Murcko scaffold
2-Phenacylsulfanyl-3-phenyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-one scaffold
53 chemicals on CompoundList share this ring system.
- Rings
- 5
- Scaffold atoms
- 30
- Chemicals
- 53
- With full pages
- 22
Scaffold SMILES
O=C(CSc1nc2sc3c(c2c(=O)n1-c1ccccc1)CCCC3)c1ccccc1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 48 of 53 chemicals
![2-{[2-(2,5-Dimethoxyphenyl)-2-oxoethyl]sulfanyl}-3-(4-methoxyphenyl)-5,6,7,8-tetrahydro[1]benzothieno[2,3-D]pyrimidin-4(3H)-one chemical structure, C27H26N2O5S2, CAS 477331-64-9](/s/UNCOHXGIKKZBBD-UHFFFAOYSA-N.svg)
2-{[2-(2,5-Dimethoxyphenyl)-2-oxoethyl]sulfanyl}-3-(4-methoxyphenyl)-5,6,7,8-tetrahydro[1]benzothieno[2,3-D]pyrimidin-4(3H)-one
CAS 477331-64-9C27H26N2O5S2
![2-{[2-(3,4-Dimethoxyphenyl)-2-oxoethyl]sulfanyl}-3-(4-methoxyphenyl)-5,6,7,8-tetrahydro[1]benzothieno[2,3-D]pyrimidin-4(3H)-one chemical structure, C27H26N2O5S2, CAS 477331-58-1](/s/MOBAQHXYVVPDSP-UHFFFAOYSA-N.svg)
2-{[2-(3,4-Dimethoxyphenyl)-2-oxoethyl]sulfanyl}-3-(4-methoxyphenyl)-5,6,7,8-tetrahydro[1]benzothieno[2,3-D]pyrimidin-4(3H)-one
CAS 477331-58-1C27H26N2O5S2
![3-(4-Ethoxyphenyl)-2-{[2-(3-methoxyphenyl)-2-oxoethyl]sulfanyl}-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4(3H)-one chemical structure, C27H26N2O4S2, CAS 499125-38-1](/s/SZUQXYKAGRJBHR-UHFFFAOYSA-N.svg)
3-(4-Ethoxyphenyl)-2-{[2-(3-methoxyphenyl)-2-oxoethyl]sulfanyl}-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4(3H)-one
CAS 499125-38-1C27H26N2O4S2
![3-(4-Chlorophenyl)-2-{[2-(4-methoxyphenyl)-2-oxoethyl]sulfanyl}-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4(3H)-one chemical structure, C25H21ClN2O3S2, CAS 499102-49-7](/s/HEIVJBRDJJBZEU-UHFFFAOYSA-N.svg)
3-(4-Chlorophenyl)-2-{[2-(4-methoxyphenyl)-2-oxoethyl]sulfanyl}-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4(3H)-one
CAS 499102-49-7C25H21ClN2O3S2
![3-(4-Chlorophenyl)-2-{[2-(2,5-dimethoxyphenyl)-2-oxoethyl]sulfanyl}-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4(3H)-one chemical structure, C26H23ClN2O4S2, CAS 499102-51-1](/s/SJMHCPBTNFKXNN-UHFFFAOYSA-N.svg)
3-(4-Chlorophenyl)-2-{[2-(2,5-dimethoxyphenyl)-2-oxoethyl]sulfanyl}-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4(3H)-one
CAS 499102-51-1C26H23ClN2O4S2
![2-({2-[2-(Difluoromethoxy)phenyl]-2-oxoethyl}sulfanyl)-3-phenyl-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4(3H)-one chemical structure, C25H20F2N2O3S2, CAS 303033-84-3](/s/UUHHKZBZLNCPDW-UHFFFAOYSA-N.svg)
2-({2-[2-(Difluoromethoxy)phenyl]-2-oxoethyl}sulfanyl)-3-phenyl-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4(3H)-one
CAS 303033-84-3C25H20F2N2O3S2
![3-(4-Bromophenyl)-2-{[2-(4-methylphenyl)-2-oxoethyl]sulfanyl}-5,6,7,8-tetrahydro[1]benzothieno[2,3-D]pyrimidin-4(3H)-one chemical structure, C25H21BrN2O2S2, CAS 476484-19-2](/s/LKIDBCBDYJVIET-UHFFFAOYSA-N.svg)
3-(4-Bromophenyl)-2-{[2-(4-methylphenyl)-2-oxoethyl]sulfanyl}-5,6,7,8-tetrahydro[1]benzothieno[2,3-D]pyrimidin-4(3H)-one
CAS 476484-19-2C25H21BrN2O2S2
