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Murcko scaffold

Ring system with 4 rings and 20 atoms

45 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
20
Chemicals
45
With full pages
16
Scaffold SMILES

c1ccc(C2=NCc3cncn3-c3ccccc32)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold c1ccc(C2=NCc3cncn3-c3ccccc32)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 45 of 45 chemicals

Midazolam chemical structure, C18H13ClFN3, CAS 59467-70-8
Midazolam
CAS 59467-70-8C18H13ClFN3
Midazolam hydrochloride chemical structure, C18H14Cl2FN3, CAS 59467-96-8
Midazolam hydrochloride
CAS 59467-96-8C18H14Cl2FN3
Climazolam chemical structure, C18H13Cl2N3, CAS 59467-77-5
Climazolam
CAS 59467-77-5C18H13Cl2N3
8-Chloro-6-(o-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid chemical structure, C19H13ClFN3O2, CAS 59468-44-9
8-Chloro-6-(o-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid
CAS 59468-44-9C19H13ClFN3O2
1'-Hydroxymidazolam chemical structure, C18H13ClFN3O, CAS 59468-90-5
1'-Hydroxymidazolam
CAS 59468-90-5C18H13ClFN3O
6-(2-Bromophenyl)-8-fluoro-4H-imidazo(1,5-a)(1,4)benzodiazepine-3-carboxamide chemical structure, C18H12BrFN4O, CAS 151271-08-8
6-(2-Bromophenyl)-8-fluoro-4H-imidazo(1,5-a)(1,4)benzodiazepine-3-carboxamide
CAS 151271-08-8C18H12BrFN4O
4-Hydroxymidazolam chemical structure, C18H13ClFN3O, CAS 59468-85-8
4-Hydroxymidazolam
CAS 59468-85-8C18H13ClFN3O
6-(2-Chlorophenyl)-4-hydroxy-4H-imidazo(1,5-a)(1,4)benzodiazepine-3-carboxamide chemical structure, C18H13ClN4O2, CAS 98602-08-5
6-(2-Chlorophenyl)-4-hydroxy-4H-imidazo(1,5-a)(1,4)benzodiazepine-3-carboxamide
CAS 98602-08-5C18H13ClN4O2
8-Chloro-6-(2-chlorophenyl)-4H-imidazo(1,5-a)(1,4)-benzodiazepine-3-carboxamide chemical structure, C18H12Cl2N4O, CAS 63176-94-3
8-Chloro-6-(2-chlorophenyl)-4H-imidazo(1,5-a)(1,4)-benzodiazepine-3-carboxamide
CAS 63176-94-3C18H12Cl2N4O
1H-1lambda~6~,2-Benzothiazole-1,1,3(2H)-trione--8-chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine (1/1) chemical structure, C25H18ClFN4O3S, CAS 134249-09-5
1H-1lambda~6~,2-Benzothiazole-1,1,3(2H)-trione--8-chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine (1/1)
CAS 134249-09-5C25H18ClFN4O3S
Midazolam lactate chemical structure, C21H19ClFN3O3, CAS 90509-04-9
Midazolam lactate
CAS 90509-04-9C21H19ClFN3O3
Desmethylmidazolam chemical structure, C17H11ClFN3, CAS 59468-56-3
Desmethylmidazolam
CAS 59468-56-3C17H11ClFN3
Ro 23-0364 chemical structure, C18H13ClN4O, CAS 113066-25-4
Ro 23-0364
CAS 113066-25-4C18H13ClN4O
Midazolam maleate chemical structure, C22H17ClFN3O4, CAS 59467-94-6
Midazolam maleate
CAS 59467-94-6C22H17ClFN3O4
1',4-Dihydroxy midazolam chemical structure, C18H13ClFN3O2, CAS 64740-68-7
1',4-Dihydroxy midazolam
CAS 64740-68-7C18H13ClFN3O2
Sh-053-r-ch3-2'f chemical structure, C23H18FN3O2, CAS 872874-14-1
Sh-053-r-ch3-2'f
CAS 872874-14-1C23H18FN3O2
SH-053-S-CH3-2'F chemical structure, C23H18FN3O2, CAS 872874-00-5
SH-053-S-CH3-2'F
CAS 872874-00-5C23H18FN3O2
8-Chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-A][1,4]benzodiazepine 2,5-dioxide chemical structure, C18H13ClFN3O2, CAS 59468-87-0
8-Chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-A][1,4]benzodiazepine 2,5-dioxide
CAS 59468-87-0C18H13ClFN3O2
1-Acetoxymethyl-8-chloro-6-(2-fluorophenyl)-4H-imidazo[1,5-a][1,4]benzodiazepine 5-Oxide chemical structure, C20H15ClFN3O3, CAS 59468-88-1
1-Acetoxymethyl-8-chloro-6-(2-fluorophenyl)-4H-imidazo[1,5-a][1,4]benzodiazepine 5-Oxide
CAS 59468-88-1C20H15ClFN3O3
8-Chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic Acid Methyl Ester chemical structure, C20H15ClFN3O2, CAS 59468-42-7
8-Chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic Acid Methyl Ester
CAS 59468-42-7C20H15ClFN3O2
8-Chloro-1-methyl-6-phenyl-4H-imidazo[1,5-a][1,4]benzodiazepine chemical structure, C18H14ClN3, CAS 59467-86-6
8-Chloro-1-methyl-6-phenyl-4H-imidazo[1,5-a][1,4]benzodiazepine
CAS 59467-86-6C18H14ClN3
Ethyl 8-chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo(1,5-a)(1,4)benzodiazepine-3-carboxylate chemical structure, C21H17ClFN3O2, CAS 59469-49-7
Ethyl 8-chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo(1,5-a)(1,4)benzodiazepine-3-carboxylate
CAS 59469-49-7C21H17ClFN3O2
Midazolam 5-oxide chemical structure, C18H13ClFN3O, CAS 59468-83-6
Midazolam 5-oxide
CAS 59468-83-6C18H13ClFN3O
4-Acetoxy-8-chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine chemical structure, C20H15ClFN3O2, CAS 59468-84-7
4-Acetoxy-8-chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine
CAS 59468-84-7C20H15ClFN3O2