Murcko scaffold
Ring system with 4 rings and 26 atoms
33 chemicals on CompoundList share this ring system.
- Rings
- 4
- Scaffold atoms
- 26
- Chemicals
- 33
- With full pages
- 11
Scaffold SMILES
O=C(c1ccccc1)N1CCN(c2cccc(N3CCOCC3)c2)CC1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 33 of 33 chemicals
![(3,4-Dichlorophenyl)-[4-(3-morpholin-4-yl-4-nitrophenyl)piperazin-1-yl]methanone chemical structure, C21H22Cl2N4O4, CAS 330634-11-2](/s/XFMFQTDOLOAESH-UHFFFAOYSA-N.svg)
(3,4-Dichlorophenyl)-[4-(3-morpholin-4-yl-4-nitrophenyl)piperazin-1-yl]methanone
CAS 330634-11-2C21H22Cl2N4O4
![(2-Chloro-4,5-difluorophenyl)-[4-(3-morpholin-4-yl-4-nitrophenyl)piperazin-1-yl]methanone chemical structure, C21H21ClF2N4O4, CAS 330633-85-7](/s/MYCMDPBZTJGUID-UHFFFAOYSA-N.svg)
(2-Chloro-4,5-difluorophenyl)-[4-(3-morpholin-4-yl-4-nitrophenyl)piperazin-1-yl]methanone
CAS 330633-85-7C21H21ClF2N4O4
![(2-Fluorophenyl)-[4-(3-morpholin-4-yl-4-nitrophenyl)piperazin-1-yl]methanone chemical structure, C21H23FN4O4, CAS 347354-67-0](/s/DWOGPMWWIZTYQB-UHFFFAOYSA-N.svg)
(2-Fluorophenyl)-[4-(3-morpholin-4-yl-4-nitrophenyl)piperazin-1-yl]methanone
CAS 347354-67-0C21H23FN4O4
![(4-Chlorophenyl)-[4-(3-morpholin-4-yl-4-nitrophenyl)piperazin-1-yl]methanone chemical structure, C21H23ClN4O4, CAS 347354-65-8](/s/GSSLMFCEMQVXRT-UHFFFAOYSA-N.svg)
(4-Chlorophenyl)-[4-(3-morpholin-4-yl-4-nitrophenyl)piperazin-1-yl]methanone
CAS 347354-65-8C21H23ClN4O4
![4-{5-[4-(2-Bromobenzoyl)piperazin-1-yl]-2-nitrophenyl}morpholine chemical structure, C21H23BrN4O4, CAS 333425-25-5](/s/SMGPCZNMHXJSSK-UHFFFAOYSA-N.svg)
4-{5-[4-(2-Bromobenzoyl)piperazin-1-yl]-2-nitrophenyl}morpholine
CAS 333425-25-5C21H23BrN4O4
![(4-Methylphenyl)-[4-(3-morpholin-4-yl-4-nitrophenyl)piperazin-1-yl]methanone chemical structure, C22H26N4O4, CAS 347355-25-3](/s/ABFMFDYEFGZMCF-UHFFFAOYSA-N.svg)
(4-Methylphenyl)-[4-(3-morpholin-4-yl-4-nitrophenyl)piperazin-1-yl]methanone
CAS 347355-25-3C22H26N4O4
![(4-Bromophenyl)-[4-(3-morpholin-4-yl-4-nitrophenyl)piperazin-1-yl]methanone chemical structure, C21H23BrN4O4, CAS 347356-04-1](/s/NATOITVDXHOKTO-UHFFFAOYSA-N.svg)
(4-Bromophenyl)-[4-(3-morpholin-4-yl-4-nitrophenyl)piperazin-1-yl]methanone
CAS 347356-04-1C21H23BrN4O4
![4-{5-[4-(3-Chlorobenzoyl)piperazin-1-yl]-2-nitrophenyl}morpholine chemical structure, C21H23ClN4O4, CAS 430456-64-7](/s/QSPCHCFJYHUCNO-UHFFFAOYSA-N.svg)
4-{5-[4-(3-Chlorobenzoyl)piperazin-1-yl]-2-nitrophenyl}morpholine
CAS 430456-64-7C21H23ClN4O4
![(2-Methylphenyl)-[4-(3-morpholin-4-yl-4-nitrophenyl)piperazin-1-yl]methanone chemical structure, C22H26N4O4, CAS 431987-24-5](/s/BXLHVPBJQKTISJ-UHFFFAOYSA-N.svg)
