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Murcko scaffold

Ring system with 3 rings and 22 atoms

42 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
22
Chemicals
42
With full pages
14
Scaffold SMILES

O=C(CSc1ccc(-c2cncs2)nn1)Nc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(CSc1ccc(-c2cncs2)nn1)Nc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 42 of 42 chemicals

2-((6-(2,4-Dimethylthiazol-5-yl)pyridazin-3-yl)thio)-N-(4-ethylphenyl)acetamide chemical structure, C19H20N4OS2, CAS 872988-12-0
2-((6-(2,4-Dimethylthiazol-5-yl)pyridazin-3-yl)thio)-N-(4-ethylphenyl)acetamide
CAS 872988-12-0C19H20N4OS2
2-((6-(2,4-Dimethylthiazol-5-yl)pyridazin-3-yl)thio)-N-(4-methoxyphenyl)acetamide chemical structure, C18H18N4O2S2, CAS 872988-16-4
2-((6-(2,4-Dimethylthiazol-5-yl)pyridazin-3-yl)thio)-N-(4-methoxyphenyl)acetamide
CAS 872988-16-4C18H18N4O2S2
N-(3,4-Dimethoxyphenyl)-2-[6-(2,4-dimethyl-1,3-thiazol-5-yl)pyridazin-3-yl]sulfanylacetamide chemical structure, C19H20N4O3S2, CAS 872988-17-5
N-(3,4-Dimethoxyphenyl)-2-[6-(2,4-dimethyl-1,3-thiazol-5-yl)pyridazin-3-yl]sulfanylacetamide
CAS 872988-17-5C19H20N4O3S2
2-((6-(2,4-Dimethylthiazol-5-yl)pyridazin-3-yl)thio)-N-(2-ethoxyphenyl)acetamide chemical structure, C19H20N4O2S2, CAS 894007-59-1
2-((6-(2,4-Dimethylthiazol-5-yl)pyridazin-3-yl)thio)-N-(2-ethoxyphenyl)acetamide
CAS 894007-59-1C19H20N4O2S2
Methyl 4-(2-((6-(2,4-dimethylthiazol-5-yl)pyridazin-3-yl)thio)acetamido)benzoate chemical structure, C19H18N4O3S2, CAS 894008-01-6
Methyl 4-(2-((6-(2,4-dimethylthiazol-5-yl)pyridazin-3-yl)thio)acetamido)benzoate
CAS 894008-01-6C19H18N4O3S2
N-(4-Acetylphenyl)-2-((6-(2,4-dimethylthiazol-5-yl)pyridazin-3-yl)thio)acetamide chemical structure, C19H18N4O2S2, CAS 894008-16-3
N-(4-Acetylphenyl)-2-((6-(2,4-dimethylthiazol-5-yl)pyridazin-3-yl)thio)acetamide
CAS 894008-16-3C19H18N4O2S2
N-(2,4-Difluorophenyl)-2-((6-(2,4-dimethylthiazol-5-yl)pyridazin-3-yl)thio)acetamide chemical structure, C17H14F2N4OS2, CAS 894009-32-6
N-(2,4-Difluorophenyl)-2-((6-(2,4-dimethylthiazol-5-yl)pyridazin-3-yl)thio)acetamide
CAS 894009-32-6C17H14F2N4OS2
2-((6-(2,4-Dimethylthiazol-5-yl)pyridazin-3-yl)thio)-N-(3-fluorophenyl)acetamide chemical structure, C17H15FN4OS2, CAS 894009-38-2
2-((6-(2,4-Dimethylthiazol-5-yl)pyridazin-3-yl)thio)-N-(3-fluorophenyl)acetamide
CAS 894009-38-2C17H15FN4OS2
N-(3-Acetylphenyl)-2-((6-(2,4-dimethylthiazol-5-yl)pyridazin-3-yl)thio)acetamide chemical structure, C19H18N4O2S2, CAS 894009-56-4
N-(3-Acetylphenyl)-2-((6-(2,4-dimethylthiazol-5-yl)pyridazin-3-yl)thio)acetamide
CAS 894009-56-4C19H18N4O2S2
2-[6-(2,4-Dimethyl-1,3-thiazol-5-yl)pyridazin-3-yl]sulfanyl-N-(2-methoxy-5-methylphenyl)acetamide chemical structure, C19H20N4O2S2, CAS 894009-80-4
2-[6-(2,4-Dimethyl-1,3-thiazol-5-yl)pyridazin-3-yl]sulfanyl-N-(2-methoxy-5-methylphenyl)acetamide
CAS 894009-80-4C19H20N4O2S2
N-(3-Chloro-4-methylphenyl)-2-((6-(2,4-dimethylthiazol-5-yl)pyridazin-3-yl)thio)acetamide chemical structure, C18H17ClN4OS2, CAS 894010-38-9
N-(3-Chloro-4-methylphenyl)-2-((6-(2,4-dimethylthiazol-5-yl)pyridazin-3-yl)thio)acetamide
CAS 894010-38-9C18H17ClN4OS2
