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Murcko scaffold

Ring system with 5 rings and 29 atoms

22 chemicals on CompoundList share this ring system.

Rings
5
Scaffold atoms
29
Chemicals
22
With full pages
5
Scaffold SMILES

O=C1CC(c2ccccc2)Cc2nc(N3CCN(c4ccccc4)CC3)ncc21

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C1CC(c2ccccc2)Cc2nc(N3CCN(c4ccccc4)CC3)ncc21

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 22 of 22 chemicals

7-(4-Fluorophenyl)-2-(4-phenylpiperazin-1-yl)-7,8-dihydroquinazolin-5(6H)-one chemical structure, C24H23FN4O, CAS 850241-36-0
7-(4-Fluorophenyl)-2-(4-phenylpiperazin-1-yl)-7,8-dihydroquinazolin-5(6H)-one
CAS 850241-36-0C24H23FN4O
7-(3-Chlorophenyl)-2-(4-phenyl-1-piperazinyl)-7,8-dihydro-6H-quinazolin-5-one chemical structure, C24H23ClN4O, CAS 775293-44-2
7-(3-Chlorophenyl)-2-(4-phenyl-1-piperazinyl)-7,8-dihydro-6H-quinazolin-5-one
CAS 775293-44-2C24H23ClN4O
7-(4-Methoxyphenyl)-4-methyl-2-(4-phenylpiperazin-1-yl)-7,8-dihydroquinazolin-5(6H)-one chemical structure, C26H28N4O2, CAS 777866-78-1
7-(4-Methoxyphenyl)-4-methyl-2-(4-phenylpiperazin-1-yl)-7,8-dihydroquinazolin-5(6H)-one
CAS 777866-78-1C26H28N4O2
7-(4-Methylphenyl)-2-(4-phenylpiperazin-1-yl)-7,8-dihydroquinazolin-5(6H)-one chemical structure, C25H26N4O, CAS 775292-89-2
7-(4-Methylphenyl)-2-(4-phenylpiperazin-1-yl)-7,8-dihydroquinazolin-5(6H)-one
CAS 775292-89-2C25H26N4O
4-Methyl-7-phenyl-2-(4-phenylpiperazin-1-yl)-7,8-dihydroquinazolin-5(6H)-one chemical structure, C25H26N4O, CAS 777866-77-0
4-Methyl-7-phenyl-2-(4-phenylpiperazin-1-yl)-7,8-dihydroquinazolin-5(6H)-one
CAS 777866-77-0C25H26N4O
7-(3,4-Dimethoxyphenyl)-2-(4-phenylpiperazin-1-yl)-7,8-dihydroquinazolin-5(6H)-one chemical structure, C26H28N4O3, CAS 777866-66-7
7-(3,4-Dimethoxyphenyl)-2-(4-phenylpiperazin-1-yl)-7,8-dihydroquinazolin-5(6H)-one
CAS 777866-66-7C26H28N4O3
7-(2-Fluorophenyl)-2-(4-phenylpiperazin-1-yl)-7,8-dihydroquinazolin-5(6H)-one chemical structure, C24H23FN4O, CAS 879576-29-1
7-(2-Fluorophenyl)-2-(4-phenylpiperazin-1-yl)-7,8-dihydroquinazolin-5(6H)-one
CAS 879576-29-1C24H23FN4O
7-(2-Hydroxyphenyl)-2-(4-phenylpiperazin-1-yl)-7,8-dihydroquinazolin-5(6H)-one chemical structure, C24H24N4O2, CAS 880074-32-8
7-(2-Hydroxyphenyl)-2-(4-phenylpiperazin-1-yl)-7,8-dihydroquinazolin-5(6H)-one
CAS 880074-32-8C24H24N4O2
7-(2-Chlorophenyl)-2-[4-(2-methoxyphenyl)piperazin-1-yl]-7,8-dihydroquinazolin-5(6H)-one chemical structure, C25H25ClN4O2, CAS 879625-29-3
7-(2-Chlorophenyl)-2-[4-(2-methoxyphenyl)piperazin-1-yl]-7,8-dihydroquinazolin-5(6H)-one
CAS 879625-29-3C25H25ClN4O2
2-[4-(2-Methoxyphenyl)piperazin-1-yl]-7-(3,4,5-trimethoxyphenyl)-7,8-dihydroquinazolin-5(6H)-one chemical structure, C28H32N4O5, CAS 879625-31-7
2-[4-(2-Methoxyphenyl)piperazin-1-yl]-7-(3,4,5-trimethoxyphenyl)-7,8-dihydroquinazolin-5(6H)-one
CAS 879625-31-7C28H32N4O5
7-(4-Fluorophenyl)-2-[4-(4-methoxyphenyl)piperazin-1-yl]-4-methyl-7,8-dihydroquinazolin-5(6H)-one chemical structure, C26H27FN4O2, CAS 879625-40-8
