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Central nervous system drugs

Midazolam

Also known as Buccolam, Midazolamum, 8-Chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine

CAS 59467-70-8Formula C18H13ClFN3Molar mass 325.77 g/molEC 261-774-5
GHS signal word: Danger. Pictograms: Acute toxicity (severe), Harmful or irritant, Serious health hazard, Hazardous to the environment Prohibited, not for trade Drug substance
Why it is not for trade
Midazolam chemical structure, C18H13ClFN3, CAS 59467-70-8
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
59467-70-8
Formula
C18H13ClFN3
Appearance
Colorless crystals from ether/methylene chloride/ hexane
Melting point
158 to 160
HS code
293391
Category
Central nervous system drugs

What is Midazolam?

Plain description, key identifiers and synonyms

Midazolam is an imidazobenzodiazepine that is 4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted by a methyl, 2-fluorophenyl and chloro groups at positions 1, 6 and 8, respectively. It has a role as an anxiolytic drug, a central nervous system depressant, an antineoplastic agent, an anticonvulsant, a sedative, a general anaesthetic, a muscle relaxant, an apoptosis inducer and a GABAA receptor agonist. It is an imidazobenzodiazepine, an organochlorine compound and a member of monofluorobenzenes.

Midazolam is a benzodiazepine sedative.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
8-chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine
CAS number
59467-70-8 CAS number cross-checked
EC number
261-774-5
Molecular formula
C18H13ClFN3
UNII
R60L0SM5BC
InChIKey
DDLIGBOFAVUZHB-UHFFFAOYSA-N
InChI
InChI=1S/C18H13ClFN3/c1-11-21-9-13-10-22-18(14-4-2-3-5-16(14)20)15-8-12(19)6-7-17(15)23(11)13/h2-9H,10H2,1H3
SMILES (canonical and isomeric)
CC1=NC=C2N1C3=C(C=C(C=C3)Cl)C(=NC2)C4=CC=CC=C4F

Synonyms

  • Buccolam
  • Midazolamum
  • 8-Chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine
  • mezolam
  • Nayzilam
  • Midazolam civ
  • 8-Chlor-6-(2-fluorphenyl)-1-methyl-4H-imidazo(1,5-a)(1,4)benzodiazepin
  • 8-Chloro-6-(o-fluorophenyl)-1-methyl-4H-imidazo(1,5-a)(1,4)benzodiazepine
  • 4H-Imidazo(1,5-a)(1,4)benzodiazepine, 8-chloro-6-(2-fluorophenyl)-1-methyl-
  • 4H-Imidazo[1,5-a][1,4]benzodiazepine, 8-chloro-6-(2-fluorophenyl)-1-methyl-
  • 8-chloro-6-(2-fluorophenyl)-1-methyl-4h-imidazo(1,5-a)(1,4)benzodiazepine
  • Epistatus
  • Maleate, Midazolam
  • 12-chloro-9-(2-fluorophenyl)-3-methyl-2,4,8-triazatricyclo(8.4.0.0^(2,6))tetradeca-1(14),3,5,8,10,12-hexaene
  • 12-chloro-9-(2-fluorophenyl)-3-methyl-2,4,8-triazatricyclo[8.4.0.0^{2,6}]tetradeca-1(14),3,5,8,10,12-hexaene
  • Hydrochloride, Midazolam
  • Midazolam in Sodium Chloride
  • Midazolam Injection, 10 mg
  • Ro 213981
  • Ro 21 3981
  • Midazolam in 0.8% sodium chloride
  • Midazolam in 0.9% sodium chloride
  • 12-chloro-9-(2-fluorophenyl)-3-methyl-2,4,8-triazatricyclo(8.4.0.02,6)tetradeca-1(10),3,5,8,11,13-hexaene
  • Dormicum
  • Versed
Show all 36 synonyms
  • Midazolam Base
  • DEA No. 2884
  • Ro 21-3981
  • 8-Chloro-6-(O-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]-benzodiazepine
  • Dazolam
  • Midazolam (1.0 mg/mL in methanol)
  • Dormicum (TN)
  • 12-chloro-9-(2-fluorophenyl)-3-methyl-2,4,8-triazatricyclo[8.4.0.0^{2,6}]tetradeca-1(10),3,5,8,11,13-hexaene
  • Medazolam
  • Buccolam (TN)
  • Nayzilam (TN)

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Colorless crystals from ether/methylene chloride/ hexaneexp.
Melting point
158 to 160exp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
325.77 g/molcalc.
Exact mass
325.0782 Dacalc.
LogP (octanol/water)
4.32calc.
Topological polar surface area
30.18 Ųcalc.
Hydrogen bond donors
0calc.
Hydrogen bond acceptors
2calc.
Rotatable bonds
1calc.
Heavy atoms
23calc.
Rings
4calc.
Aromatic rings
3calc.
Fraction sp3 carbons
0.11calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccc(C2=NCc3cncn3-c3ccccc32)cc1

c1ccc(C2=NCc3cncn3-c3ccccc32)cc1

4 rings, 20 atoms.

