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Murcko scaffold

Ring system with 2 rings and 16 atoms

28 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
16
Chemicals
28
With full pages
9
Scaffold SMILES

O=c1ccnc(NN=Cc2ccccc2)[nH]1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=c1ccnc(NN=Cc2ccccc2)[nH]1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 28 of 28 chemicals

2-[(2E)-2-[(2,3-Dimethoxyphenyl)methylidene]hydrazinyl]-5-methyl-1H-pyrimidin-6-one chemical structure, C14H16N4O3, CAS 301304-50-7
2-[(2E)-2-[(2,3-Dimethoxyphenyl)methylidene]hydrazinyl]-5-methyl-1H-pyrimidin-6-one
CAS 301304-50-7C14H16N4O3
N-[4-[(Z)-[(4-Methyl-6-oxo-3H-pyrimidin-2-yl)hydrazinylidene]methyl]phenyl]acetamide chemical structure, C14H15N5O2, CAS 92295-31-3
N-[4-[(Z)-[(4-Methyl-6-oxo-3H-pyrimidin-2-yl)hydrazinylidene]methyl]phenyl]acetamide
CAS 92295-31-3C14H15N5O2
5-Butyl-2-[(2E)-2-[1-(3,4-dichlorophenyl)ethylidene]hydrazinyl]-4-methyl-1H-pyrimidin-6-one chemical structure, C17H20Cl2N4O, CAS 5338-57-8
5-Butyl-2-[(2E)-2-[1-(3,4-dichlorophenyl)ethylidene]hydrazinyl]-4-methyl-1H-pyrimidin-6-one
CAS 5338-57-8C17H20Cl2N4O
2-Chlorobenzaldehyde (4-hydroxy-6-methyl-2-pyrimidinyl)hydrazone chemical structure, C12H11ClN4O, CAS 91398-40-2
2-Chlorobenzaldehyde (4-hydroxy-6-methyl-2-pyrimidinyl)hydrazone
CAS 91398-40-2C12H11ClN4O
2-Hydroxy-3-methoxybenzaldehyde (4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)hydrazone chemical structure, C13H14N4O3, CAS 5591-34-4
2-Hydroxy-3-methoxybenzaldehyde (4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)hydrazone
CAS 5591-34-4C13H14N4O3
2-[(2E)-2-[(2-Methoxyphenyl)methylidene]hydrazinyl]-6-methyl-1H-pyrimidin-4-one chemical structure, C13H14N4O2, CAS 92023-95-5
2-[(2E)-2-[(2-Methoxyphenyl)methylidene]hydrazinyl]-6-methyl-1H-pyrimidin-4-one
CAS 92023-95-5C13H14N4O2
6-Methyl-2-[N'-(3-nitro-benzylidene)-hydrazino]-pyrimidin-4-ol chemical structure, C12H11N5O3, CAS 35558-88-4
6-Methyl-2-[N'-(3-nitro-benzylidene)-hydrazino]-pyrimidin-4-ol
CAS 35558-88-4C12H11N5O3
4-Chlorobenzaldehyde (4-methyl-6-oxo-1,6-dihydro-2-pyrimidinyl)hydrazone chemical structure, C12H11ClN4O, CAS 65894-19-1
4-Chlorobenzaldehyde (4-methyl-6-oxo-1,6-dihydro-2-pyrimidinyl)hydrazone
CAS 65894-19-1C12H11ClN4O
2-Nitrobenzaldehyde (4-methyl-6-oxo-1,6-dihydro-2-pyrimidinyl)hydrazone chemical structure, C12H11N5O3, CAS 91843-74-2
2-Nitrobenzaldehyde (4-methyl-6-oxo-1,6-dihydro-2-pyrimidinyl)hydrazone
CAS 91843-74-2C12H11N5O3
2-Hydroxy-5-nitrobenzaldehyde (4-methyl-6-oxo-1,6-dihydro-2-pyrimidinyl)hydrazone chemical structure, C12H11N5O4, CAS 91843-81-1
2-Hydroxy-5-nitrobenzaldehyde (4-methyl-6-oxo-1,6-dihydro-2-pyrimidinyl)hydrazone
CAS 91843-81-1C12H11N5O4
2-[(2E)-2-(2,4-Dichlorobenzylidene)hydrazinyl]-6-methylpyrimidin-4-ol chemical structure, C12H10Cl2N4O, CAS 91962-05-9
2-[(2E)-2-(2,4-Dichlorobenzylidene)hydrazinyl]-6-methylpyrimidin-4-ol
