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Murcko scaffold

N-(1,1-Dioxidotetrahydrothiophen-3-yl)-2-phenoxy-N-(thiophen-2-ylmethyl)acetamide scaffold

51 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
24
Chemicals
51
With full pages
23
Scaffold SMILES

O=C(COc1ccccc1)N(Cc1cccs1)C1CCS(=O)(=O)C1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the N-(1,1-Dioxidotetrahydrothiophen-3-yl)-2-phenoxy-N-(thiophen-2-ylmethyl)acetamide page
Murcko scaffold O=C(COc1ccccc1)N(Cc1cccs1)C1CCS(=O)(=O)C1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 51 chemicals

2-(2,3-Dimethylphenoxy)-N-(1,1-dioxidotetrahydrothiophen-3-yl)-N-(thiophen-2-ylmethyl)acetamide chemical structure, C19H23NO4S2, CAS 620566-31-6
2-(2,3-Dimethylphenoxy)-N-(1,1-dioxidotetrahydrothiophen-3-yl)-N-(thiophen-2-ylmethyl)acetamide
CAS 620566-31-6C19H23NO4S2
2-(3,5-Dimethylphenoxy)-N-(1,1-dioxidotetrahydrothiophen-3-yl)-N-(thiophen-2-ylmethyl)acetamide chemical structure, C19H23NO4S2, CAS 620566-22-5
2-(3,5-Dimethylphenoxy)-N-(1,1-dioxidotetrahydrothiophen-3-yl)-N-(thiophen-2-ylmethyl)acetamide
CAS 620566-22-5C19H23NO4S2
N-(1,1-Dioxothiolan-3-yl)-2-(2-methylphenoxy)-N-(thiophen-2-ylmethyl)acetamide chemical structure, C18H21NO4S2, CAS 620564-15-0
N-(1,1-Dioxothiolan-3-yl)-2-(2-methylphenoxy)-N-(thiophen-2-ylmethyl)acetamide
CAS 620564-15-0C18H21NO4S2
N-(1,1-Dioxothiolan-3-yl)-2-(3-methylphenoxy)-N-(thiophen-2-ylmethyl)acetamide chemical structure, C18H21NO4S2, CAS 573934-44-8
N-(1,1-Dioxothiolan-3-yl)-2-(3-methylphenoxy)-N-(thiophen-2-ylmethyl)acetamide
CAS 573934-44-8C18H21NO4S2
2-(2,3-Dimethylphenoxy)-N-(1,1-dioxidotetrahydrothiophen-3-yl)-N-(thiophen-2-ylmethyl)propanamide chemical structure, C20H25NO4S2, CAS 575470-03-0
2-(2,3-Dimethylphenoxy)-N-(1,1-dioxidotetrahydrothiophen-3-yl)-N-(thiophen-2-ylmethyl)propanamide
CAS 575470-03-0C20H25NO4S2
N-(1,1-Dioxothiolan-3-yl)-2-(4-fluorophenoxy)-N-(thiophen-2-ylmethyl)acetamide chemical structure, C17H18FNO4S2, CAS 578004-68-9
N-(1,1-Dioxothiolan-3-yl)-2-(4-fluorophenoxy)-N-(thiophen-2-ylmethyl)acetamide
CAS 578004-68-9C17H18FNO4S2
N-(1,1-Dioxidotetrahydrothiophen-3-yl)-2-(2-fluorophenoxy)-N-(thiophen-2-ylmethyl)propanamide chemical structure, C18H20FNO4S2, CAS 620565-59-5
N-(1,1-Dioxidotetrahydrothiophen-3-yl)-2-(2-fluorophenoxy)-N-(thiophen-2-ylmethyl)propanamide