(2-Methylphenyl)-[4-(3-morpholin-4-yl-4-nitrophenyl)piperazin-1-yl]methanone
CAS 431987-24-5C22H26N4O4
![(4-Fluorophenyl)-[4-(3-morpholin-4-yl-4-nitrophenyl)piperazin-1-yl]methanone chemical structure, C21H23FN4O4, CAS 432511-01-8](/s/CQLBJUAAUIMCLZ-UHFFFAOYSA-N.svg)
(4-Fluorophenyl)-[4-(3-morpholin-4-yl-4-nitrophenyl)piperazin-1-yl]methanone
CAS 432511-01-8C21H23FN4O4
![(2-Chlorophenyl)-[4-(3-morpholin-4-yl-4-nitrophenyl)piperazin-1-yl]methanone chemical structure, C21H23ClN4O4, CAS 432514-65-3](/s/HSEVOGCGAIHSOE-UHFFFAOYSA-N.svg)
(2-Chlorophenyl)-[4-(3-morpholin-4-yl-4-nitrophenyl)piperazin-1-yl]methanone
CAS 432514-65-3C21H23ClN4O4
![(3-Fluorophenyl)-[4-(3-morpholin-4-yl-4-nitrophenyl)piperazin-1-yl]methanone chemical structure, C21H23FN4O4, CAS 440091-09-8](/s/WXZBPVVTWGBQGV-UHFFFAOYSA-N.svg)
(3-Fluorophenyl)-[4-(3-morpholin-4-yl-4-nitrophenyl)piperazin-1-yl]methanone
CAS 440091-09-8C21H23FN4O4
![(3-Methylphenyl)-[4-(3-morpholin-4-yl-4-nitrophenyl)piperazin-1-yl]methanone chemical structure, C22H26N4O4, CAS 432518-21-3](/s/ZZUXOFDUSHOQNI-UHFFFAOYSA-N.svg)
(3-Methylphenyl)-[4-(3-morpholin-4-yl-4-nitrophenyl)piperazin-1-yl]methanone
CAS 432518-21-3C22H26N4O4
![(4-Methoxyphenyl)-[4-(3-morpholin-4-yl-4-nitrophenyl)piperazin-1-yl]methanone chemical structure, C22H26N4O5, CAS 432528-26-2](/s/AYSVAUJGGZPIML-UHFFFAOYSA-N.svg)
(4-Methoxyphenyl)-[4-(3-morpholin-4-yl-4-nitrophenyl)piperazin-1-yl]methanone
CAS 432528-26-2C22H26N4O5
![(3-Methoxyphenyl)-[4-(3-morpholin-4-yl-4-nitrophenyl)piperazin-1-yl]methanone chemical structure, C22H26N4O5, CAS 432533-15-8](/s/HNVWGJCNQWKJPZ-UHFFFAOYSA-N.svg)
(3-Methoxyphenyl)-[4-(3-morpholin-4-yl-4-nitrophenyl)piperazin-1-yl]methanone
CAS 432533-15-8C22H26N4O5
![(4-tert-Butylphenyl)-[4-(3-morpholin-4-yl-4-nitrophenyl)piperazin-1-yl]methanone chemical structure, C25H32N4O4, CAS 432533-67-0](/s/RURPCPWADBLNNZ-UHFFFAOYSA-N.svg)
(4-tert-Butylphenyl)-[4-(3-morpholin-4-yl-4-nitrophenyl)piperazin-1-yl]methanone
CAS 432533-67-0C25H32N4O4
![(3-Bromophenyl)-[4-(3-morpholin-4-yl-4-nitrophenyl)piperazin-1-yl]methanone chemical structure, C21H23BrN4O4, CAS 432537-76-3](/s/IANUYJBASOIOGK-UHFFFAOYSA-N.svg)
(3-Bromophenyl)-[4-(3-morpholin-4-yl-4-nitrophenyl)piperazin-1-yl]methanone
CAS 432537-76-3C21H23BrN4O4
![[4-(3-Morpholin-4-yl-4-nitrophenyl)piperazin-1-yl]-phenylmethanone chemical structure, C21H24N4O4, CAS 433699-60-6](/s/LUDXGBZRUNEGNI-UHFFFAOYSA-N.svg)
[4-(3-Morpholin-4-yl-4-nitrophenyl)piperazin-1-yl]-phenylmethanone
CAS 433699-60-6C21H24N4O4
![(4-Ethoxyphenyl)-[4-(3-morpholin-4-yl-4-nitrophenyl)piperazin-1-yl]methanone chemical structure, C23H28N4O5, CAS 433700-85-7](/s/ZNGBQXUMTHMWSB-UHFFFAOYSA-N.svg)
