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Murcko scaffold

Ring system with 4 rings and 26 atoms

22 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
26
Chemicals
22
With full pages
4
Scaffold SMILES

O=C(c1ccccc1)N1CCN(c2cccc(N3CCCCC3)c2)CC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(c1ccccc1)N1CCN(c2cccc(N3CCCCC3)c2)CC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 22 of 22 chemicals

(2-Chloro-4,5-difluorophenyl)-[4-(4-nitro-3-piperidin-1-ylphenyl)piperazin-1-yl]methanone chemical structure, C22H23ClF2N4O3, CAS 330634-12-3
(2-Chloro-4,5-difluorophenyl)-[4-(4-nitro-3-piperidin-1-ylphenyl)piperazin-1-yl]methanone
CAS 330634-12-3C22H23ClF2N4O3
(3,4-Dichlorophenyl)-[4-(4-nitro-3-piperidin-1-ylphenyl)piperazin-1-yl]methanone chemical structure, C22H24Cl2N4O3, CAS 330634-10-1
(3,4-Dichlorophenyl)-[4-(4-nitro-3-piperidin-1-ylphenyl)piperazin-1-yl]methanone
CAS 330634-10-1C22H24Cl2N4O3
(2,6-Difluorophenyl)-[4-(4-fluoro-2-nitro-5-piperidin-1-ylphenyl)piperazin-1-yl]methanone chemical structure, C22H23F3N4O3, CAS 314040-19-2
(2,6-Difluorophenyl)-[4-(4-fluoro-2-nitro-5-piperidin-1-ylphenyl)piperazin-1-yl]methanone
CAS 314040-19-2C22H23F3N4O3
RefChem:381401 chemical structure, C22H24F2N4O3, CAS 5931-58-8
RefChem:381401
CAS 5931-58-8C22H24F2N4O3
(2-Chloro-5,6-difluoro-3-methylphenyl){4-[4-fluoro-2-nitro-5-(piperidin-1-yl)phenyl]piperazin-1-yl}methanone chemical structure, C23H24ClF3N4O3, CAS 6042-02-0
(2-Chloro-5,6-difluoro-3-methylphenyl){4-[4-fluoro-2-nitro-5-(piperidin-1-yl)phenyl]piperazin-1-yl}methanone
CAS 6042-02-0C23H24ClF3N4O3
(4-Bromophenyl)-[4-(4-nitro-3-piperidin-1-ylphenyl)piperazin-1-yl]methanone chemical structure, C22H25BrN4O3, CAS 346459-46-9
(4-Bromophenyl)-[4-(4-nitro-3-piperidin-1-ylphenyl)piperazin-1-yl]methanone
CAS 346459-46-9C22H25BrN4O3
(4-Fluorophenyl)-[4-(4-nitro-3-piperidin-1-ylphenyl)piperazin-1-yl]methanone chemical structure, C22H25FN4O3, CAS 312628-74-3
(4-Fluorophenyl)-[4-(4-nitro-3-piperidin-1-ylphenyl)piperazin-1-yl]methanone
CAS 312628-74-3C22H25FN4O3
(4-Chlorophenyl)-[4-(4-nitro-3-piperidin-1-ylphenyl)piperazin-1-yl]methanone chemical structure, C22H25ClN4O3, CAS 346459-45-8
(4-Chlorophenyl)-[4-(4-nitro-3-piperidin-1-ylphenyl)piperazin-1-yl]methanone
CAS 346459-45-8C22H25ClN4O3
(2-Fluorophenyl)-[4-(4-nitro-3-piperidin-1-ylphenyl)piperazin-1-yl]methanone chemical structure, C22H25FN4O3, CAS 347354-66-9
(2-Fluorophenyl)-[4-(4-nitro-3-piperidin-1-ylphenyl)piperazin-1-yl]methanone
CAS 347354-66-9C22H25FN4O3
(2-Chlorophenyl)-[4-(4-nitro-3-piperidin-1-ylphenyl)piperazin-1-yl]methanone chemical structure, C22H25ClN4O3, CAS 347355-17-3
(2-Chlorophenyl)-[4-(4-nitro-3-piperidin-1-ylphenyl)piperazin-1-yl]methanone
CAS 347355-17-3C22H25ClN4O3
