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Murcko scaffold

1-Phenyl-2-(piperazin-1-yl)ethanone scaffold

60 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
15
Chemicals
60
With full pages
7
Scaffold SMILES

O=C(CN1CCNCC1)c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1-Phenyl-2-(piperazin-1-yl)ethanone page
Murcko scaffold O=C(CN1CCNCC1)c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 60 chemicals

Acetophenone, 2-(4-(2-(2-hydroxyethoxy)ethyl)piperazinyl)-3',4',5'-trimethoxy-, hydrobromide chemical structure, C19H31BrN2O6, CAS 17766-80-2
Acetophenone, 2-(4-(2-(2-hydroxyethoxy)ethyl)piperazinyl)-3',4',5'-trimethoxy-, hydrobromide
CAS 17766-80-2C19H31BrN2O6
2-[4-[2-(4-Bromophenyl)-2-oxoethyl]piperazin-1-yl]acetonitrile chemical structure, C14H16BrN3O, CAS 406929-43-9
2-[4-[2-(4-Bromophenyl)-2-oxoethyl]piperazin-1-yl]acetonitrile
CAS 406929-43-9C14H16BrN3O
1-(4-Methoxyphenyl)-2-piperazin-1-ylethanone chemical structure, C13H18N2O2, CAS 438487-09-3
1-(4-Methoxyphenyl)-2-piperazin-1-ylethanone
CAS 438487-09-3C13H18N2O2
1-(4-Bromophenyl)-2-(4-methylpiperazin-1-yl)ethanone chemical structure, C13H17BrN2O, CAS 845289-18-1
1-(4-Bromophenyl)-2-(4-methylpiperazin-1-yl)ethanone
CAS 845289-18-1C13H17BrN2O
1-(4-Methoxyphenyl)-2-(4-methylpiperazin-1-yl)ethan-1-one chemical structure, C14H20N2O2, CAS 438025-86-6
1-(4-Methoxyphenyl)-2-(4-methylpiperazin-1-yl)ethan-1-one
CAS 438025-86-6C14H20N2O2
2-(4-Ethylpiperazin-1-yl)-1-(4-methylphenyl)ethanone chemical structure, C15H22N2O, CAS 726161-32-6
2-(4-Ethylpiperazin-1-yl)-1-(4-methylphenyl)ethanone
CAS 726161-32-6C15H22N2O
1-(2-Bromophenyl)-2-(4-ethylpiperazin-1-yl)ethan-1-one chemical structure, C14H19BrN2O, CAS 736166-36-2
1-(2-Bromophenyl)-2-(4-ethylpiperazin-1-yl)ethan-1-one
CAS 736166-36-2C14H19BrN2O
tert-Butyl 4-[2-(4-methoxyphenyl)-2-oxoethyl]piperazine-1-carboxylate chemical structure, C18H26N2O4, CAS 664362-19-0
tert-Butyl 4-[2-(4-methoxyphenyl)-2-oxoethyl]piperazine-1-carboxylate
CAS 664362-19-0C18H26N2O4
Acetamide, N-(4-(2-(4-methyl-1-piperazinyl)-1-oxopropyl)phenyl)-, dihydrochloride chemical structure, C16H25Cl2N3O2, CAS 97111-11-0
Acetamide, N-(4-(2-(4-methyl-1-piperazinyl)-1-oxopropyl)phenyl)-, dihydrochloride
CAS 97111-11-0C16H25Cl2N3O2
Ethanone, 2-(4-(2,3-dihydroxypropyl)-1-piperazinyl)-1-(2,4,6-trimethoxyphenyl)-, dihydrochloride chemical structure, C18H30Cl2N2O6, CAS 66932-99-8
Ethanone, 2-(4-(2,3-dihydroxypropyl)-1-piperazinyl)-1-(2,4,6-trimethoxyphenyl)-, dihydrochloride
CAS 66932-99-8C18H30Cl2N2O6
1-Piperazinecarboxylic acid, 4-(2-oxo-2-phenylethyl)-, ethyl ester chemical structure, C15H20N2O3, CAS 189251-55-6