(4-Ethoxyphenyl)-[4-(3-morpholin-4-yl-4-nitrophenyl)piperazin-1-yl]methanone
CAS 433700-85-7C23H28N4O5
![(4-Butoxyphenyl)-[4-(3-morpholin-4-yl-4-nitrophenyl)piperazin-1-yl]methanone chemical structure, C25H32N4O5, CAS 509113-22-8](/s/YYLLXZCLRNABCR-UHFFFAOYSA-N.svg)
(4-Butoxyphenyl)-[4-(3-morpholin-4-yl-4-nitrophenyl)piperazin-1-yl]methanone
CAS 509113-22-8C25H32N4O5
![[4-(3-Morpholin-4-yl-4-nitrophenyl)piperazin-1-yl]-(4-propan-2-ylphenyl)methanone chemical structure, C24H30N4O4, CAS 461655-32-3](/s/RNXNDOLTDZPFDU-UHFFFAOYSA-N.svg)
[4-(3-Morpholin-4-yl-4-nitrophenyl)piperazin-1-yl]-(4-propan-2-ylphenyl)methanone
CAS 461655-32-3C24H30N4O4
![(2-Methoxy-3-methylphenyl)-[4-(3-morpholin-4-yl-4-nitrophenyl)piperazin-1-yl]methanone chemical structure, C23H28N4O5, CAS 592466-80-3](/s/VWRZNTRIFHIFGY-UHFFFAOYSA-N.svg)
(2-Methoxy-3-methylphenyl)-[4-(3-morpholin-4-yl-4-nitrophenyl)piperazin-1-yl]methanone
CAS 592466-80-3C23H28N4O5
![[4-(3-Morpholin-4-yl-4-nitrophenyl)piperazin-1-yl]-(3-propan-2-yloxyphenyl)methanone chemical structure, C24H30N4O5, CAS 593237-75-3](/s/PGEZKJQRJMUPKE-UHFFFAOYSA-N.svg)
[4-(3-Morpholin-4-yl-4-nitrophenyl)piperazin-1-yl]-(3-propan-2-yloxyphenyl)methanone
CAS 593237-75-3C24H30N4O5
![(4-Ethylphenyl)-[4-(3-morpholin-4-yl-4-nitrophenyl)piperazin-1-yl]methanone chemical structure, C23H28N4O4, CAS 591765-33-2](/s/LFUNIXFKSLAVRQ-UHFFFAOYSA-N.svg)
(4-Ethylphenyl)-[4-(3-morpholin-4-yl-4-nitrophenyl)piperazin-1-yl]methanone
CAS 591765-33-2C23H28N4O4
- [4-(3-Morpholin-4-yl-4-nitrophenyl)piperazin-1-yl]-(4-propan-2-yloxyphenyl)methanone597545-67-0C24H30N4O5
- (2-Methoxyphenyl)-[4-(3-morpholin-4-yl-4-nitrophenyl)piperazin-1-yl]methanone713501-04-3C22H26N4O5
- (3-Iodophenyl)-[4-(3-morpholin-4-yl-4-nitrophenyl)piperazin-1-yl]methanone713504-07-5C21H23IN4O4
- (3-Chloro-4-methylphenyl)-[4-(3-morpholin-4-yl-4-nitrophenyl)piperazin-1-yl]methanone767316-12-1C22H25ClN4O4
- (5-Chloro-2-methoxyphenyl)-[4-(3-morpholin-4-yl-4-nitrophenyl)piperazin-1-yl]methanone831194-56-0C22H25ClN4O5
- [4-(3-Morpholin-4-yl-4-nitrophenyl)piperazin-1-yl]-(4-propoxyphenyl)methanone775302-80-2C24H30N4O5
- (2,5-Dichlorophenyl)-[4-(3-morpholin-4-yl-4-nitrophenyl)piperazin-1-yl]methanone831206-83-8C21H22Cl2N4O4
- (3,5-Dimethoxyphenyl)-[4-(3-morpholin-4-yl-4-nitrophenyl)piperazin-1-yl]methanone832123-48-5C23H28N4O6
- (3-Chloro-4-methoxyphenyl)-[4-(3-morpholin-4-yl-4-nitrophenyl)piperazin-1-yl]methanone832681-02-4C22H25ClN4O5
Related scaffolds
Same ring framework with different atoms or bond orders
![Scaffold O=c1cc(-c2ccccc2)nc(N2CCN(Cc3ccccc3)CC2)[nH]1](/scaffold/FCEYOFZXPJIJMA-UHFFFAOYSA-N/structure.svg)