![2-{[2-(4-Ethoxyphenyl)-2-oxoethyl]sulfanyl}-3-(4-methylphenyl)-5,6,7,8-tetrahydro[1]benzothieno[2,3-D]pyrimidin-4(3H)-one chemical structure, C27H26N2O3S2, CAS 499124-12-8](/s/XYHOAWWZKPMLBO-UHFFFAOYSA-N.svg)
2-{[2-(4-Ethoxyphenyl)-2-oxoethyl]sulfanyl}-3-(4-methylphenyl)-5,6,7,8-tetrahydro[1]benzothieno[2,3-D]pyrimidin-4(3H)-one
CAS 499124-12-8C27H26N2O3S2
![2-{[2-(4-Fluorophenyl)-2-oxoethyl]sulfanyl}-3-(4-methoxyphenyl)-5,6,7,8-tetrahydro[1]benzothieno[2,3-D]pyrimidin-4(3H)-one chemical structure, C25H21FN2O3S2, CAS 477329-18-3](/s/AOVKBJRWSDNQGE-UHFFFAOYSA-N.svg)
2-{[2-(4-Fluorophenyl)-2-oxoethyl]sulfanyl}-3-(4-methoxyphenyl)-5,6,7,8-tetrahydro[1]benzothieno[2,3-D]pyrimidin-4(3H)-one
CAS 477329-18-3C25H21FN2O3S2
![3-(4-Chlorophenyl)-2-{[2-(4-fluorophenyl)-2-oxoethyl]sulfanyl}-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4(3H)-one chemical structure, C24H18ClFN2O2S2, CAS 406201-26-1](/s/ZVAWEVPRCVOFGM-UHFFFAOYSA-N.svg)
3-(4-Chlorophenyl)-2-{[2-(4-fluorophenyl)-2-oxoethyl]sulfanyl}-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4(3H)-one
CAS 406201-26-1C24H18ClFN2O2S2
![3-(4-Methoxyphenyl)-2-{[2-(3-methoxyphenyl)-2-oxoethyl]sulfanyl}-5,6,7,8-tetrahydro[1]benzothieno[2,3-D]pyrimidin-4(3H)-one chemical structure, C26H24N2O4S2, CAS 477329-25-2](/s/QJMBDFVNGIKMRU-UHFFFAOYSA-N.svg)
3-(4-Methoxyphenyl)-2-{[2-(3-methoxyphenyl)-2-oxoethyl]sulfanyl}-5,6,7,8-tetrahydro[1]benzothieno[2,3-D]pyrimidin-4(3H)-one
CAS 477329-25-2C26H24N2O4S2
![3-(4-Chlorophenyl)-2-{[2-(3,4-dimethoxyphenyl)-2-oxoethyl]sulfanyl}-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4(3H)-one chemical structure, C26H23ClN2O4S2, CAS 499102-50-0](/s/DSDFNEPYXHTVOX-UHFFFAOYSA-N.svg)
3-(4-Chlorophenyl)-2-{[2-(3,4-dimethoxyphenyl)-2-oxoethyl]sulfanyl}-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4(3H)-one
CAS 499102-50-0C26H23ClN2O4S2
![2-{[2-(3-Methoxyphenyl)-2-oxoethyl]sulfanyl}-3-(4-methylphenyl)-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4(3H)-one chemical structure, C26H24N2O3S2, CAS 499124-14-0](/s/IREPBWPPGUBBCQ-UHFFFAOYSA-N.svg)
2-{[2-(3-Methoxyphenyl)-2-oxoethyl]sulfanyl}-3-(4-methylphenyl)-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4(3H)-one
CAS 499124-14-0C26H24N2O3S2
2-((2-(4-Bromophenyl)-2-oxoethyl)sulfanyl)-3-(4-ethoxyphenyl)-5,6,7,8-tetrahydro(1)benzothieno(2,3-D)pyrimidin-4(3H)-one
CAS 497240-79-6C26H23BrN2O3S2
![3-(4-Bromophenyl)-2-{[2-(4-fluorophenyl)-2-oxoethyl]sulfanyl}-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4(3H)-one chemical structure, C24H18BrFN2O2S2, CAS 498546-92-2](/s/VUENBFNLNVHPDL-UHFFFAOYSA-N.svg)
3-(4-Bromophenyl)-2-{[2-(4-fluorophenyl)-2-oxoethyl]sulfanyl}-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4(3H)-one
CAS 498546-92-2C24H18BrFN2O2S2
![3-(4-Chlorophenyl)-2-{[2-(4-ethoxyphenyl)-2-oxoethyl]sulfanyl}-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4(3H)-one chemical structure, C26H23ClN2O3S2, CAS 499102-52-2](/s/DWEMLUCLPALXQY-UHFFFAOYSA-N.svg)
