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Murcko scaffold

Ring system with 5 rings and 31 atoms

19 chemicals on CompoundList share this ring system.

Rings
5
Scaffold atoms
31
Chemicals
19
With full pages
4
Scaffold SMILES

O=C1CC(c2nc3ccccc3n2CCOc2ccccc2)CN1Cc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C1CC(c2nc3ccccc3n2CCOc2ccccc2)CN1Cc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 19 of 19 chemicals

1-Benzyl-4-{1-[2-(4-methylphenoxy)ethyl]-1H-1,3-benzodiazol-2-yl}pyrrolidin-2-one chemical structure, C27H27N3O2, CAS 847396-56-9
1-Benzyl-4-{1-[2-(4-methylphenoxy)ethyl]-1H-1,3-benzodiazol-2-yl}pyrrolidin-2-one
CAS 847396-56-9C27H27N3O2
1-Benzyl-4-{1-[2-(4-chlorophenoxy)ethyl]-1H-1,3-benzodiazol-2-yl}pyrrolidin-2-one chemical structure, C26H24ClN3O2, CAS 847396-57-0
1-Benzyl-4-{1-[2-(4-chlorophenoxy)ethyl]-1H-1,3-benzodiazol-2-yl}pyrrolidin-2-one
CAS 847396-57-0C26H24ClN3O2
1-Benzyl-4-{1-[2-(2,5-dimethylphenoxy)ethyl]-1H-1,3-benzodiazol-2-yl}pyrrolidin-2-one chemical structure, C28H29N3O2, CAS 862828-40-8
1-Benzyl-4-{1-[2-(2,5-dimethylphenoxy)ethyl]-1H-1,3-benzodiazol-2-yl}pyrrolidin-2-one
CAS 862828-40-8C28H29N3O2
1-Benzyl-4-(1-(2-(3,5-dimethylphenoxy)ethyl)-1H-benzo[d]imidazol-2-yl)pyrrolidin-2-one chemical structure, C28H29N3O2, CAS 862828-41-9
1-Benzyl-4-(1-(2-(3,5-dimethylphenoxy)ethyl)-1H-benzo[d]imidazol-2-yl)pyrrolidin-2-one
CAS 862828-41-9C28H29N3O2
4-{1-[2-(2,4-Dimethylphenoxy)ethyl]-1H-1,3-benzodiazol-2-yl}-1-[(4-fluorophenyl)methyl]pyrrolidin-2-one chemical structure, C28H28FN3O2, CAS 915189-10-5
4-{1-[2-(2,4-Dimethylphenoxy)ethyl]-1H-1,3-benzodiazol-2-yl}-1-[(4-fluorophenyl)methyl]pyrrolidin-2-one
CAS 915189-10-5C28H28FN3O2
4-{1-[2-(2,6-Dimethylphenoxy)ethyl]-1H-benzimidazol-2-yl}-1-(4-fluorobenzyl)pyrrolidin-2-one chemical structure, C28H28FN3O2, CAS 924859-82-5
4-{1-[2-(2,6-Dimethylphenoxy)ethyl]-1H-benzimidazol-2-yl}-1-(4-fluorobenzyl)pyrrolidin-2-one
CAS 924859-82-5C28H28FN3O2
4-{1-[2-(2,5-Dimethylphenoxy)ethyl]-1H-benzimidazol-2-yl}-1-(4-fluorobenzyl)pyrrolidin-2-one chemical structure, C28H28FN3O2, CAS 912890-22-3
4-{1-[2-(2,5-Dimethylphenoxy)ethyl]-1H-benzimidazol-2-yl}-1-(4-fluorobenzyl)pyrrolidin-2-one
CAS 912890-22-3C28H28FN3O2
1-Benzyl-4-(1-(2-(2,4-dimethylphenoxy)ethyl)-1H-benzo[d]imidazol-2-yl)pyrrolidin-2-one chemical structure, C28H29N3O2, CAS 887347-75-3
1-Benzyl-4-(1-(2-(2,4-dimethylphenoxy)ethyl)-1H-benzo[d]imidazol-2-yl)pyrrolidin-2-one
CAS 887347-75-3C28H29N3O2
1-Benzyl-4-(1-(2-(4-ethylphenoxy)ethyl)-1H-benzo[d]imidazol-2-yl)pyrrolidin-2-one chemical structure, C28H29N3O2, CAS 887347-81-1
1-Benzyl-4-(1-(2-(4-ethylphenoxy)ethyl)-1H-benzo[d]imidazol-2-yl)pyrrolidin-2-one
