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Murcko scaffold

Ring system with 3 rings and 18 atoms

12 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
18
Chemicals
12
With full pages
3
Scaffold SMILES

O=C(Nc1cccs1)C1COc2ccccc2O1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(Nc1cccs1)C1COc2ccccc2O1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 12 of 12 chemicals

Ethyl 5-acetyl-2-[(2,3-dihydro-1,4-benzodioxin-2-ylcarbonyl)amino]-4-methylthiophene-3-carboxylate chemical structure, C19H19NO6S, CAS 301304-94-9
Ethyl 5-acetyl-2-[(2,3-dihydro-1,4-benzodioxin-2-ylcarbonyl)amino]-4-methylthiophene-3-carboxylate
CAS 301304-94-9C19H19NO6S
Ethyl 2-[(2,3-dihydro-1,4-benzodioxin-2-ylcarbonyl)amino]-4,5-dimethylthiophene-3-carboxylate chemical structure, C18H19NO5S, CAS 302803-43-6
Ethyl 2-[(2,3-dihydro-1,4-benzodioxin-2-ylcarbonyl)amino]-4,5-dimethylthiophene-3-carboxylate
CAS 302803-43-6C18H19NO5S
Methyl 4,5-dimethyl-2-(3-methyl-2,3-dihydrobenzo[b][1,4]dioxine-2-carboxamido)thiophene-3-carboxylate chemical structure, C18H19NO5S, CAS 874464-79-6
Methyl 4,5-dimethyl-2-(3-methyl-2,3-dihydrobenzo[b][1,4]dioxine-2-carboxamido)thiophene-3-carboxylate
CAS 874464-79-6C18H19NO5S
N-(3-(Methylcarbamoyl)thiophen-2-yl)-2,3-dihydrobenzo[b][1,4]dioxine-2-carboxamide chemical structure, C15H14N2O4S, CAS 864974-75-4
N-(3-(Methylcarbamoyl)thiophen-2-yl)-2,3-dihydrobenzo[b][1,4]dioxine-2-carboxamide
CAS 864974-75-4C15H14N2O4S
Methyl 2-(2,3-dihydro-1,4-benzodioxine-3-carbonylamino)thiophene-3-carboxylate chemical structure, C15H13NO5S, CAS 888412-92-8
Methyl 2-(2,3-dihydro-1,4-benzodioxine-3-carbonylamino)thiophene-3-carboxylate
CAS 888412-92-8C15H13NO5S
Methyl 2-(2,3-dihydro-1,4-benzodioxine-3-carbonylamino)-4,5-dimethylthiophene-3-carboxylate chemical structure, C17H17NO5S, CAS 868153-65-5
Methyl 2-(2,3-dihydro-1,4-benzodioxine-3-carbonylamino)-4,5-dimethylthiophene-3-carboxylate
CAS 868153-65-5C17H17NO5S
Methyl N-[2-(2,3-dihydro-1,4-benzodioxine-2-amido)-4,5-dimethylthiophene-3-carbonyl]carbamate chemical structure, C18H18N2O6S, CAS 896309-30-1
Methyl N-[2-(2,3-dihydro-1,4-benzodioxine-2-amido)-4,5-dimethylthiophene-3-carbonyl]carbamate
CAS 896309-30-1C18H18N2O6S
N-(3-Carbamoyl-4,5-dimethylthiophen-2-yl)-2,3-dihydrobenzo[b][1,4]dioxine-2-carboxamide chemical structure, C16H16N2O4S, CAS 896310-09-1
N-(3-Carbamoyl-4,5-dimethylthiophen-2-yl)-2,3-dihydrobenzo[b][1,4]dioxine-2-carboxamide
CAS 896310-09-1C16H16N2O4S
N-[4,5-Dimethyl-3-(methylcarbamoyl)thiophen-2-yl]-2,3-dihydro-1,4-benzodioxine-2-carboxamide chemical structure, C17H18N2O4S, CAS 896299-32-4
N-[4,5-Dimethyl-3-(methylcarbamoyl)thiophen-2-yl]-2,3-dihydro-1,4-benzodioxine-2-carboxamide
CAS 896299-32-4C17H18N2O4S
N-(3-Cyano-4,5-dimethylthiophen-2-yl)-2,3-dihydro-1,4-benzodioxine-2-carboxamide chemical structure, C16H14N2O3S, CAS 896304-53-3
N-(3-Cyano-4,5-dimethylthiophen-2-yl)-2,3-dihydro-1,4-benzodioxine-2-carboxamide
CAS 896304-53-3C16H14N2O3S
N-(3-Carbamoylthiophen-2-yl)-3-methyl-2,3-dihydrobenzo[b][1,4]dioxine-2-carboxamide chemical structure, C15H14N2O4S, CAS 1172833-46-3
N-(3-Carbamoylthiophen-2-yl)-3-methyl-2,3-dihydrobenzo[b][1,4]dioxine-2-carboxamide
CAS 1172833-46-3C15H14N2O4S
3-Methyl-N-(3-(methylcarbamoyl)thiophen-2-yl)-2,3-dihydrobenzo[b][1,4]dioxine-2-carboxamide chemical structure, C16H16N2O4S, CAS 1170833-20-1
3-Methyl-N-(3-(methylcarbamoyl)thiophen-2-yl)-2,3-dihydrobenzo[b][1,4]dioxine-2-carboxamide
CAS 1170833-20-1C16H16N2O4S