1-Piperazinecarboxylic acid, 4-(2-oxo-2-phenylethyl)-, ethyl ester
CAS 189251-55-6C15H20N2O3
1-Phenyl-2-(piperazin-1-yl)ethanone chemical structure, C12H16N2O, CAS 41298-98-0
1-Phenyl-2-(piperazin-1-yl)ethanone
CAS 41298-98-0C12H16N2O
1-(4-Methylphenyl)-2-(piperazin-1-yl)ethan-1-one chemical structure, C13H18N2O, CAS 877928-05-7
1-(4-Methylphenyl)-2-(piperazin-1-yl)ethan-1-one
CAS 877928-05-7C13H18N2O
1-(4-Chlorophenyl)-2-(piperazin-1-yl)ethan-1-one chemical structure, C12H15ClN2O, CAS 199468-11-6
1-(4-Chlorophenyl)-2-(piperazin-1-yl)ethan-1-one
CAS 199468-11-6C12H15ClN2O
1-(4-Bromophenyl)-2-(piperazin-1-yl)ethanone chemical structure, C12H15BrN2O, CAS 109607-56-9
1-(4-Bromophenyl)-2-(piperazin-1-yl)ethanone
CAS 109607-56-9C12H15BrN2O
1-(3,4-Dimethylphenyl)-2-(piperazin-1-yl)ethan-1-one chemical structure, C14H20N2O, CAS 923139-16-6
1-(3,4-Dimethylphenyl)-2-(piperazin-1-yl)ethan-1-one
CAS 923139-16-6C14H20N2O
Ethanone, 2-(4-methyl-1-piperazinyl)-1-(4-(methylsulfonyl)phenyl)-, (Z)-2-butenedioate (1:2) chemical structure, C22H28N2O11S, CAS 56660-15-2
Ethanone, 2-(4-methyl-1-piperazinyl)-1-(4-(methylsulfonyl)phenyl)-, (Z)-2-butenedioate (1:2)
CAS 56660-15-2C22H28N2O11S
Benzenesulfonamide, N,N-diethyl-4-((4-methyl-1-piperazinyl)acetyl)-, (Z)-2-butenedioate (1:2) chemical structure, C25H35N3O11S, CAS 58722-41-1
Benzenesulfonamide, N,N-diethyl-4-((4-methyl-1-piperazinyl)acetyl)-, (Z)-2-butenedioate (1:2)
CAS 58722-41-1C25H35N3O11S
Ethyl 4-[2-(2,4-dihydroxyphenyl)-2-oxoethyl]piperazine-1-carboxylate chemical structure, C15H20N2O5, CAS 887209-42-9
Ethyl 4-[2-(2,4-dihydroxyphenyl)-2-oxoethyl]piperazine-1-carboxylate
CAS 887209-42-9C15H20N2O5
Ethyl 4-[2-(2,4-dihydroxy-3-methylphenyl)-2-oxoethyl]piperazine-1-carboxylate chemical structure, C16H22N2O5, CAS 887209-45-2
Ethyl 4-[2-(2,4-dihydroxy-3-methylphenyl)-2-oxoethyl]piperazine-1-carboxylate
CAS 887209-45-2C16H22N2O5
Ethyl 4-[2-(3-chlorophenyl)-2-oxoethyl]tetrahydro-1(2H)-pyrazinecarboxylate chemical structure, C15H19ClN2O3, CAS 486439-06-9
Ethyl 4-[2-(3-chlorophenyl)-2-oxoethyl]tetrahydro-1(2H)-pyrazinecarboxylate
CAS 486439-06-9C15H19ClN2O3
1-(3,5-Dimethoxyphenyl)-2-(4-methyl-1-piperazinyl)ethanone chemical structure, C15H22N2O3, CAS 736881-50-8
1-(3,5-Dimethoxyphenyl)-2-(4-methyl-1-piperazinyl)ethanone
CAS 736881-50-8C15H22N2O3
1-(4-Aminophenyl)-2-(4-methylpiperazin-1-yl)ethanone chemical structure, C13H19N3O, CAS 122379-41-3
1-(4-Aminophenyl)-2-(4-methylpiperazin-1-yl)ethanone
CAS 122379-41-3C13H19N3O
1-(4-Fluorophenyl)-2-(piperazin-1-yl)ethan-1-one chemical structure, C12H15FN2O, CAS 556807-81-9
1-(4-Fluorophenyl)-2-(piperazin-1-yl)ethan-1-one
CAS 556807-81-9C12H15FN2O