CAS 887347-81-1C28H29N3O2
4-{1-[2-(3-Methoxyphenoxy)ethyl]benzimidazol-2-yl}-1-benzylpyrrolidin-2-one chemical structure, C27H27N3O3, CAS 912903-78-7
4-{1-[2-(3-Methoxyphenoxy)ethyl]benzimidazol-2-yl}-1-benzylpyrrolidin-2-one
CAS 912903-78-7C27H27N3O3
1-(4-Fluorobenzyl)-4-[1-(2-phenoxyethyl)-1H-benzimidazol-2-yl]pyrrolidin-2-one chemical structure, C26H24FN3O2, CAS 915189-04-7
1-(4-Fluorobenzyl)-4-[1-(2-phenoxyethyl)-1H-benzimidazol-2-yl]pyrrolidin-2-one
CAS 915189-04-7C26H24FN3O2
1-(4-Fluorobenzyl)-4-(1-(2-(p-tolyloxy)ethyl)-1H-benzo[d]imidazol-2-yl)pyrrolidin-2-one chemical structure, C27H26FN3O2, CAS 915189-16-1
1-(4-Fluorobenzyl)-4-(1-(2-(p-tolyloxy)ethyl)-1H-benzo[d]imidazol-2-yl)pyrrolidin-2-one
CAS 915189-16-1C27H26FN3O2
1-(4-Fluorobenzyl)-4-{1-[2-(3-methoxyphenoxy)ethyl]-1H-benzimidazol-2-yl}pyrrolidin-2-one chemical structure, C27H26FN3O3, CAS 912890-26-7
1-(4-Fluorobenzyl)-4-{1-[2-(3-methoxyphenoxy)ethyl]-1H-benzimidazol-2-yl}pyrrolidin-2-one
CAS 912890-26-7C27H26FN3O3
4-{1-[2-(2,6-Dimethylphenoxy)ethyl]-1H-1,3-benzodiazol-2-yl}-1-[(4-fluorophenyl)methyl]pyrrolidin-2-one hydrochloride chemical structure, C28H29ClFN3O2, CAS 1049746-50-0
4-{1-[2-(2,6-Dimethylphenoxy)ethyl]-1H-1,3-benzodiazol-2-yl}-1-[(4-fluorophenyl)methyl]pyrrolidin-2-one hydrochloride
CAS 1049746-50-0C28H29ClFN3O2
1-[(4-Fluorophenyl)methyl]-4-{1-[2-(3-methylphenoxy)ethyl]-1H-1,3-benzodiazol-2-yl}pyrrolidin-2-one chemical structure, C27H26FN3O2, CAS 915189-13-8
1-[(4-Fluorophenyl)methyl]-4-{1-[2-(3-methylphenoxy)ethyl]-1H-1,3-benzodiazol-2-yl}pyrrolidin-2-one
CAS 915189-13-8C27H26FN3O2
4-{1-[2-(4-Chlorophenoxy)ethyl]-1H-1,3-benzodiazol-2-yl}-1-[(4-fluorophenyl)methyl]pyrrolidin-2-one chemical structure, C26H23ClFN3O2, CAS 915189-19-4
4-{1-[2-(4-Chlorophenoxy)ethyl]-1H-1,3-benzodiazol-2-yl}-1-[(4-fluorophenyl)methyl]pyrrolidin-2-one
CAS 915189-19-4C26H23ClFN3O2
1-[(4-Fluorophenyl)methyl]-4-{1-[2-(2-methoxyphenoxy)ethyl]-1H-1,3-benzodiazol-2-yl}pyrrolidin-2-one chemical structure, C27H26FN3O3, CAS 912890-18-7
1-[(4-Fluorophenyl)methyl]-4-{1-[2-(2-methoxyphenoxy)ethyl]-1H-1,3-benzodiazol-2-yl}pyrrolidin-2-one
CAS 912890-18-7C27H26FN3O3
4-{1-[2-(2-Chlorophenoxy)ethyl]-1H-benzimidazol-2-yl}-1-(4-fluorobenzyl)pyrrolidin-2-one chemical structure, C26H23ClFN3O2, CAS 912890-20-1
4-{1-[2-(2-Chlorophenoxy)ethyl]-1H-benzimidazol-2-yl}-1-(4-fluorobenzyl)pyrrolidin-2-one
CAS 912890-20-1C26H23ClFN3O2
1-[(4-Fluorophenyl)methyl]-4-{1-[2-(2-methoxy-4-prop-2-enylphenoxy)ethyl]benzi midazol-2-yl}pyrrolidin-2-one chemical structure, C30H30FN3O3, CAS 943101-02-8
1-[(4-Fluorophenyl)methyl]-4-{1-[2-(2-methoxy-4-prop-2-enylphenoxy)ethyl]benzi midazol-2-yl}pyrrolidin-2-one
CAS 943101-02-8C30H30FN3O3