl-3-[(E)-3-phenylprop-2-enoyl]-1H-pyridin-2-one
CAS 79072-79-0C16H15NO2
3-[(E)-3-(2-Fluorophenyl)prop-2-enoyl]-4,6-dimethyl-1H-pyridin-2-one chemical structure, C16H14FNO2, CAS 353776-02-0
3-[(E)-3-(2-Fluorophenyl)prop-2-enoyl]-4,6-dimethyl-1H-pyridin-2-one
CAS 353776-02-0C16H14FNO2
4,6-Dimethyl-3-[(E)-3-(3-nitrophenyl)prop-2-enoyl]-1H-pyridin-2-one chemical structure, C16H14N2O4, CAS 416890-22-7
4,6-Dimethyl-3-[(E)-3-(3-nitrophenyl)prop-2-enoyl]-1H-pyridin-2-one
CAS 416890-22-7C16H14N2O4
3-[(2E)-3-(4-Fluorophenyl)-2-methylprop-2-enoyl]-4,6-dimethylpyridin-2(1H)-one chemical structure, C17H16FNO2, CAS 339359-96-5
3-[(2E)-3-(4-Fluorophenyl)-2-methylprop-2-enoyl]-4,6-dimethylpyridin-2(1H)-one
CAS 339359-96-5C17H16FNO2
4-Hydroxy-6-methyl-3-(3-phenylprop-2-enoyl)-1H-pyridin-2-one chemical structure, C15H13NO3
4-Hydroxy-6-methyl-3-(3-phenylprop-2-enoyl)-1H-pyridin-2-one
C15H13NO3
trans-4-Hydroxy-3-cinnamoyl-6-methylpyrid-2-one chemical structure, C15H13NO3, CAS 19098-77-2
trans-4-Hydroxy-3-cinnamoyl-6-methylpyrid-2-one
CAS 19098-77-2C15H13NO3
(2E)-1-(2-Hydroxypyridin-3-yl)-3-phenylprop-2-en-1-one chemical structure, C14H11NO2, CAS 2377066-62-9
(2E)-1-(2-Hydroxypyridin-3-yl)-3-phenylprop-2-en-1-one
CAS 2377066-62-9C14H11NO2