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Murcko scaffold

Ring system with 3 rings and 20 atoms

14 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
20
Chemicals
14
With full pages
6
Scaffold SMILES

O=c1c(-c2n[nH]c(=S)[nH]2)cccn1Cc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=c1c(-c2n[nH]c(=S)[nH]2)cccn1Cc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 14 of 14 chemicals

1-(3-Chlorobenzyl)-3-(1-methyl-5-sulfanyl-1H-1,2,4-triazol-3-yl)-2(1H)-pyridinone chemical structure, C15H13ClN4OS, CAS 242472-29-3
1-(3-Chlorobenzyl)-3-(1-methyl-5-sulfanyl-1H-1,2,4-triazol-3-yl)-2(1H)-pyridinone
CAS 242472-29-3C15H13ClN4OS
3-(4-Allyl-5-sulfanyl-4H-1,2,4-triazol-3-yl)-1-(3-chlorobenzyl)-2(1H)-pyridinone chemical structure, C17H15ClN4OS, CAS 242472-30-6
3-(4-Allyl-5-sulfanyl-4H-1,2,4-triazol-3-yl)-1-(3-chlorobenzyl)-2(1H)-pyridinone
CAS 242472-30-6C17H15ClN4OS
1-Benzyl-3-(4-ethyl-5-sulfanyl-4H-1,2,4-triazol-3-yl)-2(1H)-pyridinone chemical structure, C16H16N4OS, CAS 329234-95-9
1-Benzyl-3-(4-ethyl-5-sulfanyl-4H-1,2,4-triazol-3-yl)-2(1H)-pyridinone
CAS 329234-95-9C16H16N4OS
3-(4-Methyl-5-sulfanyl-4H-1,2,4-triazol-3-yl)-1-[3-(trifluoromethyl)benzyl]-2(1H)-pyridinone chemical structure, C16H13F3N4OS, CAS 242797-54-2
3-(4-Methyl-5-sulfanyl-4H-1,2,4-triazol-3-yl)-1-[3-(trifluoromethyl)benzyl]-2(1H)-pyridinone
CAS 242797-54-2C16H13F3N4OS
1-(3,4-Dichlorobenzyl)-3-(4-methyl-5-sulfanyl-4H-1,2,4-triazol-3-yl)-2(1H)-pyridinone chemical structure, C15H12Cl2N4OS, CAS 242797-55-3
1-(3,4-Dichlorobenzyl)-3-(4-methyl-5-sulfanyl-4H-1,2,4-triazol-3-yl)-2(1H)-pyridinone
CAS 242797-55-3C15H12Cl2N4OS
1-(2,4-Dichlorobenzyl)-3-(4-methyl-5-sulfanyl-4H-1,2,4-triazol-3-yl)-2(1H)-pyridinone chemical structure, C15H12Cl2N4OS, CAS 242471-91-6
1-(2,4-Dichlorobenzyl)-3-(4-methyl-5-sulfanyl-4H-1,2,4-triazol-3-yl)-2(1H)-pyridinone
CAS 242471-91-6C15H12Cl2N4OS
1-(2,4-Dichlorobenzyl)-3-(4-ethyl-5-sulfanyl-4H-1,2,4-triazol-3-yl)-2(1H)-pyridinone chemical structure, C16H14Cl2N4OS, CAS 242471-92-7
1-(2,4-Dichlorobenzyl)-3-(4-ethyl-5-sulfanyl-4H-1,2,4-triazol-3-yl)-2(1H)-pyridinone
CAS 242471-92-7C16H14Cl2N4OS
3-(4-Allyl-5-sulfanyl-4H-1,2,4-triazol-3-yl)-1-(2,4-dichlorobenzyl)-2(1H)-pyridinone chemical structure, C17H14Cl2N4OS, CAS 242471-94-9
3-(4-Allyl-5-sulfanyl-4H-1,2,4-triazol-3-yl)-1-(2,4-dichlorobenzyl)-2(1H)-pyridinone
CAS 242471-94-9C17H14Cl2N4OS
1-Benzyl-3-(4-methyl-5-sulfanyl-4H-1,2,4-triazol-3-yl)-2(1H)-pyridinone chemical structure, C15H14N4OS, CAS 242472-19-1
1-Benzyl-3-(4-methyl-5-sulfanyl-4H-1,2,4-triazol-3-yl)-2(1H)-pyridinone
CAS 242472-19-1C15H14N4OS
3-(4-Allyl-5-sulfanyl-4H-1,2,4-triazol-3-yl)-1-benzyl-2(1H)-pyridinone chemical structure, C17H16N4OS, CAS 242472-20-4
3-(4-Allyl-5-sulfanyl-4H-1,2,4-triazol-3-yl)-1-benzyl-2(1H)-pyridinone
CAS 242472-20-4C17H16N4OS
3-(4-Allyl-5-thioxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)-1-[3-(trifluoromethyl)benzyl]-2(1H)-pyridinone chemical structure, C18H15F3N4OS, CAS 400074-86-4
3-(4-Allyl-5-thioxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)-1-[3-(trifluoromethyl)benzyl]-2(1H)-pyridinone
CAS 400074-86-4C18H15F3N4OS
3-(4-Allyl-5-sulfanyl-4H-1,2,4-triazol-3-yl)-1-(3,4-dichlorobenzyl)-2(1H)-pyridinone chemical structure, C17H14Cl2N4OS, CAS 477853-11-5
3-(4-Allyl-5-sulfanyl-4H-1,2,4-triazol-3-yl)-1-(3,4-dichlorobenzyl)-2(1H)-pyridinone
CAS 477853-11-5C17H14Cl2N4OS
1-(4-Chlorobenzyl)-3-(4-ethyl-5-sulfanyl-4H-1,2,4-triazol-3-yl)-2(1H)-pyridinone chemical structure, C16H15ClN4OS, CAS 400074-98-8
1-(4-Chlorobenzyl)-3-(4-ethyl-5-sulfanyl-4H-1,2,4-triazol-3-yl)-2(1H)-pyridinone
CAS 400074-98-8C16H15ClN4OS
3-(4-Allyl-5-sulfanyl-4H-1,2,4-triazol-3-yl)-1-(4-chlorobenzyl)-2(1H)-pyridinone chemical structure, C17H15ClN4OS, CAS 400074-99-9
3-(4-Allyl-5-sulfanyl-4H-1,2,4-triazol-3-yl)-1-(4-chlorobenzyl)-2(1H)-pyridinone
CAS 400074-99-9C17H15ClN4OS