CAS 91962-05-9C12H10Cl2N4O
2-[(2E)-2-(2,4-Dihydroxybenzylidene)hydrazinyl]-6-methylpyrimidin-4(3H)-one chemical structure, C12H12N4O3, CAS 92848-87-8
2-[(2E)-2-(2,4-Dihydroxybenzylidene)hydrazinyl]-6-methylpyrimidin-4(3H)-one
CAS 92848-87-8C12H12N4O3
4-Hydroxy-2-(2-hydroxybenzylidenehydrazino)-6-methylpyrimidine chemical structure, C12H12N4O2, CAS 66680-03-3
4-Hydroxy-2-(2-hydroxybenzylidenehydrazino)-6-methylpyrimidine
CAS 66680-03-3C12H12N4O2
2-[(2E)-2-Benzylidenehydrazinyl]-6-methylpyrimidin-4(3H)-one chemical structure, C12H12N4O, CAS 58010-88-1
2-[(2E)-2-Benzylidenehydrazinyl]-6-methylpyrimidin-4(3H)-one
CAS 58010-88-1C12H12N4O
4-(Dimethylamino)benzaldehyde (4-hydroxy-6-methyl-2-pyrimidinyl)hydrazone chemical structure, C14H17N5O, CAS 66680-02-2
4-(Dimethylamino)benzaldehyde (4-hydroxy-6-methyl-2-pyrimidinyl)hydrazone
CAS 66680-02-2C14H17N5O
2-(2-(4-Hydroxybenzylidene)hydrazinyl)-6-methylpyrimidin-4-ol chemical structure, C12H12N4O2, CAS 91560-27-9
2-(2-(4-Hydroxybenzylidene)hydrazinyl)-6-methylpyrimidin-4-ol
CAS 91560-27-9C12H12N4O2
2-[(2Z)-2-[(2,6-Dichlorophenyl)methylidene]hydrazinyl]-4-methyl-1H-pyrimidin-6-one chemical structure, C12H10Cl2N4O, CAS 51379-86-3
2-[(2Z)-2-[(2,6-Dichlorophenyl)methylidene]hydrazinyl]-4-methyl-1H-pyrimidin-6-one
CAS 51379-86-3C12H10Cl2N4O
Salicylaldehyde, (4-hydroxy-6-methyl-2-pyrimidinyl)hydrazone chemical structure, C12H11ClN4O2, CAS 91398-46-8
Salicylaldehyde, (4-hydroxy-6-methyl-2-pyrimidinyl)hydrazone
CAS 91398-46-8C12H11ClN4O2
2-[(2E)-2-[(3-Hydroxyphenyl)methylidene]hydrazinyl]-4-methyl-1H-pyrimidin-6-one chemical structure, C12H12N4O2, CAS 92902-70-0
2-[(2E)-2-[(3-Hydroxyphenyl)methylidene]hydrazinyl]-4-methyl-1H-pyrimidin-6-one
CAS 92902-70-0C12H12N4O2
2-[(E)-[(4-Methyl-6-oxo-1H-pyrimidin-2-yl)hydrazinylidene]methyl]benzoic acid chemical structure, C13H12N4O3, CAS 91803-56-4
2-[(E)-[(4-Methyl-6-oxo-1H-pyrimidin-2-yl)hydrazinylidene]methyl]benzoic acid
CAS 91803-56-4C13H12N4O3
2-(N'-(4-Methoxy-benzylidene)-hydrazino)-6-methyl-pyrimidin-4-ol chemical structure, C13H14N4O2, CAS 92023-96-6
2-(N'-(4-Methoxy-benzylidene)-hydrazino)-6-methyl-pyrimidin-4-ol
CAS 92023-96-6C13H14N4O2
N-[4-[(E)-[(4-Methyl-6-oxo-1H-pyrimidin-2-yl)hydrazinylidene]methyl]phenyl]acetamide chemical structure, C14H15N5O2
N-[4-[(E)-[(4-Methyl-6-oxo-1H-pyrimidin-2-yl)hydrazinylidene]methyl]phenyl]acetamide
C14H15N5O2
2-[(2Z)-2-[(2,3-Dimethoxyphenyl)methylidene]hydrazinyl]-4-methyl-1H-pyrimidin-6-one chemical structure, C14H16N4O3, CAS 92296-47-4
2-[(2Z)-2-[(2,3-Dimethoxyphenyl)methylidene]hydrazinyl]-4-methyl-1H-pyrimidin-6-one
CAS 92296-47-4C14H16N4O3
3,4-Dihydroxybenzaldehyde (4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)hydrazone chemical structure, C12H12N4O3, CAS 303024-34-2
3,4-Dihydroxybenzaldehyde (4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)hydrazone
CAS 303024-34-2C12H12N4O3