7-(4-Fluorophenyl)-2-[4-(4-methoxyphenyl)piperazin-1-yl]-4-methyl-7,8-dihydroquinazolin-5(6H)-one
CAS 879625-40-8C26H27FN4O2
7-(2-Chlorophenyl)-2-[4-(4-fluorophenyl)piperazin-1-yl]-7,8-dihydroquinazolin-5(6H)-one chemical structure, C24H22ClFN4O, CAS 879564-92-8
7-(2-Chlorophenyl)-2-[4-(4-fluorophenyl)piperazin-1-yl]-7,8-dihydroquinazolin-5(6H)-one
CAS 879564-92-8C24H22ClFN4O
7-(2-Hydroxyphenyl)-2-[4-(2-methoxyphenyl)piperazin-1-yl]-7,8-dihydroquinazolin-5(6H)-one chemical structure, C25H26N4O3, CAS 879046-03-4
7-(2-Hydroxyphenyl)-2-[4-(2-methoxyphenyl)piperazin-1-yl]-7,8-dihydroquinazolin-5(6H)-one
CAS 879046-03-4C25H26N4O3
2-[4-(2-Fluorophenyl)piperazin-1-yl]-7-(2-hydroxyphenyl)-7,8-dihydroquinazolin-5(6H)-one chemical structure, C24H23FN4O2, CAS 879046-10-3
2-[4-(2-Fluorophenyl)piperazin-1-yl]-7-(2-hydroxyphenyl)-7,8-dihydroquinazolin-5(6H)-one
CAS 879046-10-3C24H23FN4O2
2-[4-(4-Fluorophenyl)piperazin-1-yl]-7-(2-hydroxyphenyl)-4-methyl-7,8-dihydroquinazolin-5(6H)-one chemical structure, C25H25FN4O2, CAS 925194-10-1
2-[4-(4-Fluorophenyl)piperazin-1-yl]-7-(2-hydroxyphenyl)-4-methyl-7,8-dihydroquinazolin-5(6H)-one
CAS 925194-10-1C25H25FN4O2
7-(2-Hydroxyphenyl)-2-{4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}-7,8-dihydroquinazolin-5(6H)-one chemical structure, C25H23F3N4O2, CAS 878993-33-0
7-(2-Hydroxyphenyl)-2-{4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}-7,8-dihydroquinazolin-5(6H)-one
CAS 878993-33-0C25H23F3N4O2
7-(2-Hydroxyphenyl)-2-[4-(4-methoxyphenyl)piperazin-1-yl]-7,8-dihydroquinazolin-5(6H)-one chemical structure, C25H26N4O3, CAS 907972-52-5
7-(2-Hydroxyphenyl)-2-[4-(4-methoxyphenyl)piperazin-1-yl]-7,8-dihydroquinazolin-5(6H)-one
CAS 907972-52-5C25H26N4O3
2-[4-(2-Fluorophenyl)piperazin-1-yl]-7-(2-hydroxyphenyl)-4-methyl-7,8-dihydroquinazolin-5(6H)-one chemical structure, C25H25FN4O2, CAS 908555-86-2
2-[4-(2-Fluorophenyl)piperazin-1-yl]-7-(2-hydroxyphenyl)-4-methyl-7,8-dihydroquinazolin-5(6H)-one
CAS 908555-86-2C25H25FN4O2
7-(2,4-Dimethoxyphenyl)-2-[4-(4-methoxyphenyl)piperazin-1-yl]-7,8-dihydroquinazolin-5(6H)-one chemical structure, C27H30N4O4, CAS 925015-77-6
7-(2,4-Dimethoxyphenyl)-2-[4-(4-methoxyphenyl)piperazin-1-yl]-7,8-dihydroquinazolin-5(6H)-one
CAS 925015-77-6C27H30N4O4
7-(2-Hydroxyphenyl)-2-[4-(3-methoxyphenyl)piperazin-1-yl]-7,8-dihydroquinazolin-5(6H)-one chemical structure, C25H26N4O3, CAS 908555-81-7
7-(2-Hydroxyphenyl)-2-[4-(3-methoxyphenyl)piperazin-1-yl]-7,8-dihydroquinazolin-5(6H)-one
CAS 908555-81-7C25H26N4O3
2-[4-(4-Fluorophenyl)piperazin-1-yl]-7-(2-hydroxyphenyl)-7,8-dihydroquinazolin-5(6H)-one chemical structure, C24H23FN4O2, CAS 908555-84-0
2-[4-(4-Fluorophenyl)piperazin-1-yl]-7-(2-hydroxyphenyl)-7,8-dihydroquinazolin-5(6H)-one
CAS 908555-84-0C24H23FN4O2
7-(2-Hydroxyphenyl)-4-methyl-2-(4-phenylpiperazin-1-yl)-7,8-dihydroquinazolin-5(6H)-one chemical structure, C25H26N4O2, CAS 920486-25-5
7-(2-Hydroxyphenyl)-4-methyl-2-(4-phenylpiperazin-1-yl)-7,8-dihydroquinazolin-5(6H)-one
CAS 920486-25-5C25H26N4O2