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Murcko scaffold

Ring system with 4 rings and 30 atoms

66 chemicals on CompoundList share this ring system.

Rings: 4
Scaffold atoms: 30
Chemicals: 66
With full pages: 60

Scaffold SMILES

O=C(NN=Cc1ccccc1)c1cc(-c2ccc(OCc3ccccc3)cc2)n[nH]1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=C(NN=Cc1ccccc1)c1cc(-c2ccc(OCc3ccccc3)cc2)n[nH]1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 66 chemicals

N'-(1-(4-F-PH)Ethylidene)3-(4-((4-ME-benzyl)oxy)PH)-1H-pyrazole-5-carbohydrazide chemical structure, C26H23FN4O2, CAS 634896-96-1

N'-(1-(4-F-PH)Ethylidene)3-(4-((4-ME-benzyl)oxy)PH)-1H-pyrazole-5-carbohydrazide

CAS 634896-96-1C₂₆H₂₃FN₄O₂

(Z)-3-(4-(Benzyloxy)phenyl)-N'-(3-bromobenzylidene)-1H-pyrazole-5-carbohydrazide chemical structure, C24H19BrN4O2, CAS 1285526-54-6

(Z)-3-(4-(Benzyloxy)phenyl)-N'-(3-bromobenzylidene)-1H-pyrazole-5-carbohydrazide

CAS 1285526-54-6C₂₄H₁₉BrN₄O₂

N'-(1-(4-CL-PH)Ethylidene)3(4-((4-ME-benzyl)oxy)PH)-1H-pyrazole-5-carbohydrazide chemical structure, C26H23ClN4O2, CAS 634896-86-9

N'-(1-(4-CL-PH)Ethylidene)3(4-((4-ME-benzyl)oxy)PH)-1H-pyrazole-5-carbohydrazide

CAS 634896-86-9C₂₆H₂₃ClN₄O₂

N'-(1-(4-BR-PH)Ethylidene)3(4-((4-ME-benzyl)oxy)PH)-1H-pyrazole-5-carbohydrazide chemical structure, C26H23BrN4O2, CAS 634896-87-0

N'-(1-(4-BR-PH)Ethylidene)3(4-((4-ME-benzyl)oxy)PH)-1H-pyrazole-5-carbohydrazide

CAS 634896-87-0C₂₆H₂₃BrN₄O₂

3-(4-(Benzyloxy)PH)N'-(4-(diethylamino)benzylidene)-1H-pyrazole-5-carbohydrazide chemical structure, C28H29N5O2, CAS 303106-93-6

3-(4-(Benzyloxy)PH)N'-(4-(diethylamino)benzylidene)-1H-pyrazole-5-carbohydrazide

CAS 303106-93-6C₂₈H₂₉N₅O₂

(Z)-5-(4-((4-Methylbenzyl)oxy)phenyl)-N'-(1-(3-nitrophenyl)ethylidene)-1H-pyrazole-3-carbohydrazide chemical structure, C26H23N5O4, CAS 1310363-25-7

(Z)-5-(4-((4-Methylbenzyl)oxy)phenyl)-N'-(1-(3-nitrophenyl)ethylidene)-1H-pyrazole-3-carbohydrazide

CAS 1310363-25-7C₂₆H₂₃N₅O₄

(Z)-3-(4-((4-Methylbenzyl)oxy)phenyl)-N'-(1-(p-tolyl)ethylidene)-1H-pyrazole-5-carbohydrazide chemical structure, C27H26N4O2, CAS 1309664-99-0

(Z)-3-(4-((4-Methylbenzyl)oxy)phenyl)-N'-(1-(p-tolyl)ethylidene)-1H-pyrazole-5-carbohydrazide

CAS 1309664-99-0C₂₇H₂₆N₄O₂

3-(4-((4-CL-Benzyl)oxy)PH)-N'-(1-(4-F-PH)ethylidene)1H-pyrazole-5-carbohydrazide chemical structure, C25H20ClFN4O2, CAS 634896-43-8

3-(4-((4-CL-Benzyl)oxy)PH)-N'-(1-(4-F-PH)ethylidene)1H-pyrazole-5-carbohydrazide

CAS 634896-43-8C₂₅H₂₀ClFN₄O₂

(E)-Methyl 4-((2-(3-(4-(benzyloxy)phenyl)-1H-pyrazole-5-carbonyl)hydrazono)methyl)benzoate chemical structure, C26H22N4O4, CAS 1285521-12-1

(E)-Methyl 4-((2-(3-(4-(benzyloxy)phenyl)-1H-pyrazole-5-carbonyl)hydrazono)methyl)benzoate

CAS 1285521-12-1C₂₆H₂₂N₄O₄

3-(4-(Benzyloxy)phenyl)-N'-(2-ethoxybenzylidene)-1H-pyrazole-5-carbohydrazide chemical structure, C26H24N4O3, CAS 302918-63-4

3-(4-(Benzyloxy)phenyl)-N'-(2-ethoxybenzylidene)-1H-pyrazole-5-carbohydrazide

CAS 302918-63-4C₂₆H₂₄N₄O₃

3-(4-(Benzyloxy)phenyl)-N'-(4-ethylbenzylidene)-1H-pyrazole-5-carbohydrazide chemical structure, C26H24N4O2, CAS 302918-64-5

3-(4-(Benzyloxy)phenyl)-N'-(4-ethylbenzylidene)-1H-pyrazole-5-carbohydrazide

CAS 302918-64-5C₂₆H₂₄N₄O₂

3-(4-(Benzyloxy)PH)-N'-(2,5-dimethoxybenzylidene)-1H-pyrazole-5-carbohydrazide chemical structure, C26H24N4O4, CAS 302918-59-8

