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Murcko scaffold

Ring system with 3 rings and 23 atoms

47 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
23
Chemicals
47
With full pages
6
Scaffold SMILES

O=C(NC(=S)Nc1ccc(N2CCCC2)cc1)c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(NC(=S)Nc1ccc(N2CCCC2)cc1)c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 47 of 47 chemicals

2-Fluoro-N-[(4-pyrrolidin-1-ylphenyl)carbamothioyl]benzamide chemical structure, C18H18FN3OS, CAS 429649-48-9
2-Fluoro-N-[(4-pyrrolidin-1-ylphenyl)carbamothioyl]benzamide
CAS 429649-48-9C18H18FN3OS
2-Methyl-N-[(4-pyrrolidin-1-ylphenyl)carbamothioyl]benzamide chemical structure, C19H21N3OS, CAS 429649-20-7
2-Methyl-N-[(4-pyrrolidin-1-ylphenyl)carbamothioyl]benzamide
CAS 429649-20-7C19H21N3OS
3-Methyl-N-[(4-pyrrolidin-1-ylphenyl)carbamothioyl]benzamide chemical structure, C19H21N3OS, CAS 380308-78-1
3-Methyl-N-[(4-pyrrolidin-1-ylphenyl)carbamothioyl]benzamide
CAS 380308-78-1C19H21N3OS
N-[(3-Chloro-4-pyrrolidin-1-ylphenyl)carbamothioyl]-2-methylbenzamide chemical structure, C19H20ClN3OS, CAS 384799-22-8
N-[(3-Chloro-4-pyrrolidin-1-ylphenyl)carbamothioyl]-2-methylbenzamide
CAS 384799-22-8C19H20ClN3OS
3,4-Dimethyl-N-[(4-pyrrolidin-1-ylphenyl)carbamothioyl]benzamide chemical structure, C20H23N3OS, CAS 429654-78-4
3,4-Dimethyl-N-[(4-pyrrolidin-1-ylphenyl)carbamothioyl]benzamide
CAS 429654-78-4C20H23N3OS
5-Bromo-2-methoxy-N-[(4-pyrrolidin-1-ylphenyl)carbamothioyl]benzamide chemical structure, C19H20BrN3O2S, CAS 429648-26-0
5-Bromo-2-methoxy-N-[(4-pyrrolidin-1-ylphenyl)carbamothioyl]benzamide
CAS 429648-26-0C19H20BrN3O2S
5-Bromo-N-[(3-chloro-4-pyrrolidin-1-ylphenyl)carbamothioyl]-2-methoxybenzamide chemical structure, C19H19BrClN3O2S, CAS 431911-01-2
5-Bromo-N-[(3-chloro-4-pyrrolidin-1-ylphenyl)carbamothioyl]-2-methoxybenzamide
CAS 431911-01-2C19H19BrClN3O2S
N-[(3-Chloro-4-pyrrolidin-1-ylphenyl)carbamothioyl]-2-fluorobenzamide chemical structure, C18H17ClFN3OS, CAS 445417-14-1
N-[(3-Chloro-4-pyrrolidin-1-ylphenyl)carbamothioyl]-2-fluorobenzamide
CAS 445417-14-1C18H17ClFN3OS
N-[(3-Chloro-4-pyrrolidin-1-ylphenyl)carbamothioyl]-3,4,5-triethoxybenzamide chemical structure, C24H30ClN3O4S, CAS 432015-20-8
N-[(3-Chloro-4-pyrrolidin-1-ylphenyl)carbamothioyl]-3,4,5-triethoxybenzamide
CAS 432015-20-8C24H30ClN3O4S
2-Chloro-5-iodo-N-[(4-pyrrolidin-1-ylphenyl)carbamothioyl]benzamide chemical structure, C18H17ClIN3OS, CAS 364738-61-4
2-Chloro-5-iodo-N-[(4-pyrrolidin-1-ylphenyl)carbamothioyl]benzamide
CAS 364738-61-4C18H17ClIN3OS
3,4-Dimethoxy-N-[[4-(1-pyrrolidinyl)anilino]-sulfanylidenemethyl]benzamide chemical structure, C20H23N3O3S, CAS 356085-36-4
3,4-Dimethoxy-N-[[4-(1-pyrrolidinyl)anilino]-sulfanylidenemethyl]benzamide
CAS 356085-36-4C20H23N3O3S