N-(3-Chlorophenyl)-2-[6-(2,4-dimethyl-1,3-thiazol-5-yl)pyridazin-3-yl]sulfanylacetamide chemical structure, C17H15ClN4OS2, CAS 894010-51-6
N-(3-Chlorophenyl)-2-[6-(2,4-dimethyl-1,3-thiazol-5-yl)pyridazin-3-yl]sulfanylacetamide
CAS 894010-51-6C17H15ClN4OS2
N-(3-Chloro-2-methylphenyl)-2-((6-(2,4-dimethylthiazol-5-yl)pyridazin-3-yl)thio)acetamide chemical structure, C18H17ClN4OS2, CAS 894010-79-8
N-(3-Chloro-2-methylphenyl)-2-((6-(2,4-dimethylthiazol-5-yl)pyridazin-3-yl)thio)acetamide
CAS 894010-79-8C18H17ClN4OS2
2-((6-(2,4-Dimethylthiazol-5-yl)pyridazin-3-yl)thio)-N-(o-tolyl)acetamide chemical structure, C18H18N4OS2, CAS 872988-07-3
2-((6-(2,4-Dimethylthiazol-5-yl)pyridazin-3-yl)thio)-N-(o-tolyl)acetamide
CAS 872988-07-3C18H18N4OS2
2-((6-(2,4-Dimethylthiazol-5-yl)pyridazin-3-yl)thio)-N-(m-tolyl)acetamide chemical structure, C18H18N4OS2, CAS 872988-08-4
2-((6-(2,4-Dimethylthiazol-5-yl)pyridazin-3-yl)thio)-N-(m-tolyl)acetamide
CAS 872988-08-4C18H18N4OS2
2-((6-(2,4-Dimethylthiazol-5-yl)pyridazin-3-yl)thio)-N-(p-tolyl)acetamide chemical structure, C18H18N4OS2, CAS 872988-09-5
2-((6-(2,4-Dimethylthiazol-5-yl)pyridazin-3-yl)thio)-N-(p-tolyl)acetamide
CAS 872988-09-5C18H18N4OS2
N-(2,3-Dimethylphenyl)-2-((6-(2,4-dimethylthiazol-5-yl)pyridazin-3-yl)thio)acetamide chemical structure, C19H20N4OS2, CAS 894006-89-4
N-(2,3-Dimethylphenyl)-2-((6-(2,4-dimethylthiazol-5-yl)pyridazin-3-yl)thio)acetamide
CAS 894006-89-4C19H20N4OS2
N-(3,5-Dimethylphenyl)-2-((6-(2,4-dimethylthiazol-5-yl)pyridazin-3-yl)thio)acetamide chemical structure, C19H20N4OS2, CAS 872988-10-8
N-(3,5-Dimethylphenyl)-2-((6-(2,4-dimethylthiazol-5-yl)pyridazin-3-yl)thio)acetamide
CAS 872988-10-8C19H20N4OS2
N-(2,5-Dimethylphenyl)-2-((6-(2,4-dimethylthiazol-5-yl)pyridazin-3-yl)thio)acetamide chemical structure, C19H20N4OS2, CAS 894006-98-5
N-(2,5-Dimethylphenyl)-2-((6-(2,4-dimethylthiazol-5-yl)pyridazin-3-yl)thio)acetamide
CAS 894006-98-5C19H20N4OS2
2-((6-(2,4-Dimethylthiazol-5-yl)pyridazin-3-yl)thio)-N-mesitylacetamide chemical structure, C20H22N4OS2, CAS 872988-11-9
2-((6-(2,4-Dimethylthiazol-5-yl)pyridazin-3-yl)thio)-N-mesitylacetamide
CAS 872988-11-9C20H22N4OS2
N-(2,4-Dimethylphenyl)-2-[6-(2,4-dimethyl-1,3-thiazol-5-yl)pyridazin-3-yl]sulfanylacetamide chemical structure, C19H20N4OS2, CAS 872988-13-1
N-(2,4-Dimethylphenyl)-2-[6-(2,4-dimethyl-1,3-thiazol-5-yl)pyridazin-3-yl]sulfanylacetamide
CAS 872988-13-1C19H20N4OS2
2-((6-(2,4-Dimethylthiazol-5-yl)pyridazin-3-yl)thio)-N-(2-methoxyphenyl)acetamide chemical structure, C18H18N4O2S2, CAS 894007-33-1
2-((6-(2,4-Dimethylthiazol-5-yl)pyridazin-3-yl)thio)-N-(2-methoxyphenyl)acetamide
CAS 894007-33-1C18H18N4O2S2
N-(2,4-Dimethoxyphenyl)-2-((6-(2,4-dimethylthiazol-5-yl)pyridazin-3-yl)thio)acetamide chemical structure, C19H20N4O3S2, CAS 894007-45-5
N-(2,4-Dimethoxyphenyl)-2-((6-(2,4-dimethylthiazol-5-yl)pyridazin-3-yl)thio)acetamide
CAS 894007-45-5C19H20N4O3S2
N-(2,5-Dimethoxyphenyl)-2-((6-(2,4-dimethylthiazol-5-yl)pyridazin-3-yl)thio)acetamide chemical structure, C19H20N4O3S2, CAS 894007-50-2
N-(2,5-Dimethoxyphenyl)-2-((6-(2,4-dimethylthiazol-5-yl)pyridazin-3-yl)thio)acetamide
CAS 894007-50-2C19H20N4O3S2