3-(4-(Benzyloxy)PH)-N'-(2,5-dimethoxybenzylidene)-1H-pyrazole-5-carbohydrazide

CAS 302918-59-8C₂₆H₂₄N₄O₄

(E)-3-(4-(Benzyloxy)phenyl)-N'-(4-methoxybenzylidene)-1H-pyrazole-5-carbohydrazide chemical structure, C25H22N4O3, CAS 403649-46-7

(E)-3-(4-(Benzyloxy)phenyl)-N'-(4-methoxybenzylidene)-1H-pyrazole-5-carbohydrazide

CAS 403649-46-7C₂₅H₂₂N₄O₃

(E)-3-(4-(Benzyloxy)phenyl)-N'-(3-nitrobenzylidene)-1H-pyrazole-5-carbohydrazide chemical structure, C24H19N5O4, CAS 402504-19-2

(E)-3-(4-(Benzyloxy)phenyl)-N'-(3-nitrobenzylidene)-1H-pyrazole-5-carbohydrazide

CAS 402504-19-2C₂₄H₁₉N₅O₄

N'-(4-F-Benzylidene)-3-(4-((4-methylbenzyl)oxy)PH)-1H-pyrazole-5-carbohydrazide chemical structure, C25H21FN4O2, CAS 634896-60-9

N'-(4-F-Benzylidene)-3-(4-((4-methylbenzyl)oxy)PH)-1H-pyrazole-5-carbohydrazide

CAS 634896-60-9C₂₅H₂₁FN₄O₂

N'-Benzylidene-3-(4-((4-methylbenzyl)oxy)phenyl)-1H-pyrazole-5-carbohydrazide chemical structure, C25H22N4O2, CAS 634896-63-2

N'-Benzylidene-3-(4-((4-methylbenzyl)oxy)phenyl)-1H-pyrazole-5-carbohydrazide

CAS 634896-63-2C₂₅H₂₂N₄O₂

3-(4-((4-ME-Benzyl)oxy)PH)-N'-(3-nitrobenzylidene)-1H-pyrazole-5-carbohydrazide chemical structure, C25H21N5O4, CAS 634896-72-3

3-(4-((4-ME-Benzyl)oxy)PH)-N'-(3-nitrobenzylidene)-1H-pyrazole-5-carbohydrazide

CAS 634896-72-3C₂₅H₂₁N₅O₄

3-(4-((2-CL-Benzyl)oxy)PH)-N'-(4-ethylbenzylidene)-1H-pyrazole-5-carbohydrazide chemical structure, C26H23ClN4O2, CAS 634897-08-8

3-(4-((2-CL-Benzyl)oxy)PH)-N'-(4-ethylbenzylidene)-1H-pyrazole-5-carbohydrazide

CAS 634897-08-8C₂₆H₂₃ClN₄O₂

3-(4-(Benzyloxy)PH)-N'-(2-CL-6-fluorobenzylidene)-1H-pyrazole-5-carbohydrazide chemical structure, C24H18ClFN4O2, CAS 302918-10-1

3-(4-(Benzyloxy)PH)-N'-(2-CL-6-fluorobenzylidene)-1H-pyrazole-5-carbohydrazide

CAS 302918-10-1C₂₄H₁₈ClFN₄O₂

N'-(3-BR-Benzylidene)-3-(4-((2-chlorobenzyl)oxy)PH)-1H-pyrazole-5-carbohydrazide chemical structure, C24H18BrClN4O2, CAS 634897-06-6

N'-(3-BR-Benzylidene)-3-(4-((2-chlorobenzyl)oxy)PH)-1H-pyrazole-5-carbohydrazide

CAS 634897-06-6C₂₄H₁₈BrClN₄O₂

3-(4-((4-CL-Benzyl)oxy)PH)-N'-(4-nitrobenzylidene)-1H-pyrazole-5-carbohydrazide chemical structure, C24H18ClN5O4, CAS 634896-27-8

3-(4-((4-CL-Benzyl)oxy)PH)-N'-(4-nitrobenzylidene)-1H-pyrazole-5-carbohydrazide

CAS 634896-27-8C₂₄H₁₈ClN₅O₄

3-(4-((4-CL-Benzyl)oxy)PH)-N'-(4-fluorobenzylidene)-1H-pyrazole-5-carbohydrazide chemical structure, C24H18ClFN4O2, CAS 634896-09-6

3-(4-((4-CL-Benzyl)oxy)PH)-N'-(4-fluorobenzylidene)-1H-pyrazole-5-carbohydrazide

CAS 634896-09-6C₂₄H₁₈ClFN₄O₂

3-(4-((4-CL-Benzyl)oxy)PH)N'-(3-hydroxybenzylidene)-1H-pyrazole-5-carbohydrazide chemical structure, C24H19ClN4O3, CAS 303107-91-7

3-(4-((4-CL-Benzyl)oxy)PH)N'-(3-hydroxybenzylidene)-1H-pyrazole-5-carbohydrazide

CAS 303107-91-7C₂₄H₁₉ClN₄O₃

3-(4-((4-CL-Benzyl)oxy)PH)-N'-(4-ethoxybenzylidene)-1H-pyrazole-5-carbohydrazide chemical structure, C26H23ClN4O3, CAS 634896-10-9

3-(4-((4-CL-Benzyl)oxy)PH)-N'-(4-ethoxybenzylidene)-1H-pyrazole-5-carbohydrazide

CAS 634896-10-9C₂₆H₂₃ClN₄O₃