N-{[3-Chloro-4-(pyrrolidin-1-yl)phenyl]carbamothioyl}-3,5-dimethoxybenzamide chemical structure, C20H22ClN3O3S, CAS 432019-71-1
N-{[3-Chloro-4-(pyrrolidin-1-yl)phenyl]carbamothioyl}-3,5-dimethoxybenzamide
CAS 432019-71-1C20H22ClN3O3S
2-Bromo-N-[(4-pyrrolidin-1-ylphenyl)carbamothioyl]benzamide chemical structure, C18H18BrN3OS, CAS 429653-61-2
2-Bromo-N-[(4-pyrrolidin-1-ylphenyl)carbamothioyl]benzamide
CAS 429653-61-2C18H18BrN3OS
N-[(3-Chloro-4-pyrrolidin-1-ylphenyl)carbamothioyl]-2-methoxybenzamide chemical structure, C19H20ClN3O2S, CAS 432018-04-7
N-[(3-Chloro-4-pyrrolidin-1-ylphenyl)carbamothioyl]-2-methoxybenzamide
CAS 432018-04-7C19H20ClN3O2S
3-Chloro-N-[(4-pyrrolidin-1-ylphenyl)carbamothioyl]benzamide chemical structure, C18H18ClN3OS, CAS 430443-30-4
3-Chloro-N-[(4-pyrrolidin-1-ylphenyl)carbamothioyl]benzamide
CAS 430443-30-4C18H18ClN3OS
2-Chloro-4-fluoro-N-[(4-pyrrolidin-1-ylphenyl)carbamothioyl]benzamide chemical structure, C18H17ClFN3OS, CAS 593239-79-3
2-Chloro-4-fluoro-N-[(4-pyrrolidin-1-ylphenyl)carbamothioyl]benzamide
CAS 593239-79-3C18H17ClFN3OS
N-[(3-Chloro-4-pyrrolidin-1-ylphenyl)carbamothioyl]-2-nitrobenzamide chemical structure, C18H17ClN4O3S, CAS 431939-68-3
N-[(3-Chloro-4-pyrrolidin-1-ylphenyl)carbamothioyl]-2-nitrobenzamide
CAS 431939-68-3C18H17ClN4O3S
N-[(3-Chloro-4-pyrrolidin-1-ylphenyl)carbamothioyl]-4-methylbenzamide chemical structure, C19H20ClN3OS, CAS 431941-28-5
N-[(3-Chloro-4-pyrrolidin-1-ylphenyl)carbamothioyl]-4-methylbenzamide
CAS 431941-28-5C19H20ClN3OS
3-Bromo-N-[(3-chloro-4-pyrrolidin-1-ylphenyl)carbamothioyl]benzamide chemical structure, C18H17BrClN3OS, CAS 431978-37-9
3-Bromo-N-[(3-chloro-4-pyrrolidin-1-ylphenyl)carbamothioyl]benzamide
CAS 431978-37-9C18H17BrClN3OS
4-Bromo-N-[(3-chloro-4-pyrrolidin-1-ylphenyl)carbamothioyl]benzamide chemical structure, C18H17BrClN3OS, CAS 431983-37-8
4-Bromo-N-[(3-chloro-4-pyrrolidin-1-ylphenyl)carbamothioyl]benzamide
CAS 431983-37-8C18H17BrClN3OS
N-[(3-Chloro-4-pyrrolidin-1-ylphenyl)carbamothioyl]-4-methoxybenzamide chemical structure, C19H20ClN3O2S, CAS 432002-43-2
N-[(3-Chloro-4-pyrrolidin-1-ylphenyl)carbamothioyl]-4-methoxybenzamide
CAS 432002-43-2C19H20ClN3O2S
N-[(3-Chloro-4-pyrrolidin-1-ylphenyl)carbamothioyl]-3,4,5-trimethoxybenzamide chemical structure, C21H24ClN3O4S, CAS 432002-51-2
N-[(3-Chloro-4-pyrrolidin-1-ylphenyl)carbamothioyl]-3,4,5-trimethoxybenzamide
CAS 432002-51-2C21H24ClN3O4S
N-[(3-Chloro-4-pyrrolidin-1-ylphenyl)carbamothioyl]-3-methylbenzamide chemical structure, C19H20ClN3OS, CAS 432005-63-5
N-[(3-Chloro-4-pyrrolidin-1-ylphenyl)carbamothioyl]-3-methylbenzamide
CAS 432005-63-5C19H20ClN3OS
2-Chloro-N-[(3-chloro-4-pyrrolidin-1-ylphenyl)carbamothioyl]benzamide chemical structure, C18H17Cl2N3OS, CAS 431917-12-3
2-Chloro-N-[(3-chloro-4-pyrrolidin-1-ylphenyl)carbamothioyl]benzamide
CAS 431917-12-3C18H17Cl2N3OS