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Murcko scaffold

Ring system with 4 rings and 27 atoms

127 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
27
Chemicals
127
With full pages
4
Scaffold SMILES

O=C(Cn1c(=O)nc(-c2ccccc2)c2ccccc21)Nc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(Cn1c(=O)nc(-c2ccccc2)c2ccccc21)Nc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 127 chemicals

N-(3,4-Dimethylphenyl)-2-(2-oxo-4-phenylquinazolin-1-yl)acetamide chemical structure, C24H21N3O2, CAS 932530-14-8
N-(3,4-Dimethylphenyl)-2-(2-oxo-4-phenylquinazolin-1-yl)acetamide
CAS 932530-14-8C24H21N3O2
N-(3-Chloro-4-methylphenyl)-2-(2-oxo-4-phenylquinazolin-1-yl)acetamide chemical structure, C23H18ClN3O2, CAS 932320-78-0
N-(3-Chloro-4-methylphenyl)-2-(2-oxo-4-phenylquinazolin-1-yl)acetamide
CAS 932320-78-0C23H18ClN3O2
2-(6-Chloro-2-oxo-4-phenyl-1,2-dihydroquinazolin-1-yl)-N-phenylacetamide chemical structure, C22H16ClN3O2, CAS 932452-42-1
2-(6-Chloro-2-oxo-4-phenyl-1,2-dihydroquinazolin-1-yl)-N-phenylacetamide
CAS 932452-42-1C22H16ClN3O2
2-(6-Chloro-2-oxo-4-phenylquinazolin-1-yl)-N-(3,4-dimethylphenyl)acetamide chemical structure, C24H20ClN3O2, CAS 932452-59-0
2-(6-Chloro-2-oxo-4-phenylquinazolin-1-yl)-N-(3,4-dimethylphenyl)acetamide
CAS 932452-59-0C24H20ClN3O2
2-(6-Chloro-2-oxo-4-phenylquinazolin-1-yl)-N-(2,3-dimethylphenyl)acetamide chemical structure, C24H20ClN3O2, CAS 932530-67-1
2-(6-Chloro-2-oxo-4-phenylquinazolin-1-yl)-N-(2,3-dimethylphenyl)acetamide
CAS 932530-67-1C24H20ClN3O2
2-(6-Chloro-2-oxo-4-phenyl-1,2-dihydroquinazolin-1-yl)-N-(3-ethylphenyl)acetamide chemical structure, C24H20ClN3O2, CAS 932530-75-1
2-(6-Chloro-2-oxo-4-phenyl-1,2-dihydroquinazolin-1-yl)-N-(3-ethylphenyl)acetamide
CAS 932530-75-1C24H20ClN3O2
2-(2-Oxo-4-phenylquinazolin-1(2H)-yl)-N-(m-tolyl)acetamide chemical structure, C23H19N3O2, CAS 932320-68-8
2-(2-Oxo-4-phenylquinazolin-1(2H)-yl)-N-(m-tolyl)acetamide
CAS 932320-68-8C23H19N3O2
N-(4-Methylphenyl)-2-(2-oxo-4-phenylquinazolin-1-yl)acetamide chemical structure, C23H19N3O2, CAS 932451-82-6
N-(4-Methylphenyl)-2-(2-oxo-4-phenylquinazolin-1-yl)acetamide
CAS 932451-82-6C23H19N3O2
N-(2-Methoxyphenyl)-2-(2-oxo-4-phenylquinazolin-1-yl)acetamide chemical structure, C23H19N3O3, CAS 932529-99-2
N-(2-Methoxyphenyl)-2-(2-oxo-4-phenylquinazolin-1-yl)acetamide
CAS 932529-99-2C23H19N3O3
N-(3-Methoxyphenyl)-2-(2-oxo-4-phenyl-1,2-dihydroquinazolin-1-yl)acetamide chemical structure, C23H19N3O3, CAS 941907-25-1
N-(3-Methoxyphenyl)-2-(2-oxo-4-phenyl-1,2-dihydroquinazolin-1-yl)acetamide
CAS 941907-25-1C23H19N3O3
N-(3-Chlorophenyl)-2-(2-oxo-4-phenylquinazolin-1-yl)acetamide chemical structure, C22H16ClN3O2, CAS 932320-70-2
N-(3-Chlorophenyl)-2-(2-oxo-4-phenylquinazolin-1-yl)acetamide