CAS 620565-59-5C18H20FNO4S2
2-(2-Chlorophenoxy)-N-(1,1-dioxidotetrahydrothiophen-3-yl)-N-(thiophen-2-ylmethyl)propanamide chemical structure, C18H20ClNO4S2, CAS 573950-77-3
2-(2-Chlorophenoxy)-N-(1,1-dioxidotetrahydrothiophen-3-yl)-N-(thiophen-2-ylmethyl)propanamide
CAS 573950-77-3C18H20ClNO4S2
2-(4-tert-Butylphenoxy)-N-(1,1-dioxidotetrahydrothiophen-3-yl)-N-(thiophen-2-ylmethyl)acetamide chemical structure, C21H27NO4S2, CAS 620566-17-8
2-(4-tert-Butylphenoxy)-N-(1,1-dioxidotetrahydrothiophen-3-yl)-N-(thiophen-2-ylmethyl)acetamide
CAS 620566-17-8C21H27NO4S2
N-(1,1-Dioxidotetrahydrothiophen-3-yl)-2-[4-(propan-2-yl)phenoxy]-N-(thiophen-2-ylmethyl)acetamide chemical structure, C20H25NO4S2, CAS 577696-08-3
N-(1,1-Dioxidotetrahydrothiophen-3-yl)-2-[4-(propan-2-yl)phenoxy]-N-(thiophen-2-ylmethyl)acetamide
CAS 577696-08-3C20H25NO4S2
N-(1,1-Dioxidotetrahydrothiophen-3-yl)-2-(2-methoxyphenoxy)-N-(thiophen-2-ylmethyl)acetamide chemical structure, C18H21NO5S2, CAS 620564-07-0
N-(1,1-Dioxidotetrahydrothiophen-3-yl)-2-(2-methoxyphenoxy)-N-(thiophen-2-ylmethyl)acetamide
CAS 620564-07-0C18H21NO5S2
2-(4-Chloro-3,5-dimethylphenoxy)-N-(1,1-dioxidotetrahydrothiophen-3-yl)-N-(thiophen-2-ylmethyl)acetamide chemical structure, C19H22ClNO4S2, CAS 573705-25-6
2-(4-Chloro-3,5-dimethylphenoxy)-N-(1,1-dioxidotetrahydrothiophen-3-yl)-N-(thiophen-2-ylmethyl)acetamide
CAS 573705-25-6C19H22ClNO4S2
2-(4-Chloro-3,5-dimethylphenoxy)-N-(1,1-dioxidotetrahydrothiophen-3-yl)-N-(thiophen-2-ylmethyl)propanamide chemical structure, C20H24ClNO4S2, CAS 620565-88-0
2-(4-Chloro-3,5-dimethylphenoxy)-N-(1,1-dioxidotetrahydrothiophen-3-yl)-N-(thiophen-2-ylmethyl)propanamide
CAS 620565-88-0C20H24ClNO4S2
2-(2,6-Dimethylphenoxy)-N-(1,1-dioxidotetrahydrothiophen-3-yl)-N-(thiophen-2-ylmethyl)acetamide chemical structure, C19H23NO4S2, CAS 573943-48-3
2-(2,6-Dimethylphenoxy)-N-(1,1-dioxidotetrahydrothiophen-3-yl)-N-(thiophen-2-ylmethyl)acetamide
CAS 573943-48-3C19H23NO4S2
2-(4-Chlorophenoxy)-N-(1,1-dioxidotetrahydrothiophen-3-yl)-N-(thiophen-2-ylmethyl)acetamide chemical structure, C17H18ClNO4S2, CAS 620563-81-7
2-(4-Chlorophenoxy)-N-(1,1-dioxidotetrahydrothiophen-3-yl)-N-(thiophen-2-ylmethyl)acetamide
CAS 620563-81-7C17H18ClNO4S2
2-(3,4-Dimethylphenoxy)-N-(1,1-dioxidotetrahydrothiophen-3-yl)-N-(thiophen-2-ylmethyl)propanamide chemical structure, C20H25NO4S2, CAS 620566-01-0