3-(4-Chlorophenyl)-2-{[2-(4-ethoxyphenyl)-2-oxoethyl]sulfanyl}-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4(3H)-one
CAS 499102-52-2C26H23ClN2O3S2
3-(4-Chlorophenyl)-2-((2-(4-methylphenyl)-2-oxoethyl)sulfanyl)-5,6,7,8-tetrahydro(1)benzothieno(2,3-D)pyrimidin-4(3H)-one
CAS 445220-56-4C25H21ClN2O2S2
![2-Phenacylsulfanyl-3-phenyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-one chemical structure, C24H20N2O2S2, CAS 144316-11-0](/s/KOEZIVQSTXOZAM-UHFFFAOYSA-N.svg)
2-Phenacylsulfanyl-3-phenyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-one
CAS 144316-11-0C24H20N2O2S2
![2-[2-(4-Methoxyphenyl)-2-oxoethyl]sulfanyl-3-phenyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-one chemical structure, C25H22N2O3S2, CAS 327169-98-2](/s/KALGZOIYUFQDQJ-UHFFFAOYSA-N.svg)
2-[2-(4-Methoxyphenyl)-2-oxoethyl]sulfanyl-3-phenyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-one
CAS 327169-98-2C25H22N2O3S2
![2-[2-(4-Chlorophenyl)-2-oxoethyl]sulfanyl-3-phenyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-one chemical structure, C24H19ClN2O2S2, CAS 330449-42-8](/s/DMJOXAKZRNDZMS-UHFFFAOYSA-N.svg)
2-[2-(4-Chlorophenyl)-2-oxoethyl]sulfanyl-3-phenyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-one
CAS 330449-42-8C24H19ClN2O2S2
2-((2-(4-Chlorophenyl)-2-oxoethyl)sulfanyl)-3-(4-methoxyphenyl)-5,6,7,8-tetrahydro(1)benzothieno(2,3-D)pyrimidin-4(3H)-one
CAS 312585-66-3C25H21ClN2O3S2
![2-{[2-(4-Chlorophenyl)-2-oxoethyl]sulfanyl}-3-(4-methylphenyl)-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4(3H)-one chemical structure, C25H21ClN2O2S2, CAS 337350-59-1](/s/KHOFELZHWJUVSR-UHFFFAOYSA-N.svg)
2-{[2-(4-Chlorophenyl)-2-oxoethyl]sulfanyl}-3-(4-methylphenyl)-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4(3H)-one
CAS 337350-59-1C25H21ClN2O2S2
![3-(4-Methylphenyl)-2-phenacylsulfanyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-one chemical structure, C25H22N2O2S2, CAS 332393-05-2](/s/KAXXPHXYMUQKTJ-UHFFFAOYSA-N.svg)
3-(4-Methylphenyl)-2-phenacylsulfanyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-one
CAS 332393-05-2C25H22N2O2S2
![2-[2-(4-Bromophenyl)-2-oxoethyl]sulfanyl-3-phenyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-one chemical structure, C24H19BrN2O2S2, CAS 325996-39-2](/s/KZAOVEJNOBVDAV-UHFFFAOYSA-N.svg)
2-[2-(4-Bromophenyl)-2-oxoethyl]sulfanyl-3-phenyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-one
CAS 325996-39-2C24H19BrN2O2S2
- 3-(4-Bromophenyl)-2-{[2-(4-methoxyphenyl)-2-oxoethyl]sulfanyl}-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4(3H)-one498545-50-9C25H21BrN2O3S2
- 3-(4-Chlorophenyl)-2-[(2-oxo-2-phenylethyl)sulfanyl]-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4(3H)-one383885-21-0C24H19ClN2O2S2
- 3-(4-Chlorophenyl)-2-{[2-(2-chlorophenyl)-2-oxoethyl]sulfanyl}-5,6,7,8-tetrahydro[1]benzothieno[2,3-D]pyrimidin-4(3H)-one573940-83-7C24H18Cl2N2O2S2
- 2-{[2-(2,5-Dimethoxyphenyl)-2-oxoethyl]sulfanyl}-3-(4-ethoxyphenyl)-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4(3H)-one613226-57-6C28H28N2O5S2