44 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS06: Acute toxicity (severe)
Acute toxicity (severe)
GHS07: Harmful or irritant
Harmful or irritant
GHS08: Serious health hazard
Serious health hazard
GHS09: Hazardous to the environment
Hazardous to the environment

Hazard statements

  • H301Toxic if swallowed.
  • H302Harmful if swallowed.
  • H312Harmful in contact with skin.
  • H317May cause an allergic skin reaction.
  • H334May cause allergy or asthma symptoms or breathing difficulties if inhaled.
  • H361Suspected of damaging fertility or the unborn child.
  • H362May cause harm to breast-fed children.
  • H411Toxic to aquatic life with long lasting effects.
Precautionary statements (27)
  • P203Obtain, read and follow all safety instructions before use.
  • P233Keep container tightly closed.
  • P260Do not breathe dust, fume, gas, mist, vapours or spray.
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P263Avoid contact during pregnancy and while nursing.
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P271Use only outdoors or in a well-ventilated area.
  • P272Contaminated work clothing should not be allowed out of the workplace.
  • P273Avoid release to the environment.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P284In case of inadequate ventilation wear respiratory protection.
  • P301 + P316If swallowed: Get emergency medical help immediately.
  • P301 + P317If swallowed: Get medical help.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P317Get medical help.
  • P318If exposed or concerned, get medical advice.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P333 + P317If skin irritation or rash occurs: Get medical help.
  • P342 + P316If experiencing respiratory symptoms: Get emergency medical help immediately.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P391Collect spillage.
  • P403Store in a well-ventilated place.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Midazolam suppliers

Trading restrictions apply to this substance

Psychotropic substance

Midazolam is prohibited on CompoundList. Listings, quotes and messages are disabled. This page is kept for information only.

Listing and enquiries are not allowed for this substance.

Reference: UN Convention on Psychotropic Substances 1971, HS 2022 subheading 2933.91 (benzodiazepines and related substances)

Our policy on controlled substances

Midazolam price

Indicative price range per kg from live supplier offers

Prices are not shown for prohibited substances.

Uses and applications

What the substance is used for, by industry and function

Midazolam is a Schedule IV controlled substance.

Schedule IV Controlled Substance: (A) The drug or other substance has a low potential for abuse relative to the drugs or other substances in schedule III. (B) The drug or other substance has a currently accepted medical use in treatment in the United States. (C) Abuse of the drug or other substance may lead to limited physical dependence or psychological dependence relative to the drugs or other substances in schedule III.

Probe to measure cytochrome P450 3A4 activity.

Therapeutic category (veterinary): Anesthetic (intravenous), anticonvulsant, sedative, hypnotic.

Use classes: Pharmaceuticals.

Industries and functions

Pharmacological actions

  • Adjuvants, Anesthesia
  • Anesthetics, Intravenous
  • Anti-Anxiety Agents
  • GABA Modulators
  • Hypnotics and Sedatives

Roles

  • analgesic
  • anti-anaemic agent
  • anti-inflammatory agent
  • antiatherosclerotic agent
  • antidote
  • antiemetic
  • antihypertensive agent
  • antiinfective agent
  • antineoplastic agent
  • antiparkinson drug
  • antipsoriatic
  • antirheumatic drug
  • antitussive
  • bone density conservation agent
  • cardiovascular drug
  • central nervous system depressant
  • dermatologic drug
  • general anaesthetic
  • hepatoprotective agent
  • hypoglycemic agent
  • immunosuppressive agent
  • muscle relaxant
  • ophthalmology drug
  • vulnerary

Pharmacology

Midazolam is a Benzodiazepine.

How it is made

Preparation: R. I. Fryer, A. Walser, German patent 2540522, eidem, United States of America patent 4280957 (1976, 1981 both to Hoffmann-La Roche).

Regulatory status

Inventories, regulations and trade controls that list this substance

Psychotropic substance

Midazolam is prohibited on CompoundList. Listings, quotes and messages are disabled. This page is kept for information only.

Listing and enquiries are not allowed for this substance.

Reference: UN Convention on Psychotropic Substances 1971, HS 2022 subheading 2933.91 (benzodiazepines and related substances)

Our policy on controlled substances

Controls

  • US DEA controlled substance or listed chemical
  • Controlled psychotropic substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Midazolam is traded under.

HS 2933.91Exact HS code

Alprazolam (INN), camazepam (INN), chlordiazepoxide (INN), clonazepam (INN)…

World exports in 2024
$118M
−26.3% vs 2023, imports $94.2M
2019 to 2024
Top exporters
  1. Italy37.7%
  2. United States22.7%
  3. India * partner reported9.8%
Top importers
  1. Germany13.8%
  2. Spain10.4%
  3. United States10.2%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Midazolam is indicative (it was matched by name in the HS nomenclature). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Midazolam, based on the data on this page

What is Midazolam?

Midazolam is an imidazobenzodiazepine that is 4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted by a methyl, 2-fluorophenyl and chloro groups at positions 1, 6 and 8, respectively.

What is the CAS number of Midazolam?

The CAS registry number of Midazolam is 59467-70-8.

What is the molecular formula and weight of Midazolam?

The molecular formula of Midazolam is C18H13ClFN3 and its molar mass is 325.77 g/mol.

What is Midazolam used for?

Midazolam is a Schedule IV controlled substance. Schedule IV Controlled Substance: (A) The drug or other substance has a low potential for abuse relative to the drugs or other substances in schedule III. (B) The drug or other substance has a currently accepted medical use in treatment in the United States.

Is Midazolam hazardous?

Midazolam carries the GHS signal word "Danger". Main hazards: toxic if swallowed, harmful if swallowed, harmful in contact with skin. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Midazolam?

Midazolam is usually classified under HS code 293391 (Alprazolam (INN), camazepam (INN), chlordiazepoxide (INN), clonazepam (INN)…). This is indicative, confirm it with your customs broker before shipping.

Can I buy Midazolam on CompoundList?

No. Midazolam is on our prohibited list, so listings, quotes and messages for it are disabled. This page is kept for information only.

Guides for buyers

Practical guides that help when you source, ship or handle Midazolam

Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page

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