CAS 932320-70-2C22H16ClN3O2
N-(4-Chlorophenyl)-2-(2-oxo-4-phenylquinazolin-1-yl)acetamide chemical structure, C22H16ClN3O2, CAS 932451-87-1
N-(4-Chlorophenyl)-2-(2-oxo-4-phenylquinazolin-1-yl)acetamide
CAS 932451-87-1C22H16ClN3O2
N-(3-Fluorophenyl)-2-(2-oxo-4-phenylquinazolin-1-yl)acetamide chemical structure, C22H16FN3O2, CAS 932456-99-0
N-(3-Fluorophenyl)-2-(2-oxo-4-phenylquinazolin-1-yl)acetamide
CAS 932456-99-0C22H16FN3O2
N-(4-Fluorophenyl)-2-(2-oxo-4-phenylquinazolin-1-yl)acetamide chemical structure, C22H16FN3O2, CAS 932320-72-4
N-(4-Fluorophenyl)-2-(2-oxo-4-phenylquinazolin-1-yl)acetamide
CAS 932320-72-4C22H16FN3O2
N-(3,4-Dimethoxyphenyl)-2-(2-oxo-4-phenylquinazolin-1-yl)acetamide chemical structure, C24H21N3O4, CAS 941956-29-2
N-(3,4-Dimethoxyphenyl)-2-(2-oxo-4-phenylquinazolin-1-yl)acetamide
CAS 941956-29-2C24H21N3O4
N-(2,5-Dimethylphenyl)-2-(2-oxo-4-phenylquinazolin-1-yl)acetamide chemical structure, C24H21N3O2, CAS 932457-11-9
N-(2,5-Dimethylphenyl)-2-(2-oxo-4-phenylquinazolin-1-yl)acetamide
CAS 932457-11-9C24H21N3O2
N-(3-Fluoro-4-methylphenyl)-2-(2-oxo-4-phenylquinazolin-1-yl)acetamide chemical structure, C23H18FN3O2, CAS 932530-19-3
N-(3-Fluoro-4-methylphenyl)-2-(2-oxo-4-phenylquinazolin-1-yl)acetamide
CAS 932530-19-3C23H18FN3O2
N-(2,4-Difluorophenyl)-2-(2-oxo-4-phenylquinazolin-1-yl)acetamide chemical structure, C22H15F2N3O2, CAS 932320-81-5
N-(2,4-Difluorophenyl)-2-(2-oxo-4-phenylquinazolin-1-yl)acetamide
CAS 932320-81-5C22H15F2N3O2
N-(5-Fluoro-2-methylphenyl)-2-(2-oxo-4-phenylquinazolin-1-yl)acetamide chemical structure, C23H18FN3O2, CAS 942035-34-9
N-(5-Fluoro-2-methylphenyl)-2-(2-oxo-4-phenylquinazolin-1-yl)acetamide
CAS 942035-34-9C23H18FN3O2
N-(2,4-Dimethylphenyl)-2-(2-oxo-4-phenylquinazolin-1-yl)acetamide chemical structure, C24H21N3O2, CAS 932452-07-8
N-(2,4-Dimethylphenyl)-2-(2-oxo-4-phenylquinazolin-1-yl)acetamide
CAS 932452-07-8C24H21N3O2
N-(4-Ethoxyphenyl)-2-(2-oxo-4-phenylquinazolin-1-yl)acetamide chemical structure, C24H21N3O3, CAS 941907-27-3
N-(4-Ethoxyphenyl)-2-(2-oxo-4-phenylquinazolin-1-yl)acetamide
CAS 941907-27-3C24H21N3O3
Methyl 2-[[2-(2-oxo-4-phenylquinazolin-1-yl)acetyl]amino]benzoate chemical structure, C24H19N3O4, CAS 932530-23-9
Methyl 2-[[2-(2-oxo-4-phenylquinazolin-1-yl)acetyl]amino]benzoate
CAS 932530-23-9C24H19N3O4
N-(2-Ethylphenyl)-2-(2-oxo-4-phenylquinazolin-1-yl)acetamide chemical structure, C24H21N3O2, CAS 932452-12-5
N-(2-Ethylphenyl)-2-(2-oxo-4-phenylquinazolin-1-yl)acetamide
CAS 932452-12-5C24H21N3O2
N-(3-Ethylphenyl)-2-(2-oxo-4-phenylquinazolin-1-yl)acetamide chemical structure, C24H21N3O2, CAS 932530-27-3
N-(3-Ethylphenyl)-2-(2-oxo-4-phenylquinazolin-1-yl)acetamide
CAS 932530-27-3C24H21N3O2