- 2-{[2-(4-Fluorophenyl)-2-oxoethyl]sulfanyl}-3-(4-methylphenyl)-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4(3H)-one587838-34-4C25H21FN2O2S2
- 2-{[2-(4-Chlorophenyl)-2-oxoethyl]sulfanyl}-3-(4-ethoxyphenyl)-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4(3H)-one488108-50-5C26H23ClN2O3S2
- 3-(4-Ethoxyphenyl)-2-{[2-(4-fluorophenyl)-2-oxoethyl]sulfanyl}-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4(3H)-one380455-23-2C26H23FN2O3S2
- 2-{[2-(2-Chlorophenyl)-2-oxoethyl]sulfanyl}-3-(4-methylphenyl)-5,6,7,8-tetrahydro[1]benzothieno[2,3-D]pyrimidin-4(3H)-one618432-24-9C25H21ClN2O2S2
- 3-(4-Ethoxyphenyl)-2-{[2-(4-methoxyphenyl)-2-oxoethyl]sulfanyl}-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4(3H)-one421578-10-1C27H26N2O4S2
- 2-[2-(3,4-Dimethoxyphenyl)-2-oxoethyl]sulfanyl-3-phenyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-one370076-78-1C26H24N2O4S2
- 3-(4-Ethoxyphenyl)-2-[2-(4-methylphenyl)-2-oxoethyl]sulfanyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-one421578-09-8C27H26N2O3S2
- 2-{[2-(4-Ethoxyphenyl)-2-oxoethyl]sulfanyl}-3-(4-methoxyphenyl)-5,6,7,8-tetrahydro[1]benzothieno[2,3-D]pyrimidin-4(3H)-one477332-77-7C27H26N2O4S2
- 3-(4-Methoxyphenyl)-2-{[2-(4-methoxyphenyl)-2-oxoethyl]sulfanyl}-5,6,7,8-tetrahydro[1]benzothieno[2,3-D]pyrimidin-4(3H)-one477329-41-2C26H24N2O4S2
- 3-(4-Bromophenyl)-2-((2-(4-chlorophenyl)-2-oxoethyl)sulfanyl)-5,6,7,8-tetrahydro(1)benzothieno(2,3-D)pyrimidin-4(3H)-one380340-08-9C24H18BrClN2O2S2
- 2-[2-(4-Chlorophenyl)-2-oxoethyl]sulfanyl-3-[4-(difluoromethoxy)phenyl]-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-one380340-00-1C25H19ClF2N2O3S2
- N-[4-[2-[2-(4-Fluorophenyl)-2-oxoethyl]sulfanyl-4-oxo-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-3-yl]phenyl]acetamide380342-89-2C26H22FN3O3S2
- 2-[2-(4-Chlorophenyl)-2-oxoethyl]sulfanyl-7-methyl-3-phenyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-one375833-89-9C25H21ClN2O2S2
- 2-{[2-(4-Bromophenyl)-2-oxoethyl]sulfanyl}-3-(4-methoxyphenyl)-5,6,7,8-tetrahydro[1]benzothieno[2,3-D]pyrimidin-4(3H)-one337350-71-7C25H21BrN2O3S2
- 3-(4-Ethoxyphenyl)-2-{[2-(4-ethoxyphenyl)-2-oxoethyl]sulfanyl}-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4(3H)-one499125-36-9C28H28N2O4S2
- 3-(4-Bromophenyl)-2-{[2-(3-methoxyphenyl)-2-oxoethyl]sulfanyl}-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4(3H)-one498545-52-1C25H21BrN2O3S2
- 3-(4-Chlorophenyl)-2-{[2-(4-chlorophenyl)-2-oxoethyl]sulfanyl}-5,6,7,8-tetrahydro[1]benzothieno[2,3-D]pyrimidin-4(3H)-one573930-44-6C24H18Cl2N2O2S2
- 2-{[2-(3,4-Dimethoxyphenyl)-2-oxoethyl]sulfanyl}-3-(4-ethoxyphenyl)-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4(3H)-one613226-56-5C28H28N2O5S2
- 7-tert-Butyl-3-(4-methylphenyl)-2-phenacylsulfanyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-one351160-07-1C29H30N2O2S2
- 3-(4-Chlorophenyl)-2-{[2-(3,4-dichlorophenyl)-2-oxoethyl]sulfanyl}-5,6,7,8-tetrahydro[1]benzothieno[2,3-D]pyrimidin-4(3H)-one618432-10-3C24H17Cl3N2O2S2