(4-Methylphenyl)-[4-(4-nitro-3-piperidin-1-ylphenyl)piperazin-1-yl]methanone chemical structure, C23H28N4O3, CAS 347355-16-2
(4-Methylphenyl)-[4-(4-nitro-3-piperidin-1-ylphenyl)piperazin-1-yl]methanone
CAS 347355-16-2C23H28N4O3
(2-Methoxyphenyl)-[4-(4-nitro-3-piperidin-1-ylphenyl)piperazin-1-yl]methanone chemical structure, C23H28N4O4, CAS 347309-22-2
(2-Methoxyphenyl)-[4-(4-nitro-3-piperidin-1-ylphenyl)piperazin-1-yl]methanone
CAS 347309-22-2C23H28N4O4
(4-Methoxyphenyl)-[4-(4-nitro-3-piperidin-1-ylphenyl)piperazin-1-yl]methanone chemical structure, C23H28N4O4, CAS 347356-27-8
(4-Methoxyphenyl)-[4-(4-nitro-3-piperidin-1-ylphenyl)piperazin-1-yl]methanone
CAS 347356-27-8C23H28N4O4
(2-Methoxy-3-methylphenyl)-[4-(4-nitro-3-piperidin-1-ylphenyl)piperazin-1-yl]methanone chemical structure, C24H30N4O4, CAS 593237-95-7
(2-Methoxy-3-methylphenyl)-[4-(4-nitro-3-piperidin-1-ylphenyl)piperazin-1-yl]methanone
CAS 593237-95-7C24H30N4O4
[4-(4-Nitro-3-piperidin-1-ylphenyl)piperazin-1-yl]-(4-propan-2-ylphenyl)methanone chemical structure, C25H32N4O3, CAS 593237-94-6
[4-(4-Nitro-3-piperidin-1-ylphenyl)piperazin-1-yl]-(4-propan-2-ylphenyl)methanone
CAS 593237-94-6C25H32N4O3
(3-Chlorophenyl)-[4-(4-nitro-3-piperidin-1-ylphenyl)piperazin-1-yl]methanone chemical structure, C22H25ClN4O3, CAS 591765-48-9
(3-Chlorophenyl)-[4-(4-nitro-3-piperidin-1-ylphenyl)piperazin-1-yl]methanone
CAS 591765-48-9C22H25ClN4O3
(3-Methylphenyl)-[4-(4-nitro-3-piperidin-1-ylphenyl)piperazin-1-yl]methanone chemical structure, C23H28N4O3, CAS 593237-76-4
(3-Methylphenyl)-[4-(4-nitro-3-piperidin-1-ylphenyl)piperazin-1-yl]methanone
CAS 593237-76-4C23H28N4O3
(4-tert-Butylphenyl)-[4-(4-nitro-3-piperidin-1-ylphenyl)piperazin-1-yl]methanone chemical structure, C26H34N4O3, CAS 593237-73-1
(4-tert-Butylphenyl)-[4-(4-nitro-3-piperidin-1-ylphenyl)piperazin-1-yl]methanone
CAS 593237-73-1C26H34N4O3
(2-Methylphenyl)-[4-(4-nitro-3-piperidin-1-ylphenyl)piperazin-1-yl]methanone chemical structure, C23H28N4O3, CAS 597545-65-8
(2-Methylphenyl)-[4-(4-nitro-3-piperidin-1-ylphenyl)piperazin-1-yl]methanone
CAS 597545-65-8C23H28N4O3
(4-Ethylphenyl)-[4-(4-nitro-3-piperidin-1-ylphenyl)piperazin-1-yl]methanone chemical structure, C24H30N4O3, CAS 663182-32-9
(4-Ethylphenyl)-[4-(4-nitro-3-piperidin-1-ylphenyl)piperazin-1-yl]methanone
CAS 663182-32-9C24H30N4O3
(3-Ethoxyphenyl)-[4-(4-nitro-3-piperidin-1-ylphenyl)piperazin-1-yl]methanone chemical structure, C24H30N4O4, CAS 708989-75-7
(3-Ethoxyphenyl)-[4-(4-nitro-3-piperidin-1-ylphenyl)piperazin-1-yl]methanone
CAS 708989-75-7C24H30N4O4
[4-(4-Nitro-3-piperidin-1-ylphenyl)piperazin-1-yl]-(3-propan-2-yloxyphenyl)methanone chemical structure, C25H32N4O4, CAS 709005-33-4
[4-(4-Nitro-3-piperidin-1-ylphenyl)piperazin-1-yl]-(3-propan-2-yloxyphenyl)methanone
CAS 709005-33-4C25H32N4O4