2-(3,4-Dimethylphenoxy)-N-(1,1-dioxidotetrahydrothiophen-3-yl)-N-(thiophen-2-ylmethyl)propanamide
CAS 620566-01-0C20H25NO4S2
2-(2,4-Dichlorophenoxy)-N-(1,1-dioxidotetrahydrothiophen-3-yl)-N-(thiophen-2-ylmethyl)acetamide chemical structure, C17H17Cl2NO4S2, CAS 575466-32-9
2-(2,4-Dichlorophenoxy)-N-(1,1-dioxidotetrahydrothiophen-3-yl)-N-(thiophen-2-ylmethyl)acetamide
CAS 575466-32-9C17H17Cl2NO4S2
2-(4-Chloro-3-methylphenoxy)-N-(1,1-dioxidotetrahydrothiophen-3-yl)-N-(thiophen-2-ylmethyl)acetamide chemical structure, C18H20ClNO4S2, CAS 620566-09-8
2-(4-Chloro-3-methylphenoxy)-N-(1,1-dioxidotetrahydrothiophen-3-yl)-N-(thiophen-2-ylmethyl)acetamide
CAS 620566-09-8C18H20ClNO4S2
2-(4-Chloro-2-methylphenoxy)-N-(1,1-dioxidotetrahydrothiophen-3-yl)-N-(thiophen-2-ylmethyl)acetamide chemical structure, C18H20ClNO4S2, CAS 578751-31-2
2-(4-Chloro-2-methylphenoxy)-N-(1,1-dioxidotetrahydrothiophen-3-yl)-N-(thiophen-2-ylmethyl)acetamide
CAS 578751-31-2C18H20ClNO4S2
2-(4-Chloro-3-methylphenoxy)-N-(1,1-dioxidotetrahydrothiophen-3-yl)-N-(thiophen-2-ylmethyl)propanamide chemical structure, C19H22ClNO4S2, CAS 620565-84-6
2-(4-Chloro-3-methylphenoxy)-N-(1,1-dioxidotetrahydrothiophen-3-yl)-N-(thiophen-2-ylmethyl)propanamide
CAS 620565-84-6C19H22ClNO4S2
N-(1,1-Dioxidotetrahydrothiophen-3-yl)-2-(4-methoxyphenoxy)-N-(thiophen-2-ylmethyl)acetamide chemical structure, C18H21NO5S2, CAS 587005-93-4
N-(1,1-Dioxidotetrahydrothiophen-3-yl)-2-(4-methoxyphenoxy)-N-(thiophen-2-ylmethyl)acetamide
CAS 587005-93-4C18H21NO5S2
N-(1,1-Dioxidotetrahydrothiophen-3-yl)-2-(4-ethylphenoxy)-N-(thiophen-2-ylmethyl)acetamide chemical structure, C19H23NO4S2, CAS 620566-97-4
N-(1,1-Dioxidotetrahydrothiophen-3-yl)-2-(4-ethylphenoxy)-N-(thiophen-2-ylmethyl)acetamide
CAS 620566-97-4C19H23NO4S2
N-(1,1-Dioxidotetrahydrothiophen-3-yl)-2-(4-nitrophenoxy)-N-(thiophen-2-ylmethyl)acetamide chemical structure, C17H18N2O6S2, CAS 578747-11-2
N-(1,1-Dioxidotetrahydrothiophen-3-yl)-2-(4-nitrophenoxy)-N-(thiophen-2-ylmethyl)acetamide
CAS 578747-11-2C17H18N2O6S2
2-(3,4-Dimethylphenoxy)-N-(1,1-dioxidotetrahydrothiophen-3-yl)-N-(thiophen-2-ylmethyl)acetamide chemical structure, C19H23NO4S2, CAS 620566-26-9
2-(3,4-Dimethylphenoxy)-N-(1,1-dioxidotetrahydrothiophen-3-yl)-N-(thiophen-2-ylmethyl)acetamide
CAS 620566-26-9C19H23NO4S2